Prominent publications by Pierre‐François Plouin

KOL Index score: 18972

BACKGROUND: Conflicting blood pressure-lowering effects of catheter-based renal artery denervation have been reported in patients with resistant hypertension. We compared the ambulatory blood pressure-lowering efficacy and safety of radiofrequency-based renal denervation added to a standardised stepped-care antihypertensive treatment (SSAHT) with the same SSAHT alone in patients with resistant hypertension.

METHODS: The Renal Denervation for Hypertension (DENERHTN) trial was a ...

Also Ranks for: Renal Denervation |  resistant hypertension |  antihypertensive treatment |  6 months |  ssaht patients
KOL Index score: 14486

PURPOSE: To assess the yield and the clinical value of systematic screening of susceptibility genes for patients with pheochromocytoma (pheo) or functional paraganglioma (pgl).

PATIENTS AND METHODS: We studied 314 patients with a pheo or a functional pgl, including 56 patients having a family history and/or a syndromic presentation and 258 patients having an apparently sporadic presentation. Clinical data and blood samples were collected, and all five major pheo-pgl susceptibility genes ...

Also Ranks for: Genetic Testing |  functional paraganglioma |  patients pheo |  vhl ret |  sdhb sdhd
KOL Index score: 12734

CONTEXT: Pheochromocytoma-paraganglioma syndrome is caused by mutations in SDHB, SDHC, and SDHD, encoding subunits of succinate dehydrogenase (SDH), and in SDHAF2, required for flavination of SDHA. A recent report described a patient with an abdominal paraganglioma, immunohistochemically negative for SDHA, and identified a causal germline mutation in SDHA.

OBJECTIVE: In this study, we evaluated the significance of SDHA immunohistochemistry in the identification of new patients with SDHA ...

Also Ranks for: Germline Sdha |  gene mutations |  sequence analysis |  immunohistochemistry loss |  pheochromocytoma paraganglioma
KOL Index score: 12493

BACKGROUND: Head and neck paragangliomas (HNPs) occur as sporadic or familial entities, the latter mostly in association with germline mutations of the SDHB, SDHC, or SDHD (SDHx) genes. Heritable non-SDHx HNP might occur in von Hippel-Lindau disease (VHL, VHL gene), multiple endocrine neoplasia type 2 (MEN2, RET gene), and neurofibromatosis type 1 (NF1, NF1 gene). Reports of non-SDHx HNP presentations are scarce and guidance for genetic testing nonexistent.


Also Ranks for: Neck Paragangliomas |  neoplasia type |  lindau disease |  mutations patients |  vhl gene
KOL Index score: 11973

OBJECTIVE: To investigate a possible involvement of polymorphisms of the renin-angiotensin system in predisposition to moderate and severe hypertension and their relationship to parental histories of myocardial infarction and stroke.

METHODS: Hypertensive cases (453 men, 326 women) were patients followed up by general practitioners for established hypertension. Inclusion criteria were an age of onset of hypertension < or = 60 years and a diastolic blood pressure > or = 105 mmHg without ...

Also Ranks for: Myocardial Infarction |  gene polymorphisms |  type 1 receptor |  predisposition hypertension |  ace angiotensin
KOL Index score: 11784

OBJECTIVES: The aim of this report was to show that the rate of cardiovascular events is increased in patients with either subtype of primary aldosteronism (PA).

BACKGROUND: Primary aldosteronism involves hypertension (HTN), hypokalemia, and low plasma renin. The two major PA subtypes are unilateral aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia.

METHODS: During a three-year period, the diagnosis of PA was made in 124 of 5,500 patients referred for comprehensive ...

Also Ranks for: Cardiovascular Events |  primary aldosteronism |  patients pa |  clinical characteristics |  hypertension eht
KOL Index score: 11163

CONTEXT: Germline mutations in SDHx genes cause hereditary paraganglioma.

OBJECTIVE: The aim of the study was to assess the indications for succinate dehydrogenase (SDH) genetic testing in a prospective study.

DESIGN: A total of 445 patients with head and neck and/or thoracic-abdominal or pelvic paragangliomas were recruited over 5 yr in 20 referral centers. In addition to classical direct sequencing of the SDHB, SDHC, and SDHD genes, two methods for detecting large genomic deletions or ...

Also Ranks for: Genetic Testing |  succinate dehydrogenase |  sdhb sdhd |  patients mutations |  head neck
KOL Index score: 11025

Pheochromocytomas are catecholamine-producing tumors which are generally benign, but which can also present as or develop into malignancy. Molecular pathways of malignant transformation remain poorly understood. Pheochromocytomas express various trophic peptides which may influence tumoral cell behavior. Here, we investigated the expression of trophic amidated peptides, including pituitary adenylate cyclase-activating polypeptide (PACAP), neuropeptide Y (NPY), and adrenomedullin (AM), ...

Also Ranks for: Malignant Pheochromocytomas |  adrenomedullin receptors |  trophic peptides |  benign tumors |  npy pacap
KOL Index score: 10980

Hereditary paragangliomas are usually benign tumors of the autonomic nervous system that are composed of cells derived from the primitive neural crest. Even though three genes (SDHD, SDHC, and SDHB), which encode three protein subunits of cytochrome b of complex II in the mitochondrial respiratory chain, have been identified, the molecular mechanisms leading to tumorigenesis are unknown. We studied a family in which the father and his eldest son had bilateral neck paragangliomas, whereas ...

Also Ranks for: Sdhd Gene |  hereditary paraganglioma |  hypoxia pathway |  enzymatic activity |  respiratory chain
KOL Index score: 10691

We report the first administration of an orally active aldosterone synthase inhibitor, LCI699, to 14 patients with primary aldosteronism. After a 2-week placebo run-in, patients received oral LCI699 (0.5 mg BID) for 2 weeks, LCI699 (1.0 mg BID) for 2 weeks, and placebo for 1 week. We assessed changes in hormone concentrations, plasma potassium levels, and 24-hour ambulatory systolic blood pressure and safety. The supine plasma aldosterone concentration decreased from 540 pmol/L (95% CI: ...

Also Ranks for: Aldosterone Synthase |  primary aldosteronism |  mm hg lci699 |  blood pressure |  adrenocorticotropic hormone
KOL Index score: 10519

CONTEXT: Pheochromocytoma and paraganglioma are rare neural-crest-derived tumors. They are metastatic in 15% of cases, and the identification of a germline mutation in the SDHB gene is a predictive risk factor for malignancy and poor prognosis. To date, the link between SDHB mutations and malignancy is still missing.

OBJECTIVE: Epithelial to mesenchymal transition (EMT) is a developmental event, reactivated in cancer cells to promote cell mobility and invasiveness. The aim of this study ...

Also Ranks for: Mesenchymal Transition |  sdhb gene |  metastatic tumors |  transcription factors |  paraganglioma pheochromocytoma

Key People For Primary Aldosteronism

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Pierre‐François Plouin:Expert Impact

Concepts for whichPierre‐François Plouinhas direct influence:Primary aldosteronism,  Blood pressure,  Fibromuscular dysplasia,  Renal artery,  Hypertensive patients,  Essential hypertension,  Serum potassium,  Resistant hypertension.

Pierre‐François Plouin:KOL impact

Concepts related to the work of other authors for whichfor which Pierre‐François Plouin has influence:Primary aldosteronism,  Blood pressure,  Renal artery,  Resistant hypertension,  Fibromuscular dysplasia,  Hypertensive patients,  Succinate dehydrogenase.



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Assistance-publique-hôpitaux de Paris, Department of Hypertension, Hopital Européen Georges Pompidou, Paris, France | Université de Paris, INSERM U970, Paris Cardiovascular Research Centre, Integrative Epidemiology of cardiovascular disease, Paris, F