Prominent publications by Umberto Gianelli

KOL Index score: 11980

The diagnosis of an underlying chronic myeloproliferative disorder (CMPD) is often problematic in patients with primary extrahepatic portal vein obstruction (EHPVO) or Budd-Chiari syndrome (BCS); indeed, conventional clinical and hematological parameters usually yield insufficient information. To assess the diagnostic contribution of the gain-of-function mutation V617F of the JAK2 gene, 93 patients with EHPVO or BCS were investigated. JAK2 V617F was identified in 35.6% of 73 patients ...

Also Ranks for: Jak2 Mutation |  splanchnic vein thrombosis |  ehpvo bcs |  chronic myeloproliferative |  test diagnosis
KOL Index score: 11749

AIMS: The authors investigated vascular endothelial growth factor receptor 1 (VEGFR-1) protein expression in a series of Philadelphia chromosome-negative myeloproliferative neoplasms (Ph- MPNs) and its correlations with microvessel density (MVD) and vascular endothelial growth factor (VEGF).

METHODS: 83 bone marrow biopsies of Ph- MPNs patients, including 27 essential thrombocythaemia (ET), 21 polycythaemia vera (PV) and 35 primary myelofibrosis (PMF), and 10 normal controls (NCs) were ...

Also Ranks for: Vascular Endothelial |  growth factor |  microvessel density |  vegf vegfr1 |  myeloproliferative neoplasms
KOL Index score: 10913

OBJECTIVE: Inflammatory bowel diseases are characterized by disorders of immunity, thrombosis of large vessels, and microthrombosis of mucosal vessels. The expression of endothelial protein C receptor (EPCR) and thrombomodulin-two receptors of the protein C pathway involved in thrombin scavenging and inflammation-was studied in intestinal resection specimens or mucosal biopsies from patients with inflammatory bowel disease and from controls. The soluble forms of the receptors in plasma ...

Also Ranks for: Inflammatory Bowel Disease |  endothelial protein |  epcr thrombomodulin |  aged antigens |  ulcerative colitis
KOL Index score: 10428

Alemtuzumab is active in chronic lymphocytic leukaemia (CLL) patients refractory to alkylators and fludarabine. The aim of this study was to determine the efficacy and safety of subcutaneous alemtuzumab at low dose (10 mg three times per week, for 18 weeks) to 49 patients with pre-treated CLL. The overall response rate was 53%, including 27% of complete responses; it was 42% in patients over 70 years, and 54% in the fludarabine-resistant patients. Forty-five percent of the patients with ...

Also Ranks for: Alemtuzumab Antibodies |  chronic lymphocytic |  low dose |  cll patients |  18 weeks
KOL Index score: 9573

Approximately one-fourth of patients with essential thrombocythemia or primary myelofibrosis carry a somatic mutation of the calreticulin gene (CALR), the gene encoding for calreticulin. A 52-bp deletion (type I mutation) and a 5-bp insertion (type II mutation) are the most frequent genetic lesions. The mechanism(s) by which a CALR mutation leads to a myeloproliferative phenotype has been clarified only in part. We studied the interaction between calreticulin and store-operated calcium ...

Also Ranks for: Mutant Calreticulin |  myeloproliferative neoplasms |  megakaryocytes mks |  calr mutation |  essential thrombocythemia
KOL Index score: 9488

BACKGROUND AND OBJECTIVES: This study explored variations in the clinical manifestations of intravascular lymphoma (IVL) on the bases of the association with hemophagocytosis and the country where the diagnosis was made.

DESIGN AND METHODS: The clinical features of 50 Western patients with IVL were compared with those of 123 patients with IVL diagnosed in Eastern countries (87 diagnosed in Japan and 36 in other Asian countries), previously reported in English literature, and collected by ...

Also Ranks for: Intravascular Lymphoma |  clinical presentation |  large bcell |  western patients |  continental ancestry
KOL Index score: 9126

Breast implant-associated anaplastic large cell lymphoma is a new provisional entity in the revised World Health Organization classification of lymphoid malignancies, the pathogenesis and cell of origin of which are still unknown. We performed gene expression profiling of microdissected breast implant-associated anaplastic large cell lymphoma samples and compared their transcriptional profiles with those previously obtained from normal T-cells and other peripheral T-cell lymphomas and ...

Also Ranks for: Large Cell |  breast implant |  anaplastic lymphoma |  transcriptional analysis |  molecular profiles
KOL Index score: 8761

We investigated the relationship between the International Prognostic Scoring System of the International Working Group for Myelofibrosis Research and Treatment and the European Consensus on grading of bone marrow fibrosis (MF) in patients with primary myelofibrosis. We compared them in 196 consecutive primary myelofibrosis patients (median follow-up 45.7 months; range 7.4–159). International Prognostic Scoring System classified 42 cases as low risk, 73 as intermediate risk-1, 69 as ...

Also Ranks for: Bone Marrow |  primary myelofibrosis |  european consensus |  mf patients |  prognostic scoring
KOL Index score: 8125

The expression of zeta-associated protein 70 (ZAP-70) in chronic lymphocytic leukemia (CLL) seems to correlate with the mutational status of the immunoglobulin heavy-chain variable-region genes, clinical course and patient prognosis. The aim was to determine the prognostic significance of the immunohistochemical expression of ZAP-70 protein in CLL by means of the long-term follow-up of 108 patients. This study identified 3 patterns of ZAP-70 immunoreactivity: negative (58 patients, 54%), ...

Also Ranks for: Chronic Lymphocytic |  prognostic marker |  zap70 protein |  cll patients |  mutational status
KOL Index score: 7370

Increased angiogenesis has been demonstrated to be a significant prognostic factor in many solid tumors. In the oncohematological setting, it has been associated with myelodysplastic syndromes (MDS), chronic myeloid leukemia, acute lymphoid, and myeloid leukemias. Recently, increased circulating endothelial cells (CECs) have been associated with breast cancer and non-Hodgkin lymphoma (NHL). Based on these premises we analysed total and activated CECs, and endothelial precursors (CEPs) in ...

Also Ranks for: Myelodysplastic Syndromes |  endothelial cells |  peripheral blood |  cecs ceps |  bone marrow
KOL Index score: 7244

We examined microvessel density (MVD) and immunohistochemical expression of vascular endothelial growth factor (VEGF) in the bone marrow biopsy specimens of 98 patients with Philadelphia chromosome-negative (Ph-) chronic myeloproliferative disorders (CMPDs). There were significantly more MVD "hot spots" in chronic idiopathic myelofibrosis (CIMF; mean +/- SD, 25.6 +/- 6.3) and polycythemia vera (PV; 20.7 +/- 10.2) cases than in essential thrombocythemia (ET) cases (10.1 +/- 4.5) and ...

Also Ranks for: Microvessel Density |  vegf expression |  myeloproliferative disorders |  bone marrow |  philadelphia chromosome
KOL Index score: 7185

The World Health Organization classification of myelodysplastic syndromes (MDS) is based on morphological evaluation of marrow dysplasia. We performed a systematic review of cytological and histological data from 1150 patients with peripheral blood cytopenia. We analyzed the frequency and discriminant power of single morphological abnormalities. A score to define minimal morphological criteria associated to the presence of marrow dysplasia was developed. This score showed high ...

Also Ranks for: Marrow Dysplasia |  myelodysplastic syndromes |  health organization mds |  myeloid neoplasms |  ring sideroblasts
KOL Index score: 7168

It has been suggested that polycythemia vera (PV) could be preceded by an "early" phase of the disease (e-PV), in which the increase in the red cell parameters is lower than required for a PV diagnosis. In this study, we compared the clinicopathologic and molecular features of 17 patients with e-PV with those of 14 patients with essential thrombocythemia (ET) and 19 with PV. The results for e-PV were more similar to those for PV than for ET. In fact, patients with e-PV were characterized ...

Also Ranks for: Polycythemia Vera |  essential thrombocythemia |  jak2v617f mutation |  bone marrow |  differential diagnosis

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Umberto Gianelli:Expert Impact

Concepts for whichUmberto Gianellihas direct influence:Bone marrow,  Primary myelofibrosis,  Myeloproliferative neoplasms,  Essential thrombocythemia,  Myeloid neoplasms,  European consensus,  Systemic mastocytosis,  Multiple myeloma.

Umberto Gianelli:KOL impact

Concepts related to the work of other authors for whichfor which Umberto Gianelli has influence:Bone marrow,  Myeloproliferative neoplasms,  Cell lymphoma,  Primary myelofibrosis,  Myelodysplastic syndromes,  Polycythemia vera,  Essential thrombocythemia.



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Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy | Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy;, | Department of Pathophysiology and Transpla