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  • Richard J Maunder

    Prominent publications by Richard J Maunder

    KOL Index score: 15466

    A plasma lipopolysaccharide (LPS)-binding protein (LBP) has been shown to regulate the response of rabbit peritoneal macrophages and human blood monocytes to endotoxin (LPS). We investigated whether LBP is present in lung fluids and the effects of LBP on the response of lung macrophages to LPS. Immunoreactive LBP was detectable in the lavage fluids of patients with the adult respiratory distress syndrome by immunoprecipitation followed by Western blotting, and also by specific ...

    Also Ranks for: Lps Lbp |  alveolar macrophages |  bacterial lipopolysaccharide |  tnf alpha |  antigens differentiation
    KOL Index score: 11096

    To characterize the evolution of inflammation in the adult respiratory distress syndrome (ARDS) and test the hypothesis that sustained alveolar inflammation is associated with a poor outcome in patients with ARDS, we performed fiberoptic bronchoscopy and bronchoalveolar lavage (BAL) in 125 patients and compared BAL cells and protein concentrations in survivors and nonsurvivors. ARDS followed sepsis syndrome in 35 patients, major trauma in 41, and other causes in 49. When possible, BAL ...

    Also Ranks for: Patients Ards |  adult respiratory |  distress syndrome |  bronchoalveolar lavage bal |  major trauma
    KOL Index score: 11078

    To determine the possible mechanism(s) promoting alveolar fibrin deposition in the adult respiratory distress syndrome (ARDS), we investigated the initiation and regulation of both fibrinolysis and coagulation from patients with ARDS (n = 14), at risk for ARDS (n = 5), and with interstitial lung diseases (ILD) (n = 8), and normal healthy individuals (n = 13). Bronchoalveolar lavage (BAL) extrinsic pathway inhibitor activity was increased in ARDS BAL compared with patients at risk for ...

    Also Ranks for: Fibrin Deposition |  respiratory distress |  patients ards |  plasminogen activator inhibitor |  bronchoalveolar lavage
    KOL Index score: 10474

    To determine the relationship between airspace cytokines and cellular inflammatory responses in patients with the acute respiratory distress syndrome (ARDS), we performed bronchoalveolar lavage (BAL) in 82 prospectively identified, mechanically ventilated patients on Days 3, 7, 14, and/or 21 after the onset of ARDS. We studied the relationships between bronchoalveolar lavage fluid (BALF) cell populations and the concentrations of two potent neutrophil (PMN) chemoattractants, ...

    Also Ranks for: Inflammatory Cytokines |  patients ards |  distress syndrome |  acute respiratory |  bronchoalveolar lavage
    KOL Index score: 10226

    To further understanding of the epidemiology of acute respiratory distress syndrome (ARDS), we prospectively identified 695 patients admitted to our intensive care units from 1983 through 1985 meeting criteria for seven clinical risks, and followed them for development of ARDS and eventual outcome. ARDS occurred in 179 of the 695 patients (26%). The highest incidence of ARDS occurred in patients with sepsis syndrome (75 of 176; 43%) and those with multiple emergency transfusions (> or = ...

    Also Ranks for: Clinical Risks |  respiratory distress syndrome |  patients trauma |  mortality ards |  female humans injuries
    KOL Index score: 10137

    STUDY OBJECTIVE: To determine the epidemiology of multiple organ failure (MOF) in patients with the adult respiratory distress syndrome.

    PATIENTS: We followed up 50 patients with serial determinations of respiratory and nonrespiratory organ function for seven days after diagnosis.

    DESIGN: Data were stratified between patients who died and those who survived (defined as hospital discharge).

    MEASUREMENTS AND RESULTS: Values that did not differ at any time between the two groups of patients ...

    Also Ranks for: Multiple Organ Failure |  distress syndrome |  adult respiratory |  groups patients |  multiorgan dysfunction
    KOL Index score: 9160

    Alveolar fibrin deposition commonly occurs in the lungs of patients with the adult respiratory distress syndrome (ARDS). Bronchoalveolar lavage (BAL) from patients with ARDS, control patients with interstitial lung disease (ILD), congestive heart failure, or exposure to hyperoxia, and normal healthy subjects was studied to determine whether local alterations in procoagulant activity favor alveolar fibrin deposition in the lungs in ARDS. Procoagulant activity capable of shortening the ...

    Also Ranks for: Tissue Factor |  patients ards |  procoagulant activity |  bronchoalveolar lavage bal |  alveolar fibrin deposition
    KOL Index score: 9106

    Although shown to be safe in many other lung disorders, the safety of fiberoptic bronchoscopy (FOB) with bronchoalveolar lavage (BAL) in critically ill patients with adult respiratory distress syndrome (ARDS) remains unproven. We conducted a prospective study to evaluate the safety of BAL in patients with ARDS. There were 438 patients with ARDS at our institution during the study period. Of these, 110 underwent FOB and BAL for either research or clinical purposes. Data were collected at ...

    Also Ranks for: Bronchoalveolar Lavage |  bal patients |  respiratory distress |  arterial pressure |  fiberoptic bronchoscopy
    KOL Index score: 8870

    Pulmonary infection is thought to be a common complication of ARDS. We undertook this prospective study to determine the incidence of pulmonary infection in patients with ARDS, and to evaluate the impact of nosocomial pneumonia on severity of ARDS and on survival. Two hundred one bronchoscopies were performed in 105 patients with ARDS with retrieval of distal airway secretions by bronchoalveolar lavage (BAL) and protected specimen brush (PSB). Whenever possible, bronchoscopy was ...

    Also Ranks for: Pulmonary Infection |  bal psb |  respiratory distress |  patients ards |  bacterial growth
    KOL Index score: 8774

    Pulmonary infections are a frequent cause of morbidity and mortality in patients with the adult respiratory distress syndrome (ARDS), but the reason is uncertain. Because neutrophils are important for lung defense and are found in increased numbers in the bronchoalveolar lavage fluid of patients with ARDS, we compared the functional activities of neutrophils obtained from lavage fluid and pulmonary artery blood of 28 patients shortly after the onset of ARDS. The lavage fluids contained ...

    Also Ranks for: Patients Ards |  distress syndrome |  blood neutrophils |  superoxide anion |  hydrogen peroxide
    KOL Index score: 8501

    The adult respiratory distress syndrome (ARDS) is characterized by increased neutrophils within the airspaces of the lungs. In order to determine if neutrophil activating protein (NAP)-1/interleukin-8 (NAP-1/IL-8) could be an important cause of neutrophil influx and activation in ARDS, we examined fluid, which was either directly aspirated or lavaged with saline from the lungs of patients with ARDS. NAP-1/IL-8 was present in significantly higher concentrations in the fluids of patients ...

    Also Ranks for: Patients Ards |  adult respiratory |  elevated levels |  distress syndrome |  airspaces lungs
    KOL Index score: 8437

    Prostaglandin E1 (PGE1) is currently being evaluated in clinical trials to determine its usefulness in the treatment of adult respiratory distress syndrome (ARDS). The drug is administered to ARDS patients by continuous intravenous infusion at dosage rates of up to 30 ng/kg/min for 7 days. The present study was conducted to determine the pulmonary extraction efficiency and pharmacokinetics of PGE1 under these conditions. Plasma levels of PGE1 were determined by high performance liquid ...

    Also Ranks for: Prostaglandin E1 |  adult respiratory |  ards patients |  continuous intravenous infusion |  plasma levels
    KOL Index score: 7371

    Prostaglandin E1 (PGE1) was compared to placebo in a 100-patient (50 PGE1, 50 placebo) randomized, double-blind, clinical trial to determine whether PGE1 therapy enhances survival of patients with adult respiratory distress syndrome (ARDS) when infused through a central line at 30 ng/kg/min continuously for seven days. At 30 days postinfusion, 30 PGE1 and 24 placebo patients had died. Total deaths judged to be related to the syndrome were 32 and 28 in the PGE1 and placebo groups ...

    Also Ranks for: Prostaglandin E1 |  distress syndrome |  adult respiratory |  placebo patients |  oxygen consumption
    KOL Index score: 7192

    We studied the changes of coagulation and fibrinolysis in bronchoalveolar lavage (BAL) and plasma obtained serially at intervals after the onset of adult respiratory distress syndrome (ARDS). BAL procoagulant activity was increased at 3 days and tended to decrease thereafter. Tissue factor associated with factor VII was the major BAL procoagulant. Fibrinopeptide A was increased, indicating increased thrombin-mediated conversion of fibrinogen to fibrin. Fibrinolytic activity was usually ...

    Also Ranks for: Fibrin Turnover |  respiratory distress |  bronchoalveolar lavage |  tissue factor |  syndrome ards


    Richard J Maunder: Influence Statistics

    Sample of concepts for which Richard J Maunder is among the top experts in the world.
    Concept World rank
    bals patients #1
    ards contained #1
    undetectable bal #1
    ards bronchoalveolar lavage #1
    ards bronchoalveolar #1
    fibrinolytic activity bal #2
    bal desmosine #2
    marmosets patients #2
    bal desmosine patients #2
    elasticspecific cross #2
    bal correlation #2
    local insufficiency #2
    ards bal patients #2
    lavage desmosine #2
    pathways predispose #2
    ards 40 #2
    patients bal #2
    ards low levels #2
    ards difference #2
    pmol 100 microliter #2
    ards bal samples #2
    bronchoalveolar lavage desmosine #2
    bal 14 patients #2
    desmosine bleomycin #2
    pf4 ratio bal #3
    interleukin8 airspaces #3
    btg ards patients #3
    fluids nap1 #3
    nap2 beta #3
    radioimmunoassay nap2 #3
    ards control patients #3
    higher concentrations pefs #3
    bal levels tsp #3
    thromboglobulin bronchoalveolar #3
    patients63 septic patients #3
    concentrations nap1 #3
    chf plasmas #3
    ards chf #3

    Key People For Patients Ards

    Top KOLs in the world
    Michael Anthony Matthay
    acute lung injury pulmonary edema respiratory distress
    Boyd Taylor Thompson
    acute lung injury septic shock distress syndrome
    Arthur S MD Slutsky
    mechanical ventilation lung injury respiratory distress
    Alan H Morris
    computerized protocols distress syndrome mechanical ventilation
    Gordon David Rubenfeld
    mechanical ventilation acute lung injury septic shock
    Leonard D Hudson
    acute lung injury patients ards distress syndrome

    Richard J Maunder:Expert Impact

    Concepts for whichRichard J Maunderhas direct influence:Patients ards,  Respiratory distress,  Distress syndrome,  Bronchoalveolar lavage,  Prostaglandin e1,  Adult respiratory,  Septic patients,  Ards patients.

    Richard J Maunder:KOL impact

    Concepts related to the work of other authors for whichfor which Richard J Maunder has influence:Acute lung injury,  Respiratory distress,  Mechanical ventilation,  Patients ards,  Bronchoalveolar lavage,  Pulmonary surfactant,  Subcutaneous emphysema.



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    Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Washington, Seattle, Washington, USA | Department of Medicine, University of Washington, Seattle, WA, USA | Department of Biochemistry, University of Tex