Edward Luciano Giovannucci

Edward Luciano Giovannucci

Channing Division Of Network Medicine, Department Of Medicine, Brigham And Women’s Hospital, Harvard Medical School, Boston, Massachusetts Department Of Nutrition, Harvard T. ...

Direct Impact

Concepts for which Edward Luciano Giovannucci has direct influence:

prostate cancer
physical activity
colorectal adenoma
professionals follow-up
alcohol consumption
telomere length

External impact

Concepts related to the work of other authors for which Edward Luciano Giovannucci has influence:

prostate cancer
physical activity
dietary fiber
european prospective investigation
telomere length
colorectal adenoma
insulin resistance

Prominent publications by Edward Luciano Giovannucci

KOL-Index: 214 Obesity is considered a chronic inflammatory state characterized by continued secretion of adipokines and cytokines. Experimental and epidemiological evidence indicates that circulating adipokines may be associated with the development of obesity-related cancers, but it is unclear if these associations are causal or confounded. We examined potential causal associations of specific adipokines ...
Known for
Inverse-Variance Weighted Models | Chronic Inflammatory | Genetic Adiponectin | 114 530 Cancer
KOL-Index: 120 BACKGROUND: Although 20 pancreatic cancer susceptibility loci have been identified through genome-wide association studies in individuals of European ancestry, much of its heritability remains unexplained and the genes responsible largely unknown. METHODS: To discover novel pancreatic cancer risk loci and possible causal genes, we performed a pancreatic cancer transcriptome-wide association ...
Known for
Loci Identified | Cancer Transcriptome | 12 496 | Fusion
KOL-Index: 117 Immunotherapy strategies targeting immune checkpoints such as the CTLA4 and CD274 (programmed cell death 1 ligand 1, PD-L1)/PDCD1 (programmed cell death 1, PD-1) T-cell coreceptor pathways are revolutionising oncology. The approval of pembrolizumab use for solid tumours with high-level microsatellite instability or mismatch repair deficiency by the US Food and Drug Administration highlights ...
Known for
Exogenous Endogenous | Immunology
KOL-Index: 116 Prostate cancer is a highly heritable disease with large disparities in incidence rates across ancestry populations. We conducted a multiancestry meta-analysis of prostate cancer genome-wide association studies (107,247 cases and 127,006 controls) and identified 86 new genetic risk variants independently associated with prostate cancer risk, bringing the total to 269 known risk variants. The ...
Known for
Approach | Differences | East Asian Ancestry | Rates
KOL-Index: 104 Epigenetics acts as an interface between environmental/exogenous factors, cellular responses, and pathological processes. Aberrant epigenetic signatures are a hallmark of complex multifactorial diseases (including neoplasms and malignancies such as leukemias, lymphomas, sarcomas, and breast, lung, prostate, liver, and colorectal cancers). Epigenetic signatures (DNA methylation, mRNA and ...
Known for
Epigenetic Signatures
KOL-Index: 103 Accurate colorectal cancer (CRC) risk prediction models are critical for identifying individuals at low and high risk of developing CRC, as they can then be offered targeted screening and interventions to address their risks of developing disease (if they are in a high-risk group) and avoid unnecessary screening and interventions (if they are in a low-risk group). As it is likely that ...
Known for
Crc Prediction Models | 2 Snp Selection | Derived | Prs History
KOL-Index: 102 BACKGROUND: Genome-wide association studies (GWAS) identify associations of individual single-nucleotide polymorphisms (SNPs) with cancer risk but usually only explain a fraction of the inherited variability. Pathway analysis of genetic variants is a powerful tool to identify networks of susceptibility genes. METHODS: We conducted a large agnostic pathway-based meta-analysis of GWAS data ...
Known for
Pathways Gene | Snps | Sets
KOL-Index: 99 INTRODUCTION: Statin use has been examined as a potential chemopreventive strategy against colorectal cancer (CRC). Previous studies have not been able to investigate this topic with adequate follow-up time or disentangle the effects of statin use and total cholesterol level. We investigated prospectively this topic. METHODS: Eligible participants (100,300 women and 47,991 men) in the ...
Known for
Distal Colon Cancer | Adequate Follow-Up Time | Potential Chemopreventive Strategy | Ratios Users
KOL-Index: 93 Dietary factors, including meat, fruits, vegetables and fiber, are associated with colorectal cancer; however, there is limited information as to whether these dietary factors interact with genetic variants to modify risk of colorectal cancer. We tested interactions between these dietary factors and approximately 2.7 million genetic variants for colorectal cancer risk among 9,287 cases and ...
Known for
Interaction Processed | Gg Genotype | Cancer Dietary | Vegetables
KOL-Index: 92 Genome-wide association studies (GWAS) have identified many genetic susceptibility loci for colorectal cancer (CRC). However, variants in these loci explain only a small proportion of familial aggregation, and there are likely additional variants that are associated with CRC susceptibility. Genome-wide studies of gene-environment interactions may identify variants that are not detected in ...
Known for
Subpopulations | Smoking Colorectal | Marginal Gene Effects | Genetics

Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, Massachusetts Department of Epidem

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