Prominent publications by Hans Christiansen

KOL Index score: 14827

A quantitative imaging biomarker is desirable to provide a comprehensive measure of whole-body tumor burden in patients with metastatic prostate cancer, and to standardize the evaluation of treatment-related changes. Therefore, we evaluated whether prostate-specific membrane antigen (PSMA) ligand PET/CT may be applied to provide PSMA-derived volumetric parameters for quantification of whole-body tumor burden. Methods: One hundred one patients who underwent 68Ga-PSMA I&T PET/CT because of ...

Kjent for Tumor Burden |  volumetric parameters |  prostate cancer |  psa levels |  imaging biomarker
KOL Index score: 14552

Purpose68Ga-labeled prostate-specific membrane antigen (PSMA) ligand positron emission tomography/computed tomography (PET/CT) has shown promising results in patients with biochemical recurrence after primary therapy for prostate cancer. In this study, we evaluated the usefulness of PSMA I&T (imaging and therapy) PET/CT prior to radical prostatectomy.MethodsThe study population consisted of 21 patients with prostate cancer who underwent 68Ga-PSMA I&T PET/CT before either open or ...

Kjent for Radical Prostatectomy |  psma pet |  prostate cancer |  seminal vesicle |  ece svi
KOL Index score: 14456

Triple-negative breast cancer (TNBC) is an aggressive form of breast carcinoma with a poor prognosis. Recent evidence suggests that some patients with TNBC harbour germ-line mutations in DNA repair genes which may render their tumours susceptible to novel therapies such as treatment with PARP inhibitors. In the present study, we have investigated a hospital-based series of 40 German patients with TNBC for the presence of germ-line mutations in BRCA1, BRCA2, PALB2, and BRD7 genes. ...

Kjent for Brca1 Brca2 |  negative breast |  estrogen receptors |  germline mutations |  palb2 mutation
KOL Index score: 14252

PurposeThe aim of this study was to assess the value of dual-time point imaging in PET/CT for detection of biochemically recurrent or persistent prostate cancer, using the prostate-specific membrane antigen (PSMA) ligand [68Ga]PSMA I&T.Methods240 patients who underwent a [68Ga]PSMA I&T PET/CT in the context of biochemical relapse of prostate cancer were included in this retrospective analysis. Imaging consisted of a standard whole-body PET/CT (1 h p.i.), followed by delayed (3 h p.i.) ...

Kjent for Biochemical Recurrence |  prostate cancer |  delayed imaging |  specific antigen |  detection rate
KOL Index score: 12629

PURPOSE: To prospectively analyze hepcidin, hemojuvelin, and ferroportin-1 expression after x-irradiation of rat liver and isolated rat hepatocytes.

MATERIALS AND METHODS: The treatment of the rats and this study were approved by the local committee and the public authority on animal welfare. Rat livers in vivo and isolated rat hepatocytes in vitro were irradiated. The total number of rats in this study was 43. RNA extracted from livers (1, 3, 6, 12, 24, and 48 hours after irradiation) ...

Kjent for Rat Liver |  gene expression |  irradiated hepatocytes |  radiation induced |  hepcidin hemojuvelin
KOL Index score: 12510

PURPOSE: To evaluate the efficacy of an adjuvant radiotherapy after transoral laser microsurgery for advanced squamous cell carcinoma of the head and neck and to show that a less invasive surgery with organ preservation in combination with radiotherapy is an alternative to a radical treatment.

PATIENTS AND METHODS: Between 1987 and 2000, 208 patients with advanced squamous cell carcinoma of the head and neck were treated with postoperative radiotherapy after surgical CO2 laser resection. ...

Kjent for Adjuvant Radiotherapy |  transoral laser microsurgery |  head neck |  carcinoma squamous |  neoplasms laser
KOL Index score: 12481

PURPOSE: To determine the patterns of progression after 68Ga prostate-specific membrane antigen (PSMA)-ligand positron emission tomography (PET)/computed tomography (CT)-guided radiation therapy (RT) for recurrent oligometastatic prostate cancer (PCa).

METHODS AND MATERIALS: One hundred and eight patients with increased prostate-specific antigen levels, who received 68Ga-PSMA-ligand PET/CT-guided RT for recurrent oligometastatic disease after primary therapy for PCa were included. The ...

Kjent for Recurrent Prostate Cancer |  ligand pet |  patterns progression |  radiation therapy |  patients biochemical
KOL Index score: 12152

OBJECTIVE: To report the oncologic and functional outcomes of transoral laser microsurgery (TLM) in the treatment of advanced laryngeal cancer.

DESIGN: Prospective case series study.

SETTING: Multi-institution (academic, tertiary referral centers).

PATIENTS: A total of 117 patients with pathologically confirmed T2 to T4 lesions, stage III or stage IV, glottic or supraglottic carcinoma of the larynx were treated with TLM from 1997 to 2004. All patients had a minimum follow-up period of 2 ...

Kjent for Advanced Laryngeal Cancer |  transoral laser microsurgery |  tlm patients |  local control |  2 years
KOL Index score: 11656

OBJECTIVE: Acute radiation proctitis is a relevant complication of pelvic radiation. The purpose of this study was to investigate two markers of gut inflammation as non-invasive diagnostic tools to evaluate acute radiation proctitis.

MATERIAL AND METHODS: Twenty patients who underwent radiotherapy for prostate cancer took part in this prospective study. Radiation-induced toxicity was evaluated weekly during radiotherapy in compliance with the CTC toxicity criteria. Stool samples from ...

Kjent for Radiation Proctitis |  faecal calprotectin |  prostate cancer |  patients radiotherapy |  lactoferrin leukocyte
KOL Index score: 11560

PurposeTo assess the differences in the target volume (TV) delineation of metachronous lymph node metastases between 68 Ga-PSMA ligand PET/CT and conventional imaging in a comparative retrospective contouring study.Patients and methodsTwenty-five patients with biochemical prostate cancer recurrence after primary prostatectomy underwent 68 Ga-PSMA ligand PET/CT in addition to conventional imaging techniques such as CT and/or MR imaging for restaging. All patients were diagnosed with at ...

Kjent for Prostate Cancer |  lymph node |  conventional imaging |  target volume delineation |  psma ligand
KOL Index score: 11382

BACKGROUND: Approximately 40-70% of biochemically recurrent prostate cancer (PCa) is oligorecurrent after prostate-specific membrane antigen (PSMA) positron emission tomography (PET) staging. Metastasis-directed radiotherapy (MDT) of PSMA-positive oligorecurrence is now frequently used, but the role of concurrent androgen deprivation therapy (ADT) remains unclear.

OBJECTIVE: To determine the effect of concurrent ADT with PSMA PET-directed MDT on biochemical progression-free survival ...

Kjent for Androgen Deprivation |  prostate cancer |  positron emission |  directed radiotherapy |  brfs mdt
KOL Index score: 10699

ObjectiveUrinary radiotracer excretion of 68Ga-Labelled prostate-specific membrane antigen (PSMA) ligands may complicate the assessment of the prostate region and differentiation of lymph nodes from ureteral activity. The aim of this study was to assess the value of delayed imaging after forced diuresis.Materials and methodsSixty-six patients underwent 68Ga-PSMA I&T PET/CT for evaluation of prostate cancer at 60 min post-injection. In subgroups of patients, this was amended by delayed ...

Kjent for Forced Diuresis |  delayed imaging |  prostate cancer |  image quality |  tracer injection
KOL Index score: 10654

Bloom’s syndrome is a rare autosomal recessive chromosomal instability disorder with a high incidence of various types of neoplasia, including breast cancer. Whether monoallelic BLM mutations predispose to breast cancer has been a long-standing question. A nonsense mutation, p.Q548X, has recently been associated with an increased risk for breast cancer in a Russian case–control study. In the present work, we have investigated the prevalence of this Slavic BLM founder mutation in a total ...

Kjent for Breast Cancer |  nonsense mutation |  bloom syndrome |  blm gene |  disease heterozygote humans
KOL Index score: 10636

PurposeThe goal of this work was to evaluate the early efficacy of 68Ga-PSMA ligand PET/CT imaging for radiotherapy of locally recurrent and/or oligometastatic prostate cancer.Patients and methodsA total of 29 patients with biochemical recurrence received a 68Ga-PSMA ligand PET/CT for restaging of disease, followed by 3D conformal radiotherapy of metastases or intensity-modulated radiation therapy of the prostate bed. Prostate-specific antigen (PSA) levels and imaging procedures served ...

Kjent for Ligand Pet |  locally recurrent |  radiotherapy patients |  oligometastatic prostate |  median followup
KOL Index score: 10527

Purpose[68Ga]Tris(hydroxypyridinone)(THP)-PSMA is a novel radiopharmaceutical for one-step kit-based radiolabelling, based on direct chelation of 68Ga3+ at low concentration, room temperature and over a wide pH range, using direct elution from a 68Ge/68Ga-generator. We evaluated the clinical detection rates of [68Ga]THP-PSMA PET/CT in patients with biochemically recurrent prostate cancer after prostatectomy.MethodsConsecutive patients (n=99) referred for evaluation of biochemical relapse ...

Kjent for Prostate Cancer |  pet imaging |  detection rates |  biochemical recurrence |  primary therapy

Nøkkelpersoner for Prostate Cancer

Toppkols i verden
Ahmedin * *****
united states breast cancer addis ababa
Peter * ********
prostate cancer active surveillance erectile function
Rebecca * ******
united states colorectal cancer incidence rates
Johnathan * ********
prostate cancer gleason score needle biopsy
Philip * *******
prostate cancer psma adc androgen deprivation therapy
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prostate cancer specific antigen pathological stage

Hans Christiansen:Ekspertvirkning

Konsepter somHans Christiansenhar direkte innflytelse:Prostate cancer,  Breast cancer,  Adjuvant radiotherapy,  Rectal cancer,  Acute toxicity,  Transoral laser microsurgery,  Kupffer cells,  Hepatocyte transplantation.

Hans Christiansen:Kol Impact

Konsepter relatert til arbeidet til andre forfattere somfor which Hans Christiansen har innflytelse:Breast cancer,  Radiation therapy,  Psma pet,  Nasopharyngeal carcinoma,  Transoral laser microsurgery,  Squamous cell,  Biochemical recurrence.



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Department of Radiation Oncology, Hanover Medical School, Hanover, Germany. | Clinic for Radiotherapy and Special Oncology of the Hannover Medical School, Hannover, Germany. | Klinik für Strahlentherapie und Spezielle Onkologie, Medizinische Hochschu