• Disease
  • Prostate
  • Prostate Cancer
  • James William Denham

    Prominent publications by James William Denham

    KOL Index score: 27253

    BACKGROUND: We investigated whether 18 months of androgen suppression plus radiotherapy, with or without 18 months of zoledronic acid, is more effective than 6 months of neoadjuvant androgen suppression plus radiotherapy with or without zoledronic acid.

    METHODS: We did an open-label, randomised, 2 × 2 factorial trial in men with locally advanced prostate cancer (either T2a N0 M0 prostatic adenocarcinomas with prostate-specific antigen [PSA] ≥10 μg/L and a Gleason score of ≥7, or T2b-4 N0 ...

    Also Ranks for: Zoledronic Acid |  androgen suppression |  gleason score |  prostate cancer |  18 months
    KOL Index score: 25311

    BACKGROUND: Adjuvant androgen suppression and bisphosphonates with escalating doses of radiotherapy might improve efficacy outcomes in men with locally advanced prostate cancer. In this study, we investigated whether these treatments had a detrimental effect on patient-reported-outcome (PRO) scores.

    METHODS: We undertook a phase 3 trial with a 2×2 factorial design in 23 centres in Australia and New Zealand in men with non-metastatic adenocarcinoma of the prostate (stage T2b-4 or T2a, ...

    Also Ranks for: Zoledronic Acid |  18 months |  prostate cancer |  stas itas |  new zealand
    KOL Index score: 19905

    BACKGROUND: The optimal duration of androgen suppression for men with locally advanced prostate cancer receiving radiotherapy with curative intent is yet to be defined. Zoledronic acid is effective in preventing androgen suppression-induced bone loss, but its role in preventing castration-sensitive bone metastases in locally advanced prostate cancer is unclear. The RADAR trial assessed whether the addition of 12 months of adjuvant androgen suppression, 18 months of zoledronic acid, or ...

    Also Ranks for: Zoledronic Acid |  androgen suppression |  prostate cancer |  18 months |  new zealand
    KOL Index score: 16821

    BACKGROUND: The TROG 96.01 trial assessed whether 3-month and 6-month short-term neoadjuvant androgen deprivation therapy (NADT) decreases clinical progression and mortality after radiotherapy for locally advanced prostate cancer. Here we report the 10-year results.

    METHODS: Between June, 1996, and February, 2000, 818 men with T2b, T2c, T3, and T4 N0 M0 prostate cancers were randomly assigned to receive radiotherapy alone, 3 months of NADT plus radiotherapy, or 6 months of NADT plus ...

    Also Ranks for: Neoadjuvant Androgen |  prostate cancer |  6 months |  neoplasms radiotherapy |  allcause mortality
    KOL Index score: 14393

    PURPOSE: To select one of two chemoradiotherapy regimens for locally advanced squamous cell carcinoma (SCC) of the head and neck as the experimental arm for the next Trans-Tasman Radiation Oncology Group phase III trial.

    PATIENTS AND METHODS: One hundred twenty-two previously untreated patients with stage III/IV SCC of the head and neck were randomized to receive definitive radiotherapy (70 Gy in 7 weeks) concurrently with either cisplatin (75 mg/m(2)) plus tirapazamine (290 mg/m(2)/d) ...

    Also Ranks for: Tpz Cis |  neck cancer |  locally advanced head |  radiation oncology |  7 weeks
    KOL Index score: 14373

    BACKGROUND: Long-term prostate cancer (PCa) survivors are at increased risk for comorbidities and physical deconditioning.

    OBJECTIVE: To determine the effectiveness of a year-long randomised controlled trial of exercise training in PCa survivors >5 yr postdiagnosis on physical functioning.

    DESIGN, SETTING, AND PARTICIPANTS: Between 2010 and 2011, 100 long-term PCa survivors from Trans-Tasman Radiation Oncology Group 03.04 Randomised Androgen Deprivation and Radiotherapy previously ...

    Also Ranks for: Physical Function |  exercise training |  androgen suppression |  muscle strength |  prostate cancer
    KOL Index score: 13871

    PURPOSE: Prostate radiation therapy dose planning directly on magnetic resonance imaging (MRI) scans would reduce costs and uncertainties due to multimodality image registration. Adaptive planning using a combined MRI-linear accelerator approach will also require dose calculations to be performed using MRI data. The aim of this work was to develop an atlas-based method to map realistic electron densities to MRI scans for dose calculations and digitally reconstructed radiograph (DRR) ...

    Also Ranks for: Based Prostate |  resonance imaging |  electron density |  mri scans |  computerassisted radiotherapy
    KOL Index score: 13112

    BACKGROUND: The Meta-Analysis of Radiotherapy in squamous cell Carcinomas of Head and neck (MARCH) showed that altered fractionation radiotherapy is associated with improved overall and progression-free survival compared with conventional radiotherapy, with hyperfractionated radiotherapy showing the greatest benefit. This update aims to confirm and explain the superiority of hyperfractionated radiotherapy over other altered fractionation radiotherapy regimens and to assess the benefit of ...

    Also Ranks for: Fractionation Radiotherapy |  head neck |  concomitant chemotherapy |  10 years |  squamous cell
    KOL Index score: 13104

    PURPOSE: The aims of this randomized controlled trial were to determine whether there were differences in the disease-free survival (DFS) and toxicity between conventional radiotherapy (CRT) and a continuous 3 week accelerated radiotherapy regimen (ART) in stage III and IV squamous cell carcinoma of the oral cavity, oropharynx, larynx and hypopharynx.

    PATIENTS AND METHODS: Patients from 14 centres throughout Australia and New Zealand were randomly assigned to either CRT, using a single 2 ...

    Also Ranks for: Conventional Radiotherapy |  stage iii |  randomised trial |  late effects |  locoregional control
    KOL Index score: 13091

    BACKGROUND: Androgen suppression therapy and radiotherapy are used to treat locally advanced prostate cancer. 3 years of androgen suppression confers a small survival benefit compared with 6 months of therapy in this setting, but is associated with more toxic effects. Early identification of men in whom radiotherapy and 6 months of androgen suppression is insufficient for cure is important. Thus, we assessed whether prostate-specific antigen (PSA) values can act as an early surrogate for ...

    Also Ranks for: Androgen Suppression |  prostate cancer |  6 months |  surrogate endpoints |  psa nadir
    KOL Index score: 12772

    BACKGROUND: Androgen deprivation is an established treatment regimen for disseminated prostate cancer; however, its role in patients with localised cancer is less clear. We did a large randomised controlled trial to determine whether 3 months or 6 months of androgen deprivation given before and during radiotherapy improves outcomes for patients with locally advanced prostate cancer.

    METHODS: 818 men with locally advanced prostate cancer were randomly assigned to: no androgen deprivation ...

    Also Ranks for: Androgen Deprivation |  advanced prostate |  diseasefree survival |  salvage treatment |  controlled trial
    KOL Index score: 11630

    BACKGROUND: Surrogate endpoints for prostate cancer-specific mortality after curative primary treatment are not well established. We sought to assess time to biochemical failure (TTBF) and prostate-specific antigen doubling time (PSADT) after failure of curative treatment as candidates for this endpoint.

    METHODS: PSA and survival data from the Trans-Tasman Radiation Oncology Group (TROG) 96.01 trial were used to assess surrogate candidates. Between June 28, 1996, and Feb 16, 2000, 802 ...

    Also Ranks for: Biochemical Failure |  specific mortality |  prostate cancer |  time psadt |  prentice criteria
    KOL Index score: 11316

    BACKGROUND AND PURPOSE: A limited number of studies have suggested that oral sucralfate reduces the acute and late gastro-intestinal side-effects of pelvic radiotherapy and sucralfate enemas ameliorate symptoms of chronic proctitis. Sucralfate may act via local bFGF at the mucosal level in promoting angiogenesis and reducing epithelial associated microvascular injury. This multi-institutional study was designed to test the hypothesis that sucralfate given as an enema would have a ...

    Also Ranks for: Acute Radiation |  rectal sucralfate |  daily enema |  randomised study |  pelvic radiotherapy
    KOL Index score: 11309

    BACKGROUND: Resection remains the best treatment for carcinoma of the oesophagus in terms of local control, but local recurrence and distant metastasis remain an issue after surgery. We aimed to assess whether a short preoperative chemoradiotherapy regimen improves outcomes for patients with resectable oesophageal cancer.

    METHODS: 128 patients were randomly assigned to surgery alone and 128 patients to surgery after 80 mg/m(2) cisplatin on day 1, 800 mg/m(2) fluorouracil on days 1-4, ...

    Also Ranks for: Chemoradiotherapy Surgery |  progressionfree survival |  resectable oesophageal cancer |  subgroup analysis patients |  local control


    James William Denham: Influence Statistics

    Sample of concepts for which James William Denham is among the top experts in the world.
    Concept World rank
    noncontrast multiparametric mri #1
    mixture models distributions #1
    prostate cancer ijrobp #1
    prostate setup accuracy #1
    0304 #1
    decade mixture models #1
    9601 trial #1
    pyriform supraglottic #1
    surgical clips situ #1
    evaluable cases clips #1
    unhelpful psa‐testing debate #1
    margins bony #1
    blood biochemistry factors #1
    consistent predictor depressionanxiety #1
    9 mev beam #1
    pca survivors nature #1
    decade south australia #1
    cardia synchronous chemotherapy #1
    temporal lobe underpredictions #1
    total dose permutations #1
    australasian iii #1
    icru commentary #1
    dti models t2wi #1
    6month nadt arm #1
    prostate external #1
    predicted point doses #1
    distortion dose comparison #1
    rectal cancer conclusions #1
    consideration regard #1
    velocityai #1
    fldr teletherapy #1
    inflammation radiobiology topic #1
    pilot tld #1
    inflammation radiobiology #1
    supposedly identical treatments #1
    acute reaction parameters #1
    depths tld holder #1
    sites rfs #1
    geometric pelvic #1
    dosimetric intercomparison #1
    location excision site #1
    target critical organs #1
    loaded thermoluminescent #1
    perirectal space images #1
    pseudo scans #1
    prostate setup shifts #1
    rbv rfs #1
    contouring variations icc #1
    t2wi dti #1
    headandneck cancer data #1

    Key People For Prostate Cancer

    Top KOLs in the world
    Ahmedin M Jemal
    united states breast cancer addis ababa
    Peter T Scardino
    prostate cancer active surveillance erectile function
    Rebecca L Siegel
    united states colorectal cancer incidence rates
    Johnathan I Jonathan
    prostate cancer gleason score needle biopsy
    Philip W Kantoff
    prostate cancer psma adc androgen deprivation therapy
    prostate cancer specific antigen pathological stage

    James William Denham:Expert Impact

    Concepts for whichJames William Denhamhas direct influence:Prostate cancer,  Zoledronic acid,  Androgen suppression,  Radiation therapy,  Urinary symptoms,  Urinary dysfunction,  Biochemical failure,  Androgen deprivation.

    James William Denham:KOL impact

    Concepts related to the work of other authors for whichfor which James William Denham has influence:Prostate cancer,  Radiation therapy,  Androgen deprivation,  Squamous cell,  Quality life,  Head neck.



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    University of Newcastle, Callaghan, Australia; | School of Medicine and Public Health, University of Newcastle, Newcastle, NSW, Australia | Calvary Mater New Castle, Waratah, NSW, Australia | School of Medicine and Population Health, University of Ne