• Prostate Cancer
    • Johnathan I Jonathan
    • Johnathan I Jonathan: Influence Statistics

      Johnathan I Jonathan

      Johnathan I Jonathan

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      Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. | Department of Cell and Developmental Biology, Penn ...

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      Johnathan I Jonathan:Expert Impact

      Concepts for whichJohnathan I Jonathanhas direct influence:Prostate cancer,Radical prostatectomy,Gleason score,Needle biopsy,Active surveillance,Urothelial carcinoma,Urinary bladder,Specific antigen.

      Johnathan I Jonathan:KOL impact

      Concepts related to the work of other authors for whichfor which Johnathan I Jonathan has influence:Prostate cancer,Active surveillance,Gleason score,Stem cells,Specific antigen,Gene expression,Biochemical recurrence.

      KOL Resume for Johnathan I Jonathan


      Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.


      Department of Cell and Developmental Biology, Department of Medicine, Penn Cardiovascular Institute, Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia.

      The James Buchanan Brady Urological Institute, Johns Hopkins University School of Medicine, Baltimore, MD, USA



      Urology (Epstein), David Geffen School of Medicine at UCLA, Los Angeles, California (Huang).

      Department of Surgical Pathology, The Johns Hopkins Hospital, 1800 Orleans St, Baltimore, MD 21287, USA;, (C.D.);, (G.Z.);, (J.I.E.)

      Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD, USA

      Oncology, Johns Hopkins University School of Medicine, Baltimore, MD

      and Oncology (Epstein), The Johns Hopkins Medical Institutions, Baltimore, Maryland.


      Departments of Pathology, Urology, and Oncology, John Hopkins School of Medicine, Baltimore, MD

      Institute for Regenerative Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.


      Department of Cell and Developmental Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia


      Department of Medicine, Department of Cell and Developmental Biology, Institute for Regenerative Medicine, Penn Cardiovascular Institute, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA

      Urology, and Oncology, Johns Hopkins Medical Institutions, Baltimore, MD.

      Johns Hopkins University School of Medicine, Baltimore, MD;

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      Sample of concepts for which Johnathan I Jonathan is among the top experts in the world.
      Concept World rank
      gata3 uc #1
      prostate stump #1
      pafp metastatic lns #1
      carcinoma core #1
      specific immunomarker #1
      psma nkx31 #1
      cases florid hyperplasia #1
      subsequent radical prostatectomy #1
      grgp cribriform carcinoma #1
      nuclear morphometry prostate #1
      large consult service #1
      adenocarcinoma villous adenoma #1
      50 cancer #1
      tax‐3501 #1
      cystoscopic impression #1
      95 unfavourable pathology #1
      multivariate analysis gleason #1
      smooth neural crest #1
      ihc idcp #1
      gleason score grade #1
      pax3 neural #1
      tumor volume tumor #1
      pca colorectal biopsy #1
      neurovascular bundle tumor #1
      psma differential diagnosis #1
      prostate cases #1
      kidney anastomosing hemangioma #1
      equivocal cases mpvti #1
      adenocarcinoma cases #1
      nuclear roundness #1
      p63 amacr #1
      percent gp4 #1
      gleason cancer #1
      cases inverted hgpin #1
      unfavourable biopsy conversion #1
      contemporary grading #1
      secondary patterns #1
      transgenic mice hop #1
      bch squamous features #1
      needle biopsy rp #1
      gleason 7 status #1
      central zone histology #1
      male neoplasm prognosis #1
      cases hgpin #1
      orucut #1
      tumor emboli tumor #1
      cancer pathological stage #1
      extraprostatic #1
      papillary cystadenoma #1
      hmwck gata3 #1
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      Prominent publications by Johnathan I Jonathan

      KOL-Index: 75708

      PURPOSE: We investigated the relationship between the tertiary Gleason component in radical prostatectomy specimens and biochemical recurrence in what is to our knowledge the largest single institution cohort to date.

      MATERIALS AND METHODS: We evaluated data on 3,230 men who underwent radical prostatectomy at our institution from 2000 to 2005. Tertiary Gleason component was defined as Gleason grade pattern 4 or greater for Gleason score 6 and Gleason grade pattern 5 for Gleason score 7 ...

      Known for Tertiary Gleason | Biochemical Recurrence | Score 4 | Radical Prostatectomy | Specific Antigen
      KOL-Index: 24001

      OBJECTIVES: To determine the clinical significance of Gleason score 3+4 versus 4+3 on radical prostatectomy.

      METHODS: Of 2390 men who underwent radical prostatectomy by a single surgeon, 570 had Gleason score 7 tumors without lymph node metastasis, seminal vesicle invasion, or tertiary Gleason pattern 5. Patients were evaluated for biochemical recurrence (prostate-specific antigen progression) and distant metastases.

      RESULTS: Eighty percent of patients had Gleason score 3+4, 20% had 4+3. ...

      Known for Gleason Score | Radical Prostatectomy | 3 4 | Prognostic Significance | 7 Tumors
      KOL-Index: 23198

      In November, 2014, 65 prostate cancer pathology experts, along with 17 clinicians including urologists, radiation oncologists, and medical oncologists from 19 different countries gathered in a consensus conference to update the grading of prostate cancer, last revised in 2005. The major conclusions were: (1) Cribriform glands should be assigned a Gleason pattern 4, regardless of morphology; (2) Glomeruloid glands should be assigned a Gleason pattern 4, regardless of morphology; (3) ...

      Known for Gleason Grading | Prostatic Carcinoma | Pattern 4 | Urological Pathology | Consensus Conference
      KOL-Index: 22508

      Distinguishing invasive high-grade urothelial carcinoma (UC) from other carcinomas occurring in the genitourinary tract may be difficult. The differential diagnosis includes high-grade prostatic adenocarcinoma, spread from an anal squamous cell carcinoma (SCC), or spread from a uterine cervical SCC. In terms of metastatic UC, the most common problem is differentiating spread of UC to the lung from a primary pulmonary SCC. Immunohistochemical analysis (IHC) for GATA binding protein 3 ...

      Known for Gata3 Immunohistochemistry | Cell Carcinoma | Uroplakin Iii | Metastatic Uc | Lung Neoplasms
      KOL-Index: 22033

      If multiple biopsy cores contain prostate cancer with differing Gleason scores, should an overall Gleason score be assigned, or should each core be graded separately? We obtained data on 127 men with prostate cancer on needle biopsy who underwent subsequent radical prostatectomy at our institution. We compared the Gleason scores found on needle biopsy with the grade and stage (organ-confined, extra-prostatic extension, positive seminal vesicles or lymph nodes) at radical prostatectomy. ...

      Known for Gleason Score | Prostate Cancer | 4 3 | Needle Biopsy | Pattern Grade
      KOL-Index: 21488

      PURPOSE: We identified information critical for patient treatment on prostate needle biopsies diagnosed with prostatic intraepithelial neoplasia or atypical foci suspicious for carcinoma.

      MATERIALS AND METHODS: A search was performed using the MEDLINE database and referenced lists of relevant studies to obtain articles addressing the significance of finding PIN or atypical foci suspicious for carcinoma on needle biopsy.

      RESULTS: There were certain results concerning PIN. 1) Low grade PIN ...

      Known for Atypical Foci | Needle Biopsy | Diagnosis Hgpin | Risk Cancer | Prostatic Intraepithelial
      KOL-Index: 20779

      Foamy gland and pseudohyperplastic carcinomas are two uncommon variants of prostate cancer and often pose diagnostic challenges on needle biopsies. Alpha-methylacyl-CoA-racemase (AMACR) is a recently discovered tumor marker whose expression is significantly upregulated in prostate cancer. However, the original works only studied ordinary prostate cancer without reference to specific morphologic variants. Therefore, the expression and diagnostic utility of AMACR in specific variants of ...

      Known for Foamy Gland | Prostate Cancer | Diagnostic Utility | Amacr P504s | Tumor Biopsy
      KOL-Index: 20548

      Intraductal carcinoma of the prostate and high-grade prostatic intraepithelial neoplasia (PIN) have markedly different implications for patient care but can be difficult to distinguish in needle biopsies. In radical prostatectomies, we demonstrated that PTEN and ERG immunostaining may be helpful to resolve this differential diagnosis. Here, we tested whether these markers are diagnostically useful in the needle biopsy setting. Separate or combined immunostains were applied to biopsies ...

      Known for Intraductal Carcinoma | Needle Biopsy | Pten Loss | Grade Pin | Differential Humans
      KOL-Index: 19652

      PURPOSE: We determined whether contemporary practice patterns of Gleason grading for prostate needle biopsy and radical prostatectomy have evolved.

      MATERIALS AND METHODS: We correlated needle biopsy (assigned at Johns Hopkins Hospital and other institutions) and radical prostatectomy Gleason score for 1,455 men who underwent radical prostatectomy at Johns Hopkins Hospital from 2002 to 2003, and compared the results with those of a 1994 study of similar design.

      RESULTS: Outside ...

      Known for Gleason Score | Needle Biopsy | Radical Prostatectomy | Johns Hopkins Hospital | 8 10
      KOL-Index: 19354

      Small cell carcinoma of the prostate is a rare subtype with an aggressive clinical course. Despite the frequent occurrence of ERG gene rearrangements in acinar carcinoma, the incidence of these rearrangements in prostatic small cell carcinoma is unclear. In addition, molecular markers to distinguish prostatic small cell carcinomas from lung and bladder small cell carcinomas may be clinically useful. We examined the occurrence of ERG gene rearrangements by fluorescence in situ ...

      Known for Small Cell | Erg Gene | Acinar Carcinoma | Situ Hybridization | Rearrangement Prostatic
      KOL-Index: 18250

      BACKGROUND: Collecting duct carcinoma (CDC) is a relatively rare but aggressive type of renal malignancy with variable morphologic features. One of the World Health Organization diagnostic criteria for CDC is the exclusion of urothelial carcinoma of renal pelvis from the differential diagnosis. PAX8 is a novel lineage restricted transcription factor expressed in renal tubules. We investigated the expression pattern of PAX8 in CDC and its utility, in combination with p63, in resolving the ...

      Known for Duct Carcinoma | Pax8 P63 | Differential Diagnosis | Renal Collecting | Specificity 100
      KOL-Index: 18032

      Xp11 translocation cancers include Xp11 translocation renal cell carcinoma (RCC), Xp11 translocation perivascular epithelioid cell tumor (PEComa), and melanotic Xp11 translocation renal cancer. In Xp11 translocation cancers, oncogenic activation of TFE3 is driven by the fusion of TFE3 with a number of different gene partners; however, the impact of individual fusion variant on specific clinicopathologic features of Xp11 translocation cancers has not been well defined. In this study, we ...

      Known for Xp11 Translocation | Situ Hybridization | Tfe3 Fusion | Oncogene Proteins | Specific Clinicopathologic
      KOL-Index: 17845

      PURPOSE: There have been only a few contradictory publications assessing whether Gleason score 4 + 3 = 7 has a worse prognosis than 3 + 4 = 7 on biopsy material in predicting pathological stage and biochemical recurrence. Older studies predated the use of the modified Gleason grading system established in 2005.

      MATERIALS AND METHODS: We retrospectively studied 1,791 cases of Gleason score 7 on prostatic biopsy to determine whether the breakdown of Gleason score 7 into 3 + 4 vs 4 + 3 has ...

      Known for Gleason Score | Radical Prostatectomy | Needle Biopsy | 7 Prostate | Primary Pattern
      KOL-Index: 17644

      PURPOSE: We addressed whether Gleason score 3 + 4 = 7 and 4 + 3 = 7 cancers on needle biopsy behave differently and whether this behavior is independent of the number of cores involved by cancer. If it is not an independent predictor of prognosis, one may report Gleason score 7 cancer with the number of positive cores without regard to whether the primary pattern was 3 or 4. This practice would remove a source of poor interobserver reproducibility when grading prostate cancer on needle ...

      Known for Needle Biopsy | 3 4 | Gleason Scores | Score 7 | Prostate Cancer
      KOL-Index: 17142

      The stem cells of rapidly renewing tissues give rise to transiently proliferating cells, which in turn give rise to postmitotic terminally differentiated cells. Although the existence of a transiently proliferating compartment has been proposed for the prostate, little molecular anatomical evidence for its presence has been obtained to date. We used down-regulation of the cyclin-dependent kinase inhibitor p27Kip1 to identify cells capable of entering the proliferative phase of the cell ...

      Known for Cell Cycle | Prostate Stem | Inhibitor P27kip1 | Prostatic Hyperplasia | Cyclin Dependent

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      Department of Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA. | Department of Cell and Developmental Biology, Penn Cardiovascular Institute and Institute for Regenerative Medicine, Perelman School of Me

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