J Stevens Andrews

A recent report1 on the pathology and histochemistry of arcus senilis emphasized the lipid nature of the corneal deposits and suggested that an understanding of arcus formation might explain some of the factors involved in fat deposition in other nonadipose tissues of the body.Although these investigators identified the components of arcus as probably a cholesterol derivative with some associated phospholipid and glyceride, the values obtained were necessarily only semiquantitative, and ...

1.1. Incubation of rabbit cornea in a sodium oleate-serum mixture was found by silicic acid chromatography of the extracted lipid to increase markedly the triglyceride content of this tissue. In the presence of 7 μmoles of sodium oleate per ml of serum the cornea was observed to synthesize triglyceride at the rate of approx. 10 μmoles/g of wet tissue/48 h.2.2. Use of sodium [I-14C]oleate and [14C6]glucose established these compounds as precursors in this synthetic process. An isotope ...

Interocular protein transfer was demonstrated after intravitreal injection of isotopically labeled bovine serum albumin into one eye of rabbits. The transfer of the trace molecule occurs by a nonhematogenous pathway. These experiments indicate that cerebrospinal fluid route and/or the ipsilateral optic nerve-chiasm-contralateral optic nerve are probably not the pathway mediating nonhematogenous interocular protein transfer.