Prominent publications by Jin Heon Lee

KOL Index score: 14230

Antibody to hepatitis B surface antigen (HBsAg) (anti-HBs) can exist in patients with chronic hepatitis B virus (HBV) infection. To date, little is known about the association of concurrent HBsAg and anti-HBs (concurrent HBsAg/ anti-HBs) with hepatocellular carcinoma (HCC). The aim of this study was to investigate the clinical relevance of concurrent HBsAg/anti-HBs with preS deletion mutations and HCC in chronic HBV infection. A total of 755 patients with chronic HBV infection were ...

Also Ranks for: Hepatocellular Carcinoma |  chronic hepatitis |  hbsag hcc |  virus infection |  anti hbs
KOL Index score: 13779

AIM: To determine the cutoff values and to compare the diagnostic role of alpha-fetoprotein (AFP) and prothrombin induced by vitamin K absence-II (PIVKA-II) in chronic hepatitis B (CHB).

METHODS: A total of 1255 patients with CHB, including 157 patients with hepatocellular carcinoma (HCC), 879 with non-cirrhotic CHB and 219 with cirrhosis without HCC, were retrospectively enrolled. The areas under the receiver operating characteristic (AUROC) curves of PIVKA-II, AFP and their combination ...

Also Ranks for: Pivkaii Afp |  hepatocellular carcinoma |  hcc patients |  liver cirrhosis |  hepatitis chb
KOL Index score: 12588

BACKGROUND & AIMS: This study aimed to identify the predictors for early hepatitis B e antigen (HBeAg) seroconversion following acute exacerbation (AE) in patients with HBeAg-positive chronic hepatitis B (CHB).

METHODS: A total of 151 patients with HBeAg-positive CHB and AE were consecutively enrolled. AE was defined as an elevation of alanine aminotransferase level to more than 5 times the upper limit of normal and more than twice the patients' baseline value. Early HBeAg seroconversion ...

Also Ranks for: Early Hbeag Seroconversion |  acute exacerbation |  chronic hepatitis |  patients hbeag |  nonvertical transmission
KOL Index score: 11930

Hepatitis D virus (HDV) infection can cause severe acute and chronic liver disease in patients infected with hepatitis B virus (HBV). Despite the significant decline in the global HDV infection, it remains a major health concern in some countries. This study aimed to investigate the prevalence and clinical features of HDV co-infection in patients with chronic HBV infection in Korea, where HBV infection is endemic. Nine hundred forty patients [median age, 48 (18-94) years; men, 64.5%] ...

Also Ranks for: Chronic Hepatitis |  patients hdv |  hbv infection |  delta virus |  hepatocellular carcinoma
KOL Index score: 10770

OBJECTIVE: To investigate the prevalence of occult HBV infection among subjects with normal serum ALT levels in South Korea.

METHODS: A total of 195 serum samples were collected from subjects without a past history of alcohol abuse and with normal serum ALT levels. They were negative for HBsAg, anti-HCV, and anti-HIV. HBV-DNA was detected from sera by nested polymerase chain reaction (PCR) using specific primers of the surface antigen region of the HBV genome. We performed a quantitation ...

Also Ranks for: Occult Hbv Infection |  south korea |  hbv dna |  specific primers |  meticulous attention
KOL Index score: 10441

BACKGROUND/AIM: Alpha-fetoprotein (AFP) and protein induced by vitamin K absence or antagonist-II (PIVKA-II) are most widely used tumor markers in detecting hepatocellular carcinoma (HCC). Recently, there have been some studies about them as prognostic markers in hepatitis C virus-associated HCC. However, prognostic values of AFP and PIVKA-II remain clarified in hepatitis B virus (HBV)-associated HCC. This study was aimed to evaluate the prognostic values of AFP and PIVKA-II in ...

Also Ranks for: Hepatocellular Carcinoma |  afp pivkaii |  prognostic values |  liver neoplasms |  protein induced
KOL Index score: 8503

BACKGROUND AND AIM: Interleukin (IL)-1 gene polymorphism has been reported to be associated with the increment of gastric cancer (GC) and the decrement of duodenal ulcers (DU). In addition, IL-2 is known to induce Helicobacter pylori (H. pylori)-associated gastric atrophy, but it is not known whether IL-2 gene polymorphism increases the risk of GC (GC) or peptic ulcer diseases. Therefore, we compared the genotypes of IL-1B, IL-1RN, and IL-2 gene polymorphisms with risk of gastric ulcers ...

Also Ranks for: Gastric Cancer |  gene polymorphism |  korean patients |  disease humans interleukin |  helicobacter pylori
KOL Index score: 8028

Clevudine is a nucleoside analog with an unnatural beta-L configuration. In a phase I/II clinical trial, once daily doses ranging from 10 to 200 mg for 28 days were well tolerated, and produced significant antiviral activity. The present study was conducted to assess the degree and durability of the antiviral response to 12 weeks of clevudine treatment, and to investigate its safety and tolerability. A total of 98 patients with HBeAg-positive chronic hepatitis B were randomized to ...

Also Ranks for: Antiviral Activity |  clevudine therapy |  12 weeks |  chronic hepatitis |  clinical trial
KOL Index score: 6843

We performed this study to determine the role of polymorphisms of the IL-10 and TNF-alpha promoter genes in the carcinogenesis/pathogenesis of gastric cancer (GC) and peptic ulcer diseases (PUD) in Korea. A total of 232 patients with gastric diseases and 120 healthy controls were included. Polymorphisms of IL-10-1082/-592 gene and TNF-A-308 gene were genotyped by PCR-RFLP. There were no differences in genotypes and allele frequencies of IL-10 and TNF-A polymorphism between study group ...

Also Ranks for: Gastric Cancer |  polymorphism il10 |  genotypic frequencies |  gc korea |  tnf alpha
KOL Index score: 6196

BACKGROUND: We analyzed serologic data that were obtained from the Korea Association of Health from 1995 to 1999 to estimate the reliable prevalence of HBV in South Korea.

METHODS: 603,375, 639,465, 621,476, 612,705 and 650,398 serum samples were annually tested for HBsAg. Of HBsAg positive persons whose serum samples were available, HBeAg positivity was checked.

RESULTS: HBsAg positivities among subjects between 6 and 19 years old were 8.2%, 3.9%, 2.1%, 2.6% and 1.3%. HBsAg positivities ...

Also Ranks for: South Korea |  hbv infection |  hbsag positivity |  late 1990s |  positive rates
KOL Index score: 6111

PURPOSE: Pseudomembranous colitis is a severe form of antibiotic-associated diarrhea. However, there have been no reports about the factors that make patients with presumed antibiotic-associated diarrhea susceptible to pseudomembranous colitis. This study was designed to determine the clinical risk factors for pseudomembranous colitis among the patients with presumed antibiotic-associated diarrhea.

METHODS: This was a retrospective study of 150 consecutive patients admitted to our ...

Also Ranks for: Pseudomembranous Colitis |  antibiotic diarrhea |  multivariate analysis |  clinical risk factors |  clostridioides difficile
KOL Index score: 5994

BACKGROUND: The eradication rate of Helicobacter pylori (H. pylori) infection might be affected by the degree of inflammation of gastric mucosa represented by the endoscopic stage of peptic ulcer disease (PUD). The aims of this study were to evaluate the eradication rates of H. pylori infection according to the endoscopic stage of PUD and to document whether early eradication in the active stage could yield a higher eradication rate in patients with peptic ulcer bleeding (PUB).


Also Ranks for: Eradication Rate |  helicobacter pylori |  peptic ulcer |  proton pump |  anti bacterial
KOL Index score: 5322

PURPOSE: This study was performed to find clinical risk factors for developing ischemic colitis in patients experiencing lower abdominal discomfort with or without bloody diarrhea.

METHODS: A total of 467 patients who underwent sigmoidoscopy or colonoscopy because of lower abdominal discomforts with or without blood in stool were consecutively enrolled; 147 patients were diagnosed endoscopically and histologically as having ischemic colitis. The control group was composed of the ...

Also Ranks for: Ischemic Colitis |  abdominal pain |  67 patients |  adjusted odds ratio |  bloody diarrhea
KOL Index score: 5278

BACKGROUND/AIMS: The tumor-node-metastasis (TNM) staging is an useful system to assess the prognosis of any solid cancer. As new TNM staging classification of 7th stomach cancer was revised in 2009, we evaluated the prognostic predictability of the 7th International Union Against Cancer/American Joint Committee on Cancer (UICC/AJCC) TNM classification compared to 6th UICC/AJCC TNM classification in gastric cancer.

METHODS: From January 2000 to December 2009, 5-year survival rates of 266 ...

Also Ranks for: Gastric Cancer |  7th edition |  joint committee |  tnm classification |  neoplasm staging

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Jin Heon Lee:Expert Impact

Concepts for whichJin Heon Leehas direct influence:Pseudomembranous colitis,  Pylori infection,  Ischemic colitis,  Chronic hepatitis,  South korea,  Hepatocellular carcinoma,  Early hbeag seroconversion,  Cardia cancer.

Jin Heon Lee:KOL impact

Concepts related to the work of other authors for whichfor which Jin Heon Lee has influence:Gastric cancer,  Hepatocellular carcinoma,  Chronic hepatitis,  Ischemic colitis,  Helicobacter pylori,  Alcohol withdrawal,  Hbv infection.



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Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym University College of Medicine, 150, Sungnae-gil, Kangdong-gu, Seoul, Republic of Korea 134-701. | Department of Internal Medicine, Kangdong Sacred Heart Hospital, Hallym Univers