Prominent publications by Alan M Menter

KOL Index score: 28325

BACKGROUND: Ixekizumab is a humanised monoclonal antibody against the proinflammatory cytokine interleukin 17A. We report two studies of ixekizumab compared with placebo or etanercept to assess the safety and efficacy of specifically targeting interleukin 17A in patients with widespread moderate-to-severe psoriasis.

METHODS: In two prospective, double-blind, multicentre, phase 3 studies (UNCOVER-2 and UNCOVER-3), eligible patients were aged 18 years or older, had a confirmed diagnosis of ...

Also Ranks for: Placebo Etanercept |  patients ixekizumab |  2 weeks |  nonsteroidal antibodies |  phase 3
KOL Index score: 20967

BACKGROUND: Early clinical studies suggested that the anti-interleukin-17 receptor A monoclonal antibody brodalumab has efficacy in the treatment of psoriasis.

METHODS: In two phase 3 studies (AMAGINE-2 and AMAGINE-3), patients with moderate-to-severe psoriasis were randomly assigned to receive brodalumab (210 mg or 140 mg every 2 weeks), ustekinumab (45 mg for patients with a body weight ≤100 kg and 90 mg for patients >100 kg), or placebo. At week 12, patients receiving brodalumab were ...

Also Ranks for: Brodalumab Patients |  placebo week |  phase 3 studies |  ustekinumab psoriasis |  monoclonal antibodies
KOL Index score: 16421

CONTEXT: Ustekinumab and briakinumab, monoclonal antibodies to the shared p40 subunit of interleukin (IL)-12 and IL-23, have shown efficacy in treating chronic plaque psoriasis (CPP). Preliminary reports of major adverse cardiovascular events (MACEs) in psoriasis patients receiving anti-IL-12/23 agents have prompted concern.

OBJECTIVE: To evaluate a possible association between biologic therapies for CPP and MACEs via meta-analysis.

DATA SOURCES: Randomized controlled trials (RCTs) of ...

Also Ranks for: Cardiovascular Events |  biologic therapies |  chronic plaque psoriasis |  randomized controlled trials |  monoclonal antibodies
KOL Index score: 15625

BACKGROUND: The relatively recent introduction of biological agents to treat psoriasis presents clinicians with the need to objectively compare and contrast these agents to allow more effective treatment of their patients.

OBJECTIVES: To evaluate and compare the efficacy and safety of biological agents in the treatment of plaque psoriasis.


DATA SOURCES: Four parallel systematic reviews conducted through July 2006, including peer-reviewed data and U.S. Food and Drug ...

Also Ranks for: Plaque Psoriasis |  monoclonal antibodies |  etanercept infliximab |  efficacy safety |  biological agents
KOL Index score: 15442

BACKGROUND: Tofacitinib is a novel, oral Janus kinase inhibitor under investigation as a potential treatment for plaque psoriasis.

OBJECTIVES: This Phase 2b, 12-week, dose-ranging study (A3921047, NCT00678210) aimed to characterize the exposure-response, efficacy and safety of tofacitinib vs. placebo in patients with moderate-to-severe chronic plaque psoriasis.

METHODS: One hundred and ninety-seven patients were randomized. The primary endpoint was the proportion of patients achieving a ...

Also Ranks for: Janus Kinase |  tofacitinib placebo |  efficacy safety |  week pasi |  phase 2b
KOL Index score: 15403

BACKGROUND: Biologic agents offer a range of new therapeutic options for patients with psoriasis; however, the relative benefit-risk profiles of such therapies are not well known. We compared two biologic agents, ustekinumab (an interleukin-12 and interleukin-23 blocker) and etanercept (an inhibitor of tumor necrosis factor alpha), for the treatment of psoriasis.

METHODS: We randomly assigned 903 patients with moderate-to-severe psoriasis to receive subcutaneous injections of either 45 ...

Also Ranks for: Ustekinumab Etanercept |  pasi week |  75 improvement |  patients psoriasis |  monoclonal antibodies
KOL Index score: 15047

BACKGROUND: Psoriasis is a chronic disease that significantly diminishes the health-related quality of life (HRQOL). Infliximab is a chimeric, tumour necrosis factor alpha monoclonal antibody that has been shown to improve the signs and symptoms of plaque psoriasis.

OBJECTIVES: The objective of this study was to evaluate the effect of infliximab induction therapy on the HRQOL of patients with severe plaque psoriasis.

METHODS: In this double-blind, placebo-controlled trial, 249 patients ...

Also Ranks for: Severe Psoriasis |  infliximab treatment |  life hrqol |  baseline week |  dlqi scores
KOL Index score: 14726

BACKGROUND: In this phase 2, randomized, double-blind, placebo-controlled, dose-ranging study, we assessed the efficacy and safety of brodalumab (AMG 827), a human anti-interleukin-17-receptor monoclonal antibody, for the treatment of moderate-to-severe plaque psoriasis.

METHODS: We randomly assigned patients with a score of 12 or higher on the psoriasis area-and-severity index (PASI, on which scores range from 0 to 72, with higher scores indicating more severe disease) and with 10% or ...

Also Ranks for: Pasi Score |  patients brodalumab |  receptor antibody |  monoclonal antibodies |  interleukin17 severity
KOL Index score: 14681

OBJECTIVE: To assess the efficacy and safety of a 24-week course of efalizumab.

DESIGN: Phase 3, randomized, double-blind, parallel-group, placebo-controlled 12-week study followed by a 12-week open-label study.

SETTING: Outpatient dermatology clinics. Patients A total of 556 patients with moderate to severe chronic plaque psoriasis who were seeing an outpatient dermatologist were included in the study. Intervention For weeks 1 to 12, the 556 patients were randomized to receive 1 mg/kg ...

Also Ranks for: 24 Weeks |  efalizumab therapy |  plaque psoriasis |  monoclonal antibodies |  week 12
KOL Index score: 14202

BACKGROUND: Drug survival is a marker for treatment sustainability in chronic diseases such as psoriasis.

OBJECTIVE: The aim of these analyses was to assess survival of biologic treatments in the PSOriasis Longitudinal Assessment and Registry (PSOLAR).

METHODS: PSOLAR is a large, prospective, international, disease-based registry of patients with psoriasis receiving (or eligible for) systemic therapy in a real-world setting. Drug survival is defined as the time from initiation to ...

Also Ranks for: Biologic Therapy |  drug survival |  patients psoriasis |  registry psolar |  adalimumab etanercept
KOL Index score: 13897

BACKGROUND: Health-related quality of life (HRQOL) outcomes are associated with clinical response to treatment in psoriasis. However, the association between HRQOL outcomes and more substantial degrees of Psoriasis Area and Severity Index (PASI) response and physician and patient global ratings remains ill defined.

OBJECTIVE: This study examined the relationship between achieving a 75% or > or =90% improvement in PASI and HRQOL outcome measures.

METHODS: Secondary analyses were completed ...

Also Ranks for: Severe Plaque Psoriasis |  life outcomes |  monoclonal antibodies |  pasi response |  90 100
KOL Index score: 13247

BACKGROUND: Since some patients with psoriatic arthritis do not respond to typical drug treatments, alternatives are needed. Findings suggest that interleukins 12 and 23 might affect clinical symptoms and pathological joint changes of psoriatic arthritis. Ustekinumab is a human monoclonal antibody that inhibits receptor-binding of these cytokines. We aimed to assess the efficacy and safety of ustekinumab for psoriatic arthritis in this phase II study.

METHODS: We undertook a ...

Also Ranks for: Patients Week |  psoriatic arthritis |  monoclonal antibodies |  safety ustekinumab |  primary endpoint

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Alan M Menter:Expert Impact

Concepts for whichAlan M Menterhas direct influence:Psoriatic arthritis,  Monoclonal antibodies,  Patients psoriasis,  Plaque psoriasis,  Severe psoriasis,  Treatment psoriasis,  Monoclonal antibodies monoclonal,  Psoriasis patients.

Alan M Menter:KOL impact

Concepts related to the work of other authors for whichfor which Alan M Menter has influence:Psoriatic arthritis,  Patients psoriasis,  Atopic dermatitis,  Monoclonal antibodies,  Autoimmune diseases,  Th17 cells,  Metabolic syndrome.



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Baylor Scott & White Health, Dallas, Texas, USA. | Baylor University Medical Center, Dallas, TX USA | Division of Dermatology, Baylor University Medical Center, Dallas, TX, USA | Department of Dermatology, Baylor Scott & White University, 3900 Junius