• Disease
  • Psoriatic
  • Psoriatic Arthritis
  • Dennis G Mcgonagle

    Prominent publications by Dennis G McGonagle

    KOL Index score: 17150

    Recent evidence suggests a role for natural killer (NK) cells in the control of multiple myeloma. We show that expression of the NK cell receptor DNAM-1 (CD226) is reduced on CD56(dim) NK cells from myeloma patients with active disease compared with patients in remission and healthy controls. This suggested that this receptor might play a role in NK-myeloma interactions. The DNAM-1 ligands Nectin-2 (CD112) and the poliovirus receptor (PVR; CD155) were expressed by most patient myeloma ...

    Also Ranks for: Myeloma Cells |  killer cell |  nkg2d ligands |  mediated killing |  immunologic receptors
    KOL Index score: 15161

    OBJECTIVE: The ability to make an early, accurate diagnosis of rheumatoid arthritis (RA) has become increasingly important with the availability of new, expensive, and targeted therapies. However, plain radiography, the traditional method of detecting the characteristic bone erosions and an important adjunct in establishing a diagnosis of RA, is known to be insensitive. This study compared sonography, a modern imaging technique, with conventional radiography for the detection of erosions ...

    Also Ranks for: Rheumatoid Arthritis |  conventional radiography |  bone erosions |  early disease |  mcp joints
    KOL Index score: 13368

    OBJECTIVE: To evaluate the efficacy of infliximab in HLA-B27-positive patients with magnetic resonance imaging (MRI)-determined early sacroiliitis, using both clinical and MRI assessments.

    METHODS: Forty patients with recent-onset inflammatory back pain, as assessed by the Calin criteria, HLA-B27 positivity, clinical disease activity as measured by the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), pain and morning stiffness, and magnetic resonance imaging (MRI)-determined ...

    Also Ranks for: Magnetic Resonance Imaging |  disease activity week |  patients infliximab |  hla b27 |  mri scans
    KOL Index score: 13289

    OBJECTIVE: To investigate the role of metacarpophalangeal (MCP) joint anatomic and biomechanical factors in the distribution of synovitis and bone erosion in early rheumatoid arthritis (RA).

    METHODS: Thirty-three patients with early RA with clinically diagnosed MCP joint disease and 28 healthy controls were examined by magnetic resonance imaging of the second to fifth MCP joints of the dominant hand. T1 and T2 fat-suppressed coronal sequences were obtained to assess erosion, and dynamic ...

    Also Ranks for: Bone Erosion |  early rheumatoid arthritis |  mcp joints |  metacarpophalangeal joint |  synovial volumes
    KOL Index score: 13288

    BACKGROUND: Since the publication of the European League Against Rheumatism recommendations for the pharmacological treatment of psoriatic arthritis (PsA) in 2012, new evidence and new therapeutic agents have emerged. The objective was to update these recommendations.

    METHODS: A systematic literature review was performed regarding pharmacological treatment in PsA. Subsequently, recommendations were formulated based on the evidence and the expert opinion of the 34 Task Force members. ...

    Also Ranks for: European League |  pharmacological therapies |  psoriatic arthritis |  recommendations evidence |  overarching principles
    KOL Index score: 13019

    OBJECTIVE: To simultaneously image bone and synovium in the individual joints characteristically involved in early rheumatoid arthritis (RA).

    METHODS: Forty patients with early, untreated RA underwent gadolinium-enhanced magnetic resonance imaging (MRI) of the second through fifth metacarpophalangeal joints of the dominant hand at presentation, 3 months, and 12 months. In the first phase (0-3 months), patients were randomized to receive either methotrexate alone (MTX) or MTX and ...

    Also Ranks for: Bone Damage |  resonance imaging |  early rheumatoid |  individual joints |  new erosions
    KOL Index score: 12655

    OBJECTIVE: Studies comparing 500 mg rituximab and 1,000 mg rituximab doses in rheumatoid arthritis have yielded conflicting data on clinical outcomes, but in all of these studies a subgroup of patients has had excellent responses at the lower dose. Historically, it was considered that rituximab uniformly depleted B cells at both doses. Using highly sensitive assays, we have shown that B cell depletion is variable and predictive of clinical response. Using the same techniques, we ...

    Also Ranks for: Cell Depletion |  dose rituximab |  rheumatoid arthritis |  clinical response patients |  2 weeks
    KOL Index score: 12530

    BackgroundEnthesitis is one of the psoriatic arthritis (PsA) domains. Patients with enthesitis are associated with worse outcomes than those without enthesitis. The effect of secukinumab on the resolution of enthesitis in patients with PsA was explored using pooled data from the FUTURE 2 and 3 studies.MethodAssessments of enthesitis through week 104 used the Leeds Enthesitis Index. These post hoc analyses included resolution of enthesitis count (EC = 0), median time to first resolution ...

    Also Ranks for: Psoriatic Arthritis |  patients enthesitis |  secukinumab placebo |  phase 3 |  monoclonal humanized
    KOL Index score: 12502

    BACKGROUND: The new Assessment of SpondyloArthritis international Society (ASAS) criteria classify axial spondyloarthritis (SpA) into human leucocyte antigen-B27 and/or imaging-based arms. To aid implementation, ASAS has proposed a definition of a positive MRI for active sacroiliitis.

    OBJECTIVE: The authors aimed to test the diagnostic and predictive value of the ASAS criteria and definition of a 'positive' MRI.

    METHODS: Baseline MRI scans on 29 patients with early inflammatory back pain ...

    Also Ranks for: Asas Criteria |  axial spondyloarthritis |  sacroiliac joint |  positive mri |  sensitivity specificity
    KOL Index score: 12120

    OBJECTIVE: This study combined ultrasonography of the Achilles tendon enthesis at different stages of spondylarthritis (SpA) with microanatomic studies of normal cadaveric entheses, with the aim of exploring the relationship between bone erosion and new bone formation in enthesitis.

    METHODS: Thirty-seven patients with SpA and Achilles tendon enthesitis (20 with early SpA and 17 with chronic SpA) and 10 normal control subjects underwent ultrasound scanning. The presence of bone erosion ...

    Also Ranks for: Achilles Tendon |  bone formation |  early spa |  20 patients |  stress mechanical
    KOL Index score: 12055

    OBJECTIVE: Dermatologists usually see patients with psoriasis before arthritis develops, making them well placed to diagnose early PsA (ePsA). This study aimed to develop a rapid and robust screening questionnaire for predicting PsA in patients with psoriasis referred to a specialized joint dermatology-rheumatology combined clinic.

    METHODS: In all, 228 psoriasis patients naïve to DMARD treatment were administered two screening questionnaire: the new Early ARthritis for Psoriatic patients ...

    Also Ranks for: Screening Questionnaire |  early psoriatic |  arthritis patients |  earp pase |  psa diagnosis
    KOL Index score: 12026

    OBJECTIVES: A20 is an important endogenous regulator of inflammation. Single nucleotide polymorphisms in A20 have been associated with various immune-mediated inflammatory diseases, and cell-specific deletion of A20 results in diverse inflammatory phenotypes. Our goal was to delineate the underlying mechanisms of joint inflammation in myeloid-specific A20-deficient mice (A20myelKO mice).

    METHODS: Inflammation in A20myelKO mice was assessed in a time-dependent manner. Western blot ...

    Also Ranks for: Myeloid Cells |  mice a20 |  stat3 transcription |  joint inflammation |  single nucleotide polymorphisms
    KOL Index score: 11831

    OBJECTIVE: Magnetic resonance imaging (MRI) is increasingly used to detect sacroiliitis earlier. This study was undertaken to investigate what proportion of patients with MRI-evident sacroiliitis develop ankylosing spondylitis (AS) in the long term and whether there are predictors of outcome.

    METHODS: Consecutive undiagnosed patients with early inflammatory back pain (IBP) (of <2 years' duration) were assessed clinically and radiologically. Baseline imaging assessments included ...

    Also Ranks for: Magnetic Resonance |  ankylosing spondylitis |  b27 status |  new york |  lumbar spine
    KOL Index score: 11583

    OBJECTIVE: To compare work disability and job loss in early rheumatoid arthritis (RA) patients receiving adalimumab plus methotrexate (adalimumab + MTX) versus MTX alone.

    METHODS: In this multicenter, randomized, controlled trial, patients with RA for <2 years who had never taken MTX and who self-reported work impairment were randomized to adalimumab + MTX or placebo + MTX for 56 weeks. Primary outcome was job loss of any cause and/or imminent job loss at or after week 16. Secondary ...

    Also Ranks for: Necrosis Factor |  monoclonal antibodies |  early rheumatoid |  adalimumab mtx |  loss patients


    Dennis G McGonagle: Influence Statistics

    Sample of concepts for which Dennis G McGonagle is among the top experts in the world.
    Concept World rank
    hmscs size flow #1
    baricitinib female humans #1
    pulleys psa dactylitis #1
    il17a transcript expression #1
    psa ultrasonography adult #1
    “fine tuning #1
    n57 hcs #1
    skin disease efficacy #1
    peripheral enthesitis psa #1
    njd joint debris #1
    area cadaveric tissue #1
    enthesitis appendicular skeleton #1
    enthesitis psa #1
    degree ligament tears #1
    register pet #1
    sclerotic plate #1
    psoriatic disease spectrum #1
    psa emerging data #1
    13 351 dactylitis #1
    field quantitative mri #1
    epicondylitis normal structure #1
    enthesis organs #1
    splinter haemorrhages #1
    methods enthesitis #1
    psa vorliegen #1
    sites mechanical stress #1
    adjacent synovium #1
    nail psoriatic disease #1
    mefv frequent 48 #1
    ccl20 transcript #1
    synovio–entheseal complexes #1
    human origin vivo #1
    arthritis flexor #1
    achilles entheseal #1
    ongoing msc release #1
    il23il17 axis #1
    psoriatic biomechanical #1
    tissue microdamage entheses #1
    longterm msc cultivation #1
    digits systemic treatment #1
    mscs transcriptional similarities #1
    psoriatic patients arthralgia #1
    subclinical imaging enthesopathy #1
    oasf kjd #1
    inflammatory diseases continuum #1
    mechanical stress spa #1
    entheseal pathology #1
    early axial spondyloarthropathy #1
    realm immunology #1
    inflammatory bowel spa #1

    Key People For Psoriatic Arthritis

    Top KOLs in the world
    D Gladman Gladman
    psoriatic arthritis systemic lupus erythematosus patients psa
    Philip J Mease
    psoriatic arthritis eli lilly novartis pfizer
    Philip S Helliwell
    psoriatic arthritis tight control axial involvement
    Oliver M FitzGerald
    psoriatic arthritis synovial tissue patients psa
    Christopher T Ritchlin
    psoriatic arthritis radiographic progression janssen development
    Paul Emery
    rheumatoid arthritis ankylosing spondylitis radiographic progression

    Dennis G McGonagle:Expert Impact

    Concepts for whichDennis G McGonaglehas direct influence:Psoriatic arthritis,  Rheumatoid arthritis,  Ankylosing spondylitis,  Magnetic resonance,  Achilles tendon,  Bone marrow,  Magnetic resonance imaging,  Mesenchymal stem cells.

    Dennis G McGonagle:KOL impact

    Concepts related to the work of other authors for whichfor which Dennis G McGonagle has influence:Psoriatic arthritis,  Stem cells,  Ankylosing spondylitis,  Bone marrow,  Magnetic resonance imaging,  Osteogenic differentiation,  Tissue engineering.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    Leeds Institute of Rheumatic and Musculoskeletal Medicine, NIHR Leeds Biomedical Research Centre, University of Leeds, Leeds, UNITED KINGDOM | Chapel Allerton Hospital, Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, N