Prominent publications by Gerard A Silvestri

KOL Index score: 17623

OBJECTIVE: To compare baseline preoperative and 6-month postoperative functional health status and quality of life in patients undergoing lung cancer resection.

METHODS: Lung cancer surgery patients from three hospitals were administered the Short-Form 36 Health Survey (SF-36) and the Ferrans and Powers' quality-of-life index (QLI) before surgery and 6 months after surgery. Preoperative, intraoperative, hospital stay, and 6-month postoperative clinical data were collected. All p values ...

Also Ranks for: Lung Cancer Surgery |  postoperative quality life |  6 months |  adjuvant therapy |  status quality
KOL Index score: 17315

BACKGROUND: Lung cancer risks at which individuals should be screened with computed tomography (CT) for lung cancer are undecided. This study's objectives are to identify a risk threshold for selecting individuals for screening, to compare its efficiency with the U.S. Preventive Services Task Force (USPSTF) criteria for identifying screenees, and to determine whether never-smokers should be screened. Lung cancer risks are compared between smokers aged 55-64 and ≥ 65-80 y.


Also Ranks for: Lung Cancer |  plcom2012 risk |  smokers screening |  uspstf criteria |  computed tomography
KOL Index score: 15891

BACKGROUND: Early studies using Medicare data reported racial disparities in surgical treatment of localized, non-small cell lung cancer. We analyzed the independent effect of race on use of surgical resection in a recent, population-based sample of patients with localized non-small cell lung cancer, controlling for comorbidity and socioeconomic status.

METHODS: All cases of localized non-small cell lung cancer reported to our state Cancer Registry between 1996 and 2002 were identified ...

Also Ranks for: African Americans |  surgical resection |  cell lung |  racial disparities |  continental ancestry
KOL Index score: 14542

BACKGROUND: Endoscopic ultrasound (EUS)-guided fine needle aspiration is a safe, cost-effective procedure that can confirm the presence of mediastinal lymph node metastases and mediastinal tumor invasion. We studied the accuracy of EUS in a large population of lung cancer patients with and without enlarged mediastinal lymph nodes on computed tomographic (CT) scan.

METHODS: From 1996 to 2000 all patients referred to our institution with lung tumors and no proven distant metastases were ...

Also Ranks for: Endoscopic Ultrasound |  fine needle aspiration |  staging patients |  needle carcinoma |  mediastinal disease
KOL Index score: 14157

OBJECTIVES: The American College of Surgeons Oncology Group undertook a trial to ascertain whether positron emission tomography with 18F-fluorodeoxyglucose could detect lesions that would preclude pulmonary resection in a group of patients with documented or suspected non-small cell lung cancer found to be surgical candidates by routine staging procedures.

METHODS: A total of 303 eligible patients registered from 22 institutions underwent positron emission tomography after routine ...

Also Ranks for: Positron Emission Tomography |  small cell |  fluorodeoxyglucose f18 |  lung cancer |  positive findings
KOL Index score: 13832

BACKGROUND: While the complexity of flexible bronchoscopy has increased, standard options for moderate sedation medications have not changed in three decades. There is a need to improve moderate sedation while maintaining safety. Remimazolam was developed to address shortcomings of current sedation strategies.

METHODS: A prospective, double-blind, randomized, multicenter, parallel group trial was performed at 30 US sites. The efficacy and safety of remimazolam for sedation during ...

Also Ranks for: Moderate Sedation |  placebo midazolam |  safety remimazolam |  flexible bronchoscopy |  success rates
KOL Index score: 13390

BACKGROUND: The gene expression profile of cytologically-normal bronchial airway epithelial cells has previously been shown to be altered in patients with lung cancer. Although bronchoscopy is often used for the diagnosis of lung cancer, its sensitivity is imperfect, especially for small and peripheral suspicious lesions. In this study, we derived a gene expression classifier from airway epithelial cells that detects the presence of cancer in current and former smokers undergoing ...

Also Ranks for: Lung Cancer |  patients bronchoscopy |  bronchial genomic classifier |  gene expression |  current smokers
KOL Index score: 13358

BACKGROUND: Correctly staging lung cancer is important because the treatment options and prognosis differ significantly by stage. Several noninvasive imaging studies and invasive tests are available. Understanding the accuracy, advantages, and disadvantages of the available methods for staging non-small cell lung cancer is critical to decision-making.

METHODS: Test accuracies for the available staging studies were updated from the second iteration of the American College of Chest ...

Also Ranks for: Lung Cancer |  chest physicians |  pet scanning |  sensitivity specificity |  mediastinal metastasis
KOL Index score: 13233

OBJECTIVE: To determine how patients with lung cancer value the trade off between the survival benefit of chemotherapy and its toxicities.

DESIGN: Scripted interviews that included three hypothetical scenarios. Each scenario described the same patient with metastatic non-small cell lung cancer with an expected survival of 4 months without treatment. Subjects were asked to indicate the minimum survival benefit required to accept the side effects of chemotherapy in the first two scenarios ...

Also Ranks for: Chemotherapy Patients |  small cell |  survival benefit |  3 months |  severe toxicity
KOL Index score: 12910

RATIONALE: The U.S. Preventive Services Task Force recommends annual low-dose computed tomography (LDCT) for lung cancer screening in high-risk individuals. Preventive healthcare is provided predominantly by primary care providers (PCPs). Successful implementation of a screening program requires acceptance and participation by both providers and patients, with available collaboration with pulmonologists.

OBJECTIVES: To identify perceptions of and perspectives on lung cancer screening and ...

Also Ranks for: Lung Cancer |  qualitative study |  patients providers |  shared decision making |  early detection
KOL Index score: 12850

BACKGROUND: Computed tomography (CT) is the most common method of staging lung cancer. We have previously shown endoscopic ultrasound guided fine-needle aspiration (EUS-FNA) to be highly accurate in staging patients with nonsmall cell lung cancer (NSCLC) who have enlarged mediastinal lymph nodes on CT scan. In this study we report the accuracy and yield of EUS-FNA in staging patients without enlarged mediastinal lymph nodes by CT.

METHODS: Patients with NSCLC and CT scan showing no ...

Also Ranks for: Endoscopic Ultrasound |  computed tomography |  lung cancer |  normal mediastinum |  patients nsclc
KOL Index score: 12744

BACKGROUND: The National Lung Screening Trial (NLST) showed that screening with low-dose computed tomography (CT) as compared with chest radiography reduced lung-cancer mortality. We examined the cost-effectiveness of screening with low-dose CT in the NLST.

METHODS: We estimated mean life-years, quality-adjusted life-years (QALYs), costs per person, and incremental cost-effectiveness ratios (ICERs) for three alternative strategies: screening with low-dose CT, screening with radiography, ...

Also Ranks for: Lung Screening |  united states |  questionnaires tomography |  qaly 95 |  low dose
KOL Index score: 12601

BACKGROUND: The diagnosis of pulmonary sarcoidosis can be established by a variety of techniques. Transbronchial lung biopsy is often the preferred approach, but it is frequently nondiagnostic and carries a risk of pneumothorax and bleeding. Mediastinoscopy is often suggested as the next diagnostic step but entails significant cost and associated morbidity. Endobronchial ultrasound (EBUS) with transbronchial needle aspiration (TBNA) is emerging as a safe, minimally invasive tool for the ...

Also Ranks for: Pulmonary Sarcoidosis |  endobronchial ultrasound |  ebus tbna |  minimally invasive tool |  aged biopsy
KOL Index score: 12377

BACKGROUND: Correctly staging lung cancer is important because the treatment options and the prognosis differ significantly by stage. Several noninvasive imaging studies including chest CT scanning and positron emission tomography (PET) scanning are available. Understanding the test characteristics of these noninvasive staging studies is critical to decision making.

METHODS: Test characteristics for the noninvasive staging studies were updated from the first iteration of the lung cancer ...

Also Ranks for: Noninvasive Staging |  lung cancer |  2nd edition |  pet scanning |  practice guidelines
KOL Index score: 12032

BACKGROUND: Low-dose chest CT screening for lung cancer has become a standard of care in the United States in the past few years, in large part due to the results of the National Lung Screening Trial. The benefit and harms of low-dose chest CT screening differ in both frequency and magnitude. The translation of a favorable balance of benefit and harms into practice can be difficult. Here, we update the evidence base for the benefit, harms, and implementation of low radiation dose chest ...

Also Ranks for: Lung Cancer |  benefit harms |  expert panel report |  recommendations evidence |  systematic literature review

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Gerard A Silvestri:Expert Impact

Concepts for whichGerard A Silvestrihas direct influence:Lung cancer,  Lung cancer screening,  Cancer screening,  Pulmonary nodules,  Lung nodules,  Pulmonary nodule,  South carolina,  Chest physicians.

Gerard A Silvestri:KOL impact

Concepts related to the work of other authors for whichfor which Gerard A Silvestri has influence:Lung cancer,  Small cell,  Endobronchial ultrasound,  Computed tomography,  Diagnostic yield,  Early detection,  Pulmonary nodules.



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Hollings Cancer Center, MUSC, Charleston, USA | Department of Medicine, Medical University of South Carolina (MUSC), Charleston, USA | Division of Pulmonary and Critical Care Medicine, Medical University of South Carolina, Charleston, South Carolina,