• Disease
  • Eosinophilic
  • Eosinophilic Cellulitis
  • Philip H Cooper

    Prominent publications by Philip H Cooper

    KOL Index score: 11336

    Cutaneous malignant melanomas of the head and neck are prognostically engimatic. In addition to known prognostic determinants of stage and lesion microstage, lesion location also appears to have prognostic importance. The authors have reviewed a series of 83 microstaged head and neck melanoma patients in order to analyze the relative importance of these factors. There were 36 males and 47 females with a median age of 56 years. Eighty-one percent had pathologic Stage I disease, 7% were ...

    Also Ranks for: Neck Melanoma |  lesion location |  neoplasms humans |  prognosis head |  aged neoplasm
    KOL Index score: 8180

    Lymphoepithelioma of the nasopharynx has a strong association with Epstein-Barr virus (EBV). To test the hypothesis that lymphoepithelioma-like carcinomas occurring at other sites are also associated with EBV virus, we used in situ hybridization to analyze 20 cases of lymphoepithelioma and histologically similar lesions and five basaloid squamous cell carcinomas for evidence of EBV genomes. EBV genomes were demonstrated in six of six lymphoepitheliomas of the nasopharynx but in none of ...

    Also Ranks for: Situ Hybridization |  viral genomes |  ebv carcinoma |  female genes |  squamous cell
    KOL Index score: 7555

    Although a thickness of less than or equal to 0.76 mm has been used to define biologically favorable (thin) melanoma, there is evidence that 1 mm may be a reasonable cutoff to categorize favorable extremity melanomas. This is tempered, however, by the claim that histologic regression in thin melanomas is associated with an increased metastatic rate. We have therefore addressed the following questions: Is 1 mm an appropriate cutoff point to define thin melanoma on the extremities? Does ...

    Also Ranks for: 1 Mm |  regression thickness |  histologic type |  skin neoplasms |  male melanoma
    KOL Index score: 7257

    A commercially available antibody to proliferating cell nuclear antigen was used to characterize and compare proliferating cell populations in paraffin sections of benign, premalignant, and malignant lesions of human epidermis using routine immunohistochemical techniques. Three patterns emerged. An ordered pattern was found in prurigo nodularis and keratoacanthoma, wherein moderately and strongly positive nuclei were distributed in a continuous, basal-suprabasal layer of relatively ...

    Also Ranks for: Cell Nuclear |  antigen pcna |  prurigo nodularis |  bowens disease |  carcinoma squamous
    KOL Index score: 6500

    We studied fifty-seven cutaneous cysts from seven members of a kindred with Gardner's syndrome. All of the cysts had large areas indistinguishable from ordinary epidermal cysts. In addition, twenty-one (37%) contained columns of shadow cells, similar to those of pilomatricoma, that projected into the lumina. The cells at the point of attachment of the columns to the cyst lining were often indistinguishable from the hair matrix-like, basophilic cells of pilomatricoma. In twenty-nine cysts ...

    Also Ranks for: Epidermal Cysts |  shadow cells |  gardners syndrome |  epithelial lining |  pericystic connective tissue
    KOL Index score: 6280

    Acute febrile neutrophilic dermatosis (ND) consists of the abrupt onset of red, tender, cutaneous plaques on the face, extremities, and upper trunk, accompanied by fever, malaise, and neutrophilic leukocytosis. Histologically, there are distinctive, dense, dermal infiltrates of neutrophils. Response to systemic steroids is dramatic. This report describes four patients with leukemia or preleukemia and ND (LND), reviews reports of 12 similar patients, and compares LND with ND in otherwise ...

    Also Ranks for: Myeloproliferative Disorders |  myeloid leukemia |  neutrophilic dermatosis |  acute febrile |  systemic steroids
    KOL Index score: 6125

    Cutaneous squamous carcinoma with true glandular differentiation has only rarely been documented. Ten patients with such tumors are presented. There were six men and four women, aged 48 to 87 years. The tumors were located on the central face (eight), scalp (one), and hand (one) and consisted of minimally elevated, indurated, keratotic plaques, up to 6 cm in size. Microscopically, the neoplasms exhibited multifocal origin from the epidermis; deep, dispersed, infiltrative growth; ...

    Also Ranks for: Adenosquamous Carcinoma |  glandular differentiation |  carcinoembryonic antigen |  squamous cell |  skin neoplasms
    KOL Index score: 6015

    We describe a patient with microcystic adnexal carcinoma, a recently recognized cutaneous neoplasm. The patient, a middle-aged woman, had an induration of the left side of her upper lip. At the time of initial resection, the neoplasm also involved the left side of the nose. An extensive recurrence, 27 months later, involved the left turbinates and left orbit. Microscopically the tumor consisted of nests, strands, and cysts composed of mildly to moderately atypical squamous cells that ...

    Also Ranks for: Microcystic Adnexal |  neoplasms carcinoma |  upper lip |  ductular differentiation |  subcutaneous tissue
    KOL Index score: 5922

    Cutaneous squamous cell carcinomas (SCC) arising in actinically damaged skin, unassociated with chronic inflammation or injury, are generally regarded as nonaggressive lesions. These tumors occasionally recur or metastasize, however, as do de novo SCC. The authors reviewed 63 patients with cutaneous SCC of the trunk or extremities, excluding lesions that developed in known high risk settings, in order to explore the potential of histologic microstaging as a prognostic indicator. ...

    Also Ranks for: Cutaneous Squamous |  trunk extremities |  aged neoplasm |  tumor behavior |  novo scc
    KOL Index score: 5693

    One hundred eighty-seven squamous cell carcinomas of the lower lip were examined microscopically to identify parameters that might predict metastasis and patient outcome. Excision specimens of 157 nonmetastasizing carcinomas (group I) were compared with specimens from 30 tumors that had metastasized (group II). The following features were recorded: architectural pattern; microscopic thickness (mm); cytologic grade; presence of muscle, nerve, or vessel invasion; inflammatory response; and ...

    Also Ranks for: Lower Lip |  squamous cell |  perineural invasion |  cytologic grade |  mitotic rate
    KOL Index score: 5676

    Malignant angioendotheliomatosis (MAE) is a lethal intravascular proliferation which has been thought to be of endothelial origin. In order to characterize its cellular nature, we studied 15 cases of MAE immunocytochemically, using antisera for factor VIII-related antigen, cytokeratin, epithelial membrane antigen, vimentin, blood group isoantigens, thoracic duct lining cell antigens (TDLCA), common leukocyte antigen, and Ulex europaeus I lectin. In 14 of 15 cases, common leukocyte ...

    Also Ranks for: Tumor Cells |  malignant angioendotheliomatosis mae |  15 cases |  factor viii |  leukocyte common
    KOL Index score: 5595

    Patients with small cell undifferentiated carcinoma of the lung (SCUC) have a poor prognosis. Surgical excision is avoided if the diagnosis can be made with small biopsy specimens or cytologic preparations. We reviewed 323 consecutive patients with pulmonary neoplasms diagnosed as SCUC, oat cel carcinoma, and undifferentiated or poorly differentiated carcinoma. At the time of diagnosis, only 18 patients had neoplasms classified as clinical Stage I, and only one of these had SCUC after ...

    Also Ranks for: Small Cell |  atypical carcinoid |  undifferentiated carcinoma |  lung neoplasms |  15 patients


    Philip H Cooper: Influence Statistics

    Sample of concepts for which Philip H Cooper is among the top experts in the world.
    Concept World rank
    fibrokeratoma heel #1
    pilomatricoma cysts #1
    arm 52yearold #1
    diameter dark papules #1
    shadow cells lumina #1
    cent dispersed pattern #1
    glandular foci #1
    pilomatricomalike epidermal cysts #1
    thick cent #1
    infiltrates subcutaneous tissue #1
    children neh #1
    features pilomatricomas #1
    adenosquamous carcinoma skin #1
    neutrophilic infiltrates subcutis #1
    dispersed pattern cent #1
    characteristic flame figures #1
    2month scalp #1
    fibrokeratoma #1
    77 cent tumors #1
    columns shadow cells #1
    pilomatricomalike #1
    heel large size #1
    true glandular differentiation #1
    literature cutaneous lesions #1
    acquired fibrokeratoma #1
    pyogenic granuloma 43yearold #1
    fibrous myxoid tissue #1
    cellulitis urticaria #1
    lesions dsap #1
    fibrous proliferations infancy #1
    twentynine cysts #1
    peripheral eosinophilia etiology #1
    neutrophilic infiltrates #1
    evolving hematologic disorder #1
    lesions cent #1
    formation pyogenic granuloma #1
    typical episode patient #1
    multiple perifollicular fibromas #1
    pericystic connective tissue #1
    marked facial involvement #1
    foregoing features #1
    single lesion recurrence #1
    neh feet #1
    deposits shadow cells #1

    Key People For Eosinophilic Cellulitis

    Top KOLs in the world
    G C Wells
    pyoderma gangrenosum follicular mucinosis urticaria pigmentosa
    Neil P SMITH
    mycosis fungoides sézary syndrome malignant melanoma
    GC Wells
    lichen simplex eosinophilic cellulitis hydrolysing enzymes
    Gerald J Gleich
    eosinophil granule major basic protein mast cells
    Werner Aberer
    hereditary angioedema icatibant outcome survey contact dermatitis
    Klaus S Wolff
    langerhans cells epiluminescence microscopy pigmented skin lesions

    Philip H Cooper:Expert Impact

    Concepts for whichPhilip H Cooperhas direct influence:Eosinophilic cellulitis,  White sponge nevus,  Pyogenic granuloma,  Dyskeratosis congenita,  Microcystic adnexal carcinoma,  Neck melanoma,  Undifferentiated carcinoma,  Lesion location.

    Philip H Cooper:KOL impact

    Concepts related to the work of other authors for whichfor which Philip H Cooper has influence:Cell carcinoma,  Pyogenic granuloma,  Dermatofibrosarcoma protuberans,  Skin neoplasms,  Intravascular lymphoma,  Malignant melanoma,  Microcystic adnexal.



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    From the Department of Dermatology, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA | the Department of Pathology, University of Virginia Health Sciences Center, Charlottesville, Virginia, USA | Department of Dermatology