• Disease
  • Ras
  • Ras Mutations
  • Francis H Straus

    Prominent publications by Francis H Straus

    KOL Index score: 12421

    BACKGROUND: Adenocarcinomas and carcinoid tumors are the most common malignant tumors of the small intestine. K-ras oncogene mutations at codon 12 are common in gastric, pancreatic, and colon carcinomas, with an incidence of 35-88%. K-ras mutations have not been extensively studied in either adenocarcinomas or carcinoid tumors of the small bowel. The purpose of this study was to determine whether ras mutations play an important role in the formation of these tumors.

    METHODS: Archival ...

    Also Ranks for: Carcinoid Tumors |  small bowel |  ras mutations |  duodenal adenocarcinomas |  neoplasms genes
    KOL Index score: 10565

    A replication defective adenovirus transducing thymidine kinase (TK) gene under the control of the rat thyroglobulin (rTg) promoter (AdrTgtk) was developed to evaluate its cell-specific killing activity in gene therapy. We also developed adenoviruses containing the TK gene driven by the cytomegalovirus (CMV) promoter (AdCMVtk), and luciferase (Luc) gene driven by the rTg or CMV promoter (AdrTgLuc or AdCMVLuc). Luc activity in FRTL-5, HepG2, COS1, rMTC, hMTC, Hela, GH3, T98G, and CA77 ...

    Also Ranks for: Gene Therapy |  thymidine kinase |  thyroid carcinoma |  thyroglobulin promoter |  frtl5 cells
    KOL Index score: 8574

    Laparoscopic pelvic lymph node dissection is a recently introduced technique for the surgical evaluation of the regional pelvic lymph nodes in genitourinary malignancies. We report the results of a laparoscopic pelvic lymph node dissection performed on 103 consecutive patients for staging of clinically localized prostatic, bladder and penile carcinomas. In 20 patients (group 1) the adequacy of the laparoscopic pelvic lymph node dissection was evaluated with a subsequent open dissection. ...

    Also Ranks for: Laparoscopic Pelvic |  lymph node |  complication rate |  operative time |  laparoscopy length
    KOL Index score: 7514

    To study the role of Th0 and Th1 cells in autoimmune thyroid disease, thyroid tissues from patients with Graves' disease (GD), Hashimoto's thyroiditis (HT), and colloid nodular disease were xenografted into SCID mice, followed by ip injection of peripheral blood mononuclear cells (PBMC), T cell lines, and T cell clones (TCC). The antigen-specific TCC reactive to TSH receptor (TSH-R), thyroid peroxidase (TPO), or thyroglobulin (Tg), and their respective peptides, were classified into Th0 ...

    Also Ranks for: Thyroid Disease |  th1 cells |  gd patients |  peroxidase tpo |  ifn gamma
    KOL Index score: 7244

    A total of 29 patients with muscle invasive bladder cancer, clinical stage T2N0 (12), T3aN0 (9), T3bN0 (5), T3N2 (2) or T4N2 (1), underwent 2 to 4 cycles of neoadjuvant methotrexate, vinblastine, doxorubicin and cisplatin (M-VAC) chemotherapy followed by either radiotherapy (15), radical cystectomy (11) or no local therapy (3). The overall response rate to M-VAC chemotherapy was 69%, with 31% clinical complete responses and 38% clinical partial responses. A functioning bladder was ...

    Also Ranks for: Bladder Cancer |  muscle invasive |  median followup |  neoplasms vinblastine |  neoadjuvant chemotherapy
    KOL Index score: 7149

    Intravesical instillation of methylene blue resulted in selective surface staining of bladder tumors in vivo without staining the background of normal urothelium. Staining of human bladder tumors in vivo was accomplished by the intravesical instillation of 0.1% methylene blue in 0.9% saline through a foley catheter under 20 cm of hydrostatic pressure up to a maximum volume of 400 ml. After 5 minutes contact time, the methylene blue solution was drained, and the bladder was washed with ...

    Also Ranks for: Methylene Blue |  bladder tumors |  transitional cell |  vivo staining |  5 minutes
    KOL Index score: 7093

    We have analyzed data on a group of 269 patients with papillary thyroid carcinoma followed on average for 12 years to determine (1) if a prognostic classification scheme can be used to predict an appropriate surgical approach; (2) the effect of treatment on prognosis; and (3) if patients with a “excellent” prognosis benefit from more extensive surgical resection and 131I ablation. Prognostic classification schemes developed by the American Joint Commission, Cady et al., Hay et al., the ...

    Also Ranks for: Papillary Thyroid Carcinoma |  131i ablation |  groups patients |  extensive surgery |  excellent prognosis
    KOL Index score: 6924

    Epididymal cysts and/or hypoplastic testes have been found in 31.5 per cent of 308 men exposed to diethylstilbestrol in utero, compared to 7.8 per cent of 307 placebo-exposed controls. Analyses of the spermatozoa have revealed severe pathological changes (Eliasson score greater than 10) in 134 diethylstilbestrol-exposed men (18 per cent) and 87 placebo-exposed men (8 per cent). Further investigation of the 26 diethylstilbestrol-exposed men with testicular hypoplasia has revealed that 65 ...

    Also Ranks for: Diethylstilbestrol Exposure |  cryptorchidism testicular |  publication abnormalities |  luteinizing hormone |  male maternal


    Francis H Straus: Influence Statistics

    Sample of concepts for which Francis H Straus is among the top experts in the world.
    Concept World rank
    pheochromocytomas metastases evidence #1
    pathology hyperparathyroidism #1
    parathyroid glands aged #1
    patient reported discovery #1
    thiazide diuretics onset #1
    pancreatitis thiazide #1
    thiazide administration role #1
    diffuse squamous metaplasia #1
    time parathyroids #1
    calcitonin medullary cancer #1
    defect familial pheochromocytoma #1
    sipples syndrome concentrations #1
    earlier series pancreatitis #1
    parathyroid adenomas patient #1
    pancreas thiazide administration #1
    adenomas carcinoma female #1
    pancreatitis thiazide administration #1
    thiazide administration time #1
    k‐12 ras mutations #2
    tk xtc1 cells #2
    adenocarcinomas carcinoid #2
    infection adrtgluc #2
    adcmvluc frtl5 cells #2
    38 gastrinomas #2
    promoter adcmvtk #2
    adenovirus rtg promoter #2
    large bowel adenocarcinomas #2
    adrtgtk gene therapy #2
    treated adrtgtk #2
    adrtgtk therapy #2
    infected xtc1 #2
    adrtgluc adcmvluc #2
    intractable ulcer disease #2
    gcv compared #2
    rtg promoter tk #2
    adrtgtk tk #2
    cysts diethylstilbestrol #2
    adrtgluc frtl5 cells #2
    spleen adrtgluc #2
    xtc1 cell #2
    parathyroid glands total #2
    adrtgluc #2
    intestine carcinoid #2

    Key People For Ras Mutations

    Top KOLs in the world
    Bert Vogelstein
    colorectal cancer somatic mutations tumor dna
    Johannes L Bos
    cell adhesion signal transduction protein kinase
    Frank P McCormick
    ras proteins protein kinase tumor cells
    James A Fagin
    thyroid cancer smooth muscle transgenic mice
    Stanley R Hamilton†
    colorectal cancer familial adenomatous polyposis microsatellite instability
    J L Bos
    ras mutation xeroderma pigmentosum esophageal cancers

    Francis H Straus:Expert Impact

    Concepts for whichFrancis H Straushas direct influence:Ras mutations,  Hürthle cell tumors,  Carcinoid tumors,  Rectal carcinoid tumors,  Medullary thyroid carcinoma,  Methylene blue,  Small bowel,  Thyroid cancer.

    Francis H Straus:KOL impact

    Concepts related to the work of other authors for whichfor which Francis H Straus has influence:Thyroid cancer,  Carcinoid tumors,  Lymph node,  Graves disease,  Papillary carcinoma,  Gene therapy,  Tumor size.



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    Department of Pathology, University of Chicago, Chicago, IL, 60637 | Department of Pathology, The University of Chicago, Chicago, IL 60637, USA | Department of Pathology, The University of Chicago, Pritzker School of Medicine, and Rosalind Franklin S