• Disease
  • Serum
  • Serum Albumin
  • Richard S Farr

    Prominent publications by Richard S Farr

    KOL Index score: 10315

    The capacity of antibodies in 102 human sera to bind components of aspergilli was studied. Sera were from patients with pulmonary aspergillosis or a variety of other clinical disorders and from healthy individuals. The antigens employed were anionic mucopolysaccharide components derived from A. fumigatus and A. nidulans and were not precipitated by antibodies in either human or rabbit sera. The antigens were soluble in 10 per cent trichloroacetic add and 50 per cent saturated ammonium ...

    Also Ranks for: Primary Interaction |  normal persons |  antibodies sera |  patients aspergillosis |  antigens fungal
    KOL Index score: 8432

    Four of six adult rabbits drinking skimmed cow's milk produced antibody against BSA and ALA. Anti-BSA was first detected in some sera 14 days after the initiation of milk feedings and anti-ALA was present when first studied on the thirty-fifth day. Three of the four antisera bound more I*BSA than I*ALA during the entire study. The specificities of the antibodies which bind ALA and BSA in human serum were very similar to the specificities of the respective antibodies in the sera from ...

    Also Ranks for: Serum Albumin |  anti bsa |  immune sera |  milk rabbits |  radio iodinated
    KOL Index score: 8050

    Investigations were carried out to examine the possible causes of the low incidence and low levels of anti-BSA in human adults as compared to those of normal children. To determine if the reduced amount of BSA in the adult diet was an important factor, childhood levels of dietary BSA in the form of oral supplemental doses were administered to 17 normal human volunteers for 21 days. To learn if the manner in which dietary protein was catabolized by the gastrointestinal tract of the adult ...

    Also Ranks for: Serum Albumin |  immune responses |  anti bsa |  injections intradermal |  intestinal absorption
    KOL Index score: 7328

    Acetylsalicylic acid (aspirin) acetylates human serum albumin under physiologic conditions in vitro. These investigations were done to determine whether this phenomenon occurs in vivo and to delineate the site(s) of acetylation on the albumin molecule. Albumin was reacted in vitro with aspirin labeled with (14)carbon at the acetyl-1 or the carboxyl carbon. The altered albumin was hydrolyzed with trypsin and peptide mapping performed. Albumin so treated contains a unique peptide, ...

    Also Ranks for: Serum Albumin |  acetylsalicylic acid |  phenomena chemistry |  transacetylation reaction |  patients aspirin
    KOL Index score: 7064

    The nasal and respiratory symptoms observed after oral challenge to aspirin (ASA), tartrazine, and other nonsteroidal anti-inflammatory substances are best described as idiosyncratic reactions. A positive response to oral challenge, defined as a 20% fall in forced expiratory volume in 1 sec (FEV1) from baseline for up to 4 hr, occurred in 44 of 230 patients with ASA, 11 of 277 with tartrazine, 2 of 93 with sodium salicylate, and 2 of 69 with acetaminophen. No one had a positive response ...

    Also Ranks for: Positive Response |  oral challenge |  sodium salicylate |  adult asthmatic patients |  nasal polyps
    KOL Index score: 7042

    The possibility that ingested antigens may play a role in the pathogenesis of systemic lupus erythematosus (SLE) has not been previously studied. Because this might be of considerable importance, a study was undertaken to examine the occurrence of antibodies to bovine gamma globulin (BGG) and bovine serum albumin (BSA) in SLE sera. In addition, an assay for the detection o f trace amounts o f BGG in human serum was developed. Antibodies to BGG were found in over 60 per cent of SLE sera ...

    Also Ranks for: Lupus Erythematosus |  serum albumin |  gamma globulin |  sle sera |  antibodies bovine
    KOL Index score: 6996

    Five human sera with reaginic activity to a number of allergens were fractionated using anion exchange chromatography. In each serum, fractions which contained detectable IgG and no detectable IgA had capacity to fix to skin and subsequently elicit a P-K reaction. Four of these sera had reaginic activity about equally distributed between fractions containing only IgG and fractions containing mixtures of IgG and IgA. A fifth serum contained reaginic activity to crystalline bovine serum ...

    Also Ranks for: Reaginic Activity |  igg fractions |  pollen rhinitis |  human sera |  antigen antibody
    KOL Index score: 6993

    We investigated the possibility that the inflammatory reaction in primary acquired cold urticaria might be associated with the release of platelet-activating factor. Six patients with the disease and five normal controls were subjected to cold-water challenges during which blood samples were obtained for measurement of the release of possible mediators: i.e., histamine, neutrophilic chemotactic activity, and platelet-activating factor-like lipid (PAF-LL). Four of the patients had ...

    Also Ranks for: Cold Urticaria |  activating factor |  primary acquired |  histamine release |  paf patients
    KOL Index score: 6905

    1.1. Ragweed pollen extract was fractionated with 50 per cent saturated ammonium sulfate (SAS) and the supernatant labeled with I131.2.2. When 0.02 γ N of this heterogenous mixture (I∗RW) was incubated with normal human or rabbit sera, approximately 10 per cent was nonspecifically precipitated with the globulins after the addition of 40 per cent SAS.3.3. After incubation with sera from humans or rabbits immunized with ragweed pollen extract as much as 40 to 60 per cent of the I∗RW was ...

    Also Ranks for: Ragweed Pollen |  primary interaction |  plant humans plant |  specific antibody |  rabbit antisera
    KOL Index score: 6869

    The acquired cold urticaria (ACU) syndromes consists of nonfamilial heterogeneous disorders characterized by urticaria, angioedema, and occasionally symptoms of hypotension after cold exposure. In a study of 50 consecutive patients with ACU syndromes, it was observed that 70% experienced cold-induced systemic reactions, most frequently with aquatic activities. Patients with ACU syndromes were categorized by their response to an experimental cold-stimulation time test (CSTT) i.e., minimum ...

    Also Ranks for: Cold Urticaria |  systemic reactions |  diagnostic classification |  patients acu |  aquatic activities
    KOL Index score: 6344

    An improved protocol was developed for the use of troleandomycin (TAO) in severe, steroid-requiring subjects with asthma. Compared to previous reports, this protocol uses a lower starting dose of TAO and a rapid steroid taper. Fifteen patients were treated with TAO following the new guidelines. Steroid requirements in the 15 patients dropped by 68% within 2 weeks, and 13 of the 15 patients were able to be maintained on alternate day steroids. In spite of rapid steroid taper, both FEV1 ...

    Also Ranks for: Troleandomycin Tao |  requiring asthma |  15 patients |  male methylprednisolone |  2 weeks
    KOL Index score: 6297

    Sera from normal rabbits were shown to have antibodies that bound radiolabeled test antigens derived from many taxonomically unrelated bacteria. Sera from rabbits that had been immunized with sonically treated material of 12 different bacteria, including M. bovis strain BCG, had antibodies that bound not only radiolabeled homologous test antigens but also radiolabeled antigens from many unrelated bacteria. Binding by normal and immunized sera to radiolabeled test antigens was inhibited ...

    Also Ranks for: Bacterial Antigens |  listeria monocytogenes |  sera rabbits |  antibody reactions |  animals antibodies
    KOL Index score: 6225

    A solid-phase radioimmunoassay to detect antibodies that react with antigens derived from human melanoma cells is described. A soluble preparation derived from Nonidet P-40 lysates of tissue-cultured melanoma cells was dried on the surfaces of wells of polyvinyl chloride microtiter plates and fixed with 0.02% glutaraldehyde. Antibody preparations were added and incubated for 18 h at 4° C. The wells were washed and bound antibodies were detected using radioactive Staphyloccoccal protein A ...

    Also Ranks for: Melanoma Cells |  antigens derived |  hybridoma supernatants |  antibodies antigen |  phase radioimmunoassay
    KOL Index score: 5669

    Studies were undertaken to find a substance or substances for use in primary binding types of tests to detect humoral antibodies in rabbits and monkeys exposed to the tubercle bacillus that would distinguish between strains of mycobacteria. The antigen employed was a component of the 5159 strain of Mycobacterium tuberculosis that was obtained following sonification, ultracentrifugation, electrophoresis, and elution from a preparative polyacrylamide column. When the antigen was labeled ...

    Also Ranks for: Mycobacterium Tuberculosis |  humoral antibodies |  molecular weight |  antigen antibody |  immunoelectrophoresis iodine


    Richard S Farr: Influence Statistics

    Sample of concepts for which Richard S Farr is among the top experts in the world.
    Concept World rank
    acetylsalicylic acid aspirin #1
    immunoglobulindeficient children #1
    nacetylhsa derivative aspirin #1
    prolactin ribonucleases #1
    heterophile bordetella pertussis #1
    bgg bovine #1
    albumin acetylsalicylic #1
    antigenic groups component #1
    intradermal injections bsa #1
    antigenic differences pool #1
    pollen antisera #1
    acetrizoic #1
    type paraproteins inhibitors #1
    alternaria immunological alternaria #1
    atopic sera #1
    5159 organisms #1
    occurrence bgg #1
    labeled antigens #1
    aspirin preservatives #1
    commercial house dust #1
    acidlabile factor ralf #1
    131ibcgr antibcgr #1
    bgg serum albumin #1
    mycobacterium shared antigens #1
    pollen antigens antigens #1
    inhibitors type paraproteins #1
    inhibition enhanced acetrizoate #1
    electrophoresis binding salicylates #1
    presidential message #1
    intradermal injection bsa #1
    slight increases γa #1
    labeled antigens components #1
    antibovine #1
    gammaglobulins deae #1
    regard elution characteristics #1
    improvement tao #1
    aspergilli antigens #1
    single class immunoglobulins #1
    125iclf #1
    mycobacteria antigenic groups #1
    bsa demonstrated #1
    aspergilli sera #1
    neisseria rabbits salmonella #1
    majority antigenic groups #1
    components labeled antigens #1
    dilutions test antisera #1

    Key People For Serum Albumin

    Top KOLs in the world
    Daniel C Carter
    serum albumin protein crystal growth vaccine development
    serum albumin oxidative stress liver microsomes
    Stephen Curry
    serum albumin mouth disease crystal structure
    Ulrich Kragh‐Hansen
    serum albumin fatty acids membrane vesicles
    Xiao Min He
    internal vibrations human serum albumin parabanic acid
    Theodore Peters
    serum albumin dna synthesis new zealand

    Richard S Farr:Expert Impact

    Concepts for whichRichard S Farrhas direct influence:Serum albumin,  Reaginic activity,  Primary interaction,  Cold urticaria,  Bovine serum albumin,  Acetylsalicylic acid,  Ragweed pollen,  Human serum.

    Richard S Farr:KOL impact

    Concepts related to the work of other authors for whichfor which Richard S Farr has influence:Activating factor,  Airway responsiveness,  Systemic lupus erythematosus,  Occupational asthma,  Allergic rhinitis,  Cold urticaria,  Bronchial reactivity.



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    From National Jewish Medical and Research Center, Denver | Denver, Colo | From the Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colo., USA | Department of Medicine, National Jewish Center for Immunol