• Pelvic Pain
    • Luigi Fedele
    • Luigi Fedele: Influence Statistics

      Luigi Fedele

      Luigi Fedele

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      Department of Obstetrics and Gynecology, Fondazione "Policlinico-Mangiagalli-Regina Elena" University of Milan, Milan, Italy. Electronic address: luigi.fedele@unimi.it. | ...

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      Luigi Fedele:Expert Impact

      Concepts for whichLuigi Fedelehas direct influence:Pelvic pain,Rectovaginal endometriosis,Unicornuate uterus,Hysteroscopic metroplasty,Rokitansky syndrome,Recurrent endometriosis,Spontaneous abortion,Transvaginal ultrasonography.

      Luigi Fedele:KOL impact

      Concepts related to the work of other authors for whichfor which Luigi Fedele has influence:Pelvic pain,Women endometriosis,Ovarian reserve,Uterine fibroids,Vitro fertilization,Endometrial cancer,Surgical treatment.

      KOL Resume for Luigi Fedele


      Department of Obstetrics and Gynecology, Fondazione "Policlinico-Mangiagalli-Regina Elena" University of Milan, Milan, Italy. Electronic address:


      Department of Gynecology & Obstetrics, Ospedale San Raffaele Scientific Institute, Vita-Salute San Raffaele University School of Medicine, Milan (Drs. Origoni, Fedele, Parma, Di Fatta, Candiani, and Fedele).


      Department of Obstetrics and Gynecology, IRCCS San Raffaele Hospital, Vita-Salute San Raffaele University, Olgettina, 60, 20132, Milan, MI, Italy


      Department of Clinical Sciences and Community Health, Università degli Studi di Milano, Milan, Italy; ; Gynaecology Unit, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan, Italy;, http://orcid.org/0000-0001-6297-7165

      Dipartimento per la Salute della Donna, del Bambino e del Neonato, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy


      Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy


      Department of Obstetrics and Gynecology “L. Mangiagalli,” Fondazione IRCCS “Ca' Granda” - Ospedale Maggiore Policlinico, Milan, Department of Obstetrics and Gynecology, Reproductive Medicine and Fetal Medicine Unit - Misericordia Hospital, Grosseto, and, Department of Obstetrics and Gynecology, Humanitas San Pio X, Milan, Italy


      Department of Obstetrics and Gynecology ‘L. Mangiagalli', Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, NICU, Department of Clinical Sciences and Community Health, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, University of Milan, and, Department of Pediatric Surgery, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy


      Obstetrics-Gynecology Department, Policlinic Maggiore Hospital (Ospedale Maggiore), University of Milan, Milan - Italy

      Obstetric and Gynecology Unit


      Fondazione Ca' Granda, Ospedale Maggiore Policlinico, Milan, Italy


      Department of Obstetrics and Gynecology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, University of Milan, Milan20122, Italy


      Clinica Ostetrica e Ginecologica, Istituto ‘Luigi Mangiagalli’, Università Statale di Milano, and Fondazione IRCCS ‘Ca’ Granda’– Ospedale Maggiore Policlinico, Milan, Italy

      Department of Obstetrics and Gynecology, University of Milan and Fondazione IRCCS Ca’ Granda – Ospedale Maggiore Policlinico, Milan


      Istituto Ostetrico e Ginecologico “Luigi Mangiagalli,”, Università degli Studi di Milano, Via Commenda, 12-20122, Milan, Italy

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      Sample of concepts for which Luigi Fedele is among the top experts in the world.
      Concept World rank
      paradigmatic patient clinician #1
      142 473 #1
      acetate danazol #1
      rectovaginal septum cases #1
      2 patients oligomenorrhea #1
      dose adjustment women #1
      endometriosis stage #1
      275 36 #1
      instrument sets #1
      19 patients light #1
      dysmenorrhea pelvic #1
      17 pregnancies women #1
      vesical base #1
      pregnancy 32 women #1
      multiple extrauterine #1
      partial septate uterus #1
      ultrasonography vaginal #1
      removal excision #1
      association endometriosis stage #1
      scanning female microscopy #1
      anatomic success patients #1
      schillers test #1
      uterine rudiments presence #1
      total absence vaginas #1
      frequently anomalies #1
      satisfaction”∗ #1
      follicular iron ferritin #1
      surgical paradox #1
      dysmenorrhea pelvic pain #1
      amenora #1
      buserelin acetate buserelin #1
      ivf iqr #1
      20 vitamin insufficiency #1
      hypothyroid treated #1
      uterine nodule #1
      medical terms endometriosis #1
      endometrial patterns #1
      stage logrank test #1
      inguinal endometriosis patients #1
      depression asymptomatic endometriosis #1
      deep endometriosis removal #1
      leiomyoma study design #1
      unremarkable cvs #1
      neovaginal mucosa #1
      perilesional fibrosis #1
      perinatal environmental exposure #1
      endometriosis 125 levels #1
      vaginal patterns #1
      endometriotic cysts pregnancy #1
      visceral adipose thickness #1
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      Prominent publications by Luigi Fedele

      KOL-Index: 14077

      INTRODUCTION: No prior study of endometriosis has investigated the psychological impact of having asymptomatic endometriosis versus endometriosis with pelvic pain in a systematic way. This study aimed at examining the impact of endometriosis on quality of life, anxiety and depression by comparing asymptomatic endometriosis, endometriosis with pelvic pain, and healthy, pain-free controls. The psychological impact of different types of endometriosis pain was also tested.

      METHODS: One ...

      Known for Pelvic Pain | Mental Health | Quality Life | Asymptomatic Endometriosis | Anxiety Depression
      KOL-Index: 12313

      BACKGROUND: There is a growing consensus that ovarian endometriomas should not be systematically removed in women selected for IVF. However, some recent evidence suggested that the presence of these cysts may negatively affect the course of pregnancy.

      METHODS: We set up a multicenter retrospective cohort study, including two infertility units. We analyzed data from patients achieving singleton clinical pregnancies through IVF comparing the pregnancy outcome between 78 pregnant women with ...

      Known for Pregnancy Outcome | Women Ivf | Newborn Infant | Live Birth | Ovarian Endometriomas
      KOL-Index: 11693

      BACKGROUND: Thyroid autoimmunity (TAI) is the most frequent autoimmune condition and the first cause of thyroid dysfunction among women of reproductive age. Notably, it has been associated with adverse obstetric outcomes during all trimesters of pregnancy. Furthermore, since most studies show an increased prevalence of TAI among women attending infertility clinics, a detrimental impact of this condition on natural fertility and on the rate of success of assisted reproductive ...

      Known for Thyroid Autoimmunity | Icsi Outcome | Pregnancy Rate | Serum Tsh | Systematic Review Metaanalysis
      KOL-Index: 11456

      The role of reproductive factors in endometrial cancer risk has been analyzed in a case-control study conducted since 1983 in the greater Milan area on 568 women (cases) with histologically confirmed endometrial cancer and 1925 women (controls) who were admitted for acute, nonmalignant, hormonal, gynecologic conditions to hospitals that cover a comparable catchment area. Compared with nulliparous women, parous women had a 30% lower risk of endometrial cancer, but there was no evidence of ...

      Known for Reproductive Factors | Endometrial Cancer | Birth Risk | Parous Women | Induced Abortions
      KOL-Index: 10787

      STUDY QUESTION: Does surgical or medical treatment for endometriosis-associated severe deep dyspareunia achieve better results in terms of patients' satisfaction (main study outcome), variation of coital pain and frequency of intercourse?

      SUMMARY ANSWER: Surgery and progestin therapy were equally effective in the treatment of deep dyspareunia in women with rectovaginal endometriosis, whereas medical therapy performed significantly better than excisional treatment in those without deeply ...

      Known for Medical Treatment | Deep Dyspareunia Women | Norethisterone Acetate | Conservative Surgery | Dyspareunia Endometriosis
      KOL-Index: 10642

      STUDY QUESTION: Does surgical and low-dose progestin treatment differentially affect endometriosis-associated severe deep dyspareunia in terms of sexual functioning, psychological status and health-related quality of life?

      SUMMARY ANSWER: Surgery and progestin treatment achieved essentially similar benefits at 12-month follow-up, but with different temporal trends.

      WHAT IS ALREADY KNOWN: Conservative surgery and hormonal therapies have been used independently for endometriosis-associated ...

      Known for Deep Dyspareunia | Sexual Functioning | Life Women | Psychological Status | Treatment Endometriosis
      KOL-Index: 10236

      OBJECTIVES: To estimate fetal brain volume from head circumference and published postmortem data; to determine normal values for the fetal brain/liver volume ratio relative to gestational age; to establish the relationship between the brain/liver volume ratio and fetal circulatory parameters during normal and restricted (SGA) fetal growth.

      PATIENTS AND METHOD: This was a cross-sectional study involving a total of 47 uncomplicated pregnancies appropriate-for-gestational age (AGA) and 23 ...

      Known for Fetal Brain | Liver Volume | Gestational Age | Newborn Infant | Ductus Venosus
      KOL-Index: 10139

      OBJECTIVE: To compare Vecchietti's and Davydov's laparoscopic techniques for creation of a neovagina in patients with Rokitansky syndrome.

      DESIGN: Comparative retrospective study.

      SETTING: Tertiary referral center for the treatment of Rokitansky syndrome.

      PATIENT(S): Eighty patients with Rokitansky syndrome.

      INTERVENTION(S): Patients underwent surgical creation of a neovagina. Fifteen patients who underwent the Vecchietti procedure from October 2003 to December 2004 and 30 patients who ...

      Known for Neovagina Patients | Sex Development Abnormalities | 12 Months | Davydov Procedure | Follow Studies
      KOL-Index: 10032

      The effect of rectovaginal endometriosis on fertility is unclear. Several authors foster radical surgery, including colorectal resection, as a fertility-enhancing procedure. However, interpretation of data is difficult, as the baseline fertility status is often undefined and it is not always possible to discriminate between spontaneous conceptions and those resulting from IVF. A systematic literature review was performed with the aim of defining the pregnancy rate specifically in ...

      Known for Rectovaginal Endometriosis | Infertile Patients | Pregnancy Rate | Colorectal Resection | Literature Review
      KOL-Index: 9967

      AIM: To analyse the relationship between reproductive and menstrual factors and different stages of pelvic endometriosis.

      METHODS: Between 1987 and 1990 a case-control study of risk factors for pelvic endometriosis was conducted. Cases comprised 376 women (median age 32 years) with pelvic endometriosis confirmed by laparoscopy or laparotomy admitted to any one of three clinics in Lombardy, northern Italy. A total of 129 (34.3%) of these women were at stage 1, 76 (20.2%) at stage 2, 96 ...

      Known for Pelvic Endometriosis | Northern Italy | Estimated Ors | Case Control | Disease Women
      KOL-Index: 9692

      BACKGROUND: The association between lesion type, disease stage and severity of pain was studied in a large group of women with endometriosis to verify whether endometrial implants at different sites determine specific complaints and to evaluate the validity of the current classification system in women with symptomatic disease.

      METHODS: A total of 1054 consecutive women with endometriosis undergoing first-line conservative or definitive surgery were included. Data on age at surgery, ...

      Known for Endometriosis Stage | Pain Symptoms | Multivariate Analysis | Patient Characteristics | Lesion Type
      KOL-Index: 9674

      OBJECTIVE: About one out of two women with primary hypothyroidism has to increase the dosage of exogenous levothyroxine (L-T4) during pregnancy. Considering the detrimental impact of IVF on thyroid function, it has been claimed but not demonstrated that L-T4 dose adjustment may be more significant in hypothyroid women who become pregnant after IVF.

      DESIGN: Retrospective cohort study.

      METHODS: Hypothyroid-treated women who achieved a live birth through IVF were reviewed. Women could be ...

      Known for Dose Adjustment | Thyroid Function | Serum Tsh | Ivf Lt4 | Live Birth
      KOL-Index: 9580

      OBJECTIVES: To establish the risk factors for monozygotic twin (MZT) and monochorionic twin (MCT) pregnancies after in vitro fertilization (IVF).

      DESIGN: Systematic review and meta-analysis.

      SETTING: Not applicable.

      PATIENT(S): Women who achieved MZT and non-MZT pregnancies through IVF.

      INTERVENTION(S): Systematic search of Medline from January 1995 to October 2018 with cross-checking of references from relevant articles in English.

      MAIN OUTCOME MEASURE(S): Possible risk factors for MZT ...

      Known for Vitro Fertilization | Monozygotic Twinning | Embryo Transfer | Female Age | Mzt Pregnancies
      KOL-Index: 9571

      BACKGROUND: Endoscopic laser coagulation of placental anastomoses is the first-line treatment for severe twin-to-twin transfusion syndrome. A recent randomized controlled trial reported that laser coagulation along the entire vascular equator was associated with a similar dual survival and survival of at least 1 twin compared with the group that was treated with the selective technique. In addition, there was a significantly lower incidence of postoperative recurrence of twin-to-twin ...

      Known for Twin Transfusion | Laser Coagulation | Placental Anastomoses | Gestational Age | Neonatal Survival
      KOL-Index: 9527

      To evaluate risk factors for cervical intraepithelial neoplasia (CIN), data were collected in a case-control study based on 366 patients (58 with CIN class 1, 70 with CIN class 2, and 238 with CIN class 3) and 323 control subjects with normal cervical smears interviewed on selected days at the same screening clinics where cases had been identified. No relationship emerged between indicators of socioeconomic status (education and social class) and risk of mild/moderate (considered ...

      Known for Cervical Intraepithelial | Risk Cin | Age Birth | Factors Sexual | Dysplasia Uterine

      Key People For Pelvic Pain

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      John Richard Landis
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      Luigi Fedele
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      Anthony J Schaeffer
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      Department of Obstetrics and Gynecology, Fondazione "Policlinico-Mangiagalli-Regina Elena" University of Milan, Milan, Italy. Electronic address: luigi.fedele@unimi.it. | Department of Gynecology & Obstetrics, Ospedale San Raffaele Scientific Institu

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