• Disease
  • Confocal
  • Confocal Microscopy
  • Rainer Hofmann‐wellenhof
  • Rainer Hofmann‐Wellenhof

    Rainer Hofmann‐Wellenhof


    Prominent publications by Rainer Hofmann‐Wellenhof

    KOL Index score: 14199

    BACKGROUND: Preliminary studies have described morphological features of basal cell carcinoma (BCC) imaged by high-definition optical coherence tomography (HD-OCT) and suggested that this technique may aid in its diagnosis and management. However, systematic studies evaluating the accuracy of HD-OCT for the diagnosis of BCC are lacking.

    OBJECTIVE: The aim of this study was to identify three-dimensional (3-D) HD-OCT features able i) to distinguish BCC from clinical BCC imitators and ii) ...

    Also Ranks for: Optical Coherence |  basal cell carcinoma |  bcc subtypes |  hd oct |  diagnostic algorithm
    KOL Index score: 14119

    BACKGROUND: Preliminary studies described morphological features of actinic keratosis (AK) and squamous cell carcinoma (SCC) imaged by High-Definition Optical Coherence Tomography (HD-OCT) and suggested that this technique may aid in their diagnosis. However, systematic studies evaluating the accuracy of HD-OCT for the diagnosis of AK and SCC are lacking so far.

    OBJECTIVE: In this study, we sought to design an algorithm for AK classification that could (i) distinguish SCC from AK and ...

    Also Ranks for: Normal Skin |  optical coherence |  actinic keratosis |  squamous cell carcinoma |  tomography algorithm
    KOL Index score: 11738

    Exposing human skin to ultraviolet radiation causes DNA damage, sunburn, immune alterations, and eventually, skin cancer. We wished to determine whether liposomes containing a DNA repair enzyme could prevent any of the acute effects of irradiation when applied after ultraviolet exposure. Fifteen human patients with a prior history of skin cancer were exposed to two minimal erythema doses of ultraviolet radiation on their buttock skin. Liposomes containing T4 endonuclease V or ...

    Also Ranks for: T4 Endonuclease |  necrosis factor |  topical treatment |  human skin |  ultraviolet radiation
    KOL Index score: 11555

    Importance: Deep learning convolutional neural networks (CNNs) have shown a performance at the level of dermatologists in the diagnosis of melanoma. Accordingly, further exploring the potential limitations of CNN technology before broadly applying it is of special interest.

    Objective: To investigate the association between gentian violet surgical skin markings in dermoscopic images and the diagnostic performance of a CNN approved for use as a medical device in the European market.

    Design ...

    Also Ranks for: Dermoscopic Images |  diagnostic performance |  melanoma recognition |  skin markings |  roc auc
    KOL Index score: 10874

    BACKGROUND: There is a need for better standardization of the dermoscopic terminology in assessing pigmented skin lesions.

    OBJECTIVE: The virtual Consensus Net Meeting on Dermoscopy was organized to investigate reproducibility and validity of the various features and diagnostic algorithms.

    METHODS: Dermoscopic images of 108 lesions were evaluated via the Internet by 40 experienced dermoscopists using a 2-step diagnostic procedure. The first-step algorithm distinguished melanocytic versus ...

    Also Ranks for: Pigmented Skin Lesions |  consensus meeting |  diagnostic algorithms |  basal cell diagnosis |  pattern analysis
    KOL Index score: 10823

    BACKGROUND: Convolutional neural networks (CNNs) efficiently differentiate skin lesions by image analysis. Studies comparing a market-approved CNN in a broad range of diagnoses to dermatologists working under less artificial conditions are lacking.

    MATERIALS AND METHODS: One hundred cases of pigmented/non-pigmented skin cancers and benign lesions were used for a two-level reader study in 96 dermatologists (level I: dermoscopy only; level II: clinical close-up images, dermoscopy, and ...

    Also Ranks for: Skin Lesions |  cnn dermatologists |  sensitivity specificity |  neural network |  management decisions
    KOL Index score: 10631

    BACKGROUND: Several dermoscopic and in vivo reflectance confocal microscopy (RCM) diagnostic criteria of lentigo maligna (LM)/lentigo maligna melanoma (LMM) have been identified. However, no study compared the diagnostic accuracy of these techniques.

    OBJECTIVE: We evaluated the diagnostic accuracy of dermoscopy and RCM for LM/LMM using a holistic assessment of the images.

    METHODS: A total of 223 facial lesions were evaluated by 21 experts. Diagnostic accuracy of the clinical, dermoscopic ...

    Also Ranks for: Confocal Microscopy |  lm lmm |  dermoscopy rcm |  lentigo maligna |  techniques diagnosis
    KOL Index score: 10362

    BACKGROUND: Benign melanocytic skin lesions may be difficult to differentiate from melanoma both clinically and dermoscopically. One of the most confounding dermoscopic features, commonly seen in melanoma but in our experience also in melanocytic naevi, is represented by the so-called blue-white structures (BWS).

    OBJECTIVES: To evaluate diagnostic significance and histopathological correlates of BWS seen by dermoscopy in a series of clinically equivocal melanocytic skin lesions that were ...

    Also Ranks for: Skin Lesions |  melanocytic naevi |  histopathological correlates |  spontaneous nevus |  lesion surface
    KOL Index score: 9944

    BACKGROUND: Based on the dermoscopic classification of acquired melanocytic naevi, six different dermoscopic types can be distinguished by morphology (globular, globular-reticular, globular-homogeneous, reticular, reticular-homogeneous, homogeneous) and by pigment distribution (uniform, central hyperpigmentation, central hypopigmentation, peripheral hyperpigmentation, peripheral hypopigmentation, multifocal hyper/hypopigmentation). It has been suggested that most individuals harbour one ...

    Also Ranks for: Melanocytic Naevi |  dermoscopy patterns |  dermoscopic types |  individuals age |  reticular globular
    KOL Index score: 9285

    IMPORTANCE: The comparative diagnostic performance of dermoscopic algorithms and their individual criteria are not well studied.

    OBJECTIVES: To analyze the discriminatory power and reliability of dermoscopic criteria used in melanoma detection and compare the diagnostic accuracy of existing algorithms.

    DESIGN, SETTING, AND PARTICIPANTS: This was a retrospective, observational study of 477 lesions (119 melanomas [24.9%] and 358 nevi [75.1%]), which were divided into 12 image sets that ...

    Also Ranks for: Dermoscopic Criteria |  abcd rule |  differentiate nevi |  melanoma detection |  algorithms dermoscopy
    KOL Index score: 9094

    BACKGROUND: Superficial BCCs (sBCCs) usually appear as multiple lesions in chronic sun-damaged skin of elderly people and may show a destructive growth if left untreated. Non-invasive treatment modalities, such as cryotherapy have been employed for sBCCs, all failing to provide tissue for confirming diagnosis and assessing adequacy of tumour removal. Reflectance confocal microscopy (RCM), a new non-invasive imaging technique has proven to be a useful tool for detection of basal cell ...

    Also Ranks for: Confocal Microscopy |  basal cell |  vivo reflectance |  cryotherapy treatment |  upper dermis
    KOL Index score: 9049

    BACKGROUND: Skin self-examinations supplemented with mobile teledermoscopy might improve early detection of skin cancers compared with naked-eye skin self-examinations. We aimed to assess whether mobile teledermoscopy-enhanced skin self-examination can improve sensitivity and specificity of self-detection of skin cancers when compared with naked-eye skin self-examination.

    METHODS: This randomised, controlled trial was done in Brisbane (QLD, Australia). Eligible participants (aged ≥18 ...

    Also Ranks for: Skin Cancer |  participants intervention |  controlled trial |  sensitivity specificity |  mobile teledermoscopy
    KOL Index score: 8948

    BACKGROUND: Even though progress has been made, the detection of melanoma still poses a challenge. In light of this situation, the Nevisense electrical impedance spectroscopy (EIS) system (SciBase AB, Stockholm, Sweden) was designed and shown to have the potential to be used as an adjunct diagnostic tool for melanoma detection.

    OBJECTIVES: To assess the effectiveness and safety of the Nevisense system in the distinction of benign lesions of the skin from melanoma with electrical ...

    Also Ranks for: Melanoma Detection |  clinical performance |  observed sensitivity |  basal cell carcinoma |  skin lesions
    KOL Index score: 8904

    BACKGROUND: The dermoscopic classification is a useful tool for handling patients with atypical naevi (Clark naevi).

    OBJECTIVES: To investigate if the dermoscopic classification of atypical naevi is of any value to discriminate benign from malignant melanocytic lesions.

    METHODS: Consecutive patients (n = 205) were included with 254 suspicious melanocytic lesions, confirmed by histopathology at the Pigmented Lesions Clinic of the Department of Dermatology, University Medical Center, ...

    Also Ranks for: Melanocytic Lesions |  threestructure type |  dermoscopic images |  clark naevi |  reticular homogeneous


    Rainer Hofmann‐Wellenhof: Influence Statistics

    Sample of concepts for which Rainer Hofmann‐Wellenhof is among the top experts in the world.
    Concept World rank
    6020 dermoscopic images #1
    images pigmented #1
    pregiven answers #1
    ziel qualitätssteigerung #1
    periodic assessment state #1
    hälfte benutzte #1
    blue scalp dermatoses #1
    nichtmelanozytären #1
    kosmetisch #1
    in‐situ‐plattenepithelkarzinoms #1
    nonmelanocytic skin tumors #1
    frequency unna type #1
    melanomas external ear #1
    acanthoma dermoscopy #1
    patient acceptance dlqi #1
    perception melanocytic nevi #1
    dermatology survey #1
    recurrent nevi #1
    dotted glomerular #1
    atypical melanocytes cases #1
    erstdiagnostiken #1
    high‐need patients #1
    cis balanitis carcinoma #1
    mamillary eczema #1
    nm breslow thickness #1
    facial lentigo maligna #1
    image quality gps #1
    sheets dendritic melanocytes #1
    benign papillomatous #1
    zusätzliche rcm verbesserte #1
    kommunikationsmittel qualitätssteigerung #1
    dermatology medical university #1
    dermoscopy epidermis #1
    age 8058 years #1
    zweckmäßigsten wurde #1
    cordlike rete ridges #1
    patients twostep algorithm #1
    17 lesion areas #1
    life nevi #1
    regionale teledermatologische #1
    therapy relevant events #1
    metastatic disease ssms #1
    body weight photos #1
    66 97 years #1
    corneal pseudocysts #1
    naevi background #1
    treatment rcm images #1
    hair repigmentation melanoma #1
    increased melanoma risk #1
    balanitis #1

    Key People For Confocal Microscopy

    Top KOLs in the world
    Milind M Rajadhyaksha
    confocal microscopy human skin mohs surgery
    Salvador González
    confocal microscopy photodynamic therapy polypodium leucotomos
    Roger Yonchien Tsien
    fluorescent proteins living cells protein kinase
    Watt W Webb
    multiphoton microscopy fluorescence correlation cell surface
    Pellacani Pellacani
    confocal microscopy actinic keratosis basal cell
    Caterina Longo
    confocal microscopy basal cell carcinoma melanocytic lesions

    Rainer Hofmann‐Wellenhof:Expert Impact

    Concepts for whichRainer Hofmann‐Wellenhofhas direct influence:Confocal microscopy,  Image analysis,  Scalp naevi,  Reflectance confocal microscopy,  Normal skin,  Melanocytic nevi,  Skin cancer,  Dermoscopic criteria.

    Rainer Hofmann‐Wellenhof:KOL impact

    Concepts related to the work of other authors for whichfor which Rainer Hofmann‐Wellenhof has influence:Skin cancer,  Confocal microscopy,  Dermoscopic features,  Basal cell carcinoma,  Actinic keratosis,  Melanocytic lesions,  Cutaneous melanoma.



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    Department of Dermatology, Medical University of Graz, Graz, Austria | Department of Dermatology, Medical University of Graz, Graz, Austria. | Department of Dermatology and Venereology, Medical University of Graz, Graz, Austria | Abteilung für Dermat