Prominent publications by John Dent

KOL Index score: 14723

BACKGROUND AND AIMS: Transient lower oesophageal sphincter relaxations (TLOSRs) are the major cause of gastro-oesophageal reflux in normal subjects and in most patients with reflux disease. The gamma aminobutyric acid (GABA) receptor type B agonist, baclofen, is a potent inhibitor of TLOSRs in normal subjects. The aim of this study was to investigate the effect of baclofen on TLOSRs and postprandial gastro-oesophageal reflux in patients with reflux disease.

METHODS: In 20 patients with ...

Also Ranks for: Reflux Disease |  lower oesophageal |  agonist baclofen |  sphincter relaxations |  esophagogastric junction
KOL Index score: 14064

OBJECTIVE: The aim of this study was to determine the accuracy of the diagnosis of gastro-oesophageal reflux disease (GORD) by the Reflux Disease Questionnaire (RDQ), family practitioners, gastroenterologists and a test of esomeprazole therapy.

METHODS: This was a single-blind, single-arm study over 3-4 weeks from September 2005 to November 2006. Each symptom-based diagnostic assessment was made blinded to prior diagnoses. Patients were those presenting to their family practitioner with ...

Also Ranks for: Diamond Study |  proton pump |  patients gord |  symptombased diagnosis |  symptom response
KOL Index score: 13585

BACKGROUND: Helicobacter pylori gastritis may progress to glandular atrophy and intestinal metaplasia, conditions that predispose to gastric cancer. Profound suppression of gastric acid is associated with increased severity of H pylori gastritis. This prospective randomised study aimed to investigate whether H pylori eradication can influence gastritis and its sequelae during long term omeprazole therapy for gastro-oesophageal reflux disease (GORD).

METHODS: A total of 231 H pylori ...

Also Ranks for: Reflux Disease |  helicobacter pylori |  antrum corpus |  term omeprazole |  intestinal metaplasia
KOL Index score: 13480

We have studied the response of erosive or ulcerative esophagitis to treatment with omeprazole and its subsequent relapse on cessation of therapy in 196 patients. In the first phase of the study omeprazole (20 or 40 mg daily) was compared with placebo in 64 patients. After 4 wk there was endoscopic healing in 81% (25 of 31) of omeprazole-treated patients and in only 6% (2 of 32) of placebo-treated patients. Endoscopic healing of esophagitis was accompanied by symptom relief and ...

Also Ranks for: Peptic Esophagitis |  endoscopic healing |  patients grade |  treatment omeprazole |  20 40
KOL Index score: 12829

BACKGROUND & AIMS: Transient lower esophageal sphincter (LES) relaxations are the major mechanism of gastroesophageal reflux in normal subjects and in most patients with reflux disease. gamma-Aminobutyric acid (GABA) is an important inhibitory neurotransmitter within the central nervous system which is present in regions of the brainstem that are believed to mediate transient LES relaxations. The aim of this study was to investigate the effect of a GABA(B) agonist baclofen on ...

Also Ranks for: Gabab Agonist Baclofen |  normal subjects |  transient relaxations |  lower esophageal sphincter |  reflux patients
KOL Index score: 12332

BACKGROUND: Dyspepsia and irritable bowel syndrome (IBS) are common in Western populations.

AIM: To determine the epidemiology of dyspepsia and IBS in China.

METHODS: A representative sample of 18 000 adults from five regions of China were asked to complete the modified Rome II questionnaire; 20% were asked to complete the 36-item Short Form Health Survey (SF-36). Participants from Shanghai were invited to provide blood samples and undergo oesophago-gastroduodenoscopy. Odds ratios (ORs) ...

Also Ranks for: Bowel Syndrome |  dyspepsia ibs |  western populations |  odds ratios |  blood samples
KOL Index score: 11799

There is little information about the organisation of antroduodenal contractions or pyloric motility in patients with gastroparesis. The mechanisms responsible for the acceleration of gastric emptying by cisapride in patients with gastroparesis are also poorly understood. Simultaneous manometric and scintigraphic recordings were performed in 12 patients with gastroparesis and nine healthy volunteers before and after cisapride administration. Antropyloroduodenal pressures were recorded ...

Also Ranks for: Gastric Emptying |  cisapride patients |  pressure waves |  gastrointestinal motility humans |  gastroparesis healthy
KOL Index score: 11361

OBJECTIVE: To identify a body-positioning regimen that promotes gastric emptying (GE) and reduces gastroesophageal reflux (GER) by changing body position 1 hour after feeding.

STUDY DESIGN: Ten healthy preterm infants (7 male; mean postmenstrual age, 36 weeks [range, 33 to 38 weeks]) were monitored with combined esophageal impedance-manometry. Infants were positioned in the left lateral position (LLP) or right lateral position (RLP) and then gavage-fed. After 1 hour, the position was ...

Also Ranks for: Gastric Emptying |  body position |  premature infant |  gastroesophageal reflux |  rlp llp
KOL Index score: 11171

BACKGROUND: There is little information on the effects of Helicobacter pylori eradication in patients with a primary diagnosis of gastro-oesophageal reflux disease (GORD). Our aim was to investigate the effect of H pylori eradication in this group of patients.

METHODS: We did a double-blind, randomised, placebo-controlled study in 70 patients with GORD. We assigned individuals to three groups. All patients received lansoprazole 30 mg twice daily for 10 days, followed by 30 mg once daily ...

Also Ranks for: Patients Pylori |  oesophageal reflux |  randomised controlled trial |  agents anti |  8 weeks
KOL Index score: 11097

BACKGROUND: The abnormally high postprandial rate of transient lower oesophageal sphincter relaxations seen in patients with reflux disease may be related to altered proximal gastric motor function. Heightened visceral sensitivity may also contribute to reporting of symptoms in these patients.

AIMS: To assess motor function of the proximal stomach and visceral perception in reflux disease with a barostat.

METHODS: Fasting and postprandial proximal gastric motility, sensation, and ...

Also Ranks for: Proximal Stomach |  reflux disease |  motor function |  symptoms patients |  gastric emptying
KOL Index score: 11091

BACKGROUND: Delivery of radiofrequency energy to the lower esophageal sphincter and gastric cardia is a new endoluminal technique proposed for the treatment of reflux disease. The mechanisms by which it achieves its effects are unclear. The study assessed the effect of radiofrequency energy delivery to the gastric cardia on the triggering of transient lower esophageal sphincter relaxations and gastroesophageal reflux in dogs.

METHODS: In 13 dogs, esophageal motility and pH were measured ...

Also Ranks for: Gastroesophageal Reflux |  radiofrequency energy delivery |  gastric cardia |  esophageal sphincter |  transient lower
KOL Index score: 10853

OBJECTIVES: A globally acceptable definition and classification of gastroesophageal reflux disease (GERD) is desirable for research and clinical practice. The aim of this initiative was to develop a consensus definition and classification that would be useful for patients, physicians, and regulatory agencies.

METHODS: A modified Delphi process was employed to reach consensus using repeated iterative voting. A series of statements was developed by a working group of five experts after a ...

Also Ranks for: Montreal Definition |  based consensus |  gastroesophageal reflux disease |  patients physicians |  global evidence
KOL Index score: 10690

The postprandial motor activity of the antrum, pylorus, and duodenum in 15 healthy volunteers was compared with the profiles of emptying of the solid and liquid components of a meal. The liquid component of the meal emptied rapidly in an exponential manner, whereas the solid remained in the fundus of the stomach until approximately 80% of the liquid had emptied and then emptied in a linear manner. The onset of solid emptying was associated with an increase in the rate of occurrence of ...

Also Ranks for: Motor Activity |  solid emptying |  antrum pylorus |  coordinated contractions |  liquid component

Key People For Reflux Disease

Top KOLs in the world
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Peter ***** ********
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Nicholas ****** ******
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Joel * *******
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Stuart *** ********
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John Dent:Expert Impact

Concepts for whichJohn Denthas direct influence:Reflux disease,  Gastroesophageal reflux,  Gastric emptying,  Oesophageal reflux,  Pyloric motility,  Reflux oesophagitis,  Sleeve sensor,  Gastroesophageal reflux disease.

John Dent:KOL impact

Concepts related to the work of other authors for whichfor which John Dent has influence:Gastroesophageal reflux disease,  Reflux esophagitis,  Gastric emptying,  Helicobacter pylori,  Barrett esophagus,  Proton pump,  Patients gerd.



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Faculty of Health and Medical Sciences, The University of Adelaide, Australia. | Department of Medicine, University of Adelaide, Adelaide, SA, Australia | Department of Medicine, University of Adelaide and Royal Adelaide Hospital, Adelaide, South Aus