Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom | NeuroMetrology Lab, Nuffield Department of Clinical Neurosciences, University of ...
KOL Resume for Christopher Kennard (adnexa, eye, eye adnexa)
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom
NeuroMetrology Lab, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX3 9DU, UK.
Medical Sciences Division, University of Oxford, Oxford, United Kingdom
Medical Sciences Division, John Radcliffe Hospital, University of Oxford, Oxford, UK
Department of Clinical Neurology, University of Oxford, Oxford, United Kingdom
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford OX3 9DU, England, UK
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, OX1 2JD, United Kingdom, and
National Institute for Health Research (NIHR) Biomedical Research Centre, Oxford, United Kingdom
Nuffield Department of Clinical Neurosciences and.
University of Oxford
Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, OX3 9DU, UK
NIHR Biomedical Research Centre, Oxford, United Kingdom
Department of Clinical Neurosciences, University of Oxford, Oxford, UK
Department of Clinical Neurology, University of Oxford, John Radcliffe Hospital, Oxford, UK
Department of Clinical Neurology, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Oxford OX3 9DU, UK
Department of Clinical Neurology, University of Oxford, Level 6, West Wing, John Radcliffe Hospital, Headley Way, Headington, Oxford, OX3 9DU UK
Department of Clinical Neuroscience, Imperial College London, St Dunstan's Road, W6 8RP, London, UK
West London Neurosciences Centre, Charing Cross Hospital, London W6 8RF, UK
From the Department of Clinical Neuroscience (C.V.P.G., C.D., C.K.), Faculty of Medicine, Imperial College; School of Psychology (T.L.H.), Exeter University; and Department of Neurodegenerative Disease (S.J.T.), Institute of Neurology and National Hospital for Neurology and Neurosurgery, London, UK.
Imperial College London
Division of Neuroscience and Mental Health, Imperial College Faculty of Medicine, Charing Cross Site, London
Department of Neurology, University of Newcastle upon Tyne, Framlington, Newcastle upon Tyne NE2 4HH, UK
JNNP, Division of Neuroscience and Psychological Medicine, Imperial College London, Charing Cross Hospital, London W6 8RF
Division of Neuroscience and Psychological Medicine, Faculty of Medicine, Imperial College, Charing Cross Hospital Campus, 10th Floor East Wing, St Dunstans Road, London W6 8RP, UK
Department of Sensorimotor Control, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, St Dunstan's Road, London W6 8RP, UK, UK
Department of Sensorimotor Systems, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Campus, St. Dunstan's Road, London, W6 8RP, UK,
Imperial Colege Schol of Medicine, London
From the Department of Neurology (Drs. Schon and Hart), Atkinson Morley's Hospital, Copse Hill; Department of Neurology (Drs. Hodgson, Pambakian, and Kennard), Charing Cross Hospital; The Medical Toxicology Laboratory (Dr. Ruprah), Guy's and St Thomas' Hospital Trust; and the Centre for Pharmacognosy (Dr. Williamson), The School of Pharmacy, London, UK.
Department of Sensorimotor Systems, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, U.K.
Division of Sensorimotor Systems, Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, London W6 8RF, UK Tel.: +44-181-8467598, Fax: +44-181-8467715, GB
From the Department of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, Royal Postgraduate Medical School, and The Rookery, Queen Mary's University Hospital, London; and Mental Health and Neural Systems Research Unit, Department of Psychology, University of Lancaster
Division of Neuroscience and Psychological Medicine, Imperial College School of Medicine, Charing Cross Hospital, London, UK W6 8RF
Department of Clinical Neuroscience, Charing Cross and Westminster Medical School, Fulham Palace Road, London W6 8RF, UK,
Department of Clinical Neuroscience, Charing Cross Hospital, Fulham Palace Road, W6 8RF, London, UK
Academic Unit of Neuroscience, Charing Cross and Westminster Medical School London, W6 8RF, United Kingdom
Charing Cross Hospital, London
Prominent publications by Christopher Kennard
Potential endpoints for clinical trials in premanifest and early Huntington's disease in the TRACK-HD study: analysis of 24 month observational data
[ PUBLICATION ]
BACKGROUND: TRACK-HD is a prospective observational biomarker study in premanifest and early Huntington's disease (HD). In this report we define a battery of potential outcome measures for therapeutic trials.
METHODS: We assessed longitudinal data collected at baseline, 12 months, and 24 months at sites in Leiden (Netherlands), London (UK), Paris (France), and Vancouver (Canada). Participants were individuals without HD but carrying the mutant HTT gene (ie, premanifest HD), patients with ...
|Known for Early Hd | 24 Month | Potential Endpoints | Longitudinal Data | Brain Atrophy|
Biological and clinical changes in premanifest and early stage Huntington's disease in the TRACK-HD study: the 12-month longitudinal analysis
[ PUBLICATION ]
BACKGROUND: TRACK-HD is a prospective observational study of Huntington's disease (HD) that examines disease progression in premanifest individuals carrying the mutant HTT gene and those with early stage disease. We report 12-month longitudinal changes, building on baseline findings.
METHODS: we did a 12-month follow-up of patients recruited from the four TRACK-HD study sites in Canada, France, the Netherlands, and the UK. Participants were premanifest individuals (preHD) carrying the ...
|Known for Early Hd | Month Longitudinal | Premanifest Individuals | Stage Huntington | Brain Atrophy|
Theta burst stimulation reduces disability during the activities of daily living in spatial neglect
[ PUBLICATION ]
Left-sided spatial neglect is a common neurological syndrome following right-hemispheric stroke. The presence of spatial neglect is a powerful predictor of poor rehabilitation outcome. In one influential account of spatial neglect, interhemispheric inhibition is impaired and leads to a pathological hyperactivity in the contralesional hemisphere, resulting in a biased attentional allocation towards the right hemifield. Inhibitory transcranial magnetic stimulation can reduce the ...
|Known for Spatial Neglect | Burst Stimulation | Activities Daily Living | Repeated Application | Stroke Rehabilitation|
Key PointsThe dorsomedial frontal cortex contains a cluster of areas that are designated the supplementary motor area (SMA), the supplementary eye field (SEF) and the pre-supplementary motor area (pre-SMA). The defining functional feature of the members of this supplementary motor complex (SMC) is a marked sensitivity to various aspects of action.The anatomical features of the SMC are not homogeneous: there is a gradient of morphological and connectional change where affinity with the ...
|Known for Functional Role | Supplementary Motor | Smc Sma | Visual Cortex | Switching Actions|
Structural Organization of the Corpus Callosum Predicts Attentional Shifts after Continuous Theta Burst Stimulation
[ PUBLICATION ]
Repetitive transcranial magnetic stimulation (rTMS) applied over the right posterior parietal cortex (PPC) in healthy participants has been shown to trigger a significant rightward shift in the spatial allocation of visual attention, temporarily mimicking spatial deficits observed in neglect. In contrast, rTMS applied over the left PPC triggers a weaker or null attentional shift. However, large interindividual differences in responses to rTMS have been reported. Studies measuring changes ...
|Known for Corpus Callosum | Structural Organization | Spatial Attention | Magnetic Stimulation | Ips Participants|
Motion area V5/MT+ response to global motion in the absence of V1 resembles early visual cortex
[ PUBLICATION ]
Motion area V5/MT+ shows a variety of characteristic visual responses, often linked to perception, which are heavily influenced by its rich connectivity with the primary visual cortex (V1). This human motion area also receives a number of inputs from other visual regions, including direct subcortical connections and callosal connections with the contralateral hemisphere. Little is currently known about such alternative inputs to V5/MT+ and how they may drive and influence its activity. ...
|Known for Visual Cortex | Global Motion | Area V5 | Callosal Connections | Resonance Imaging|
Biological and clinical manifestations of Huntington's disease in the longitudinal TRACK-HD study: cross-sectional analysis of baseline data
[ PUBLICATION ]
BACKGROUND: Huntington's disease (HD) is an autosomal dominant, fully penetrant, neurodegenerative disease that most commonly affects adults in mid-life. Our aim was to identify sensitive and reliable biomarkers in premanifest carriers of mutated HTT and in individuals with early HD that could provide essential methodology for the assessment of therapeutic interventions.
METHODS: This multicentre study uses an extensive battery of novel assessments, including multi-site 3T MRI, clinical, ...
|Known for Baseline Data | Early Hd | Premanifest Carriers | Agematched Controls | Disease Genetic|
We have used positron emission tomography (PET), which measures regional cerebral blood flow (rCBF), to demonstrate directly the specialization of function in the normal human visual cortex. A novel technique, statistical parametric mapping, was used to detect foci of significant change in cerebral blood flow within the prestriate cortex, in order to localize those parts involved in the perception of color and visual motion. For color, we stimulated the subjects with a multicolored ...
|Known for Functional Specialization | Visual Cortex | Direct Demonstration | Blood Flow | Color Perception|
When the primary visual cortex (V1) is damaged, there are a number of alternative pathways that can carry visual information from the eyes to extrastriate visual areas. Damage to the visual cortex from trauma or infarct is often unilateral, extensive and includes gray matter and white matter tracts, which can disrupt other routes to residual visual function. We report an unusual young patient, SBR, who has bilateral damage to the gray matter of V1, sparing the adjacent white matter and ...
|Known for Damage V1 | Visual Cortex | Gray Matter | Lgn V5 | Magnetic Resonance|
A saccade involves both a step in eye position and an obligatory shift in spatial attention. The traditional division of saccades into two types, the "reflexive" saccade made in response to an exogenous stimulus change in the visual periphery and the "voluntary" saccade based on an endogenous judgement to move gaze, is supported by lines of evidence which include the longer onset latency of the latter and the differential effects of lesions in humans and primates on each. It has been ...
|Known for Reflexive Saccades | Angular Gyrus | Image Processing | Voluntary Saccade | Spatial Attention|
Impaired spatial working memory across saccades contributes to abnormal search in parietal neglect
[ PUBLICATION ]
Visual neglect of left space following right parietal damage in humans involves a lateral bias in attention, apparent in many search tasks. We hypothesized that parietal neglect may also involve a failure to remember which locations have already been examined during visual search: an impairment in retaining searched locations across saccades. Using a new paradigm, we monitored gaze during search, while simultaneously probing whether observers judged they had found a new target, or judged ...
|Known for Searched Locations | Lateral Bias | Visual Neglect | Search Tasks | Parietal Damage|
Response-Dependent Contributions of Human Primary Motor Cortex and Angular Gyrus to Manual and Perceptual Sequence Learning
[ PUBLICATION ]
Motor sequence learning on the serial reaction time task involves the integration of response-, stimulus-, and effector-based information. Human primary motor cortex (M1) and the inferior parietal lobule (IPL) have been identified with supporting the learning of effector-dependent and -independent information, respectively. Current neurocognitive data are, however, exclusively based on learning complex sequence information via perceptual-motor responses. Here, we investigated the effects ...
|Known for Sequence Learning | Motor Cortex | Angular Gyrus | Conscious Awareness | Ctbs M1|
Within the medial frontal cortex, the supplementary eye field (SEF), supplementary motor area (SMA), and pre-SMA have been implicated in the control of voluntary action, especially during motor sequences or tasks involving rapid choices between competing response plans. However, the precise roles of these areas remain controversial. Here, we study two extremely rare patients with microlesions of the SEF and SMA to demonstrate that these areas are critically involved in unconscious and ...
|Known for Frontal Cortex | Unconscious Inhibition | Voluntary Action | Sma Areas | Magnetic Resonance|
OBJECTIVES: This study examined the scanpaths of patients with homonymous hemianopia while viewing naturalistic pictures in their original and also spatially filtered forms. Features of their scanpaths with respect to various saccade and fixation parameters were examined to determine whether they develop compensatory eye movement strategies. The effects of various lesion parameters including location, size, and age on the evolution of such strategies were considered.
METHODS: Eye ...
|Known for Homonymous Hemianopia | Scanpaths Patients | Eye Movements | Blind Hemifield | Controls Saccade|
Christopher Kennard: Influence Statistics
|greater clinical specificity||#1|
|temporal responsiveness visual||#1|
|pprf imaging studies||#1|
|peripheral led targets||#1|
|saccades hemianopic subjects||#1|
|saccade paradigms abnormality||#1|
|neurological conditions prosopagnosia||#1|
|wider basal ganglia||#1|
|visual responses patient||#1|
|prosopagnosia topographical agnosia||#1|
|unified hypothesis patients||#1|
|oculomotor onset capture||#1|
|parkinsons disease delays||#1|
|time spent task||#1|
|gain highest frequency||#1|
|cones fixationrelated inhibition||#1|
|hmt visual performance||#1|
|imperative cue paradigms||#1|
|new object saccades||#1|
|verbally coloured stimuli||#1|
|accurate targeting ppn||#1|
|saccade amplitude controls||#1|
|oculomotor dysfunction oculomotor||#1|
|ocular flutter lesions||#1|
|circumscribed pontine lesion||#1|
|individuals v1 damage||#1|
|inhibitory visual distractors||#1|
|type cortical damage||#1|
|chapter cerebral blindness||#1|
|patients adl tasks||#1|
|saccadic speed fatigue||#1|
|homologue brocas area||#1|
Open the FULL List in Excel
Key People For Eye Movements
Christopher Kennard:Expert Impact
Concepts for whichChristopher Kennardhas direct influence:Eye movements, Remembered saccades, Smooth pursuit, Visual search, Parkinsons disease, Residual vision, Oculomotor abnormalities, Letter migration.
Christopher Kennard:KOL impact
Concepts related to the work of other authors for whichfor which Christopher Kennard has influence:Eye movements, Huntington disease, Multiple sclerosis, Magnetic resonance, Visual cortex, Basal ganglia, Spatial neglect.
Is this your profile? Claim your profile Copy URL Embed Link to your profile