• Disease
  • Iga
  • Iga Nephropathy
  • F Paolo Principal Discussant: Schena
  • F Paolo Principal discussant: Schena

    F Paolo Principal discussant: Schena


    Prominent publications by F Paolo Principal discussant: Schena

    KOL Index score: 16704

    BACKGROUND: IgA nephropathy is the most common glomerulonephritis world-wide. IgA nephropathy causes end-stage kidney disease (ESKD) in 15% to 20% of affected patients within 10 years and in 30% to 40% of patients within 20 years from the onset of disease. This is an update of a Cochrane review first published in 2003 and updated in 2015.

    OBJECTIVES: To determine the benefits and harms of immunosuppression strategies for the treatment of IgA nephropathy.

    SEARCH METHODS: We searched the ...

    Also Ranks for: Immunosuppressive Agents |  iga nephropathy |  uncertain effects |  infection malignancy |  complete remission
    KOL Index score: 15467

    BACKGROUND: IgA nephropathy (IgAN) is the most common glomerulonephritis world-wide and a cause of end-stage kidney disease (ESKD) in 15% to 20% of patients within 10 years and in 30% to 40% of patients within 20 years from the onset of disease. This is an update of a review first published in 2003.

    OBJECTIVES: To determine the benefits and harms of immunosuppression for the treatment of IgAN.

    SEARCH METHODS: For this review update we searched the Specialised Register to 19 February 2015 ...

    Also Ranks for: Immunosuppressive Agents |  iga nephropathy |  progression eskd |  bias included studies |  serum creatinine
    KOL Index score: 14976

    BACKGROUND: The efficacy and safety of converting maintenance renal transplant recipients from calcineurin inhibitors (CNIs) to sirolimus (SRL) was evaluated.

    METHODS: Eight hundred thirty renal allograft recipients, 6 to 120 months posttransplant and receiving cyclosporine or tacrolimus, were randomly assigned to continue CNI (n=275) or convert from CNI to SRL (n=555). Primary endpoints were calculated Nankivell glomerular filtration rate (GFR; stratified at baseline: 20-40 vs. >40 ...

    Also Ranks for: Calcineurin Inhibitors |  renal allograft recipients |  srl conversion |  convert trial |  maintenance therapy
    KOL Index score: 14696

    OBJECTIVE: To evaluate the effects of angiotensin converting enzyme (ACE) inhibitors and angiotensin II receptor antagonists (AIIRAs) on renal outcomes and all cause mortality in patients with diabetic nephropathy.

    DATA SOURCES: Medline, Embase, the Cochrane controlled trials register, conference proceedings, and contact with investigators.

    STUDY SELECTION: Trials comparing ACE inhibitors or AIIRAs with placebo or with each other in patients with diabetic nephropathy.


    Also Ranks for: Renal Outcomes |  diabetic nephropathy |  ace inhibitors |  converting enzyme |  receptor antagonists
    KOL Index score: 14613

    BACKGROUND: The aim of this multicentre collaborative study was to compare the progression of renal disease in children and adults with Henoch-Schönlein purpura (HPS) nephritis selected on the basis of IgA-dominant renal deposits and biopsy material available for review.

    METHODS: The analysis was performed in 152 patients (95 adults and 57 children < 16 years old at diagnosis) with a follow-up (> or = 1 year up to 20 years (4.9 +/- 3.4 years in adults and 4.8 +/- 3.9 years in ...

    Also Ranks for: Children Adults |  schönlein nephritis |  5 years |  clinical presentation |  renal disease
    KOL Index score: 14547

    BACKGROUND: As many as 15-50% of end-stage kidney disease patients are on peritoneal dialysis (PD), but peritonitis limits its more widespread use. Several PD catheter-related interventions have been purported to reduce the risk of peritonitis in PD.

    OBJECTIVES: To evaluate the use of catheter-related interventions for the prevention of peritonitis in PD.

    SEARCH STRATEGY: The Cochrane Renal Group's specialised register (June 2004), The Cochrane CENTRAL Register of Controlled Trials (The ...

    Also Ranks for: Insertion Techniques |  risk peritonitis |  peritoneal dialysis |  catheter type |  exit site
    KOL Index score: 14318

    BACKGROUND: Obstructive nephropathy is characterized at the histologic level by tubular atrophy and interstitial monocyte infiltration. The molecular mechanisms underlying these histologic changes are still poorly defined. Epidermal growth factor (EGF) produced by tubular cells seems to play a pivotal role in the modulation of tubular cell growth, while monocyte chemotactic peptide-1 (MCP-1) is a powerful and specific chemotactic and activating factor for monocytes.

    METHODS: Twenty-four ...

    Also Ranks for: Obstructive Nephropathy |  mcp1 egf |  renal expression |  obstructed kidney |  antigens differentiation
    KOL Index score: 14303

    BACKGROUND: Change in albuminuria has strong biological plausibility as a surrogate endpoint for progression of chronic kidney disease, but empirical evidence to support its validity is lacking. We aimed to determine the association between treatment effects on early changes in albuminuria and treatment effects on clinical endpoints and surrograte endpoints, to inform the use of albuminuria as a surrogate endpoint in future randomised controlled trials.

    METHODS: In this meta-analysis, we ...

    Also Ranks for: Treatment Effects |  surrogate endpoint |  chronic kidney disease |  baseline albuminuria |  30 decrease
    KOL Index score: 14282

    BACKGROUND: Angiotensin II (Ang II) has been shown to be implicated in the development of renal fibrosis in several forms of chronic glomerulonephritides, but the precise mechanisms of its effects remain unclear. It has recently been reported that Ang II stimulates the expression of plasminogen activator inhibitor-1 (PAI-1) in several cell lines. PAI-1 is a major physiological inhibitor of the plasminogen activator/plasmin system, a key regulator of fibrinolysis and extracellular matrix ...

    Also Ranks for: Plasminogen Activator |  messenger receptor |  epithelial cells |  proximal tubular |  pai1 mrna expression
    KOL Index score: 13861

    PURPOSE: This report describes data collected by the Italian Registry of Renal Biopsies (IRRB) (E mail http://www.teseo.it/nephrology/irrb), which includes 15461 renal biopsies (RB) performed over a period of 7 years (1987-1993).

    METHODS: From 1987 to 1988, the Registry recorded only the histological diagnosis of 3686 RB, whereas beginning in 1989, additional records (sex, age, clinical symptoms and renal function) were obtained from 11,775 patients undergoing RB. This is the first ...

    Also Ranks for: Renal Biopsies |  italian registry |  primary gn |  nephrotic syndrome |  clinical data
    KOL Index score: 13618

    T helper type 1 (Th1)-type CD4(+) antitumor T cell help appears critical to the induction and maintenance of antitumor cytotoxic T lymphocyte (CTL) responses in vivo. In contrast, Th2- or Th3/Tr-type CD4(+) T cell responses may subvert Th1-type cell-mediated immunity, providing a microenvironment conducive to disease progression. We have recently identified helper T cell epitopes derived from the MAGE-6 gene product; a tumor-associated antigen expressed by most melanomas and renal cell ...

    Also Ranks for: Renal Cell |  helper type |  messenger rna |  th1 th2 |  tumor antigen
    KOL Index score: 13569

    BACKGROUND: Sirolimus (Rapamune; SRL) in combination with cyclosporine (CsA) reduces the incidence of acute rejection episodes in renal allograft recipients. This study evaluated whether renal function could be improved by elimination of CsA from an SRL-based regimen.

    METHODS: This phase 2, open-label, controlled, randomized study was conducted at 17 centers in the United States and Europe. Two hundred forty-six first cadaveric renal allograft recipients were enrolled, and 197 were ...

    Also Ranks for: Renal Function |  12 months |  early cyclosporine |  black recipients |  graft survival
    KOL Index score: 12496

    Interleukin 6 (IL-6) is produced by human mesangial and tubular cells, and its urinary levels has been proposed as a marker of mesangial proliferation and tubulointerstitial damage. Epidermal growth factor (EGF) is expressed within the Henle's loop and the distal tubule and has been shown to accelerate recovery from renal injury. In the present study we have defined renal gene and protein expression of IL-6 and EGF in 10 normal, 10 nonproliferative glomerulonephritis (NPGN) and 30 IgA ...

    Also Ranks for: Renal Damage |  prognostic marker |  il6 egf |  iga nephropathy |  female glomerulonephritis
    KOL Index score: 12212

    BACKGROUND: Anaemia affects 60-80% of patients with renal impairment, reduces quality of life and is a risk factor for early death. Treatment options are blood transfusion, erythropoietin (EPO) alpha or beta and darbepoetin alfa. Recently higher haemoglobin (Hb) and haematocrit targets have been widely advocated because of positive data from observational studies. However, higher targets may lead to access thrombosis and hypertension and are costly.

    OBJECTIVES: This review assesses the ...

    Also Ranks for: Chronic Kidney Disease |  quality life |  haematocrit targets |  reduced risk |  patients renal


    F Paolo Principal discussant: Schena: Influence Statistics

    Sample of concepts for which F Paolo Principal discussant: Schena is among the top experts in the world.
    Concept World rank
    cells arpcs #1
    generation hemodialysis #1
    hyperactivation pathways #1
    auc test study #1
    mild renal lesions #1
    healthy subjects hss #1
    secondary gn females #1
    simpler histological #1
    failure arteriovenous fistula #1
    immunosuppressive treatment igan #1
    mir1225 expression #1
    igan eskd #1
    igan immunosuppression #1
    messenger adolescent #1
    galnt2 biomarkers blotting #1
    treatment immunosuppressive #1
    secondary gn #1
    remission gfr #1
    ckd healthy subjects #1
    criticism1 1work #1
    glomerular level #1
    cahr types #1
    citrate igan patients #1
    repair tubular #1
    c1galt1 association #1
    mirnas arpcs #1
    specific disease hand #1
    nephropathy candidate #1
    dgf 2c #1
    nephropathy acei #1
    trials igan #1
    underlying delayed #1
    nephrology precision #1
    increase iga1igg ics #1
    mirnas critical role #1
    cnitox cd68 cells #1
    neutral endopeptidase mpa #1
    cahr cnitox #1
    patients proteinuric igan #1
    data renal biopsy #1
    transcriptomics glomerular diseases #1
    cd103 cells cases #1
    urinary evs cells #1
    kidney diseases micrornas #1
    mir148b models #1
    il17 cells dgf #1
    arpc activation #1
    igan members #1
    gender c1galt1 #1
    illness cnvs #1

    Key People For Iga Nephropathy

    Top KOLs in the world
    Bruce A Julian
    iga nephropathy african americans renal transplantation
    Yasuhiko Tomino
    iga nephropathy diabetic rats chronic kidney disease
    John Feehally
    iga nephropathy renal function acute kidney injury
    Rosanna Coppo
    iga nephropathy glomerular disease oxford classification
    F Paolo Principal discussant: Schena
    iga nephropathy renal damage growth factor
    Robert J Wyatt
    iga nephropathy complement activation serum levels

    F Paolo Principal discussant: Schena:Expert Impact

    Concepts for whichF Paolo Principal discussant: Schenahas direct influence:Iga nephropathy,  Treatment effects,  Igan patients,  Cytokine production,  Growth factor,  Immunosuppressive agents,  Renal damage,  Dendritic cells.

    F Paolo Principal discussant: Schena:KOL impact

    Concepts related to the work of other authors for whichfor which F Paolo Principal discussant: Schena has influence:Iga nephropathy,  Chronic kidney disease,  Kidney transplantation,  Renal function,  Oxidative stress,  Peritoneal dialysis,  Transplant recipients.



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    Department of Emergency and Organ Transplantation, University of Bari, Bari, Italy | Department of Emergency and Organ Transplants, University of Bari, Bari, Italy | Department of Electrical and Information Engineering, Polytechnic of Bari, Bari, Ita