• Disease
  • Iga
  • Iga Nephropathy
  • John Feehally

    Prominent publications by John Feehally

    KOL Index score: 14714

    Diabetic renal disease is more common in patients of Asian ethnic origin than White Caucasians in the United Kingdom. This study determines whether a disparity in the incidence of end-stage renal failure secondary to diabetes mellitus exists between these ethnic groups. The incidence of treated end-stage renal failure was estimated using the person-time at risk incidence rate for patients receiving renal replacement therapy secondary to diabetes mellitus in the county of Leicestershire ...

    Also Ranks for: United Kingdom |  diabetes mellitus |  renal failure |  ethnic groups |  white caucasians
    KOL Index score: 13014

    BACKGROUND: Epidemiological data for acute kidney injury are scarce, especially in low-income countries (LICs) and lower-middle-income countries (LMICs). We aimed to assess regional differences in acute kidney injury recognition, management, and outcomes.

    METHODS: In this multinational cross-sectional study, 322 physicians from 289 centres in 72 countries collected prospective data for paediatric and adult patients with confirmed acute kidney injury in hospital and non-hospital settings ...

    Also Ranks for: Acute Kidney Injury |  international society |  global snapshot |  income countries |  nephrology 0by25
    KOL Index score: 12468

    BACKGROUND: Skeletal muscle wasting in chronic kidney disease (CKD) is associated with morbidity and mortality. Resistance exercise results in muscle hypertrophy in the healthy population, but is underinvestigated in CKD. We aimed to determine the feasibility of delivering a supervised progressive resistance exercise program in CKD, with secondary aims to investigate effects on muscle size, strength, and physical functioning.

    STUDY DESIGN: Parallel randomized controlled feasibility ...

    Also Ranks for: Resistance Exercise |  feasibility study |  patients ckd |  muscle strength |  physical functioning
    KOL Index score: 12193

    BACKGROUND: Glomerular deposition of IgA1 is a common feature of Henoch-Schönlein purpura, and is indistinguishable from that seen in IgA nephropathy. Serum IgA1 is abnormally O-glycosylated in IgA nephropathy, and this may contribute to mesangial IgA1 deposition and the development of glomerular injury. This altered O-glycosylation of IgA1 can be detected by its increased binding to the lectin Vicia villosa.

    METHODS: To investigate whether IgA1 is abnormally glycosylated in ...

    Also Ranks for: Schönlein Purpura |  iga glycosylation |  lectin binding |  renal involvement |  adults children
    KOL Index score: 12143

    In IgA nephropathy (IgAN), serum IgA1 with abnormal O-glycosylation preferentially deposits in the glomerular mesangium. The control of O-glycosylation is poorly understood. Among Ig isotypes, only IgD, produced early in B cell development, and IgA1, produced by mature B cells, are O-glycosylated. For investigation of the stage of B cell maturation at which the defect seen in IgAN arises, the O-glycosylation of serum IgA1 and IgD was studied in IgAN and controls. Serum was obtained from ...

    Also Ranks for: Igd Iga1 |  iga nephropathy |  glomerular mesangium |  glycosylation serum |  20 patients
    KOL Index score: 11884

    Importance: Kidney disease is a substantial worldwide clinical and public health problem, but information about available care is limited.

    Objective: To collect information on the current state of readiness, capacity, and competence for the delivery of kidney care across countries and regions of the world.

    Design, Setting, and Participants: Questionnaire survey administered from May to September 2016 by the International Society of Nephrology (ISN) to 130 ISN-affiliated countries with ...

    Also Ranks for: Kidney Health |  peritoneal dialysis |  chronic surveys |  international society |  east asia
    KOL Index score: 11872

    The Oxford Classification of IgA Nephropathy (IgAN) identified mesangial hypercellularity (M), endocapillary proliferation (E), segmental glomerulosclerosis (S), and tubular atrophy/interstitial fibrosis (T) as independent predictors of outcome. Whether it applies to individuals excluded from the original study and how therapy influences the predictive value of pathology remain uncertain. The VALIGA study examined 1147 patients from 13 European countries that encompassed the whole ...

    Also Ranks for: Oxford Classification |  iga glomerulosclerosis |  endocapillary proliferation |  independent predictors |  studies glomerular
    KOL Index score: 11812

    Importance: Guidelines recommend corticosteroids in patients with IgA nephropathy and persistent proteinuria, but the effects remain uncertain.

    Objective: To evaluate the efficacy and safety of corticosteroids in patients with IgA nephropathy at risk of progression.

    Design, Setting, and Participants: The Therapeutic Evaluation of Steroids in IgA Nephropathy Global (TESTING) study was a multicenter, double-blind, randomized clinical trial designed to recruit 750 participants with IgA ...

    Also Ranks for: Oral Methylprednisolone |  patients iga nephropathy |  clinical trial |  egfr 173 |  participants iga
    KOL Index score: 11167

    BACKGROUND: IgA nephropathy is thought to be associated with mucosal immune system dysfunction, which manifests as renal IgA deposition that leads to impairment and end-stage renal disease in 20-40% of patients within 10-20 years. In this trial (NEFIGAN) we aimed to assess safety and efficacy of a novel targeted-release formulation of budesonide (TRF-budesonide), designed to deliver the drug to the distal ileum in patients with IgA nephropathy.

    METHODS: We did a randomised, double-blind, ...

    Also Ranks for: Iga Nephropathy |  placebo patients |  trf budesonide |  9 months |  treatment phase
    KOL Index score: 10888

    The Oxford Classification of IgA nephropathy (IgAN) includes the following four histologic components: mesangial (M) and endocapillary (E) hypercellularity, segmental sclerosis (S) and interstitial fibrosis/tubular atrophy (T). These combine to form the MEST score and are independently associated with renal outcome. Current prediction and risk stratification in IgAN requires clinical data over 2 years of follow-up. Using modern prediction tools, we examined whether combining MEST with ...

    Also Ranks for: Mest Score |  risk prediction |  clinical data |  lga nephropathy |  2 years
    KOL Index score: 10797

    BACKGROUND: Idiopathic membranous nephropathy is a major cause of the nephrotic syndrome in adults, but its etiologic basis is not fully understood. We investigated the genetic basis of biopsy-proven cases of idiopathic membranous nephropathy in a white population.

    METHODS: We performed independent genomewide association studies of single-nucleotide polymorphisms (SNPs) in patients with idiopathic membranous nephropathy from three populations of white ancestry (75 French, 146 Dutch, and ...

    Also Ranks for: Idiopathic Membranous |  single nucleotide receptors |  white ancestry |  risk hla |  autoimmune response
    KOL Index score: 10755

    The mechanism of IgA deposition in the kidneys in IgA nephropathy is unknown. Mesangial IgA is of the IgA1 subclass, and since no consistent antigenic target for the IgA1 has been described, we have investigated the glycosylation of the molecule, as a potential non-immunological abnormality which may contribute to its deposition. IgA1 is rich in carbohydrate, carrying N-linked moieties in common with IgG, but also O-linked sugars, which are rare in serum proteins, and not expressed by ...

    Also Ranks for: Iga Nephropathy |  carbohydrate moieties |  olinked sugars |  linked glycosylation |  hinge region
    KOL Index score: 10445

    BACKGROUND: In an attempt to address the shortage of conventional kidney donors, a non-heart-beating donor (NHBD) organ retrieval program has been established. We compared the results of kidney transplants from NHBDs (N = 77) with those from heart-beating cadaveric (HBD; N = 224) and living donors (LD; N = 49), performed in the same eight-year period.

    METHODS: Patients dying after failed attempts at resuscitation in the accident department or after intracerebral hemorrhage/anoxia were ...

    Also Ranks for: Living Donors |  renal transplantation |  nhbd hbd |  kidney transplants |  graft survival
    KOL Index score: 9933

    Since the Oxford Classification of IgA nephropathy (IgAN) was published in 2009, MEST scores have been increasingly used in clinical practice. Further retrospective cohort studies have confirmed that in biopsy specimens with a minimum of 8 glomeruli, mesangial hypercellularity (M), segmental sclerosis (S), and interstitial fibrosis/tubular atrophy (T) lesions predict clinical outcome. In a larger, more broadly based cohort than in the original Oxford study, crescents (C) are predictive ...

    Also Ranks for: Oxford Classification |  iga nephropathy |  mest score |  segmental sclerosis |  clinical data
    KOL Index score: 9809

    OBJECTIVE: To determine the global capacity (availability, accessibility, quality, and affordability) to deliver kidney replacement therapy (dialysis and transplantation) and conservative kidney management.

    DESIGN: International cross sectional survey.

    SETTING: International Society of Nephrology (ISN) survey of 182 countries from July to September 2018.

    PARTICIPANTS: Key stakeholders identified by ISN's national and regional leaders.

    MAIN OUTCOME MEASURES: Markers of national capacity ...

    Also Ranks for: Kidney Disease |  replacement therapy |  sectional survey |  global capacity |  182 countries


    John Feehally: Influence Statistics

    Sample of concepts for which John Feehally is among the top experts in the world.
    Concept World rank
    oglycosylation specific iga1 #1
    radioisotopic situ #1
    substantial minority populations #1
    iga1 o‐linked glycosylation #1
    galactosyltransferase cosmc #1
    ide programmes #1
    mesangial immunoglobulin iga #1
    patient biopsies reduction #1
    persistent urine abnormalities #1
    igan piga production #1
    methods staff training #1
    igan controls #1
    cell development iga1 #1
    specimens immunoglobulin #1
    29 patients age #1
    ckd lowresource settings #1
    combined ish reduction #1
    bergers report #1
    adult iga nephropathy #1
    igd iga1 oglycosylation #1
    labelling isotopic ish #1
    bm piga #1
    low antibody affinity #1
    tubular cells proteinuria #1
    llmics complete recovery #1
    parisian pathologist #1
    ish chain #1
    referral language barriers #1
    henoch wiskott #1
    igan analysis #1
    vdelta3 cdr3 spectratyping #1
    292 049 years #1
    galactosylation linked #1
    igan phenotypic variation #1
    acids exercising #1
    iga nephropathy genes #1
    nifedipine renal #1
    needle fibrosis #1
    haematuria relationship #1
    кои #1
    igan amino #1
    tonsils 12 patients #1
    phn vgecs #1
    challenge acute dialysis #1
    dialysis minority populations #1
    response igan #1
    iga glycosylation patients #1
    indian origin anio #1
    iga fcalpha #1
    macroscopic haematuria relapse #1

    Key People For Iga Nephropathy

    Top KOLs in the world
    Bruce A Julian
    iga nephropathy african americans renal transplantation
    Yasuhiko Tomino
    iga nephropathy diabetic rats chronic kidney disease
    John Feehally
    iga nephropathy renal function acute kidney injury
    Rosanna Coppo
    iga nephropathy glomerular disease oxford classification
    F Paolo Principal discussant: Schena
    iga nephropathy renal damage growth factor
    Robert J Wyatt
    iga nephropathy complement activation serum levels

    John Feehally:Expert Impact

    Concepts for whichJohn Feehallyhas direct influence:Iga nephropathy,  Kidney day,  Renal function,  Acute kidney injury,  South asian,  Bone marrow,  Oxford classification,  Peritoneal dialysis.

    John Feehally:KOL impact

    Concepts related to the work of other authors for whichfor which John Feehally has influence:Iga nephropathy,  Kidney disease,  Nephrotic syndrome,  Renal function,  Oxford classification,  Peritoneal dialysis,  Systemic lupus erythematosus.



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    University of Leicester, Leicester, United Kingdom | College of Medicine Biological Sciences and Psychology, University of Leicester, Leicester, UK | Department of Renal Medicine, University of Leicester, Leicester, United Kingdom. | Department of In