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    • Reinout Van Schilfgaarde


      Department of Surgery, University Hospital Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands | Department of Surgery, University Hospital Groningen, PO Box 30001, ...





      Department of Surgery, University Hospital Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands


      Department of Surgery, University Hospital Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands


      Surgical Research Laboratory, Department of Surgery, Groningen University Hospital, Groningen, The Netherlands.

      Department of Surgery, Department of Pathology, Department of Laboratory Medicine, Medical Biology Section, and Biological Psychiatry, University Hospital Groningen, Groningen, The Netherlands


      Department of Surgery, University Hospital of Groningen, The Netherlands


      Department of Surgery, Groningen University Hospital, Groningen, The Netherlands


      Department of Surgery, University Hospital, Groningen, The Netherlands


      Department of Surgery, University of Groningen, The Netherlands.


      Surgical Research Laboratory, Groningen, The Netherlands.


      Surgical Research Laboratory, Department of Surgery, University of Groningen, Bloemsingel 1, 9713 BZ Groningen, The Netherlands


      Department of Surgery, University Hospital Groningen, The Netherlands.


      Department of Surgery, University of Groningen Groningen, The Netherlands Specialty Laboratories Santa Monica California


      Laboratory for Surgical Research, Department of Surgery, University of Groningen, Bloemsingel 1, 9713 BZ, Groningen, The Netherlands

      From the Departments of Surgery, Gastroenterology and Nuclear Medicine, University Hospital, Groningen


      Groningen, The Netherlands


      Department of Surgery, University of Groningen, Groningen


      Department of Surgery, University of Groningen Groningen, Netherlands


      Departments of Surgery, Gastroenterology, and Endocrinology, University Hospital, Leiden, and the Department of Surgery, University Hospital Groningen, The Netherlands


      Leiden, The Netherlands


      Departments of Surgery (Drs. van Bockel, van Schilfgaarde, Terpstra, and M. Felthuis), Nephrology (Dr. van Brummelen), and Medical Statistics (Dr. Hermans) of the University Hospital Leiden. Leiden, The Netherlands

      Department of Surgery, University Hospital Groningen.,


      Departments of Surgery and Chemical Pathology of the University Hospital Leiden Leiden, The Netherlands


      Department of Surgery, University Hospital Leiden, 2333 AA Leiden, The Netherlands.


      Departments of Surgery and Pathology, University Hospital, Leiden, The Netherlands and Department of Immunopathology, Biomedical Center, University of Limburg, The Netherlands



      REINOUT VAN SCHILFGAARDE: Influence Statistics

      Sample of concepts for which REINOUT VAN SCHILFGAARDE is among the top experts in the world.
      Concept World rank
      rat weak #1
      alginate polylysine membrane #1
      secondary complications disease #1
      nitrite mcp1 #1
      islet isolation procedures #1
      defined endocrine volume #1
      islets cell #1
      acinar septa #1
      encapsulated islets1 #1
      pmoll1min1 insulin #1
      successful graft survival #1
      89±04 mmol #1
      overgrown capsules #1
      kinetics intraperitoneally #1
      coculture encapsulated #1
      duct obliteration autotransplantation #1
      pancreatic tissue dissociation #1
      decapsulation procedure #1
      insulin levels controls #1
      nozzle production rate #1
      methods encapsulated islets #1
      infusion response #1
      alginate nozzle #1
      insulin 20 pmoll1min1 #1
      mcp1 assessed #1
      microencapsulation order #1
      rats microencapsulated islets #1
      collagenase islet #1
      pig reaction #1
      collagen islets #1
      clostridium islets #1
      increased islet yield #1
      rats interleukin1 islets #1
      islet function vitality #1
      collagen low #1
      degradation islet isolation #1
      degradation collagens #1
      required bead size #1
      islets wistar #1
      autotransplantation endocrine function #1
      weak rat #1
      male polylysine #1
      peritoneal cavity bloodstream #1


      Prominent publications by REINOUT VAN SCHILFGAARDE

      KOL-Index: 17241

      BACKGROUND: Eighty percent of donor organs come from donors who have suffered brain trauma (brain-dead donors). This unphysiological state alters the hemodynamic and hormonal status of the organ donor. This can cause organ injury, which has been suggested to alter the immunological or inflammatory status of the organ after transplantation, and may lead to increased sensitivity of the organ to preservation/transplantation injury. In this study we asked the question: does brain death cause ...

      Known for Brain Death | Organ Transplantation | Rats Liver | Dead Donors
      KOL-Index: 14634

      After a Roux-en-Y gastrojejunostomy, patients frequently complain of abdominal pain, fullness, nausea, and vomiting. This so-called Roux-en-Y syndrome is caused by slow gastric emptying, Roux-limb stasis, or both. The pathogenesis of these transit disorders is unknown. The aim of the present study was to investigate whether slow gastric emptying and Roux-limb stasis can be attributed to motility disturbances in the Roux limb. Thirty-seven patients with a Roux-en-Y gastrojejunostomy after ...

      Known for Roux Limb | Motility Disorders | Gastric Emptying | Abdominal Pain | Partial Gastrectomy
      KOL-Index: 12924

      The presence and distribution in the peri-insular region of extracellular matrix, and in particular basement membrane, was investigated in a comparative study comprising pancreata of rat, dog, pig, and man. Basement membrane markers, collagen type-IV and laminin, were determined immunohistochemically. Additional information pertaining to the structural relationships between endocrine and exocrine pancreas, in particular cell-to-cell and cell-to-matrix contacts, was obtained by electron ...

      Known for Extracellular Matrix | Langerhans Islets | Islet Isolation | Rat Pig | Basement Membrane
      KOL-Index: 12901

      PURPOSE: To evaluate endovascular repair of abdominal aortic aneurysms (AAA) under local anesthesia in the acute setting.

      METHODS: Between 1998 and 2001, 47 patients with an acute AAA were evaluated for endovascular repair after informed consent, provided they were in a stable, albeit hypotensive condition. The patients underwent urgent computed tomography to assess suitability for endovascular repair; 16 were eligible for stent-graft repair: 9 were frank ruptures and 7 were symptomatic ...

      Known for Endovascular Repair | Local Anesthesia | Acute Aaa | 16 Patients | Bifurcated Endografts
      KOL-Index: 10868

      BACKGROUND: Marginal donors exposed to the full array of effects induced by brain death are characterized by low success rates after transplantation. This study examined whether organs from marginal brain dead animals show any change in organ function or tissue activation making them eventually more susceptible for additional damage during preservation and transplantation.

      METHODS: To study this hypothesis we first focused on effects of brain death on donor organ quality by using a brain ...

      Known for Inflammatory Markers | Brain Death | Dead Rats | Tissue Activation | Marginal Donors
      KOL-Index: 10348

      BACKGROUND: Consistent difference in graft survival after renal transplantation has been shown when cadaveric transplants are compared to the living related donor situation, in favor of the latter. Recently, evidence has been put forward that brain death has significant effects on the donor organ quality. In this study, we aimed to assess the relation between brain death-induced hemodynamic instability in combination with the duration of brain death on the function and immunogenicity ...

      Known for Brain Death | Donor Kidneys | Hemodynamic Instability | 6 Hours | Graft Survival
      KOL-Index: 10201

      We have analysed the graft function of rat islet isografts of identical and well-defined endocrine volumes after transplantation to three different sites (kidney, liver and spleen). Graft endocrine mass was determined by measuring the total islet volume prior to transplantation and was chosen to be similar to the endocrine volume in the normal adult rat pancreas. Graft function was tested in unanaesthetized, unstressed rats by the responses to glucose infusion and to a meal. All ...

      Known for Insulin Secretion | Heterotopic Transplantation | Rat Islet | Liver Spleen | Graft Function
      KOL-Index: 9765

      INTRODUCTION: A proximal neck of 15 mm length is usually required to allow endovascular repair of abdominal aortic aneurysms (EVAR). Many patients have been refused EVAR due to a short neck. By customising fenestrated grafts to the patients' anatomy, we can offer an endovascular solution, especially for patients who are unsuitable for open repair.

      METHODS: Eighteen patients were selected for fenestrated stent-grafting if they presented with an abdominal aneurysm of at least 55 mm in ...

      Known for Aortic Aneurysm | Fenestrated Stent | Proximal Neck | Endovascular Repair | Evar Patients
      KOL-Index: 9326

      The survival of microencapsulated islet grafts is limited, even if capsular overgrowth is restricted to a small percentage of the capsules. In search of processes other than overgrowth contributing to graft failure, we have studied the islets in non-overgrown capsules at several time points after allotransplantation in the rat. All recipients of islet allografts became normoglycemic. Grafts were retrieved at 4 and 8 weeks after implantation and at 15.3 +/- 2.3 weeks postimplant, 2 weeks ...

      Known for Islet Grafts | Overgrowth Capsules | 4 Weeks | Graft Failure | Cell Death
      KOL-Index: 8986

      Alginate-polylysine (PLL) capsules are commonly applied for immunoprotection of endocrine tissues. Alginate is composed of mannuronic acid (M) and guluronic acid (G). Different types of alginate have different ratios of G to M, but little is known of the influence of these differences on biocompatibility. Therefore, we have investigated in vivo the effect of the G-content of the alginate on the biocompatibility of the capsules. Capsules prepared of commercially available alginates with ...

      Known for Alginate Composition | Biocompatibility Capsules | Peritoneal Cavity | Fibrotic Reaction | Rats Langerhans
      KOL-Index: 8860

      BACKGROUND: A difference in short- and long-term function between living-related and cadaveric donor organs is consistently shown in kidney- and liver-transplant studies. We hypothesize that this is caused by induction of apoptosis and inflammation of the potential graft because of the phase of brain death (BD) in the cadaveric donor that predisposes for additional transplant injury. Previously, we have shown inflammation in the liver of brain-dead donors by increased expression of cell ...

      Known for Donor Liver | Brain Death | Mrna Levels | Increased Expression | Nick Labeling
      KOL-Index: 8729

      To date, the gold standard for performing a microvascular anastomosis has been the penetrating suture with attached needle. During the last two decades, non-penetrating techniques have been introduced, including the Unilink system for end-to-end anastomoses, and the VCS clip-applier system for both end-to-end and end-to-side anastomoses. The aim of this study was to compare the results of different techniques used to create microvascular anastomoses in free-flap reconstructions. Between ...

      Known for Venous Anastomoses | Clips Sutures | Microvascular Anastomosis | Surgical Flaps | Flap Failure
      KOL-Index: 8695

      Crude Clostridium histolyticum collagenase is widely used for the enzymatic degradation of pancreatic extracellular matrix in order to isolate the islets of Langerhans. The variable enzymatic composition of crude collagenases is a critical issue which contributes to the poor reproducibility of islet isolation procedures. In this study, the separate contributions of collagenase and protease to the islet isolation process were analysed by testing various combinations of purified ...

      Known for Islet Isolation | Rat Pancreas | Extracellular Matrix | Collagenase Protease | Enzymatic Dissociation
      KOL-Index: 8157

      Several aspects of false aneurysm development after prosthetic resconstruction for aortoiliac obstructive disease were studied. For this purpose the long-term results (up to 20 years of follow-up) of 518 patients with implanted arterial prostheses in the aortoiliofemoral tract were retrospectively evaluated. Completeness of follow-up data was 83.2% 15 years after operation. A total of 101 false aneurysms (21 aortic, 53 iliac, and 27 femoral) were detected in 69 patients and verified by ...

      Known for False Aneurysm | Prosthetic Reconstructions | 518 Patients | Aortic Iliac | Femoral Artery

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      Concepts for whichREINOUT VAN SCHILFGAARDEhas direct influence:Renovascular hypertension,  Brain death,  Duct obliteration,  Islets langerhans,  Islet isolation,  Roux limb,  Endovascular repair,  Langerhans islets.


      Concepts related to the work of other authors for whichfor which REINOUT VAN SCHILFGAARDE has influence:Brain death,  Islets langerhans,  Islet transplantation,  Insulin secretion,  Aortic aneurysm,  Bioartificial pancreas,  Endovascular repair.



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      Department of Surgery, University Hospital Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands | Department of Surgery, University Hospital Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands | Surgical Research Laboratory, Departm

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