• Disease
  • Respiratory
  • Respiratory Syncytial
  • Respiratory Syncytial Virus
  • Larry J Anderson

    Prominent publications by Larry J Anderson

    KOL Index score: 17343

    CONTEXT: Influenza and respiratory syncytial virus (RSV) cause substantial morbidity and mortality. Statistical methods used to estimate deaths in the United States attributable to influenza have not accounted for RSV circulation.

    OBJECTIVE: To develop a statistical model using national mortality and viral surveillance data to estimate annual influenza- and RSV-associated deaths in the United States, by age group, virus, and influenza type and subtype.


    Also Ranks for: United States |  deaths influenza |  syncytial virus |  elderly persons |  rsv age
    KOL Index score: 17140

    CONTEXT: Pneumonia causes significant mortality and morbidity among persons aged 65 years or older. However, few studies have explored trends according to age groups, which may affect intervention strategies.

    OBJECTIVES: To examine trends in hospitalizations for pneumonia among persons aged 65 years or older and to compare characteristics, outcomes, and comorbid diagnoses.

    DESIGN, SETTING, AND PATIENTS: Data from 1988 through 2002 on pneumonia and comorbid diagnoses among patients aged ...

    Also Ranks for: United States |  65 years |  pneumonia patients |  hospitalization rates |  1000 population
    KOL Index score: 16142

    The newly emerged human coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has caused a pandemic of respiratory illness. Current evidence suggests that severe cases of SARS-CoV-2 are associated with a dysregulated immune response. However, little is known about how the innate immune system responds to SARS-CoV-2. In this study, we modeled SARS-CoV-2 infection using primary human airway epithelial (pHAE) cultures, which are maintained in an air-liquid interface. We ...

    Also Ranks for: Type Iii |  epithelial cultures |  human airway |  sarscov2 infection |  ifn response
    KOL Index score: 15891

    CONTEXT: Respiratory syncytial virus (RSV) causes more lower respiratory tract infections, often manifested as bronchiolitis, among young children than any other pathogen. Few national estimates exist of the hospitalizations attributable to RSV, and recent advances in prophylaxis warrant an update of these estimates.

    OBJECTIVES: To describe rates of bronchiolitis-associated hospitalizations and to estimate current hospitalizations associated with RSV infection.


    Also Ranks for: Bronchiolitis Children |  hospitalizations rsv |  younger 1 year |  national estimates |  health statistics
    KOL Index score: 15666

    BACKGROUND: Respiratory syncytial virus (RSV) is the most common cause of lower respiratory tract disease among young children in the United States. RSV-associated hospitalization increased among children in the United States during 1980 through 1996. In this study, we updated national estimates of RSV hospitalization rates among US children through 2006.

    METHODS: We conducted a retrospective analysis of hospital discharges for lower respiratory tract illness (LRTI) in children <5 years ...

    Also Ranks for: United States |  young children |  respiratory syncytial |  viral child |  rsv hospitalizations
    KOL Index score: 14833

    Respiratory syncytial virus (RSV) is a major cause of severe pneumonia and bronchiolitis in infants and young children, and causes disease throughout life. Understanding the biology of infection, including virus binding to the cell surface, should help develop antiviral drugs or vaccines. The RSV F and G glycoproteins bind cell surface heparin sulfate proteoglycans (HSPGs) through heparin-binding domains. The G protein also has a CX3C chemokine motif which binds to the fractalkine ...

    Also Ranks for: Rsv Infection |  epithelial cells |  syncytial virus |  human airway |  cell surface
    KOL Index score: 14450

    OBJECTIVE: To determine the burden of respiratory syncytial virus (RSV) disease among American Indian (AI) and Alaska Native (AN) infants, by examining RSV-associated hospitalizations.

    METHODS: Infant hospitalizations from 1997 through 2001 with RSV listed as a diagnosis were selected by using Indian Health Service/tribal hospital discharge data for AIs/ANs and National Hospital Discharge Survey data for the general US population.

    RESULTS: In 2000-2001, RSV disease was listed as a ...

    Also Ranks for: United States |  respiratory syncytial |  virus hospitalizations |  rsv infection |  infant population
    KOL Index score: 14030

    A reverse transcription-PCR (RT-PCR) assay based on automated fluorescent capillary electrophoresis and GeneScan software analysis was developed to detect six common respiratory viruses in clinical specimens from young children. Assays for human respiratory syncytial virus (HRSV); human parainfluenza viruses 1, 2, and 3 (HPIV1, -2, and -3, respectively); and influenza A and B viruses were incorporated into a single standard assay format. The optimized assay panel was used to test 470 ...

    Also Ranks for: Respiratory Virus |  young children |  pcr assay |  human parainfluenza |  newborn influenza
    KOL Index score: 13397

    Respiratory syncytial virus (RSV) in Alaska Native children from the Yukon Kuskokwim (YK) Delta is associated with a hospitalization rate five times higher than that reported for the general US child population. The role of other viral respiratory pathogens has not been studied in this population. YK Delta children <3 years of age hospitalized with respiratory infections and same aged community control children were prospectively enrolled between October 2005 and September 2007. ...

    Also Ranks for: Respiratory Infections |  hospitalized children |  rsv hmpv |  rhinovirus adenovirus |  newborn influenza
    KOL Index score: 13360

    To determine the diagnostic use of different markers of acute parvovirus B19 infection, serum specimens obtained from 128 persons with erythema infectiosum were tested for specific immunoglobulin G (IgG), IgA, and IgM antibodies by capture enzyme immunoassay (EIA) using Chinese hamster ovary (CHO) cell-expressed B19 antigen, and tested for circulating B19 DNA by polymerase chain reaction (PCR). A significant rise in specific IgG and IgA antibodies was detected in 87% and 77%, ...

    Also Ranks for: Erythema Infectiosum |  igm antibodies |  human parvovirus |  b19 specific |  preschool dna
    KOL Index score: 12901

    Respiratory syncytial virus (RSV) belongs to the family Paramyxoviridae and is the single most important cause of serious lower respiratory tract infections in young children, yet no highly effective treatment or vaccine is available. Through a CX3C chemokine motif (182CWAIC186) in the G protein, RSV binds to the corresponding chemokine receptor, CX3CR1. Since RSV binding to CX3CR1 contributes to disease pathogenesis, we investigated whether a mutation in the CX3C motif by insertion of ...

    Also Ranks for: Cx3c Motif |  syncytial virus |  protein rsv |  disease pathogenesis |  cx4c mutation
    KOL Index score: 12794

    BACKGROUND: Respiratory syncytial virus (RSV) lower respiratory tract infection (LRI) during infancy has been consistently associated with an increased risk of childhood asthma. In addition, evidence supports that this relationship is causal. However, the mechanisms through which RSV contributes to asthma development are not understood. The INSPIRE (Infant Susceptibility to Pulmonary Infections and Asthma Following RSV Exposure) study objectives are to: 1) characterize the host ...

    Also Ranks for: Pulmonary Infections |  infant susceptibility |  rsv infection |  inspire study |  childhood asthma


    Larry J Anderson: Influence Statistics

    Sample of concepts for which Larry J Anderson is among the top experts in the world.
    Concept World rank
    analyses surveillance data #1
    sarscov2 infection production #1
    rsv sequence duplication #1
    cx4c #1
    pbmcs ena78 #1
    infection calu3 #1
    proteins subgroup viruses #1
    encephalitisassociated deaths impact #1
    hrsv outbreaks community #1
    rsv nonrsv #1
    vbpare outputs #1
    case canine meningoencephalitis #1
    trfia detected adenovirus #1
    cx3cr1 haecs #1
    hrv species variation #1
    anderson finberg #1
    supplementary patients #1
    algorithms child #1
    rsv antibodies #1
    disease host responses #1
    vaccination il12 mrna #1
    patients 84 years #1
    hadv14 infection #1
    rsvinfected patients #1
    rhinovirus adults #1
    college bus trip #1
    mab assays assays #1
    ohio pneumonia #1
    rsv 30 children #1
    2stopa4 genotype #1
    antirsv titers #1
    adult volunteer study #1
    oral specimens cfrb #1
    united states proportions #1
    rsv hawaii #1
    bronchiolitis trend #1
    hrv 14 species #1
    new paramyxovirus responsible #1
    nucleolin dysregulation #1
    antibody rsv stimulation #1
    potential antigenic differences #1
    bronchiolitis hospitalizations rsv #1
    1312glike antibodies #1
    variation hn #1
    transcriptional cx3cr1 engagement #1
    morbidity rsv infection #1
    distinct clusters gene #1
    rsv disease patients #1
    igg infants postvaccination #1
    restricted ctlp #1

    Key People For Respiratory Syncytial Virus

    Top KOLs in the world
    Larry J Anderson
    respiratory syncytial virus united states monoclonal antibodies
    Caroline Breese Hall
    respiratory syncytial virus young children united states
    Edward E Walsh
    respiratory syncytial virus rsv infection monoclonal antibodies
    Eric A F SIMOES†
    respiratory syncytial virus young children preterm infants
    influenza virus young children respiratory syncytial
    Peter L Collins
    respiratory syncytial parainfluenza virus rna replication

    Larry J Anderson:Expert Impact

    Concepts for whichLarry J Andersonhas direct influence:Respiratory syncytial virus,  United states,  Respiratory syncytial,  Syncytial virus,  Monoclonal antibodies,  Rsv infection,  Young children,  Cx3c motif.

    Larry J Anderson:KOL impact

    Concepts related to the work of other authors for whichfor which Larry J Anderson has influence:Respiratory syncytial virus,  Influenza vaccination,  United states,  Rsv infection,  Young children,  Monoclonal antibodies,  Immune response.



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    Department of Pediatrics, Emory University School of Medicine and Children’s Healthcare of Atlanta, Atlanta, GA, United States | Division of Infectious Diseases, Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United State