Robert M Chanock: Influence Statistics

Robert M Chanock

Robert M Chanock

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland | From the *University of ...


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Robert M Chanock: Expert Impact

Concepts for which Robert M Chanock has direct influence: Respiratory syncytial virus , Influenza virus , Respiratory syncytial , Syncytial virus , Mycoplasma pneumoniae , Eaton agent , Cotton rats .

Robert M Chanock: KOL impact

Concepts related to the work of other authors for which for which Robert M Chanock has influence: Respiratory syncytial , Influenza virus , Monoclonal antibodies , Mycoplasma pneumoniae , Rsv infection , Young children , Cotton rats .

KOL Resume for Robert M Chanock

Year
2006

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

2005

National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

2003

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA

2002

Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6308, 50 South Drive MSC 8026, Bethesda, MD 20892-8026, USA

2001

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, 7 Center Drive, Bethesda, MD 20892-0720, USA

2000

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892, USA

1999

Laboratory of Infectious Diseases National Institute of Allergy and Infectious Diseases Bethesda, Maryland 20892-0720

1998

Respiratory Viruses Section, Laboratory of Infectious Diseases, NIAID, National Institutes of Health, Bethesda, Maryland, 20892-0720

1997

Epidemiology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

1996

Molecular Viral Biology Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.

Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

1995

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892-0720, USA.

1994

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892, USA.

Epidemiology Section, National Institute of Allergy and Infectious Diseases, Bethesda, MD 20892.

1993

Virion Systems, Inc., Rockville, Maryland 20850.

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.

1992

Respiratory Viruses Section, Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 7, Room 106, 9000 Rockville Pike, Bethesda, MD 20892, USA

Department of Immunology, Scripps Research Institute, La Jolla, CA 92037.

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD.

Biotechnology and Microbiology Division, Wyeth-Ayerst Research, Philadelphia, Pennsylvania 19101.

1991

Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, NY 10032.

National Institutes of Health, Bethesda, MD, USA

1990

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032

1989

The Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY 10032.

1988

Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, Maryland 20814.

Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892.

1987

The Laboratory of Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA

1986

From the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health (GAP, RMC), and the Uniformed Services University of the Health Sciences (VGH), Bethesda, MD.

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland, USA

1985

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Disease, Bethesda, Maryland 20205, USA

1984

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA

Department of Pediatrics, NIAID, National Institutes of Health, Uniformed Services University, Bethesda, MD

1983

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20205, USA

1982

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases Bethesda, Maryland 20205

1981

Laboratory of Infectious Diseases National Institute of Allergy and Infectious Disease National Institutes of Health Bethesda, Maryland 20205

1980

Center for Disease Control, Atlanta, Georgia 30333, U. S. A.

George Washington University, Washington, D. C. 20052, USA

Laboratory of Infectious Diseases National Institute of Allergy and Infectious Diseases National Institutes of Health Bethesda, Maryland 20205

1979

Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20014

1978

NIAID, Bethesda, Md

Children's Hospital National Medical Center, George Washington Un., Washington, D.C.

National Institute of Allergy and Infectious Diseases, Rockville, Maryland

Department of Veterinary Science, University of Nebraska, Lincoln, Nebraska 68508, USA

1977

Department of Child Health and Development, George Washington University School of Medicine and Health Care Sciences, Washington, D. C. USA

1976

Laboratory of Infectious Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014 USA

1975

the Molecular Anatomy Program, Oak Ridge National Laboratory, 5640 Fishers Lane, Rockville, Maryland, USA

LOBUND LABORATORY, UNIVERSITY OF NOTRE DAME, NOTRE DAME, INDIANA

Prominent publications by Robert M Chanock

KOL-Index: 20714 . In studies conducted in the 1960s, children previously immunized with a formalin-inactivated respiratory syncytial virus (RSV) vaccine (FI-RSV) developed a greater incidence and severity of pulmonary disease during subsequent natural RSV infection than did controls. It was previously shown that cotton rats immunized with FI-RSV or immunoaffinity-purified fusion (F) glycoprotein developed ...
Known for Cotton Rats | Viral Antigens | Rsv Challenge | Enhanced Pulmonary
KOL-Index: 17334 . cDNA clones representing the VP4 gene of symptomatic human rotavirus strain KU (VP7 serotype 1) or DS-1 (VP7 serotype 2) or asymptomatic human rotavirus strain 1076 (VP7 serotype 2) were constructed and inserted into a baculovirus expression vector under the control of the polyhedrin promoter. The resulting recombinants expressed the appropriate authentic VP4 rotavirus outer capsid ...
Known for Human Rotaviruses | Vp4 Serotype | Outer Capsid | Antigenic Relationships
KOL-Index: 16876 . Three antigenic chimeric live attenuated tick-borne encephalitis virus (TBEV) vaccine candidates were compared for level of replication in murine and human neuroblastoma cells, for neurovirulence and neuroinvasiveness in mice, and for safety, immunogenicity and efficacy in rhesus monkeys. Two chimeric viruses were generated by replacing the membrane precursor and envelope protein genes of ...
Known for Rhesus Monkeys | Lgt Den4 | Borne Encephalitis | Neuroinvasiveness Mice
KOL-Index: 16013 . The dengue type 4 virus (DEN4) genome contains a 384-nucleotide (nt) 3' noncoding sequence in which the last 81 nt, predicted to form a secondary structure, are thought to be essential for virus replication. Immediately upstream of the secondary structure, short RNA sequences that are conserved among mosquito-borne flaviviruses have been identified. A series of deletions that range from 30 ...
Known for Dengue Type | Rhesus Monkeys | Rna Genome | Cell Culture
KOL-Index: 15875 . Within the past few years, rotavirus strains were recovered from four discrete prolonged outbreaks of infection in newborn nurseries in which affected infants failed to develop significant symptoms. The virus strains recovered from each outbreak belonged to a different human rotavirus serotype and thus each of the four human rotavirus serotypes was associated with asymptomatic infection of ...
Known for Amino Acid | Cleavage Region | Capsid Protein | Viral Humans Infant
KOL-Index: 15344 . The serum antibody response of infants and children immunized with Formalin-inactivated respiratory syncytial virus (RSV) vaccine 20 years ago was determined by using an enzyme-linked immunosorbent assay specific for the RSV fusion (F) and large (G) glycoproteins and a neutralization assay. Twenty-one young infants (2 to 6 months of age) developed a high titer of antibodies to the F ...
Known for Antibody Response | Inactivated Respiratory | Viral Child | Neutralizing Antibodies
KOL-Index: 14994 . In young infants who possess maternally derived respiratory syncytial virus (RSV) antibodies, the antibody response to RSV glycoproteins is relatively poor, despite extensive replication of RSV. In the present study, it was found that cotton rat RSV hyperimmune antiserum suppressed the antibody response to the RSV glycoproteins but not the response to vaccinia virus antigens when the ...
Known for Immune Response | Vaccinia Virus | Respiratory Syncytial | Viral Antigens
KOL-Index: 14543 . A cDNA clone representing the mRNA coding sequence of the fusion glycoprotein (F) gene of human respiratory syncytial virus (RSV) was constructed and inserted into the thymidine kinase gene of vaccinia virus (WR strain) under the control of a vaccinia virus promoter. The resulting recombinant vaccinia virus, vaccinia F, expressed the F1 and F2 cleavage products (48 and 20 kDa, ...
Known for Vaccinia Virus | Individual Contributions | Respiratory Syncytial | Fusion Glycoprotein
KOL-Index: 14307 . A series of reassortants was isolated from coinfection of cell cultures with wild-type bovine rotavirus (UK strain [serotype 6]) or rhesus rotavirus (strain MMU18006 [serotype 3]) and a tissue culture-adapted human rotavirus strain, ST3 (serotype 4). Monospecific antiserum or a set of monoclonal antibodies to the major outer capsid neutralization glycoprotein, VP7, of the animal rotavirus ...
Known for Rotavirus Reassortants | Serotype 4 | Gene Substitution | Neutralization Protein
KOL-Index: 14171 . Previously, the influenza A/Hong Kong/68-ts-1[E] virus and its recombinants (38° shutoff temperature of plaque formation) were shown to be insufficiently attenuated for persons who lacked immunity to both the hemagglutinin and neuraminidase surface glycoproteins, i.e., doubly seronegative individuals. To meet the need for immunization of such individuals, a virus more defective than the ...
Known for Influenza Virus | Surface Antigens | Nasal Turbinates | Udorn 72
KOL-Index: 14082 . Expression of dengue virus gene products involves specific proteolytic cleavages of a precursor polyprotein. To study the flanking sequences required for expression of the dengue virus nonstructural glycoprotein NS1, we constructed a series of recombinant vaccinia viruses that contain the coding sequence for NS1 in combination with various lengths of upstream and downstream sequences. The ...
Known for Virus Nonstructural | Ns1 Ns2a | Signal Sequence | Proper Processing
KOL-Index: 13906 . Respiratory syncytial virus (RSV) is the most common cause of viral bronchiolitis and pneumonia in children. The present study compares the level of attenuation, genetic stability and efficacy of three conditional-lethal temperature-sensitive (ts) mutants of the RSV A2 wild-type virus, designated ts-1, ts-1-NG1, and ts-4, in seronegative chimpanzees and also compares their efficacy with ...
Known for Attenuated Respiratory | Vaccinia Virus | Rsv Mutants | Viral Vaccines
KOL-Index: 13876 . An avian influenza A virus, A/Mallard/NY/6750/78(H2N2), was restricted in in replication in the respiratory tract of squirrel monkeys. Avian-human influenza A reassortant viruses possessing the six RNA segments coding for nonsurface proteins (i.e., internal genes) of this avian virus were as restricted in replication in squirrel monkeys as their avian influenza parent. These findings ...
Known for Respiratory Tract | Avian Influenza | Virus Replication | Internal Genes
KOL-Index: 13871 . Ten serologically distinct avian influenza A viruses were administered to squirrel monkeys and hamsters to compare their replication and virulence with those of human influenza A virus, A/Udorn/307/72 (H3N2). In squirrel monkeys, the 10 avian influenza A viruses exhibited a spectrum of replication and virulence. The levels of virus replication and clinical response were closely correlated. ...
Known for Avian Influenza | Squirrel Monkeys | Virus Replication | Udorn 307 72
KOL-Index: 13747 . A formalin-inactivated respiratory syncytial virus (RSV) vaccine tested 22 years ago failed to protect infant vaccinees against RSV infection or disease. Instead, lower respiratory tract disease was enhanced during subsequent infection by RSV. Enhancement of pulmonary pathology is also observed when cotton rats are immunized with formalin-inactivated RSV and subsequently infected with this ...
Known for Cotton Rats | Rsv Challenge | Viral Antigens | Cytotoxic Vaccines

Key People For Respiratory Syncytial Virus

Top KOLs in the world
#1
Larry J Anderson
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#2
Caroline Breese Hall
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#3
Edward E Walsh
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#4
Eric A F SIMOES†
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#5
PETER FARNUM Wright
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#6
Peter L Collins
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Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland | From the *University of Tampere Medical School, Tampere, Finland; †Wyeth Vaccines Research, Henriett