• Disease
  • Rectal
  • Rectal Cancer
  • Peter Kienle

    Prominent publications by Peter Kienle

    KOL Index score: 30119

    BACKGROUND: Fluorouracil-based chemoradiotherapy is regarded as a standard perioperative treatment in locally advanced rectal cancer. We investigated the efficacy and safety of substituting fluorouracil with the oral prodrug capecitabine.

    METHODS: This randomised, open-label, multicentre, non-inferiority, phase 3 trial began in March, 2002, as an adjuvant trial comparing capecitabine-based chemoradiotherapy with fluorouracil-based chemoradiotherapy, in patients aged 18 years or older ...

    Also Ranks for: Capecitabine Patients |  3 trial |  grade 2 |  fluorouracil chemoradiotherapy |  rectal cancer
    KOL Index score: 17845

    BACKGROUND: The outcome of patients with locally advanced gastroesophageal adenocarcinoma (adenocarcinoma of the esophagus, gastroesophageal (GE) junction, and stomach) is poor. There is conflicting evidence regarding the effects of perioperative chemotherapy on survival and other outcomes.

    OBJECTIVES: To assess the effect of perioperative chemotherapy for gastroesophageal adenocarcinoma on survival and other clinically relevant outcomes in the overall population of participants in ...

    Also Ranks for: Gastroesophageal Junction |  perioperative chemotherapy |  lower esophagus |  primary surgery |  rcts ipd
    KOL Index score: 17349

    BACKGROUND: After low anterior resection for rectal cancer, creation of a diverting stoma is recommended. Data on the impact of a diverting stoma on quality of life are conflicting. Optimal timing of stoma closure in the setting of adjuvant chemotherapy is unclear.

    OBJECTIVE: The purpose of this study was to investigate the impact of a diverting stoma on quality of life in patients undergoing rectal cancer resection before and after stoma closure. Furthermore, the study was conducted to ...

    Also Ranks for: Stoma Closure |  rectal cancer |  low anterior resection |  quality life |  adjuvant chemotherapy
    KOL Index score: 14720

    OBJECTIVE: To determine the extent of pre- and intraoperative hematogenic tumor cell dissemination in patients undergoing liver resection for metastatic colorectal cancer.

    SUMMARY BACKGROUND DATA: For patients with hepatic metastases of colorectal cancer, liver resection is the only potentially curative therapy. However, 38% to 53% of patients develop extrahepatic tumor recurrence, probably caused by tumor cells disseminated before or during surgery not detected by current staging ...

    Also Ranks for: Liver Metastases |  colorectal cancer |  tumor cell |  patients resection |  blood samples
    KOL Index score: 13407

    PURPOSE: Mutations in KRAS and BRAF genes as well as the loss of expression of phosphatase and tensin homolog (PTEN) (deleted on chromosome 10) are associated with impaired activity of antibodies directed against epidermal growth factor receptor in patients with metastatic colorectal cancer. The predictive and prognostic value of the KRAS and BRAF point mutations as well as PTEN expression in patients with locally advanced rectal cancer (LARC) treated with cetuximab-based neoadjuvant ...

    Also Ranks for: Braf Mutation |  monoclonal antibodies |  advanced rectal |  patients larc |  tumor regression
    KOL Index score: 13349

    BACKGROUND: A parastomal hernia is defined as an incisional hernia related to a stoma and belongs to the most common stoma-related complications. Many factors concerning the operative technique which are considered to influence the incidence of parastomal herniation have been investigated. However, it remains unclear whether the enterostomy should be placed through or lateral to the rectus abdominis muscle in order to prevent parastomal herniation and other important stoma complications ...

    Also Ranks for: Parastomal Herniation |  lateral pararectal |  transrectal stoma placement |  randomized studies |  stoma complications
    KOL Index score: 13263

    OBJECTIVE: To examine the prognostic significance of disseminated tumor cells in blood and bone marrow of patients undergoing surgical resection of colorectal liver metastases.

    SUMMARY BACKGROUND DATA: Despite curative hepatic resection of colorectal liver metastases, a high percentage of patients develop tumor recurrence. These recurrences probably originate from disseminated tumor cells released into the circulation before or during surgery.

    METHODS: Thirty-seven patients with ...

    Also Ranks for: Colorectal Liver Metastases |  surgical resection |  tumor cell |  bone marrow |  blood samples
    KOL Index score: 12432

    BACKGROUND & AIMS: Colorectal cancers (CRC) associated with the hereditary nonpolyposis colorectal cancer (HNPCC) syndrome display high-level microsatellite instability (MSI-H) as a consequence of mismatch repair deficiency. HNPCC-associated CRC frequently show features of a pronounced immune response, most likely resulting from the MSI-induced generation of novel tumor-specific carboxy-terminal frameshift peptides (FSPs). However, the role of FSP-specific immune surveillance mechanisms ...

    Also Ranks for: Hnpcc Patients |  immune response |  mutation carriers |  cellular lymphocytes |  peripheral blood
    KOL Index score: 12122

    PURPOSE: To evaluate the safety and efficacy of preoperative radiotherapy (RT) in combination with cetuximab, capecitabine, and irinotecan in patients with locally advanced rectal cancer.

    METHODS AND MATERIALS: Patients with rectal cancer (clinical stage T3/4 or N+) were scheduled to receive cetuximab (400 mg/m(2) Day 1, 250 mg/m(2) Days 8, 15, 22, 29) in combination with weekly irinotecan 40 mg/m(2) and capecitabine 500 mg/m(2) twice daily (Days 1-38). RT was given to a dose of 50.4 Gy ...

    Also Ranks for: Rectal Cancer |  cetuximab capecitabine |  monoclonal antibodies |  pcr rate |  preoperative radiotherapy
    KOL Index score: 11741

    BACKGROUND: Metastatic disease in colorectal cancer results from hematogenic dissemination of tumor cells. This dissemination can be explained by 2 concepts: (1) regional spread of tumor cells via portal venous drainage into the liver as the first site of metastasis and (2) early spread of tumor cells into central and peripheral venous blood as evidence of systemic hematogenic tumor cell dissemination.

    HYPOTHESIS: Tumor cell detection in different blood compartments could help to ...

    Also Ranks for: Colorectal Cancer |  venous blood |  tumor cell |  detection rate |  chain reaction
    KOL Index score: 11545

    Microsatellite instability (MSI) occurs in most hereditary nonpolyposis colorectal cancers (HNPCC) and less frequently in sporadic tumors as the result of DNA mismatch repair (MMR) deficiency. Instability at coding microsatellites (cMS) in specific target genes causes frameshift mutations and functional inactivation of affected proteins, thereby providing a selective growth advantage to MMR deficient cells. At present, little is known about Selective Target Gene frameshift mutations in ...

    Also Ranks for: Microsatellite Instability |  target genes |  frameshift mutations |  colorectal adenomas |  functional inactivation
    KOL Index score: 10553

    PurposeThe aim of this study was to assess quality of life (QOL) in a long-term follow-up of patients with ulcerative colitis (UC) 10 years and more after ileal pouch–anal anastomosis (IPAA) to correlate these results with pouch function and to assess the long-term pouch failure rate.MethodsIn a unicentric study, 294 consecutive patients after IPAA between 1988 and 1996 were identified from a prospective database. QOL was evaluated according to the validated Gastrointestinal Quality of ...

    Also Ranks for: Anal Anastomosis |  restorative proctocolectomy |  ulcerative colitis |  life qol |  10 years


    Peter Kienle: Influence Statistics

    Sample of concepts for which Peter Kienle is among the top experts in the world.
    Concept World rank
    study appendicular #1
    appendix stump closure #1
    76 series #1
    adenomas endosonography #1
    unaffected individuals distress #1
    mortality oncologic outcome #1
    innovative titanium clip #1
    139 cancer patients #1
    ileocolic pedicle division #1
    innovative titanium #1
    transgastric appendicectomy paper #1
    adenomas undergone #1
    endosonography rectal #1
    herniation stoma #1
    patients transgastric appendicectomy #1
    patients worse continence #1
    patients therapeutic regimes #1
    rectal endosonography patients #1
    pararectal versus #1
    undergone endosonography #1
    pha postoperative #1
    chirurgie beim crohn #1
    potential prognostic impact #1
    ewl roc curve #1
    small anecdotal reports #1
    continence function influence #1
    patients unaffected individuals #1
    endosonography series #1
    bariatric weight ewl #1
    bowel resection medications #1
    transrectal stoma #1
    kirwan parks #1
    local septic complications #1
    chemoradiation tumor #1
    patrastom #1
    lateral pararectal #1
    pararectal stoma #1
    protective ileostomy #1
    pararectal #1
    patients intraoperative radiotherapy #1
    counselling colorectal neoplasms #1
    iii kirwanparks classification #1
    wound ileostomy #1
    protective ileostomy patients #1
    76 major problem #1
    curve pha #1
    tumor agreement #1
    overstaging adenomas #1
    introduction staging method #1

    Key People For Rectal Cancer

    Top KOLs in the world
    Cornelis J H van de van de Velde
    rectal cancer adjuvant chemotherapy lymph node
    Lars A Påhlman
    rectal cancer preoperative radiotherapy adjuvant chemotherapy
    Bengt G Glimelius
    rectal cancer adjuvant chemotherapy preoperative radiotherapy
    Richard John Heald
    rectal cancer abdominoperineal excision low anterior resection
    Harm J T Rutten
    rectal cancer anastomotic leakage multimodality treatment
    Claus Michael Rödel
    rectal cancer radiation therapy survivin expression

    Peter Kienle:Expert Impact

    Concepts for whichPeter Kienlehas direct influence:Rectal cancer,  Colorectal cancer,  Tumor cells,  Parastomal herniation,  Stoma closure,  Restorative proctocolectomy,  Adjuvant chemotherapy,  Ulcerative colitis.

    Peter Kienle:KOL impact

    Concepts related to the work of other authors for whichfor which Peter Kienle has influence:Colorectal cancer,  Tumor cells,  Ulcerative colitis,  Lynch syndrome,  Microsatellite instability,  Bariatric surgery,  Adjuvant chemotherapy.



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    Allgemein- und Viszeralchirurgie, Theresienkrankenhaus und Sankt Hedwig-Klinik GmbH, Mannheim, Deutschland | Allgemein-und Viszeralchirurgie, Theresienkrankenhaus und St. Hedwig-Klinik GmbH, Mannheim, Germany | Department of General and Visceral Surg