Edwin M Stone: Influence Statistics

Edwin M Stone

Edwin M Stone

Department of Ophthalmology and Visual Sciences, University of Iowa, IA, USA | Institute for Vision Research, The University of Iowa, Iowa City, IA 52242, USA | Institute for ...

Edwin M Stone: Expert Impact

Concepts for which Edwin M Stone has direct influence: Retinitis pigmentosa , Stargardt disease , Leber congenital amaurosis , Macular degeneration , Retinal degeneration , Visual acuity .

Edwin M Stone: KOL impact

Concepts related to the work of other authors for which for which Edwin M Stone has influence: Gene therapy , Retinitis pigmentosa , Stargardt disease , Visual acuity , Stem cells , Leber congenital amaurosis , Trabecular meshwork .

KOL Resume for Edwin M Stone

Year
2022

Department of Ophthalmology and Visual Sciences, University of Iowa, IA, USA

2021

Institute for Vision Research, The University of Iowa, Iowa City, Iowa

2020

The Institute for Vision Research, University of Iowa, Iowa City, IA, USA; Department of Ophthalmology and Visual Sciences, Carver College of Medicine, University of Iowa, Iowa City, IA, USA.

Institute for Vision Research, Department of Ophthalmology and Visual Sciences, University of Iowa Hospital and Clinics, Iowa City, Iowa.

2019

Institute for Vision Research, Department of Ophthalmology and Visual Sciences, University of Iowa, Iowa City, IA 52241, USA.

Department of Ophthalmology and Visual Sciences, Carver College of Medicine, Iowa City, IA 52242

The University of Iowa Carver College of Medicine

2018

Department of Ophthalmology and Visual Sciences, The University of Iowa, Iowa City, IA, USA

Institute for Vision Research, University of Iowa, Iowa City, Iowa.

2017

Department of Ophthalmology andVisual Sciences, University of Iowa Hospitals and Clinics, Iowa City, Iowa, USA

Stephen A. Wynn Institute for Vision Research, the University of Iowa, Iowa City, Iowa

2016

Department of Ophthalmology and Visual Sciences The University of Iowa Iowa City, Iowa USA

Howard Hughes Medical Institute, Iowa City, Iowa

Prominent publications by Edwin M Stone

KOL-Index: 15233 . OBJECTIVE: To investigate the phenotype and age-related penetrance of primary open-angle glaucoma (POAG) in Australian families with the most common Myocilin mutation (Gln368STOP). DESIGN: Cross-sectional genetic study. PARTICIPANTS: Eight pedigrees carrying the Gln368STOP mutation were ascertained from 1730 consecutive cases of POAG in the Glaucoma Inheritance Study in Tasmania. METHODS: ...
Known for Gln368stop Mutation | Oht Poag | Glaucoma Families | Age Diagnosis
KOL-Index: 15149 . OBJECTIVE: To report the spectrum of ophthalmic findings in patients with Stargardt dystrophy or fundus flavimaculatus who have a specific sequence variation in the ABCR gene. PATIENTS: Twenty-nine patients with Stargardt dystrophy or fundus flavimaculatus from different pedigrees were identified with possible disease-causing sequence variations in the ABCR gene from a group of 66 patients ...
Known for Sequence Variations | Stargardt Dystrophy | Abcr Gene | Clinical Phenotypes
KOL-Index: 14770 . PURPOSE: Mutations of the forkhead transcription factor gene FOXC1 result in anterior segment anomalies. No description of the spectrum of defects resulting from a single point mutation of this gene exists in the ophthalmology literature. We have screened all available patients with Axenfeld-Rieger genes (PITX2 and FOXC1). In this report, we clinically characterize the spectrum of ocular ...
Known for Peters Anomaly | Rieger Syndrome | Foxc1 Gene | Anterior Segment
KOL-Index: 14754 . OBJECTIVE: To determine the safety and efficacy of subretinal gene therapy in the RPE65 form of Leber congenital amaurosis using recombinant adeno-associated virus 2 (rAAV2) carrying the RPE65 gene. DESIGN: Open-label, dose-escalation phase I study of 15 patients (range, 11-30 years of age) evaluated after subretinal injection of the rAAV2- RPE65 vector into the worse-functioning eye. Five ...
Known for Rpe65 Mutations | Gene Therapy | Leber Congenital Amaurosis | 3 Years
KOL-Index: 14703 . PURPOSE: To evaluate the outcome of intravitreal injection of aflibercept in cases with exudative age-related macular degeneration, (AMD) resistant to injections of bevacizumab or ranibizumab. DESIGN: Retrospective observational case series. METHODS: A retrospective chart review at a single institution was conducted to identify patients with exudative AMD and choroidal neovascularization ...
Known for Aflibercept Therapy | Bevacizumab Ranibizumab | Degeneration Resistant | Exudative Age
KOL-Index: 14313 . OBJECTIVE: To weight the rod-, cone-, and melanopsin-mediated activation of the retinal ganglion cells, which drive the pupil light reflex by varying the light stimulus wavelength, intensity, and duration. DESIGN: Experimental study. PARTICIPANTS: Forty-three subjects with normal eyes and 3 patients with neuroretinal visual loss. METHODS: A novel stimulus paradigm was developed using ...
Known for Pupil Responses | Blue Light | Normal Eyes | Cells Retinal
KOL-Index: 14264 . PURPOSE: To correlate visual acuity of patients with Leber's congenital amaurosis (LCA) and early childhood-onset retinitis pigmentosa (RP) with mutations in underlying LCA genes. DESIGN: Multicentered retrospective observational study. PARTICIPANTS: After exclusion of 28 subjects, 169 patients with the diagnosis of LCA and 27 patients with early childhood-onset RP were included in the ...
Known for Visual Acuity | Congenital Amaurosis | Patients Lca | Retinitis Pigmentosa
KOL-Index: 14047 . Age-related macular degeneration (AMD) is the most common cause of vision loss in developed countries. A defining characteristic of this disorder is the accumulation of material between Bruch's membrane and the retinal pigment epithelium (RPE), first as microscopic basal deposits and later as clinically evident drusen. The pathogenesis of these deposits remains to be defined. Biochemical ...
Known for R345w Mutation | Rpe Amd | Basal Deposits | Bruchs Membrane
KOL-Index: 13615 . PURPOSE: To evaluate genotypic and macular morphologic correlations in patients with RPE65-, CEP290-, GUCY2D-, or AIPL1-related Leber congenital amaurosis (LCA) using spectral-domain optical coherence tomography (SD-OCT). METHODS: SD-OCT macular scans were performed in 21 patients, including 10 with RPE65, 7 with CEP290, 3 with GUCY2D, and 1 with AIPL1 mutations. An image processing ...
Known for Congenital Amaurosis | Patients Rpe65 | Cep290 Mutations | Visual Acuity
KOL-Index: 13391 . Retinitis pigmentosa (RP) is a genetically heterogeneous heritable disease characterized by apoptotic death of photoreceptor cells. We used exome sequencing to identify a homozygous Alu insertion in exon 9 of male germ cell-associated kinase (MAK) as the cause of disease in an isolated individual with RP. Screening of 1,798 unrelated RP patients identified 20 additional probands homozygous ...
Known for Retinitis Pigmentosa | Stem Cells | Induced Pluripotent | Exome Sequencing
KOL-Index: 13311 . BACKGROUND AND OBJECTIVES: Mutations of the peripherin/RDS gene have been reported in autosomal dominant retinitis pigmentosa, pattern macular dystrophy, and retinitis punctata albescens. We report herein the occurrence of three separate phenotypes within a single family with a novel 3-base pair deletion of codon 153 or 154 of the peripherin/RDS gene. DESIGN: Case reports with clinical ...
Known for Fundus Flavimaculatus | Pattern Dystrophy | Retinitis Pigmentosa | Rds Gene

Key People For Retinitis Pigmentosa

Top KOLs in the world
#1
Eliot L Berson
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#2
THADDEUS P Dryja
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#3
Gerald Allen Fishman
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#4
Michael A Sandberg
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#5
John R Heckenlively
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#6
Samuel G Jacobson
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Department of Ophthalmology and Visual Sciences, University of Iowa, IA, USA | Institute for Vision Research, The University of Iowa, Iowa City, IA 52242, USA | Institute for Vision Research, Department of Ophthalmology and Visual Sciences, Universit