• Disease
  • Infantile
  • Infantile Spasms
  • James D Frost

    Prominent publications by James D Frost

    KOL Index score: 10500

    PURPOSE: The main objective of this research is the development of automated video processing and analysis procedures aimed at the recognition and characterization of the types of neonatal seizures. The long-term goal of this research is the integration of these computational procedures into the development of a stand-alone automated system that could be used as a supplement in the neonatal intensive care unit (NICU) to provide 24-h per day noninvasive monitoring of infants at risk for ...

    Also Ranks for: Neonatal Seizures |  video recordings |  computational tools |  quantitative features |  motion analysis
    KOL Index score: 10003

    PURPOSE: Infantile spasms is one of the most severe epileptic syndromes of infancy and early childhood. Progress toward understanding the pathophysiology of this disorder and the development of effective therapies has been hindered by the lack of a relevant animal model. We report here the creation of such a model.

    METHODS: The sodium channel blocker, tetrodotoxin (TTX), was chronically infused into the developing neocortex or hippocampus of infant rats by way of an osmotic minipump ...

    Also Ranks for: Infantile Spasms |  animal model |  unprovoked persistent seizures |  infant rats |  postnatal day
    KOL Index score: 9378

    Twenty-four patients with infantile spasms were entered in a double-blind, placebo-controlled, crossover study to compare the therapeutic effectiveness of ACTH (20 to 30 units/day) with that of prednisone (2 mg/kg/day). Response to therapy was determined by utilizing a comprehensive monitoring system and was defined as a complete cessation of spasms and disappearance of the hypsarrhythmic EEG pattern. A major difference between the effectiveness of ACTH and that of prednisone in stopping ...

    Also Ranks for: Prednisone Therapy |  infantile spasms |  patients acth |  eeg pattern |  complete cessation
    KOL Index score: 8740

    Infantile spasms syndrome (ISS) is a catastrophic pediatric epilepsy with motor spasms, persistent seizures, mental retardation, and in some cases, autism. One of its monogenic causes is an insertion mutation [c.304ins (GCG)(7)] on the X chromosome, expanding the first polyalanine tract of the interneuron-specific transcription factor Aristaless-related homeobox (ARX) from 16 to 23 alanine codons. Null mutation of the Arx gene impairs GABA and cholinergic interneuronal migration but ...

    Also Ranks for: Spasms Syndrome |  mouse model |  repeat expansion |  arx gene |  inbred c57bl mice
    KOL Index score: 8569

    Sleep organization of infants may be influenced by differences in nutrient intakes from human milk and formula. Because sleep/awake and sleep stage patterns affect energy expenditure, we hypothesized that differences in sleep organization between breast-fed and formula-fed infants might account in part for differences in energy expenditure between feeding groups. Sleep stages and cycling of 4-mo-old breast-fed (n = 10) formula-fed (n = 10) infants were studied with simultaneous ...

    Also Ranks for: Energy Expenditure |  sleep stages |  fed infants |  breast feeding |  human milk
    KOL Index score: 8397

    This paper presents two methods developed to extract quantitative information from video recordings of neonatal seizures in the form of temporal motion strength and motor activity signals. Motion strength signals are extracted by measuring the area of the body parts that move during the seizure and the relative speed of motion using a combination of spatiotemporal subband decomposition of video, nonlinear filtering, and segmentation. Motor activity signals are extracted by tracking ...

    Also Ranks for: Neonatal Seizures |  motor activity |  motion strength |  video recordings |  body parts
    KOL Index score: 8041

    A new experimental model of developmental epilepsy is reported. Behavioral and EEG features of seizures produced by unilateral intrahippocampal injection of tetanus toxin in postnatal day 9-11 rats, are described. Within 24-72 h of tetanus toxin injection, rat pups developed frequent and often prolonged seizures which included combinations of repetitive wet dog shakes, and wild running-jumping seizures. Intrahippocampal and cortical surface EEG recordings showed that coincident with ...

    Also Ranks for: Tetanus Toxin |  infant rats |  electrographic seizures |  newborn behavior |  area ca3

    Infantile Spasms

    KOL Index score: 7978

    Infantile spasms constitute a relatively rare disorder of infancy and early childhood; their onset is usually within the first 6 to 8 months of life. A large percentage of patients with this disorder (85-90 per cent) show various degrees of retardation. Infantile spasms typically occur in clusters immediately on arousal, or soon thereafter, but rarely occur while the infant is actually asleep. The usual interictal EEG pattern associated with infantile spasms is hypsarrhythmia, but ...

    Also Ranks for: Infantile Spasms |  valproic acid |  early childhood |  brain stem |  eeg pattern
    KOL Index score: 7889

    Abnormal high frequency oscillations (HFOs) in EEG recordings are thought to be reflections of mechanisms responsible for focal seizure generation in the temporal lobe and neocortex. HFOs have also been recorded in patients and animal models of infantile spasms. If HFOs are important contributors to infantile spasms then anticonvulsant drugs that suppress these seizures should decrease the occurrence of HFOs. In experiments reported here, we used long-term video/EEG recordings with ...

    Also Ranks for: Infantile Spasms |  animal model |  frequency oscillations |  eeg recordings |  neocortex rats
    KOL Index score: 7841

    This paper presents an automated procedure developed to extract quantitative information from video recordings of neonatal seizures in the form of motor activity signals. This procedure relies on optical flow computation to select anatomical sites located on the infants' body parts. Motor activity signals are extracted by tracking selected anatomical sites during the seizure using adaptive block matching. A block of pixels is tracked throughout a sequence of frames by searching for the ...

    Also Ranks for: Neonatal Seizures |  video recordings |  motor activity |  block matching |  computer assisted
    KOL Index score: 7153

    We report the long-term outcome of 64 infants with infantile spasms, followed prospectively, using controlled treatment schedules and objective techniques (24-hour EEG and video monitoring) to determine response. Average age at follow-up was 50 months. Of the 64 infants, three (5%) died; of the others, 41 (67%) had developmental retardation of 50% or more or an IQ of 50 or less. Eight patients (13%) composed our cryptogenic study group and were so classified on the basis of normal CT ...

    Also Ranks for: Infantile Spasms |  controlled studies |  normal development |  longterm outcome |  average age
    KOL Index score: 6598

    OBJECTIVE: This study was aimed at the development of a seizure detection system by training neural networks using quantitative motion information extracted by motion segmentation methods from short video recordings of infants monitored for seizures.

    METHODS: The motion of the infants' body parts was quantified by temporal motion strength signals extracted from video recordings by motion segmentation methods based on optical flow computation. The area of each frame occupied by the ...

    Also Ranks for: Neonatal Seizures |  automated detection |  video recordings |  neural networks |  quantitative features
    KOL Index score: 6579

    An electronic averaging technique was used to detect consistent correlations between single unit discharges and EEG configuration in an isolated cortex preparation. These relationships were usually not evident by visual inspection of unprocessed data. Although each spontaneously active single unit was associated with a different averaged EEG wave form, the point of single unit discharge in almost all cases occurred during an initial positive phase and was followed by a rapid negative ...

    Also Ranks for: Single Unit |  eeg activity |  cerebral cortex |  unprocessed data |  visual inspection
    KOL Index score: 6487

    Epileptic seizures are reported to occur frequently in Rett syndrome (RS). We evaluated the hypothesis that many events classified as seizures in RS represent other paroxysmal, non-epileptic events; thus, the overall incidence of seizures in RS is overestimated. We conducted video/polygraphic/EEG monitoring sessions (8-120 h duration) in 82 RS females (ages 2-30 years). Fifty-five patients (67%) had a history of seizures and 43 (52%) were receiving anticonvulsants. All had abnormal EEGs. ...

    Also Ranks for: Rett Syndrome |  epileptic seizures |  clinical stage |  abnormal eegs |  motor activity


    James D Frost: Influence Statistics

    Sample of concepts for which James D Frost is among the top experts in the world.
    Concept World rank
    eeg elimination #1
    selected generalized seizures #1
    hazard quantitative manner #1
    relationship epileptiform events #1
    25 prompt reduction #1
    diurnal 448 #1
    disorder infantile spasms #1
    encephalopathic event interval #1
    cyclic processes treatment #1
    secondderivative measure #1
    microprocessorbased detection #1
    acth initial drug #1
    time modulation interaction #1
    consistent wave forms #1
    sharp eeg waveforms #1
    highdose longduration #1
    initial transient detection #1
    correctly detected foci #1
    humans spasms #1
    microprocessors multichannel configurations #1
    decreasing cost microprocessors #1
    desynchronization infantile #1
    interval brain injury #1
    regression analysis typical #1
    eeg intracellular oscillations #1
    duration sharpness #1
    spike discharges neuron #1
    infantile spasms near‐drowning #1
    relation pathophysiological mechanism #1
    spike foci treatment #1
    systems design expansion #1
    asymmetrical hypsarrhythmia #1
    properties spike distribution #1
    brain injury onset #1
    eeg spasms #1
    context electrooculography epilepsies #1
    fluctuations visual analysis #1
    higherorder analytical functions #1
    neardrowning 1st year #1
    initials ability #1
    atypical absence tonic #1
    additional processing modules #1
    period 100 minutes #1
    eeg recording interval #1
    sharpness decreasing cost #1
    onset infantile spasms #1
    hypsarrhythmic eegs #1
    attainment seizure control #1

    Key People For Infantile Spasms

    Top KOLs in the world
    Richard A Hrachovy
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    James D Frost
    infantile spasms neonatal seizures video recordings
    W Donald Shields
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    Raili Sylvia Riikonen
    infantile spasms rett syndrome cerebrospinal fluid
    Orlando Carter Carter Snead
    infantile spasms absence seizures epilepsy surgery
    John P Osborne
    tuberous sclerosis infantile spasms hormonal treatment

    James D Frost:Expert Impact

    Concepts for whichJames D Frosthas direct influence:Infantile spasms,  Neonatal seizures,  Video recordings,  Automated detection,  Animal model,  Energy expenditure,  Controlled study,  Neonatal eeg.

    James D Frost:KOL impact

    Concepts related to the work of other authors for whichfor which James D Frost has influence:Infantile spasms,  Rett syndrome,  Neonatal seizures,  Adrenocorticotropic hormone,  Evoked potentials,  Preterm infants,  Seizure detection.



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    Department of Neurology, Baylor College of Medicine, Houston, TX | Department of Neurology, Baylor College of Medicine, Houston, TX 77030, United States. | Department of Neuroscience, Baylor College of Medicine, Houston, TX, USA | Department of Neuro