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    • Marcel Kool
    • Marcel Kool

      Marcel Kool

      Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands | Hopp Children’s Cancer Center (KiTZ), Heidelberg, Germany | Princess Máxima Center for Pediatric ...



      KOL Resume for Marcel Kool


      Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands

      Hopp Children’s Cancer Center (KiTZ), Heidelberg, Germany


      Hopp-Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.

      Division of Pediatric Neurooncology, German Cancer Research Center DKFZ and German Cancer Consortium DKTK, 69120 Heidelberg, Germany

      Princess Maxima Center for Pediatric Oncology, Utrecht, The Netherlands

      Hopp Children’s Cancer Center (KiTZ)


      Department of Pediatric Hematology and Oncology, Heidelberg University Hospital, Heidelberg, Germany

      Princess Máxima Center for Pediatric Oncology, 3584 CS Utrecht, The Netherlands

      German Cancer Research Center (DKFZ)

      Wellcome Sanger Institute, Hinxton, UK



      Marcel Kool: Influence Statistics

      Sample of concepts for which Marcel Kool is among the top experts in the world.
      Concept World rank
      current consensus #1
      etmr diagnosis #1
      epn fgfr3 #1
      new model ldha #1
      myc atrtshh #1
      p53 pathway induction #1
      libraries test #1
      otx2bound promoters #1
      astrocyte progenitors myc #1
      medulloblastoma clinical #1
      mben #1
      overexpression medulloblastoma #1
      expression profiling mycn #1
      promoters bivalent state #1
      mrp6 protein #1
      joint binding #1
      wip1phosphatase #1
      scid organoids pyrimidines #1
      bcor majority #1
      shhactivated medulloblastomas #1
      cerebellum pathologic features #1
      molecular data rigs #1
      singlecell mrna readouts #1
      rigs pdgfra #1
      chemotherapy leptomeningeal disease #1
      pharmacological rock inhibition #1
      overexpression minichromosome maintenance #1
      spry1 triggers #1
      foxm1 medulloblastoma #1
      fusion proteins tumors #1
      rocks medulloblastoma #1
      otx2 myc #1
      patients etmr #1
      ato gli1 #1
      preoperative systemic levels #1
      infants m0 disease #1
      chemosensitivity dnaalkylating drugs #1
      sufu tumor #1
      cellular regulation mirna4521 #1
      medulloblastoma cellular proliferation #1
      specific tag libraries #1
      p2a86 female wistar #1
      aggressive shh medulloblastomas #1
      pediatric gains #1
      atrt atrtmyc #1
      platforms ratio difference #1
      strains mice ephb1 #1
      atrt prdm16 #1
      barhl1 expression medulloblastomas #1
      epn subtypes #1


      Prominent publications by Marcel Kool

      KOL-Index: 18217

      BACKGROUND: Medulloblastoma is associated with rare hereditary cancer predisposition syndromes; however, consensus medulloblastoma predisposition genes have not been defined and screening guidelines for genetic counselling and testing for paediatric patients are not available. We aimed to assess and define these genes to provide evidence for future screening guidelines.

      METHODS: In this international, multicentre study, we analysed patients with medulloblastoma from retrospective cohorts ...

      Known for Genetic Predisposition | Patients Medulloblastoma | Germline Mutations | Brca2 Palb2 | Highest Prevalence
      KOL-Index: 18083

      BACKGROUND: Patients with incomplete surgical resection of medulloblastoma are controversially regarded as having a marker of high-risk disease, which leads to patients undergoing aggressive surgical resections, so-called second-look surgeries, and intensified chemoradiotherapy. All previous studies assessing the clinical importance of extent of resection have not accounted for molecular subgroup. We analysed the prognostic value of extent of resection in a subgroup-specific ...

      Known for Molecular Subgroup | Medulloblastoma Extent | Gross Total Resection | Progressionfree Survival | Craniospinal Irradiation
      KOL-Index: 16355

      BACKGROUND: Recurrent medulloblastoma is a therapeutic challenge because it is almost always fatal. Studies have confirmed that medulloblastoma consists of at least four distinct subgroups. We sought to delineate subgroup-specific differences in medulloblastoma recurrence patterns.

      METHODS: We retrospectively identified a discovery cohort of all recurrent medulloblastomas at the Hospital for Sick Children (Toronto, ON, Canada) from 1994 to 2012 (cohort 1), and established molecular ...

      Known for Medulloblastoma Subgroups | Molecular Analysis | Recurrence Patients | 4 Tumours | Integrated Clinical
      KOL-Index: 15221

      BACKGROUND: Young children with medulloblastoma have a poor overall survival compared with older children, due to use of radiation-sparing therapy in young children. Radiotherapy is omitted or reduced in these young patients to spare them from debilitating long-term side-effects. We aimed to estimate event-free survival and define the molecular characteristics associated with progression-free survival in young patients with medulloblastoma using a risk-stratified treatment strategy ...

      Known for Young Children | Chemotherapy Patients | Adapted Therapy | Adjuvant Child | Methylation Profiling
      KOL-Index: 14067

      Gliomas are the most common primary brain tumors in children and adults. We recently identified frequent alterations in chromatin remodelling pathways including recurrent mutations in H3F3A and mutations in ATRX (α-thalassemia/mental-retardation-syndrome-X-linked) in pediatric and young adult glioblastoma (GBM, WHO grade IV astrocytoma). H3F3A mutations were specific to pediatric high-grade gliomas and identified in only 3.4 % of adult GBM. Using sequencing and/or immunohistochemical ...

      Known for Atrx Mutations | Adult Diffuse | Neoplastic Humans | Grade Gliomas | Idh1 2
      KOL-Index: 13567

      The DNA repair enzyme O6-methylguanine-DNA methyltransferase (MGMT) is commonly overexpressed in cancers and is implicated in the development of chemoresistance. The use of drugs inhibiting MGMT has been hindered by their haematologic toxicity and inefficiency. As a different strategy to inhibit MGMT we investigated cellular regulators of MGMT expression in multiple cancers. Here we show a significant correlation between Wnt signalling and MGMT expression in cancers with different origin ...

      Known for Gene Expression | Catenin Pathway | Wnt Signalling | Dna Repair | Neoplastic Glioma
      KOL-Index: 13268

      BACKGROUND: Identification of robust biomarkers of malignancy and methods to establish disease progression is a major goal in paediatric neuro-oncology. We investigated whether methylation of the TERT promoter can be a biomarker for malignancy and patient outcome in paediatric brain tumours.

      METHODS: For the discovery cohort, we used samples obtained from patients with paediatric brain tumours and individuals with normal brain tissues stored at the German Cancer Research Center ...

      Known for Tert Promoter | Risk Stratification | Utss Region | Paediatric Brain Tumours | Retrospective Studies
      KOL-Index: 12871

      Three histological variants are known within the family of embryonal rosette-forming neuroepithelial brain tumors. These include embryonal tumor with abundant neuropil and true rosettes (ETANTR), ependymoblastoma (EBL), and medulloepithelioma (MEPL). In this study, we performed a comprehensive clinical, pathological, and molecular analysis of 97 cases of these rare brain neoplasms, including genome-wide DNA methylation and copy number profiling of 41 tumors. We identified uniform ...

      Known for Embryonal Tumor | True Rosettes | Abundant Neuropil | Germ Cell | Local Neoplasms
      KOL-Index: 12093

      Telomerase reverse transcriptase (TERT) promoter mutations were recently shown to drive telomerase activity in various cancer types, including medulloblastoma. However, the clinical and biological implications of TERT mutations in medulloblastoma have not been described. Hence, we sought to describe these mutations and their impact in a subgroup-specific manner. We analyzed the TERT promoter by direct sequencing and genotyping in 466 medulloblastomas. The mutational distributions were ...

      Known for Tert Promoter | Shh Subgroup | Mutations Medulloblastoma | Wnt Tumors | Highly Recurrent
      KOL-Index: 11775

      The human multidrug transporter MDR1 P-glycoprotein and the multidrug resistance proteins MRP1 and MRP2 transport a range of cytotoxic drugs, resulting in multidrug resistance in tumour cells. To overcome this form of drug resistance in patients, several inhibitors (reversal agents) of these transporters have been isolated. Using polarized cell lines stably expressing human MDR1, MRP1 or MRP2cDNA, and 2008 ovarian carcinoma cells stably expressing MRP1 cDNA, we have investigated in this ...

      Known for Pluronic L61 | Reversal Agents | Multiple Drug Resistance | Mdr1 Pgp | Cytotoxic Drugs
      KOL-Index: 11752

      Recurrent mutations affecting the histone H3.3 residues Lys27 or indirectly Lys36 are frequent drivers of pediatric high-grade gliomas (over 30% of HGGs). To identify additional driver mutations in HGGs, we investigated a cohort of 60 pediatric HGGs using whole-exome sequencing (WES) and compared them to 543 exomes from non-cancer control samples. We identified mutations in SETD2, a H3K36 trimethyltransferase, in 15% of pediatric HGGs, a result that was genome-wide significant (FDR = ...

      Known for Setd2 Mutations | Grade Gliomas | Histone H3k36 | Pediatric Hggs | Older Children

      Key People For Rhabdoid Tumor

      Top KOLs in the world
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      rhabdoid tumor situ hybridization central nervous
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      central nervous brain tumors primitive neuroectodermal
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      Olivier Delattre
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      Roger J Packer
      brain tumors neurofibromatosis type central nervous
      Nigel F Palmer
      wilms tumor congenital anomalies testicular biopsy

      Marcel Kool:Expert Impact

      Concepts for whichMarcel Koolhas direct influence:Rhabdoid tumor,  Gene expression,  Dna methylation.

      Marcel Kool:KOL impact

      Concepts related to the work of other authors for whichfor which Marcel Kool has influence:Breast cancer,  Gene expression,  Multidrug resistance,  Dna methylation,  Brain tumors,  Tumor cells,  Mutational signatures.



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      Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands | Hopp Children’s Cancer Center (KiTZ), Heidelberg, Germany | Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands | Division of Pediatric Neuro-Oncology (B062

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