Jean Pierre P Famaey

ObjectivesA new once-a-day (o.a.d.) formulation of molsidomine (16 mg) was evaluated in patients with stable angina pectoris. The aims were to characterize its pharmacokinetics after a single dose, to demonstrate its clinical efficacy and safety versus placebo and to investigate correlations between pharmacokinetics and pharmacodynamics.MethodsForty-two patients were recruited in a double-blind, crossover, randomized placebo-controlled trial. The pharmacokinetics of molsidomine and ...

The action of various non-steroidal anti-inflammatory drugs (NSAID) that are also potent uncoupling agents for oxidative phosphorylation has been studied by measuring light scattering by rat liver mitochondria in different media. These drugs all induce a pseudo-energized high amplitude swelling, except gold salts and salicylates. The amplitude of this swelling is not very dependent on the concentration of the drugs, but the rapidity of the swelling is closely concentration-dependent. ...

Background and aim: Because in vitro studies have shown that nimesulide not only preferentially inhibits COX-2 but also reduces the action/release of pro-inflammatory cytokines, down-regulates the synthesis and/or activity of collagenase(s), and releases reactive oxygen species and other toxic substances from neutrophils, this study investigated whether nimesulide and ibuprofen could affect levels of biochemical markers of joint inflammation and collagen catabolism in patients with ...

1 Eleven non-steroidal anti-inflammatory drugs (NSAID) reversibly inhibited contractions of the longitudinal muscle of the guinea pig isolated ileum induced by acetylcholine, histamine, electrical transmural stimulation and nicotine in this order of increasing potency. 2. After the addition of prostaglandins E1, E2 or F2alpha, with partially effective concentrations of NSAID (but not with higher concentrations which almost totally prevented the responses) the inhibitory effects of NSAID ...

Non-steroidal anti-inflammatory drugs (NSAID) that are known to induce pseudo-energized high-amplitude swelling of mitochondrial preparations also induce swelling in various types of lymphocytes, namely: rat and rabbit thymocytes, rat and rabbit lymph node cells, and human and rat circulating lymphocytes obtained by thoracic duct drainage. The swelling of these immunocompetent cells was measured by light scattering. With the important exception of gold salts (no effect) and salicylates ...

Twelve different non steroidal antiinflammatory drugs (NSAID), five steroidal antiinflammatory drugs, morphine and chloroquine have been added at various concentrations to in vitro electrically-stimulated preparations of guinea-pig ileum. They all inhibit the electrically-induced contractions. Prostaglandins E as well as nicotine reverse this inhibition. These reversing effects are less evident on totally inhibiting drug concentrations than on partially inhibiting drug concentrations.It ...

Molsidomine, a sydnonimine acting as a heterocyclic direct nitric oxide donor, has been used for many years in several European countries for the treatment of patients with stable angina pectoris. The efficacy and tolerability of a novel oncedaily 16-mg formulation of molsidomine (M16) were compared with those of the currently used twice-daily 8-mg molsidomine tablet (M8) in 666 patients. Study 1, a multicenter, randomized, double-blind, placebo-controlled, twin crossover study, involved ...

Twenty-five patients suffering from osteoarthritis (O.A.) of the hip or knee were treated with nabumetone (1 g at night) or naproxen (250 mg b.i.d.) during 4 weeks starting either with nabumetone (twelve patients) or with naproxen (thirteen patients). The results of the study were subjected to a statistical analysis which showed good efficacy for both drugs. Tolerance was better with nabumetone than with naproxen. Nabumetone (1 g at night) appeared, thus, to be a good and very well ...

Prolonged-release molsidomine 16 mg once daily (QD) has proved effective in the short-term treatment of patients with stable angina. The purpose of this multi-center study was to assess its long-term tolerability and clinical effectiveness. A total of 320 patients with stable angina were treated for 1 year with molsidomine 16 mg QD administered open label as monotherapy or add-on therapy, when beta blockers and/or calcium antagonists were prescribed concomitantly (in 128 patients, ie, ...

This was a double-blind, parallel-group, multiple-dose study designed to compare the efficacy and tolerability of the sustained-release (SR) formulations of ibuprofen and diclofenac sodium for patients suffering from chronic back pain. The patients were randomly allocated to treatment with either the recommended once-daily dosage of ibuprofen SR (1600 mg) or diclofenac SR (100 mg) for 14 days; 30 patients were treated with ibuprofen and 32 with diclofenac. Clinical assessments of the ...

Fifty patients with periarthritis of the shoulder were entered into this randomized double-blind trial, twenty-five on ibuprofen 1600 mg daily and twenty-five on diclofenac 100 mg daily, in order to compare the efficacy and side-effects of these two drugs over a 14-day treatment period. Based on forty-six patients with adequate follow-up data, statistically significant improvements within both treatments (p less than 0.001) were noted during the course of the study with respect to all of ...

BACKGROUND: The objective of this study was to compare the efficacy and tolerability of molsidomine prolonged-release 16 mg once-a-day (o.a.d.) with 8 mg twice-a-day (b.i.d.) and placebo in patients with stable angina pectoris.

METHODS: After a run-in placebo period of 7 days, the two formulations were compared acutely and then chronically (2 weeks) using cycloergometric tests and a randomized, multicenter, double-blind, double-dummy, crossover design in 533 patients. The quality of life ...

Analysis of the hands in paintings attributed to Peter Paul Rubens during the last 30 years of his life seems to show progressive rheumatoid arthritis. Not only does this suggest that rheumatoid arthritis was present at the time, 200 years before some modern authors are willing to date its appearance, but also that Rubens or a major and consistent collaborator suffered from the disease.

Trace elements such as zinc, copper and selenium are involved in the pathogenesis of inflammatory diseases. In order to obtain more information about the overall movements of these minerals during the evolution of an experimental chronic inflammatory process, trace element levels were determined in five body compartments of the rat at several time intervals after induction of adjuvant arthritis. Rapid and significant changes in plasma zinc and copper levels and in liver zinc levels were ...