• Rheumatoid Arthritis
    • Jean Pierre P Famaey
    • Jean Pierre P Famaey: Influence Statistics

      Jean Pierre P Famaey

      Jean Pierre P Famaey

      Laboratory of Pharmacology, Rheumatology Unit, School of Medicine, Campus Plaine 205/7, 1050 Brussels, Belgium | School of Medicine, University of Brussels, Campus Plaine ...

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      Jean Pierre P Famaey:Expert Impact

      Concepts for whichJean Pierre P Famaeyhas direct influence:Rheumatoid arthritis,Rheumatic diseases,Angina pectoris,Stable angina pectoris,Arthritic rats,Stable angina,Inhibitory effects,Isolated ileum.

      Jean Pierre P Famaey:KOL impact

      Concepts related to the work of other authors for whichfor which Jean Pierre P Famaey has influence:Rheumatoid arthritis,Opioid peptides,Immune function,Inosine pranobex,Topical nsaids,Selenium supplementation,Fibromyalgia syndrome.

      KOL Resume for Jean Pierre P Famaey


      Laboratory of Pharmacology, Rheumatology Unit, School of Medicine, Campus Plaine 205/7, 1050 Brussels, Belgium


      Therabel Pharma S.A./N.V., Brussels, Belgium


      Therabel Pharma S.A./N.V., Rue Van Ophem 108, B-1180, Brussels, Belgium


      Department of Physical Therapy and Rheumatology, Free University of Brussels and Therabel Pharma, Brussels, Belgium


      Therabel Pharma S.A., Brussels, Statistical Center Squarepoint-Pointcarré, Ecaussinnes, Belgium


      Therabel Pharma S.A., Rue Van Ophem 108, 1180, Brussels, Belgium


      Free University of Brussels (U.L.B.), Therabel Research S.A./N.V., Brussels, Belgium


      Professor of Physical Medicine, University of Brussels, and Member of the Board, Therabel Research SA, B-1150 Brussels, Belgium


      Department of Rheumatology, Erasme University Hospital, Brussels, Belgium


      ULB Hôpital Saint-Pierre, Brussels, Belgium


      Department of Rheumatology, Saint Pierre University Hospital, Interdisciplinary Group on Osteoporosis, Free Universities of Brussels, Belgium


      From the Departments of Rheumatology and Physical Medicine and Immunology, Saint-Pierre Hospital; the Laboratory of Medicinal Chemistry, Institute of Pharmacy; the Pacheco Institute; and the Laboratory of Epidemiology, School of Public Health, University of Brussels.

      Department of Rheumatology, Saint-Pierre Hospital, Brussels, Belgium


      Department of Rheumatology and Physical Medicine, Saint Pierre Hospital, Free Universities of Brussels, Belgium


      Department of Rheumatology and Physical Medicine, University Hospital Saint-Pierre, Saint-Pierre, Belgium


      Department of Rheumatology, University of Brussels, Belgium




      Hôpital Universitaire Saint Pierre, University of Brussels, Brussels, Belgium


      Department of Rheumatology, University of Brussels, 115 Bd. Waterloo, 1000, Brussels, Belgium


      Department of Rheumatology, Hôpilal Universitare St. Pierre


      Department of Rheumatology, Saint-Pierre University hospital, University of Brussels, Belgium


      Laboratory of Pharmacology, Rheumatology Unit, School of Medicine and Institute of Pharmacy, University of Brussels, Belgium


      Laboratory of Pharmacology, Rheumatology Unit, School of Medicine, 115, Boulevard de Waterloo, B-1000, Brussels, Belgium


      Laboratory of Pharmacology, School of Medicine, University of Brussels, Boulevard du Triomphe, CP 205/7, B-1050, Brussels, Belgium


      Laboratory of Pharmacology, Rheumatology Unit, School of Medicine and Institute of Pharmacy, University of Brussels, 115, Boulevard de Waterloo, 1000 Bruxelles, Belgium


      Department of Medicine, University of California, Los Angeles, Belgium School of Medicine and Laboratory of Pharmacology, Rheumatology Unit, School of Medicine, University of Brussels, Los Angeles, Belgium


      Clinique Physiotherapique et Rheumatologique, Université Libre de Bruxelles, Brussels, Belgium

      UCLA School of Medicine, Department of Medicine, Los Angeles, Calif. 90024, U.S.A.

      Department of Medecine, University of California, School of Medecine, Los Angeles, USA


      Department of medicine, University of California, School of medicine, Los Angeles, California, USA


      Department of Medicine, University of California, School of Medicine, Los Angeles, Calif., U.S.A.

      Laboratory of Pharmacology (Rheumatological Unit), Free University of Brussels (ULB), Belgium

      Sample of concepts for which Jean Pierre P Famaey is among the top experts in the world.
      Concept World rank
      m8 study #1

      Prominent publications by Jean Pierre P Famaey

      KOL-Index: 9783

      ObjectivesA new once-a-day (o.a.d.) formulation of molsidomine (16 mg) was evaluated in patients with stable angina pectoris. The aims were to characterize its pharmacokinetics after a single dose, to demonstrate its clinical efficacy and safety versus placebo and to investigate correlations between pharmacokinetics and pharmacodynamics.MethodsForty-two patients were recruited in a double-blind, crossover, randomized placebo-controlled trial. The pharmacokinetics of molsidomine and ...

      Known for Angina Pectoris | Molsidomine 16 | Plasma Concentration | Patients Stable | Controlled Study
      KOL-Index: 9583

      The action of various non-steroidal anti-inflammatory drugs (NSAID) that are also potent uncoupling agents for oxidative phosphorylation has been studied by measuring light scattering by rat liver mitochondria in different media. These drugs all induce a pseudo-energized high amplitude swelling, except gold salts and salicylates. The amplitude of this swelling is not very dependent on the concentration of the drugs, but the rapidity of the swelling is closely concentration-dependent. ...

      Known for Mitochondrial Swelling | Membrane Permeability | Steroidal Anti | Mersalyl Medium | Gold Salts
      KOL-Index: 8972

      Background and aim: Because in vitro studies have shown that nimesulide not only preferentially inhibits COX-2 but also reduces the action/release of pro-inflammatory cytokines, down-regulates the synthesis and/or activity of collagenase(s), and releases reactive oxygen species and other toxic substances from neutrophils, this study investigated whether nimesulide and ibuprofen could affect levels of biochemical markers of joint inflammation and collagen catabolism in patients with ...

      Known for Collagen Type | Matrix Metalloproteinase | Patients Nimesulide | Aged Osteoarthritis | Anti Inflammatory
      KOL-Index: 6547

      1 Eleven non-steroidal anti-inflammatory drugs (NSAID) reversibly inhibited contractions of the longitudinal muscle of the guinea pig isolated ileum induced by acetylcholine, histamine, electrical transmural stimulation and nicotine in this order of increasing potency. 2. After the addition of prostaglandins E1, E2 or F2alpha, with partially effective concentrations of NSAID (but not with higher concentrations which almost totally prevented the responses) the inhibitory effects of NSAID ...

      Known for Isolated Ileum | Induced Contractions | Smooth Muscle | Acetylcholine Histamine | Inhibitory Effects
      KOL-Index: 6484

      Non-steroidal anti-inflammatory drugs (NSAID) that are known to induce pseudo-energized high-amplitude swelling of mitochondrial preparations also induce swelling in various types of lymphocytes, namely: rat and rabbit thymocytes, rat and rabbit lymph node cells, and human and rat circulating lymphocytes obtained by thoracic duct drainage. The swelling of these immunocompetent cells was measured by light scattering. With the important exception of gold salts (no effect) and salicylates ...

      Known for Membrane Permeability | Steroidal Anti | Mitochondrial Swelling | Drugs Nsaid | Flufenamic Acid
      KOL-Index: 5594

      Twelve different non steroidal antiinflammatory drugs (NSAID), five steroidal antiinflammatory drugs, morphine and chloroquine have been added at various concentrations to in vitro electrically-stimulated preparations of guinea-pig ileum. They all inhibit the electrically-induced contractions. Prostaglandins E as well as nicotine reverse this inhibition. These reversing effects are less evident on totally inhibiting drug concentrations than on partially inhibiting drug concentrations.It ...

      Known for Pig Ileum | Steroidal Anti | Induced Contractions | Prostaglandin Synthesis | Smooth Muscle
      KOL-Index: 5259

      Molsidomine, a sydnonimine acting as a heterocyclic direct nitric oxide donor, has been used for many years in several European countries for the treatment of patients with stable angina pectoris. The efficacy and tolerability of a novel oncedaily 16-mg formulation of molsidomine (M16) were compared with those of the currently used twice-daily 8-mg molsidomine tablet (M8) in 666 patients. Study 1, a multicenter, randomized, double-blind, placebo-controlled, twin crossover study, involved ...

      Known for Angina Pectoris | Drugrelated Aes | Molsidomine Patients | 2week Treatment | Exercise Capacity
      KOL-Index: 5223

      Twenty-five patients suffering from osteoarthritis (O.A.) of the hip or knee were treated with nabumetone (1 g at night) or naproxen (250 mg b.i.d.) during 4 weeks starting either with nabumetone (twelve patients) or with naproxen (thirteen patients). The results of the study were subjected to a statistical analysis which showed good efficacy for both drugs. Tolerance was better with nabumetone than with naproxen. Nabumetone (1 g at night) appeared, thus, to be a good and very well ...

      Known for Nabumetone Naproxen | Treatment Osteoarthritis | Anti Inflammatory | Agents Butanones
      KOL-Index: 5105

      Prolonged-release molsidomine 16 mg once daily (QD) has proved effective in the short-term treatment of patients with stable angina. The purpose of this multi-center study was to assess its long-term tolerability and clinical effectiveness. A total of 320 patients with stable angina were treated for 1 year with molsidomine 16 mg QD administered open label as monotherapy or add-on therapy, when beta blockers and/or calcium antagonists were prescribed concomitantly (in 128 patients, ie, ...

      Known for Stable Angina | Daily Molsidomine | Study Drug | Calcium Antagonists | Year Treatment
      KOL-Index: 5086

      This was a double-blind, parallel-group, multiple-dose study designed to compare the efficacy and tolerability of the sustained-release (SR) formulations of ibuprofen and diclofenac sodium for patients suffering from chronic back pain. The patients were randomly allocated to treatment with either the recommended once-daily dosage of ibuprofen SR (1600 mg) or diclofenac SR (100 mg) for 14 days; 30 patients were treated with ibuprofen and 32 with diclofenac. Clinical assessments of the ...

      Known for Patients Ibuprofen | Chronic Pain | Clinical Assessments | Diclofenac Treated | Efficacy Tolerability
      KOL-Index: 5045

      Fifty patients with periarthritis of the shoulder were entered into this randomized double-blind trial, twenty-five on ibuprofen 1600 mg daily and twenty-five on diclofenac 100 mg daily, in order to compare the efficacy and side-effects of these two drugs over a 14-day treatment period. Based on forty-six patients with adequate follow-up data, statistically significant improvements within both treatments (p less than 0.001) were noted during the course of the study with respect to all of ...

      Known for Patients Periarthritis | Shoulder Diclofenac | Joint Adult | Comparison Ibuprofen | 100 Daily
      KOL-Index: 4851

      BACKGROUND: The objective of this study was to compare the efficacy and tolerability of molsidomine prolonged-release 16 mg once-a-day (o.a.d.) with 8 mg twice-a-day (b.i.d.) and placebo in patients with stable angina pectoris.

      METHODS: After a run-in placebo period of 7 days, the two formulations were compared acutely and then chronically (2 weeks) using cycloergometric tests and a randomized, multicenter, double-blind, double-dummy, crossover design in 533 patients. The quality of life ...

      Known for Angina Pectoris | Molsidomine Placebo | Patients Quality | Exercise Test | Oxide Donors
      KOL-Index: 4530

      Analysis of the hands in paintings attributed to Peter Paul Rubens during the last 30 years of his life seems to show progressive rheumatoid arthritis. Not only does this suggest that rheumatoid arthritis was present at the time, 200 years before some modern authors are willing to date its appearance, but also that Rubens or a major and consistent collaborator suffered from the disease.

      Known for Rheumatoid Arthritis | 16th Century | Peter Paul Rubens | Arts Netherlands Paintings | Hand Deformities
      KOL-Index: 4499

      Trace elements such as zinc, copper and selenium are involved in the pathogenesis of inflammatory diseases. In order to obtain more information about the overall movements of these minerals during the evolution of an experimental chronic inflammatory process, trace element levels were determined in five body compartments of the rat at several time intervals after induction of adjuvant arthritis. Rapid and significant changes in plasma zinc and copper levels and in liver zinc levels were ...

      Known for Zinc Copper | Adjuvant Arthritis | Disease Induction | Trace Elements | Body Compartments

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      Laboratory of Pharmacology, Rheumatology Unit, School of Medicine, Campus Plaine 205/7, 1050 Brussels, Belgium | School of Medicine, University of Brussels, Campus Plaine 205/7, Brussels, Belgium | School of Medicine, University of Brussels, Campus P

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