• Arthritis
  • Arthritis Kols

    Prominent publications by JeanMichel MD Dayer

    KOL Index score: 18917

    OBJECTIVE: To determine whether direct cell-cell contact with stimulated T lymphocytes (a) differentially modulates the production of interstitial collagenase (matrix metalloproteinase 1 [MMP-1]) and tissue inhibitor of metalloproteinases 1 (TIMP-1) on human synoviocytes and dermal fibroblasts, and (b) induces the production of prostaglandin E2 (PGE2); and to identify the membrane-associated factors on T cell surfaces involved in these mechanisms.

    METHODS: Dermal fibroblasts and ...

    Also Ranks for: Tissue Inhibitor |  direct contact |  stimulated cells |  mmp1 timp1 |  production pge2
    KOL Index score: 15981

    Abstract Fever without localising signs in very young children remains a diagnostic problem. Until present, a clinical scoring system combined with leucocyte count, urine analysis and determination of CRP are recognised as being helpful to identify patients at risk of serious bacterial illness. In this study we asked the question whether the determination of procalcitonin (PCT), interleukin (IL)-6, IL-8 and interleukin-1 receptor antagonist (IL-1Ra) was superior to these commonly used ...

    Also Ranks for: Bacterial Infections |  sbi children |  reactive protein |  pct crp |  sensitivity specificity
    KOL Index score: 15897

    Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by the production of several autoantibodies. Among the multiple factors involved in SLE development, apoptotic defects and impaired clearance of cellular debris have gained considerable interest, as they contribute to autoantigen overload. Several molecules of the innate immunity, also participate in the removal of damaged and apoptotic cells. Among them are C1q, C-reactive protein (CRP), serum amyloid P protein ...

    Also Ranks for: Protective Molecules |  patients sle |  reactive protein |  c1q crp |  elevated titers
    KOL Index score: 15511

    CONTEXT: Studies have shown that an inflammatory response may be elicited by mechanical ventilation used for recruitment or derecruitment of collapsed lung units or to overdistend alveolar regions, and that a lung-protective strategy may reduce this response.

    OBJECTIVE: To test the hypothesis that mechanical ventilation induces a pulmonary and systemic cytokine response that can be minimized by limiting recruitment or derecruitment and overdistention.

    DESIGN AND SETTING: Randomized ...

    Also Ranks for: Inflammatory Mediators |  mechanical ventilation |  randomized controlled trial |  patients control |  recruitment derecruitment
    KOL Index score: 15201

    OBJECTIVE: In systemic sclerosis (SSc; scleroderma), T cells infiltrate organs undergoing fibrotic changes and may participate in dysregulated production of collagen by fibroblasts. The objective of this study was to functionally characterize T cells infiltrating skin lesions in early SSc and investigate their capacity to affect production of type I collagen and interstitial collagenase (matrix metalloproteinase 1 [MMP-1]) by dermal fibroblasts.

    METHODS: Four-color cytometric analysis ...

    Also Ranks for: Collagen Production |  dermal fibroblasts |  th2 cells |  necrosis factor |  messenger scleroderma
    KOL Index score: 14949

    Tumor necrosis factor (TNF) has been implicated in the pathogenesis of experimental cerebral malaria (CM), but the respective role of its two types of receptors has not been established. A significant increase in the expression of TNF-receptor 2 (TNFR2, p75), but not of TNFR1 (p55), was found on brain microvessels at the time of CM in susceptible animals. Moreover, mice genetically deficient for TNFR2 (Tnfr2null) were significantly protected from experimental CM, in contrast to ...

    Also Ranks for: Tumor Necrosis Factor |  experimental cerebral malaria |  type receptors |  tnf tnfr2 |  inbred balb mice
    KOL Index score: 14135

    Imbalance in cytokine homeostasis plays an important part in the pathogenesis of chronic inflammatory diseases such as multiple sclerosis and rheumatoid arthritis. We demonstrated that T cells might exert a pathological effect through direct cellular contact with human monocytes/macrophages, inducing a massive up-regulation of the prototypical proinflammatory cytokines IL-1beta and TNF. This mechanism that might be implicated in chronic inflammation is specifically inhibited by ...

    Also Ranks for: Human Monocytes |  cellular contact |  high‐density lipoproteins |  cytokine production |  cells mp
    KOL Index score: 14004

    Tumour necrosis factor (TNF)-alpha and interleukin (IL-)1beta, essential players in the pathogenesis of immuno-inflammatory diseases, are strongly induced in monocytes by direct contact with stimulated T lymphocytes. The present study shows that the latter mechanism is inhibited by interferon (IFN)-beta. In co-cultures of autologous T lymphocytes and monocytes stimulated by phytohaemagglutinin (PHA), IFN-beta inhibited the production of TNF-alpha and IL-1beta by 88 and 98%, respectively, ...

    Also Ranks for: Cell Contact |  ifnbeta production |  tnfalpha il1beta |  interferon beta |  activation monocytes
    KOL Index score: 13658

    OBJECTIVE: Interferon-beta (IFNbeta) treatment is emerging as a potentially effective form of therapy in various immune-mediated conditions. This study evaluated the effects of IFNbeta therapy on the cell infiltrate, cytokine profile, and expression of metalloproteinase 1 (MMP-1) in synovial tissue from patients with rheumatoid arthritis (RA). To further assess the mechanism of action, in vitro experiments were conducted to determine the effects of IFNbeta on the production of MMP-1, ...

    Also Ranks for: Rheumatoid Arthritis |  synovial inflammation |  mmp3 timp1 |  ifnbeta therapy |  metalloproteinase 1
    KOL Index score: 13205

    Prointerleukin 1 beta (IL-1 beta) is a cytokine that mediates a broad range of biological activities. Genomic sequences that regulate IL-1 beta transcription include both inducible regulatory elements located more than 2,700 bp upstream of the transcriptional start site (cap site) and proximal elements located near the TATA box of this gene. In this study, we focused on the identification and characterization of trans-acting nuclear regulatory proteins that bind to the cap site-proximal ...

    Also Ranks for: Beta Gene |  cap site |  tata motif |  prointerleukin 1 |  dna sequence
    KOL Index score: 13125

    The role of human T cells in the induction and regulation, upon cell/cell contact, of inflammatory responses by monocytic cells was investigated. The production of interleukin (IL)-1beta and IL-1 receptor antagonist (IL-1Ra) by the monocytic THP-1 cell line was measured upon contact with either Th1 or Th2 cell clones. CD4+ T cell clones specific for purified protein derivative of Mycobacterium tuberculosis, predominantly Th1 [high interferon (IFN)-gamma and low IL-4 producers], or ...

    Also Ranks for: Th2 Cells |  receptor antagonist |  cell contact |  il1beta production |  mycobacterium tuberculosis
    KOL Index score: 12689

    BACKGROUND: Interferon γ (IFNγ) is considered a seminal cytokine in the pathogenesis of giant cell arteritis (GCA), but its functional role has not been investigated. We explored changes in infiltrating cells and biomarkers elicited by blocking IFNγ with a neutralising monoclonal antibody, A6, in temporal arteries from patients with GCA.

    METHODS: Temporal arteries from 34 patients with GCA (positive histology) and 21 controls were cultured on 3D matrix (Matrigel) and exposed to A6 or ...

    Also Ranks for: Giant Cell Arteritis |  cultured arteries |  patients gca |  infiltrating cells |  chemokines cxcl9


    JeanMichel MD Dayer: Influence Statistics

    Sample of concepts for which JeanMichel MD Dayer is among the top experts in the world.
    Concept World rank
    synoviocytes fibroblasts #1
    ril1ra il1 #1
    cell lysates supernatants #1
    chicheportiche #1
    timp balf #1
    tnf human monocytes #1
    adh factors #1
    ifngammamacrophages #1
    myelomonocytic gene #1
    human regulatory cytokines #1
    mmp1 afa #1
    sr55 #1
    pon1 activity oxldl #1
    presf #1
    il1 activity serum #1
    production pge2 #1
    antidsdna igg variations #1
    microinjections mycoplasma #1
    plasma cytokines patients #1
    years interleukin1 #1
    sil6ralpha pg #1
    timp1 ltm #1
    trifluoperazine pge2 response #1
    apparent salmon calcitonin #1
    phosphoinositide 3‐kinase‐mediated intracellular #1
    cpn 24 #1
    interleukins‐1 #1
    prevalence antiapo autoantibodies #1
    serum dmard treatment #1
    dfx 125itnfalpha #1
    pi3 stat1 #1
    factors fibroblast functions #1
    dissociation cell activation #1
    1 immunoreactive #1
    normal fibroblasts findings #1
    interleukin 1 alpha #1
    obesity obese humans #1
    hrtnf alpha #1
    stnfr55 stnfr75 #1
    diseases tissue destruction #1
    j5 study #1
    supernatants lung macrophages #1
    field cytokines #1
    mst cd18 #1
    sjca #1
    principal receptor form #1
    release tnfsr75 #1
    tnfsr75 fold #1
    tnf receptor concept #1
    serum levels degree #1

    Key People For Rheumatoid Arthritis

    Top KOLs in the world
    Paul Emery
    rheumatoid arthritis ankylosing spondylitis radiographic progression
    Josef Sebastian Smolen
    rheumatoid arthritis systemic lupus erythematosus radiographic progression
    James F Fries
    rheumatoid arthritis physical function systemic lupus erythematosus
    John Turner Sharp
    rheumatoid arthritis radiographic progression joint space width
    Frederick J Wolfe
    rheumatoid arthritis work disability rheumatic diseases
    Matthew H Liang
    rheumatoid arthritis systemic lupus erythematosus lyme disease

    JeanMichel MD Dayer:Expert Impact

    Concepts for whichJeanMichel MD Dayerhas direct influence:Rheumatoid arthritis,  Necrosis factor,  Tumor necrosis,  Human monocytes,  Tumor necrosis factor,  Receptor antagonist,  Synovial cells,  Direct contact.

    JeanMichel MD Dayer:KOL impact

    Concepts related to the work of other authors for whichfor which JeanMichel MD Dayer has influence:Rheumatoid arthritis,  Necrosis factor,  Oxidative stress,  Lung injury,  Gene expression,  Mechanical ventilation,  Adipose tissue.



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    Emeritus Professor of Medicine, School of Medicine, Geneva University, Geneva, Switzerland | Faculty of Medicine, University of Geneva, Switzerland. | Faculty of Medicine, University of Geneva, Geneva, Switzerland | Faculty of Medicine, Centre Médica