Prominent publications by Paul Peter Tak

KOL Index score: 20277

BACKGROUND: Sirukumab, a human monoclonal antibody that selectively binds to the interleukin-6 cytokine with high affinity, is under development for the treatment of rheumatoid arthritis and other diseases. We aimed to assess the efficacy and safety of sirukumab for rheumatoid arthritis in a phase 3 study (SIRROUND-T).

METHODS: We did a randomised, double-blind, placebo-controlled, parallel-group, multicentre study at 183 hospitals and private rheumatology clinics in 20 countries ...

के लिए जाना जाता है Sirukumab Patients |  rheumatoid arthritis |  2 weeks |  monoclonal antibodies |  phase 3 study
KOL Index score: 18685

OBJECTIVE: To investigate how antibodies against anti-tumour necrosis factor (anti-TNF) agents influence response after switching from infliximab to adalimumab in rheumatoid arthritis (RA).

METHODS: This cohort study consisted of 235 patients with RA, all treated with adalimumab. At baseline 52 patients (22%) had been previously treated with infliximab ('switchers'), and 183 (78%) were anti-TNF naive. Disease activity (using the 28-joint count Disease Activity Score (DAS28)) and presence ...

के लिए जाना जाता है Adalimumab Antibodies |  patients anti |  necrosis factor |  response infliximab |  illness treatment outcome
KOL Index score: 17819

BACKGROUND: Synovial tissue (ST) from end stage destructive rheumatoid arthritis (RA) and arthroscopic biopsies obtained during active inflammation might exhibit different characteristics.

OBJECTIVE: To define the cell infiltrate and the expression of proinflammatory cytokines, angiogenic factors, and matrix metalloproteinases (MMPs) in ST selected at arthroscopy compared with that from end stage RA.

METHODS: Synovial biopsy specimens were obtained from the actively inflamed knee joints ...

के लिए जाना जाता है Proinflammatory Cytokines |  matrix metalloproteinases |  cell infiltrate |  myelomonocytic arthritis |  synovial biopsies
KOL Index score: 15782

OBJECTIVE: To evaluate the efficacy and safety of secukinumab, a fully human, anti-interleukin (IL)-17A monoclonal antibody, in patients with psoriatic arthritis (PsA).

METHODS: 42 patients with active PsA fulfilling ClASsification for Psoriatic ARthritis (CASPAR) criteria were randomly assigned (2:1) to receive two intravenous secukinumab doses (10 mg/kg; n=28) or placebo (n=14) 3 weeks apart. The primary endpoint was the proportion of American College of Rheumatology (ACR) 20 responses ...

के लिए जाना जाता है Psoriatic Arthritis |  placebo week |  monoclonal antibodies |  primary endpoint |  safety secukinumab
KOL Index score: 15663

OBJECTIVE: To evaluate the safety and efficacy of ocrelizumab plus methotrexate (MTX) or leflunomide (LEF) in patients with active rheumatoid arthritis (RA) and an inadequate response to tumor necrosis factor α inhibitors.

METHODS: This was a multicenter randomized, double-blind, placebo-controlled, parallel-group study that continued over 48 weeks. Patients receiving stable doses of MTX or LEF were randomized to receive 2 infusions of placebo (n = 277), ocrelizumab 200 mg (n = 278), or ...

के लिए जाना जाता है Inadequate Response |  ocrelizumab patients |  rheumatoid arthritis |  48 weeks placebo |  necrosis factor
KOL Index score: 15475

BACKGROUND: A substantial proportion of patients with rheumatoid arthritis (RA) do not respond, or lose initial response, to adalimumab treatment. One explanation for non-response is that patients develop anti-adalimumab antibodies.

OBJECTIVES: To evaluate the incidence of formation of antibody against adalimumab and the association with serum adalimumab concentrations and clinical response.

METHODS: In a cohort of 121 consecutive patients with RA treated with adalimumab, serum ...

के लिए जाना जाता है Adalimumab Antibodies |  rheumatoid arthritis |  28 weeks |  substantial proportion |  initial response
KOL Index score: 15159

BACKGROUND: Chemokine receptors and chemokines have a crucial role in leucocyte recruitment into inflamed tissue.

OBJECTIVE: To examine the expression of an extensive number of chemokines and receptors in a unique bank of paired samples of synovial tissue (ST) and peripheral blood (PB) from patients with different forms of arthritis to assist in identifying suitable targets for therapeutic intervention.

METHODS: Synovial biopsy specimens were obtained from 23 patients with rheumatoid ...

के लिए जाना जाता है Reactive Arthritis |  synovial tissue |  chemokine receptor |  peripheral blood |  ccr1 ccr5
KOL Index score: 15155

OBJECTIVE: To determine if treatment with a B cell-targeted therapy can inhibit the progression of structural joint damage in patients with rheumatoid arthritis (RA), exhibiting an inadequate response to tumour necrosis factor (TNF) inhibitors.

METHODS: In this phase III study, patients with an inadequate response to a TNF inhibitor and receiving methotrexate were randomised to rituximab or placebo. Radiographs were obtained at baseline, week 24 and week 56 after randomisation. Patients ...

के लिए जाना जाता है Inadequate Response |  structural joint damage |  rituximab patients |  monoclonal antibodies |  necrosis factor
KOL Index score: 15046

OBJECTIVE: Bacteria are considered to be important in the pathogenesis of several forms of arthritis. The goal of this study was to apply the 16S ribosomal RNA (rRNA)-polymerase chain reaction method for the detection of bacterial DNA in synovial fluid (SF) and synovial tissue (ST) from inflamed joints.

METHODS: Samples from 5 patients with septic arthritis and from 7 with osteoarthritis or arthritis secondary to joint trauma were used as controls. Samples from 6 patients with ...

के लिए जाना जाता है Bacterial Dna |  joint samples |  undifferentiated arthritis |  16s ribosomal |  polymerase chain
KOL Index score: 14194

OBJECTIVE: In approximately 25% of synovial tissues from rheumatoid arthritis (RA) patients, infiltrates of T cells, B cells, and follicular dendritic cells (FDCs) are spatially organized into structures resembling lymph nodes with germinal centers. The remainder of the tissues lack FDCs and show either a diffuse or an aggregated T cell and B cell infiltrate. To gain more insight into this specific disease process, we sought to identify the genes expressed in RA tissues with ectopic ...

के लिए जाना जाता है Lymphoid Neogenesis |  arthritis synovial |  cells dendritic cells |  increased expression |  lymph nodes
KOL Index score: 14068

OBJECTIVE: The objective of this exploratory study was to evaluate the effects and costs of a 6-month course of tumour necrosis factor (TNF) inhibitors on work ability, quality of life, and fatigue in patients with rheumatoid arthritis (RA).

METHODS: In this prospective single-arm intervention study 59 consecutive patients of working age with established RA were recruited from an outpatient clinic in Amsterdam, the Netherlands. All patients received fortnightly subcutaneous injections of ...

के लिए जाना जाता है Rheumatoid Arthritis |  work ability |  quality life |  monoclonal antibodies |  fatigue patients
KOL Index score: 13896

Psoriasis and psoriatic arthritis are inflammatory diseases that respond well to anti-tumour necrosis factor-alpha therapy. To evaluate the effects of anti-tumour necrosis factor-alpha treatment on expression of adhesion molecules and angiogenesis in psoriatic lesional skin and synovial tissue, we performed a prospective single-centre study with infliximab therapy combined with stable methotrexate therapy. Eleven patients with both active psoriasis and psoriatic arthritis received ...

के लिए जाना जाता है Psoriatic Skin |  infliximab therapy |  adhesion molecules |  monoclonal arthritis |  blood vessels
KOL Index score: 13830

BACKGROUND: The synovial tissue is a primary target of many inflammatory arthropathies, including psoriatic arthritis (PsA). Identification of proinflammatory molecules in the synovium may help to identify potentially therapeutic targets.

OBJECTIVE: To investigate extensively the features of cell infiltration and expression of mediators of inflammation and joint destruction in the synovium of patients with PsA compared with patients with rheumatoid arthritis matched for disease duration ...

के लिए जाना जाता है Psoriatic Arthritis |  patients psa |  synovial inflammation |  joint destruction |  cell infiltrate
KOL Index score: 13746

OBJECTIVE: To investigate the relationship between serum trough infliximab levels and clinical response to infliximab treatment in patients with rheumatoid arthritis (RA).

METHODS: Disease activity and serum trough infliximab levels before and 2, 6, and 14 weeks after initiation of infliximab treatment at a dose of 3 mg/kg in a cohort of 105 patients with RA were assessed. Serum trough infliximab levels in responders and non-responders were compared. Additionally, the clinical responses ...

के लिए जाना जाता है Infliximab Treatment |  serum trough |  rheumatoid arthritis |  14 weeks |  responders patients

के लिए प्रमुख लोग Rheumatoid Arthritis

दुनिया में शीर्ष kols
Paul *****
rheumatoid arthritis ankylosing spondylitis radiographic progression
Josef ********* ******
rheumatoid arthritis systemic lupus erythematosus radiographic progression
James * *****
rheumatoid arthritis physical function systemic lupus erythematosus
John ****** *****
rheumatoid arthritis radiographic progression joint space width
Frederick * *****
rheumatoid arthritis work disability rheumatic diseases
Matthew * *****
rheumatoid arthritis systemic lupus erythematosus lyme disease
एक खोज वाक्यांश का चयन करें   rheumatoid arthritis , rheumatoid arthritis patients , rheumatoid arthritis treatment , rheumatoid arthritis risk , rheumatoid arthritis study

Paul Peter Tak:विशेषज्ञ प्रभाव

जिसके लिए अवधारणाएंPaul Peter Takप्रत्यक्ष प्रभाव है:Rheumatoid arthritis,  Synovial tissue,  Psoriatic arthritis,  Patients rheumatoid arthritis,  Arthritis rheumatoid,  Monoclonal antibodies,  Synovial inflammation,  Rheumatoid arthritis patients.

Paul Peter Tak:कोल इम्पैक्ट

अन्य लेखकों के काम से संबंधित अवधारणाएं जिनके लिएfor which Paul Peter Tak प्रभाव है:Rheumatoid arthritis,  Autoimmune diseases,  Gene expression,  Systemic lupus erythematosus,  Necrosis factor,  Monoclonal antibodies,  Synovial tissue.



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Amsterdam Rheumatology & Immunology Center (ARC), Department of Rheumatology & Clinical Immunology, 1007 MB Amsterdam, The Netherlands;,, (D.C.A.);,, (T.H.R.);,, (J.S.H.);, b.van