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    • Rikard Holmdahl
    • Rikard Holmdahl

      Rikard Holmdahl

      National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China | Medical ...

       

       

      Currículum de kol para Rikard Holmdahl

      Year
      2022

      National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

      Medical Inflammation Research, MediCity Research Laboratory, University of Turku, Turku, Finland

      2021

      The Second Affiliated Hospital of Xi’an Jiaotong University (Xibei Hospital), Xi’an, China

      Department Medical Biochemistry and Biophysics, Division Medical Inflammation Research, Karolinska Institute, 171 77 Stockholm, Sweden;, (M.A.);, (X.C.);, (B.X.);, (G.F.L.);, (M.Y.B.);, (Y.H.);, (L.B.)

      Division of Medical Inflammation Research, Dept. of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

      2020

      Dept. of Medical Inflammation Research, Section of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm

      Section for Medical Inflammation Research, BMCI11, Lund University, Lund, Sweden

      National & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital, Xi'an Jiaotong University, 710004 Xi’an, China

      Karolinska Institutet

      2019

      Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solnavägen 9, 171 65, Solna, Sweden

      Center for Medical Inflammation Research, Southern Medical University, Guangzhou, China

      R. Holmdahl and C.I. Svensson contributed equally to this paper.

      2018

      School of Pharmaceutical Science, Southern Medical University, Guangzhou, China

      Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden. Electronic address:

      Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden

      Medicity Research Laboratory, University of Turku, Turku, Finland

      2017

      Karolinska Institutet Division of Medical Inflammation Research Stockholm Sweden

      Center for Medical Immunopharmacology Research, Southern Medical University, 510515 Guangzhou, China.

      Medicity Research Laboratory, University of Turku, Turku, Finland, .

       

       

      Rikard Holmdahl: Estadísticas de influencia

      Muestra de conceptos para los cuales Rikard Holmdahl se encuentra entre los principales expertos del mundo.
      Concept World rank
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      antigen monoclonal arthritis #3
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      type collagen vivo #3
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      positional cloning genes #4
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      arthritis models #6
      induced psoriasis #6
      k8 mice #6
      murine loci #6
      hdac1 class #6
      region syntenic #7
      impact cia #7
      response immunization #7
      cii anti #7
      congenic mouse #7
      rheumatoid arthritis role #7
      cryogel column #7
      hydrolases polymorphism #7
      ciireactive cells #7
      raassociated molecules #7
      autoantibodies lymphocytes #7
      oestrogen rats #7
      cii apc #7
      glycosylated collagen #7
      collagen arthritis cia #7
      cognate activation #7
      chronic phase arthritis #7
      role raloxifene #7
      impaired induction #7
      mice constant darkness #7
      polychondritis relapsing #7
      type collagen #7
      arthritis genes #7
      protective influences #7
      arthritis strains #7
      arthritis type collagen #7
      rats phases #7
      strains disease #7
      yaa gene #7
      regulatory cells macrophages #7
      nonarthritogenic #7
      autoimmune human #7
      aplec #7
      chronic experimental #7
      effector phase #7
      castrated females #7
      periodontitis arthritis #7
      citrullinated peptide antigens #7
      g6pi #7
      antibodies citrullinated antigens #7
      collagen arthritis rats #7
      3xi #7
      macrophages alternative activation #7
      locus chromosome #7
      collagen epitope #7
      animal immunization injections #7
      antibodyinduced arthritis #7
      isomerase peptide #7
      mediated vasculitis #7
      induction arthritis #7
      cia mice #7
      mbp peptide #7
      mouse collagen #7
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      autoantibodies citrullinated peptides #7
      murine psoriasis #7
      conventional environment #7
      cia5 #7
      congenic strains #7
      acpa titres #7
      autoimmunity collagen #7
      analysis crosses #7
      symptoms disease onset #7
      antigens differentiation arthritis #7
      responses cii #7
      ean animals #7
      snecs #7
      psoriasiform skin disease #7
      cab3 #7
      clinical signs ean #8
      cia animal model #8
      b10 background #8
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      eae genetic encephalomyelitis #8
      experimental binding #8
      onset day day #8
      mumt mice #8
      cosphox #8
      antibodies acpas #8
      arthritis lymphocytes #8
      ptpn22620w #8
      polymeric cryogels #8
      chromosomes loci #8
      underlying genes #8
      rheumatoid autoimmunity #8
      oia2 #8
      diseases loci #8
      autoantibodies subset #8
      dominant cell epitope #8
      chronic autoimmune arthritis #8
      hlase alleles #8
      autoantibodies collagen type #8
      induced neuropathology #8
      non‐mhc #8
      mbp mog #8
      neutrophil cytosolic #8
      inflamed synovia #8
      antigenspecific priming #8
      lyme arthritis severity #8
      ros interplay #8
      treatment monoclonal #8
      parathyroid glands receptors #8
      autologous peptide #8
      heterologous peptide #8
      cia2 #8
      destructive effects #8
      murine locus #8
      antibody vivo #8
      autoimmune congenic mice #8
      sialadenitis mrl #8
      rats mhc #8
      mice techniques #8
      297 cases #8
      42 rats #8
      illness igg #8
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      typeii collagen #8
      experimental autoimmune disease #8
      ifa cii #8
      incidence cia #8
      hladrb11001 #8
      patients type collagen #8
      eae3 #8
      onset incidence #8
      t‐cell priming #8
      hdac3 expression #8
      rt1f #8
      medium mem #8
      supermacroporous cryogel #8
      haematogenously #8
      persistent joint pain #8
      hybridomas antibodies #8
      murinised #8
      rheumatoid chromosome #8
      α1‐microglobulin #8
      humans experimental arthritis #8
      oxidized peptides #8
      expression hdac3 #8
      rheumatoid autoantibodies #9
      pristane #9
      early joint erosions #9
      induced metabolic syndrome #9
      arthritis skg mice #9
      variants acpa #9
      rt1u #9
      rats rat #9
      cia transgenic mice #9
      mammalian disease models #9
      loci rats #9
      2 nadph #9
      animal models urgent #9
      postmenopausal arthritis #9
      antibody alpha #9
      development autoimmune arthritis #9
      acpas patients #9
      specific nox2 #9
      inbred dba mice #9
      posttranslational glycosylation #9
      autoimmunogenic #9
      differentiation autoimmune #9
      hgpi325 #9
      murine collagen #9
      bound carbohydrates #9
      intranasal animals arthritis #9
      class allele #9
      disease strains #9
      b10riii mice #9
      mouse peptide #9
      patients acpas #9
      eae immunization #9
      reduced arthritis #9
      idiotype‐specific #9
      illness receptor #9
      collagen complement #9
      experimental arthritis rats #9
      serum interferon #9
      ox19 #9
      avridine #9
      hitr #9
      oil adjuvants #9
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      arthritis cross #9
      inbred lew tlymphocytes #9
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      oligomeric matrix #9
      rheumatoid joints #9
      collagen female #9
      psychological tyrosine #9
      response mouse #9
      effects mabs #9
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      il10 role #9
      human immunopeptidome #9
      antibodies vivo #9
      ean myelin #9
      experimental genes #9
      specific sets #9
      adaptive inflammation #9
      nodp #9
      ifnbeta mice #10
      cell‐deficient #10
      native collagen type #10
      pain animal models #10
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      collagen autoimmunity #10
      immunization rats #10
      oestrogen #10
      knockout nadph #10
      nih heterogeneous stock #10
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      antibody collagen #10
      cells increased production #10
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      mice cii #10
      antibodies specific #10
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      extracellular cartilage #10
      monoclonal antigens rats #10
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      prl effects #10
      mice nadph #10
      acutephase response rats #10
      beta 11 #10
      axotomized motor neurons #10
      experimental cartilage #10
      inbred dba #10
      rats lewis rats #10
      cartilage collagen fibrils #10
      reactivity acpas #10
      hlase smoking #10
      tertbutylacrylamide #10
      o2• h2o2 #10
      genetic experiments #10
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      cartilage arthritis #10
      animal models #10
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      cd4 cells spleen #10
      cells development #10
      passive transfer experiments #10
      mbp peptides #10
      citrullinated antigen #10
      mutated mice #10
      acpa diagnosis #10
      cartilage oligomeric #10
      monoclonal arthritis #10
      development severity #10
      cii mice #10
      mice genistein #10
      activation male #10
      presence acpa #10
      endogenous collagen #10
      species respiratory #11
      mhc control #11
      monoclonal rheumatoid factors #11
      gad6 #11
      cia7 #11
      arthritis absence #11
      chronic arthritis #11
      mice mhc #11
      tailbase #11
      cia30 #11
      antibody type collagen #11
      inflammatory arthritis role #11
      isotypes #11
      antibodies association #11
      loci regulating #11
      2xi #11
      potential autoantigens #11
      nodb10h2b mice #11
      ptpn22 smoking #11
      chondrocytes ecm #11
      mice cd1 #11
      dss wt #11
      fragments anti #11
      cells pia #11
      84–102 #11
      individuals onset #11
      rat arthritis #11
      naïve cells cells #11
      lentiviral vector expression #11
      antigen variability #11
      development rheumatoid #11
      stromal cells macrophages #11
      rat liver rats #11
      liver receptor lxrα #11
      rat collagen #11
      genetic contamination #12
      loci disease #12
      mutation nadph #12
      fpr2 agonists #12
      psoriasis mouse model #12
      autoimmune monoclonal antigens #12
      major haplotype #12
      immunodominant #12
      pia1 #12
      role arthritis #12
      cell responses cii #12
      lung macrophages mice #12
      α1ii #12
      antibodies structures #12
      peptide study #12
      natural polymorphism #12
      structure antibodies #12
      study arthritis #12
      natural loss #12
      animal immunohistochemistry #12
      type collagen immunization #12
      psoriasis arthritis #12
      hydroxylysines #12
      riiis #12
      matrilin #12
      stages pathogenesis #12
      frequencies antibodies #12
      mutated mouse #12
      cii patients #12
      reduces severity #12
      rats cia #12
      illness sex characteristics #12
      associations antibodies #12
      mice comp #12
      bovine type collagen #12
      increased litter size #12
      onset symptoms #12
      lymphoid cells development #12
      backgroundantibodies #12
      serum concentrations comp #12
      encephalomyelitis induced #12
      qa2 #12
      rats expression #12
      stage cia #12
      myelin ean #12
      treatment experimental arthritis #12
      nonselfdiscrimination #12
      icmediated #12
      cross rats #12
      chronic erosive arthritis #12
      mbp response #12
      species deficiency #13
      l012 #13
      genes mouse chromosome #13
      idd5 #13
      development type collagen #13
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      cells salivary glands #13
      oxidase nox2 #13
      advanced intercross #13
      sequence collagen #13
      behavioral alterations rats #13
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      lew1w #13
      epitope immunization #13
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      native type collagen #13
      cell epitope #13
      arthritis knowledge #13
      nonobese diabetic mouse #13
      expression egfp #13
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      major loci #13
      mtec aire #13
      bcelldeficient mice #13
      levels nabs #13
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      macroscopic scoring #13
      anticii #13
      antibodies citrullinated proteins #13
      oxidative regulation #13
      ho4 #13
      doses ici #13
      joints blood #13
      μ chain #13
      24dinitro1fluorobenzene #13
      ccp2 antibodies #13
      immunohistochemistry interferon #13
      rfigg #13
      complement complement activation #13
      factor isotypes #13
      hladrb1 ptpn22 #13
      t‐cell epitope #13
      multispecific #13
      experimental interferon #14
      deficient production #14
      macrophages immune response #14
      smallmolecule compound #14
      nasal inhalation #14
      humans nadph #14
      collagen comp #14
      antifilaggrin antibodies #14
      loci rheumatoid #14
      aggregated nets #14
      autoimmune arthritis #14
      osteoclasts vivo #14
      loci interaction #14
      thr233 #14
      arlacel #14
      cia expression #14
      protein collagen #14
      gut protection #14
      blymphocyte female humans #14
      collagen disease #14
      arthritic paws #14
      specific inflammation #14
      autoimmunity animals #14
      molecular disease models #14
      peptides anti #14
      immune regulators #14
      presence mcv #14
      candidate autoantigens #14
      murine collageninduced arthritis #14
      sirt1 mmp9 #14
      b6n mice #14
      efficient promotion #14
      immunized rat #14
      mhc class region #14
      involvement cells #14
      nodb10h2b #15
      neuritis rats #15
      integrated bioprocess #15
      apcs macrophages #15
      tflask #15
      arthritis role #15
      antibodies arthritis #15
      immune complex formation #15
      regulation adaptive immunity #15
      monolithic cryogel #15
      anticollagen #15
      aire mtec #15
      rats monoclonal antigens #15
      involvement pathogenesis #15
      monoclonal arthritis rats #15
      rat genetics #15
      rt1a #15
      translationally modified #15
      cdr regions #15
      mice type collagen #15
      arthritis development #15
      exaggerates #15
      cultured human chondrocytes #15
      mice immunization #15
      osteoporosis development #15
      dcii #15
      2 weight #15
      amps development #15
      murine cia #15
      treatment cia #15
      polychondritis #15
      raloxifene estradiol #15
      rheumatoid arthritis presence #15
      lentiviral gene delivery #15
      experimental allergic neuritis #15
      type collagen development #15
      mhc class molecule #15
      antigenic epitope #15
      congenic rats #15
      presence anticarp antibodies #15
      citrullinated peptides patients #15
      ros cii #15
      pparγ lxrα #16
      antinuclear autoimmunity #16
      staphylococcal arthritis #16
      class transplantation #16
      cep1 #16
      matrilin proteins #16
      h2p #16
      arthritis severity mice #16
      anti‐t #16
      nonglycosylated form #16
      n305 #16
      hla–drb1 shared epitope #16
      levels natural antibodies #16
      acute inflammation mice #16
      oligomeric matrix protein #16
      mhcii ciita #16
      fewer osteoclasts #16
      mhc genes #16
      disease mice mice #16
      rno10 #16
      subspecificities #16
      congenic mice mice #16
      epitopes mice mice #16
      rats experimental arthritis #16
      rheumatoid arthritis genes #16
      autologous collagen #16
      genes animals #16
      arthritis cii #16
      development rheumatoid arthritis #16
      males onset #16
      lew1 #16
      rheumatoid factor production #16
      mumt #16
      rt1 #16
      indirect genetic predisposition #16
      lethal inflammatory #16
      cells female mice #17
      arthritis rheumatoid autoantibodies #17
      rt1av1 #17
      allergic neuritis #17
      leuphe #17
      periodontitis antibodies #17
      rats lewis #17
      triplehelical conformation #17
      progesterone development #17
      inbred lew #17
      ethanol development #17
      strains lymphocytes #17
      rheumatoid arthritis subsets #17
      collagen induced arthritis #17
      cells presenting cells #17
      onset rheumatoid arthritis #17
      cells collagen #17
      human fcγriia #17
      animals congenic #17
      spleen peyers patches #17
      cartilage collagen #17
      genistein mice #17
      nox2 derived #17
      collagen specific #17
      clever1 #17
      skg #17
      polyphosphate4 #17
      native denatured #17
      cab4 #17
      mice rheumatoid arthritis #17
      langerhans cells cells #18
      cartilage type collagen #18
      ros data #18
      addition ros #18
      h2z #18
      day immunization #18
      ealkene #18
      anti cd44 #18
      collagen autoantibodies #18
      dra0101 #18
      purified anti #18
      disease duration onset #18
      keratinocytes induction #18
      adjuvant arthritis rats #18
      short‐term administration #18
      joint inflammatory #18
      defined epitope #18
      genes spleen #18
      arthritis anti #18
      humanized transgenic mice #18
      phenotypic feature #18
      salivary glands mice #18
      day arthritis #18
      galactose moiety #18
      hybridomas mice mice #18
      autoimmune illness #18
      moginduced eae #18
      expression lxrα #18
      cuiiida #18
      supermacroporous #19
      vivo elimination #19
      inflammatory attack #19
      castrated female rats #19
      future utility #19
      collagen response #19
      suppression dth #19
      cd4 transgenic #19
      rats snp #19
      new avenues #19
      patients polychondritis #19
      mice congenic mice #19
      protein comp #19
      mrl mp mice #19
      trimolecular complex #19
      peyers patches spleen #19
      blood monocytes neutrophils #19
      single intradermal injection #19
      mice develop #19
      tbetarii gene #19
      protective alleles #19
      gly262 #19
      elisa cia #19
      beta oestradiol #19
      cia eae #19
      citrullinated proteins acpa #19
      three‐dimensional culture #19
      experimental autoimmunity #20
      serm raloxifene #20
      development disease #20
      stress phospholipids #20
      antibody treatment #20
      matrilin1 #20
      role nox #20
      ciita mhcii #20
      ncr3 #20
      loci chromosomes #20
      5r5 #20
      nox1deficient mice #20
      knockout mice transgenic #20
      fls tnfα #20
      5p14 #20
      imaging reactive #20
      prominent infiltration #20
      underlying gene #20
      monkeys rodents #20
      glycosylated #20
      enhanced tcr #20
      inflammation mice #20
      mbp rats #20
      littermate #20
      mice cia #20
      highly susceptible #20
      pvg1av1 #20
      mhc class alleles #20
      response mbp #20
      progesterone oestrogen #20
      rt1d #20
      human rheumatoid arthritis #20
      muscle ros #21
      olahsd #21
      genes controlling #21
      nitratenitriteno pathway #21
      diseases lymphocytes #21
      α1acidglycoprotein #21
      nox2 mice #21
      triplehelical peptides #21
      onset severity #21
      nox2 activity #21
      igg fcgammar #21
      drb11001 #21
      n141 #21
      chronic relapsing #21
      granule mobilization #21
      arthritis pregnancy #21
      rats development #21
      illness autoimmune #21
      n286 #21
      mice mutant strains #21
      pathogenesis rheumatoid #21
      linomide treatment #21
      cells adaptive immune #21
      cia treatment #21
      ean rats #21
      suppressor cytotoxic cells #21
      individual acpa #21
      supermacroporous cryogels #21
      conserved haplotype #21
      experimental rheumatoid #21
      positional cloning #21
      serum levels comp #21
      ul1 #22
      rats nonalcoholic steatohepatitis #22
      experimental phenotype #22
      270 #22
      vh j558 #22
      rats loss #22
      animal epitopes humans #22
      81a #22
      mice independent #22
      cultured hepatic cells #22
      samples onset #22
      ccp negative #22
      induced eae #22
      response myelin #22
      determinant selection #22
      c57bl mice subfamily #22
      identification susceptibility genes #22
      association pv #22
      semiallogenic #22
      antiidiotypic antibody #22
      cells b10 #23
      castration rats #23
      complex influences #23
      citrullinated antigens #23
      peptide activation #23
      phage clones #23
      lymphocytes amino #23
      loss collagen #23
      comp #23
      cells presentation #23
      arthritis type #23
      inflammation absence #23
      experimental chromatography #23
      experimental autoimmune diseases #23
      mace association #23
      cryogel beads #23
      citrullinated epitopes #23
      immunopeptides #23
      4npa #23
      diseases autoimmunity #23
      onset cia #23
      monoclonal antigens autoimmune #23
      tgfbeta resistance #23
      b10r #23
      antibodies acpa #23
      animal genes #23
      17 betaoestradiol #23
      rats inbred lew #23
      anti‐cd5 #23
      mbp eae #23
      citrullinated protein #23
      experimental cells #24
      cells c3h #24
      rat induction #24
      new mouse #24
      y35 #24
      severity chronicity #24
      monoclonal anti #24
      loci chromosome #24
      inflammation arthritis #24
      subloci #24
      secondary immune response #24
      mice nox2 #24
      experimental lupus #24
      mediated arthritis #24
      controls anti #24
      animal epistasis #24
      339 #24
      antinuclear apoptosis #24
      levels comp #24
      chronic autoimmune diseases #24
      severity ali #24
      autoantibodies rheumatoid #24
      ftirm #24
      c57bl 10 mice #24
      flss patients #24
      postpartum flare #24
      mouse models development #24
      production monoclonal #25
      common autoimmune disease #25
      relapsing polychondritis #25
      ros #25
      autoimmune diseases humans #25
      8 antibodies #25
      monocytes nadph #25
      arthritis experimental arthritis #25
      autoimmune messenger #25
      cell hybridomas #25
      rat mhc #25
      cells immunization #25
      murine lyme arthritis #25
      inbred lew rats #25
      bnda #25
      cix #25
      proteinarginine deiminase type #25
      b6 balb #25
      congenic animals #25
      specific epitopes #25
      complex male #25
      immunodominant epitope #25
      massive infiltration #25
      beta lymphocytes #25
      autoantibody response #25
      rno4 #25
      arginine arthritis #25
      interleukin2 mice receptors #25
      tolerized rats #25
      parasitemia survival #25
      collagen cartilage #25
      immunization development #25
      helperinducer animals antibodies #26
      viable chondrocytes #26
      post translationally #26
      igg2a mice #26
      glutamax #26
      cb11 #26
      polychondritis rp #26
      cells joints #26
      nitrophenylalanine #26
      local exposure #26
      hydrocarbon oil #26
      eae development #26
      mice gammadelta cells #26
      granulocytes cells #26
      anti citrullinated #26
      autoantibodies citrullinated proteins #26
      gene regions #26
      hladrb1 shared epitope #27
      pannus tissue #27
      nonmhc genes #27
      innate interleukin10 #27
      perforin deficiency #27
      interleukin21 tlymphocytes #27
      immunospecific #27
      individuals antibodies #27
      intercrossed #27
      disease immunoglobulin #27
      antibodies type #27
      immunodominant response #27
      ccp2 #27
      trypsination #27
      c1i #27
      physiological level #27
      rheumatoid factor isotypes #27
      pointmutation #27
      ros induction #28
      w3 25 #28
      onset day #28
      protein peptides #28
      mrna ifngamma #28
      rat strain #28
      antibodies mab #28
      antily6g #28
      nr8383 #28
      mediated effects #28
      cia3 #28
      anti rat #28
      lysine position #28
      antigenspecific tolerance #28
      autoimmune inflammatory #28
      chronicity #28
      eae susceptibility #28
      upregulation cytokines #28
      severity day #28
      animal models neurodegeneration #28
      cartilage vivo #28
      chronic dss #29
      mice mab #29
      hiit exercise #29
      presence synovial fluid #29
      rfigm #29
      suboptimal doses #29
      glucose transport capacity #29
      acpa #29
      ros production macrophages #29
      membrane lymphocytes #29
      antibody producing cells #29
      smoking presence #29
      parotid secretory protein #29
      immunopathogenicity #29
      246trinitrophenyl #29
      absence inflammation #29
      cfa cia #29
      ls2616 #29
      phenomes #29
      peptide anti #29
      metabolic syndrome rats #30
      chain collagen #30
      vivo exercise #30
      paws #30
      treatment raloxifene #30
      disease immunity #30
      ctla4 mice #30
      synovial cells patients #30
      hlase #30
      vpba #30
      adult thymectomy #30
      increased salt #30
      plasminogendeficient mice #30
      translational rats #30
      cultivation cells #30
      variable heavy chain #30
      alphabetat #30
      chronic autoimmune #30
      vgenes #30
      linkage disease #30
      development experimental #30
      dba mice #30
      acpa fine #30
      11 cells #30
      hiit training #31
      phytol #31
      human type collagen #31
      perpetuated #31
      monoclonal antibody production #31
      common chain #31
      trimolecular #31
      expressing cells #31
      selfprotein #31
      ige cd23 #31
      disease development #31
      pristaneinduced lupus #31
      rats autoimmune #31
      psoriasis model #31
      acute‐phase response #31
      apc development #31
      immunization #31
      synovial fluid blood #31
      littermate controls #31
      drugs addition #31
      nox2 nox1 #31
      comparative genetic analysis #31
      bound peptides #32
      receptor preference #32
      hladrb104 #32
      specificity function #32
      mucosal tolerance #32
      epitope antibodies #32
      type antibody #32
      presence acpas #32
      influence genes #32
      nadph oxidases nox #32
      nonb cells #32
      cell ratio #32
      rt11 #32
      arthritis therapy #32
      congenic mice #32
      caia mice #32
      11 cell #32
      genomewide genotyping #32
      steen #32
      cells uterus #32
      beta mice #32
      ros rns #32
      role osteoclastogenesis #32
      acpa rheumatoid arthritis #32
      h2aq #32
      polymorphic genes #32
      differentiation arthritis #32
      methods serum samples #32
      ra33 #32
      nodes mice #32
      modified collagen #33
      type cross #33
      induced immunization #33
      tcell receptor #33
      epitopes antibodies #33
      multiplex analysis #33
      arthritic mice #33
      autoantibody activity #33
      autoimmune demyelinating disease #33
      role vav1 #33
      tolerance immunization #33
      rheumatoid joint #33
      antigenpresenting cells cells #33
      cytosolic factor #33
      delayed type #33
      skews #33
      joint pathology #34
      heterogeneous stock #34
      cells dendritic cells #34
      c4bp #34
      interferon activity #34
      natural antibodies nabs #34
      chronic polyarthritis #34
      patients animal models #34
      neurodegeneration role #34
      fpr1 #34
      promiscuous expression #34
      nox2 deficiency #34
      infectious disease models #35
      arthritis disease #35
      complex arthritis #35
      antirat #35
      triple helical #35
      1xi #35
      vdr cells #35
      monoclonal rheumatoid #35
      hybridomas #35
      phagotope #35
      autoreactive #35
      plasminogen deficiency #35
      patients populations #35
      destructive arthritis #35
      antiarthritis #35
      acs stroke #35
      development chronic #35
      major regulators #35
      accessible sites #35
      psoriasiform skin #35
      nets neutrophils #35
      h2r #36
      nk cells recognition #36
      comparative genetics #36
      protein specific #36
      animals antigen #36
      dth #36
      dinitro1 #36
      flow cytometry expression #36
      induction tregs #36
      oxidases rna #36
      cartilage joints #36
      female histocompatibility #36
      specificity sera #36
      h2g7 #36
      tolerance tlymphocytes #36
      techniques mice #36
      phagocyte #36
      variance animals antibodies #36
      cii cfa #36
      arthritis cartilage #36
      synthetic glycopeptides #37
      joint cartilage #37
      cii protein #37
      genetic control #37
      recombinant vaccine #37
      spontaneous arthritis #37
      c129 #37
      acpa positive #37
      rich lipid #37
      role gamma interferon #37
      susceptibility autoimmune diseases #37
      dba1 #37
      encephalomyelitis #37
      immunopathological features #37
      lymphocytes disease #37
      oxidases oxidation #37
      mif pathogenesis #37
      peptides binding #37
      cochranmantelhaenszel test #38
      sialophorin #38
      human blood neutrophils #38
      innovative tools #38
      cldn4 #38
      snat #38
      animal models pain #38
      target autoantigens #38
      antibodies animals #38
      nitrogen species #38
      autoreactive cells #39
      b6n #39
      endoβnacetylglucosaminidase #39
      benoist #39
      oestrogen treatment #39
      ccia #39
      cell tolerance #39
      nfr #39
      ym1 #39
      resultsrats #39
      wasting syndrome #39
      data myelin #39
      clonal expansion cells #39
      nzw #39
      acpa response #39
      allogeneically #39
      measurement activity #39
      addition impact #40
      rt1c #40
      disease animal models #40
      antigens arthritis #40
      adjuvant induced #40
      positive rheumatoid #40
      polyclonal cell activation #40
      isostere #40
      peptide cell #40
      genetic complexity #40
      ncii #41
      genes loci #41
      rat myelin #41
      aq #41
      congenic mapping #41
      mhc haplotype #41
      autoimmune #41
      rats anti #41
      immunocap isac #41
      priming phase #41
      severity incidence #41
      effects experiments #41
      autoimmune inflammatory diseases #41
      drb1 shared #42
      th17 axis #42
      mhc class class #42
      cartilage bone destruction #42
      pineal gland melatonin #42
      species receptors #42
      antibody isotypes #42
      ptpn22 locus #42
      spleen weight #42
      articular collagen #42
      p38 mapk nfκb #42
      expected onset #42
      fibroblasts mice #42
      arthritis data #43
      type‐ii #43
      anticitrullinated #43
      lew rats #43
      rats sex #43
      spinal glia #43
      kgf treatment #43
      autoreactive cell #43
      cd11bly6g #43
      crosses genetic #43
      lew lymphocytes #43
      mice autoimmune #43
      anticyclic #43
      collagen #43
      treatment autoimmune diseases #43
      congeneic #43
      pc8 #43
      immunodominant epitopes #43
      homozygous form #44
      inflammation animals #44
      chloro23 #44
      provocations #44
      defensins humans #44
      c4bbinding protein c4bp #44
      genetic linkage analysis #44
      neuritis ean #44
      addition order #44
      mice adulthood #44
      mathis #44
      epitopes lymphocyte #44
      mice mice autoimmune #44
      peptide induced #44
      phagotopes #45
      potent suppression #45
      disease histocompatibility #45
      outbred rats #45
      genetic encoding #45
      relapsing disease #45
      chromosome development #45
      susceptibility arthritis #45
      nzb #45
      cocrystallisation #46
      mhc class humans #46
      affinity purified #46
      specific tolerance #46
      posttranslationally #46
      neuritis autoimmune #46
      locus controlling #46
      isosteres #46
      carp antibodies #46
      rat2 #46
      eae mbp #46
      lower severity #46
      disease induction #46
      alphachains #46
      c227 #46
      posttranslational rats receptors #47
      association hladrb1 alleles #47
      antibody reactivities #47
      protective allele #47
      intercrosses #47
      f1 hybrid mice #47
      diagnostic accuracy diagnosis #47
      complex mediated #47
      idiotypic antibody #47
      rheumatoid factors #47
      humanized model #48
      mice nzb #48
      collagen glycosylation #48
      experimental arthritis mice #48
      mice carrying #48
      cia rats #48
      antibody specificity #48
      synovial lining layer #48
      lupus disease #48
      tlr12 #48
      collagen peptide #48
      f1 crosses #48
      peptide recognized #48
      γchains #48
      acetylchitobiose #48
      polyvinylcaprolactam #49
      sex genes #49
      bystander activation #49
      experimental crosses #49
      histone hdacs #49
      immune nervous #49
      class major #49
      mice caia #49
      monoclonal autoimmune diseases #49
      comp levels #49
      tcell stimulation #49
      mouse cartilage #49
      glycosylated form #50
      cytometry analyses #50
      loci animals #50
      alagly #50
      dependent chronic #50
      animal cell culture #50
      disease rats #50
      parathyroid cells #50
      monoclonal epitopes #50
      anticarbamylated protein #50
      ciiia #50
      mice tolerance #50
      antigenantibody #50
      inflammation kynurenine #50
      complex region #50
      glutamine uptake #50
      tracheal cartilage #51
      fewer cells #51
      cells ova #51
      antibodies cells #51
      inbred c57bl autoimmune #51
      lentiviral particles #51
      rheumatoid factor activity #51
      autoantibodies rheumatoid arthritis #51
      aire mice #51
      tolerized #51
      delayed immunization #51
      c57bl 6j background #51
      derived type #51
      evidence animal models #51
      runting #51
      antigenpresenting cells #52
      matrix protein #52
      model collagen #52
      macrophages skin #52
      ptpn22 #52
      xor activity #52
      physiological doses #53
      gastric parietal cell #53
      production reactive #53
      patients rheumatic conditions #53
      lysosomal compartments #53
      protein antibodies #53
      triple helical structure #53
      antibodies epitopes #53
      melatonin day #53
      induced autoimmunity #53
      aged peptides #53
      cartilage erosion #53
      carbamylated proteins #53
      arthritis induction #53
      crossbreeding #54
      rats social isolation #54
      predating #54
      major epitope #54
      strain rats #54
      nodes lymphocyte #54
      imitating #54
      melatonin animals #54
      development individuals #54
      yaa #54
      animals autoimmune #54
      carbamylated protein #54
      antigens myelomonocytic arthritis #54
      macrophage mannose receptor #55
      inflammatory manifestations #55
      autoimmune reactions #55
      complex genetic disease #55
      susceptibility autoimmune disease #55
      arthritis genetic #55
      autoimmune nzb #55
      new animal #56
      mhc #56
      selfreactive cells #56
      alpha1microglobulin #56
      cells salivary #56
      animals antibody #56
      labels superoxide #56
      cd1 mice #57
      vivo depletion #57
      igg abs #57
      animals antirheumatic #57
      antibodies bind #57
      arthritis pathogenesis #57
      development autoimmune #57
      collagen sequence #57
      antibodies #57
      rat type #58
      urokinase activity #58
      oestrogen progesterone #58
      peptide response #58
      schafer #58
      chronic eae #58
      hydroxylase diet #59
      genes mhc #59
      encephalitogenicity #59
      oligoclonal igg bands #59
      anticarp antibodies #59
      cartilage matrix protein #59
      anti cd8 #59
      anti cell #59
      resistance eae #59
      articular joints #59
      hpaaxis #60
      macrophage mannose #60
      protein peptide #60
      immunohistopathology #60
      dichotomous effects #60
      inflammatory cells macrophages #60
      alternative activation macrophages #60
      joint erosions #60
      assay epitopes #60
      epitope spreading #61
      major histocompatibility #61
      serum comp #61
      alpha1m #61
      experimental rats rats #61
      species reactive #61
      incidence severity #61
      cells innate immune #61
      differentiation myelomonocytic arthritis #61
      experimental evoked potentials #61
      antigens class histocompatibility #62
      syngeneically #62
      interferon‐β #62
      cyclic sensitivity #62
      fpr2 #62
      reduced oxidative #62
      adaptive immune #62
      basic characterization #62
      toxin1 #62
      placenta uterus #62
      autoantibody formation #62
      mice susceptibility #62
      mice polyi #63
      delayed interferon #63
      rats strain #63
      glycoprotein myelin #63
      peptide specific #63
      specificity tumor #63
      duval #63
      mog1 #63
      transfer animals #63
      protein disease #63
      igaproducing cells #63
      specific stages #63
      constant darkness #63
      post‐partum #63
      induced experimental #63
      collagen cell #63
      nadph oxidases #63
      hypersensitivity dth #63
      secondary immune #64
      maternal origin #64
      lower capacity #64
      role apc #64
      freund adjuvant #64
      tolerance model #64
      model chronic #65
      autoimmunity humans #65
      weight variation #65
      hindpaws #65
      flss #65
      major subset #65
      histocompatibility complex #65
      induced suppression #65
      acute arthritis #66
      hladr2 #66
      chromosomes mammalian #66
      phagocytosis oxidative burst #66
      rheumatoid synovial cells #66
      multispecificity #66
      thy1 antigen #66
      experimental lymphocytes #66
      resemblances #66
      peripheral joints #66
      negative rheumatoid #66
      spontaneous disease #66
      mice induced #67
      strains susceptible #67
      endos #67
      experimental encephalomyelitis #67
      experimental allergic #67
      key interactions #67
      myelomonocytic arthritis #67
      development cell #67
      fibrinogen genotype #67
      dendritic cells epitopes #67
      rheumatoid arthritis susceptibility #67
      mice cell #67
      frequent infections #68
      individuals positive #68
      sodium diethyldithiocarbamate #68
      tolerized mice #68
      cells mhc class #68
      rheumatoid chromosomes #68
      anti carp #68
      severity periodontitis #68
      class region #68
      female sex hormones #68
      complex class #68
      iggrf #68
      helper phenotype #68
      frequency antibodies #69
      lymphocytes chronic #69
      direct damage #69
      cells mouse #69
      vertebrate immune #69
      relapsing #69
      zap‐70 #69
      rheumatoid disease #69
      presence rheumatoid factor #70
      translationally #70
      prolonged graft survival #70
      mrl mice #70
      role cells #70
      response type #70
      immunoglobulin interferon #70
      susceptibility female #71
      cb10 #71
      cartilage mice #71
      expression pparγ #71
      human psoriasis #71
      ztm #71
      isolated rats #71
      swr #71
      interphalangeal joints #72
      naïve mice #72
      study antibodies #72
      antibodies binding #72
      autoimmunity lymphocytes #72
      dark agouti rats #72
      lathyritic #72
      napdh #72
      delayedtype hypersensitivity dth #72
      species ros #73
      type ifn signature #73
      oxidase complex #73
      treatment stages #73
      membrane animals #73
      mrl lpr #73
      knockout protein processing #73
      bovine type #73
      environmental lighting #73
      pregnancyinduced #74
      antigens class #74
      igarf #74
      hypersensitivity delayed #74
      cartilage explants #74
      peptides sequences #74
      diabetes arthritis #75
      genetic disease models #75
      inbred dba receptors #75
      dth mice #75
      oestradiol #75
      effects development #75
      acpapositive #75
      cell reactivity #75
      rat splenocytes #76
      anti carbamylated #76
      type collagens #76
      disease rheumatoid arthritis #76
      peptide mhc #76
      eae induced #77
      cyp7a1 #77
      pain inflammation #77
      nerve conduction velocity #77
      lpr mrl #77
      development insulitis #77
      inbred mouse strains #77
      rt1n #77
      oligomeric #77
      collagen chains #77
      new animal model #77
      cell deficient #77
      rats eae #77
      regulatory vaccines #77
      clinical arthritis #78
      pythons #78
      autoantigenic #78
      rats respiratory #78
      pathogenesis rheumatoid arthritis #78
      cartilage integrity #78
      mhc expression #78
      inflammatory autoimmune #79
      mononuclear lung #79
      autoimmune experimental epitopes #79
      1ii #79
      susceptibility disease #79
      shared epitope #79
      erosive arthritis #80
      detection autoantibodies #80
      oxidases #80
      chromosome study #80
      class antigen expression #81
      spleen study #81
      aspartic acid position #81
      dr1 antigen #81
      expression ll37 #81
      sex linkage #81
      type macrophages #81
      mrl mp #81
      induced leukocyte #81
      mog mbp #81
      estrogen suppression #81
      arthritis cells #81
      hnrnpa2 #81
      mhcii expression #81
      inflammatory phase #81
      pannus formation #82
      14weeks #82
      nadphoxidase #82
      cell independent #83
      tlymphocyte genes #83
      expression mhc #83
      drug encephalomyelitis #83
      mice igg #83
      bcg infection #83
      strains animals #84
      reactive cells #84
      spontaneous development #84
      naïve cells #84
      arthritis day #84
      rat cardiac allografts #84
      multiple sclerosis evidence #84
      epidermal cells #84
      cells recognize #85
      inflammation joint #85
      class molecule #85
      knockout receptors #85
      inflammation joints #85
      homopentamer #85
      antiifngamma #85
      anti cd4 #86
      animal humans #86
      severe eae #86
      contribution genes #86
      preclinical stage #86
      mutant strains #86
      classical humans #86
      gfoger #86
      phagocyte nadph #86
      monoclonal antibodies mab #86
      estrogen induced #87
      alpha1acid glycoprotein #87
      mhc class gene #87
      smash #87
      inbred rat strains #87
      inguinal lymph nodes #88
      narac #88
      thps #88
      levels anti #88
      copy variation #88
      fine specificities #88
      mice antibodies #89
      genetic quantitative #89
      arthritic #89
      peptide immunization #89
      mabs mab #89
      experimental autoimmune #89
      depletion cd8 cells #89
      autoimmune inbred c57bl #90
      rheumatoid arthritis cells #90
      mediated mechanisms #90
      ilc2 activation #90
      monkeys mice #90
      susceptible #90
      genistein treatment #90
      adjuvant arthritis #90
      arthritis compared #90
      pineal hormone melatonin #90
      synovial fluid serum #91
      backgroundan #91
      activation cd4 cells #91
      histological sections #91
      protein induced #91
      cells apc #91
      cattle collagen #91
      nod mhc #92
      abdominal region #92
      difco #92
      humans immunodominant #92
      experimental mouse models #92
      anticitrullinated protein #92
      cellspecific #93
      knockout myelin #93
      290 patients #93
      animals autoantibodies #93
      xor #93
      mice melatonin #93
      natural polymorphisms #93
      autosomal genes #94
      fcγrs #94
      macrophages development #94
      galactosylated #94
      endosomal acidification #94
      activated cells cells #94
      induced sarcoma #95
      moderateintensity exercise #95
      binding integrins #95
      chronic phase disease #95
      nonglycosylated #96
      pregnancy disease #96
      data rats #96
      fetal rejection #96
      cell alpha #96
      lung emphysema #96
      romani #96
      messenger tolllike receptor #96
      macrophages stimulation #96
      ifnbeta #96
      hydroxylysine #97
      macrophages fibroblasts #97
      il33r #97
      genetic female genes #97
      cathelicidins #97
      citrullinated fibrinogen #97
      rheumatoid lymphocytes #97
      antiimmunoglobulin #97
      complex mice #97
      rheumatoid cartilage #98
      autoimmune experimental #98
      ean #98
      acpa igg #98
      swr mice #98
      autoimmune rats #98
      alternative pathways #99
      interleukin‐4 #99
      collagen cytokines #99
      rat chromosomes #99
      protein antibody #100
      thy1 antigens #100
      cultured crosses #100
      peptides cells #100
      invading pathogens #100
      ccp anti #100
      tap2 #100
      tlymphocyte immunity #100
      inducer animals #100
      rats monoclonal antibodies #100
      safety drugs #101
      fprs #101
      cell determinants #101
      susceptible strain #101
      eira #101
      diarthrodial #101
      bone degradation #101
      singlenucleotide polymorphism #101
      mouse monoclonal antibodies #102
      eae animal encephalomyelitis #102
      findings treatment #102
      candidate autoantigen #102
      brucei infection #102
      oxidative burst #103
      drb10401 #103
      agalactosyl #103
      hla dr1 #103
      ros homeostasis #103
      pathogenesis emphysema #103
      nonarthritic #104
      male mice mice #104
      arthritic disease #104
      mhcii #104
      mutation mice #104
      synchrotron infrared #104
      haplotypes histocompatibility #104
      thelper cells #104
      f1 males #104
      skg mice #104
      development antibodies #105
      autoreactivity #105
      type 22 #105
      osteoclasts mice #105
      hybridoma cell #105
      vivo macrophages #105
      dmaam #105
      fcγr #105
      disease dose #106
      tcell immunity #106
      primed cells #106
      limited cross #106
      proteoglycan loss #106
      arthritis hla #106
      273 #106
      c3h mice #107
      cells synovial #107
      nzb mice #107
      development autoimmune disease #108
      fpr #108
      littermates #108
      study tolerance #108
      monoclonal igg #109
      type hypersensitivity #109
      structural polymorphism #109
      reactive cell #109
      enthesophytes #109
      presentation cells #109
      delayedtype hypersensitivity #109
      citrullinated proteins #109
      autoantibodies autoantigens #109
      autoimmune encephalomyelitis #110
      carcinoma tumors #110
      cartilage #111
      experimental female #111
      toxic shock syndrome #111
      inbred dba microscopy #111
      streptococcal cell wall #111
      female hypersensitivity #111
      dba 1j mice #111
      mog eae #111
      backcross #111
      alphabeta receptors antigen #112
      anti idiotypic antibodies #112
      amide bond #112
      humoral autoimmunity #112
      extensive literature search #112
      presymptomatic individuals #112
      restricted cell #113
      trait loci #113
      adjuvant properties #113
      mice collageninduced arthritis #113
      autoimmune c57bl mice #113
      xid mice #113
      tcra #113
      db1 #113
      oligoclonality #113
      adjuvantinduced arthritis #114
      ifngammaproducing cells #114
      mice disease #115
      anti mcv #115
      drb10402 #115
      rats collagen #115
      proinflammatory cytokine #115
      autoantigens autoimmunity #115
      transgenic peptides receptors #116
      ccp patients #116
      glycopeptides #116
      pathogenesis autoimmune diseases #116
      glyco #116
      experimental epitopes #116
      lymphocyte female #116
      susceptibility eae #116
      immunosorbents #116
      lutz #116
      fluorescence nf #117
      antiarthritic #117
      encephalomyelitis autoimmune #117
      antibodies reactive #117
      congenic lines #117
      mice type #117
      tolerance induced #117
      rats immunized #118
      psoriasiform dermatitis #118
      pineal hormone #118
      samples individuals #118
      class expression #118
      myelin oligodendrocyte #118
      α enolase #118
      alpha1acid #118
      radiological damage #119
      rheumatoid arthritis review #119
      cd4 tcells #119
      response cells #119
      05m #119
      psa rheumatoid arthritis #119
      protein mbp #120
      neutrophils nets #120
      vivo animal models #121
      chondrocyte cultures #121
      experimental animal models #121
      t‐lymphocyte #122
      transfer arthritis #122
      transgenic neurons receptors #122
      genes age #122
      pharmacological potential #122
      acpa negative #122
      immune complex deposition #122
      patients acpa #122
      treatment progesterone #122
      symptoms associations #123
      cell monoclonal #123
      alphabeta cells #123
      nox2 activation #123
      c5b #123
      type cytokines #123
      tlr4 stimulation #124
      inbred mouse #124
      cartilage surface #124
      cryogel #125
      preimmunized #125
      blocking antigens #125
      helperinducer #125
      general mechanisms #125
      allelic variations #125
      oxidases neutrophils #125
      disease mechanisms #125
      qtl genes #125
      immunodominant peptide #125
      genetic rats #125
      nzb nzw #126
      female immunization #126
      nonobese diabetic #126
      pnipaam #126
      cyclic polymorphism #126
      microarray detection #127
      atp8 #127
      knockout murine #127
      animal enzyme #127
      absence cells #127
      anticitrullinated peptide #128
      chronic inflammatory disease #128
      dominant epitope #128
      deiminases #128
      lining layer #128
      bxsb #129
      multiple epitopes #129
      spleen rats #129
      rats patients #129
      oestradiol testosterone #130
      psd1 #130
      disease induced #130
      nos2 #130
      vivo absence #130
      cells eae #130
      onset arthritis #131
      epitope specific #131
      lipomannan #131
      kgf #132
      linomide #132
      intercross #132
      mineral oils #132
      disease cgd #132
      pronociceptive #132
      induction regulatory cells #132
      rat chromosome #133
      reduced severity #133
      ggaa #133
      leukosialin #133
      myocellular #134
      mice estrogen #134
      accentuate #134
      interstitial collagens #134
      species animals #134
      eae #134
      plasma synovial fluid #134
      patients cytokines #134
      knockout receptors antigen #134
      peptides cyclic #135
      spinal glial #135
      igg immune complexes #135
      chronic autoimmune disease #136
      macrophages dendritic #136
      intracellular reactive #136
      immunizing #136
      receptor upregulation #137
      innate lymphocytes #137
      stimulated muscle #137
      immunopathological #137
      mice deficient #138
      ditiocarb #138
      dmannitol #139
      autoimmune mice #139
      control development #139
      immunomodulatory drug #139
      tcrdelta #140
      oligoclonal expansion #141
      producing cell #141
      thermoresponsive polymer #141
      rejection tolerance #142
      single subcutaneous injection #142
      gamma lymphocyte #142
      smfish #142
      interferon‐γ #142
      genetic factors development #142
      phadia #142
      or113 #142
      phosphate isomerase #143
      mice beta #143
      tcell alphabeta receptors #143
      cell hybridoma #143
      class haplotypes #143
      rheumatoid arthritis #144
      mhc haplotypes #144
      synovial hyperplasia #144
      rat strains #144
      inbred buf rats #145
      treatment ici #145
      tnf production #145
      tcr gamma delta #145
      severe chronic #145
      syngenic #145
      lyme arthritis #145
      neonatal growth #146
      rats induced #146
      ccp antibodies #147
      pregnancy levels #147
      systemic challenge #147
      function cells #147
      cellular heterogeneity #147
      gammainterferon #147
      α2i #148
      cell surface antigen #148
      redox regulation #148
      interestingly #148
      autoimmune disease #148
      phagocyte nadph oxidase #148
      human autoimmune diseases #149
      complex diseases #149
      drb104 #150
      mhc binding #150
      larsen score #150
      levels antibodies #151
      epicutaneously #151
      mice animals #151
      humans hybridomas #151
      differential gene expression #151
      receptor rats #151
      alphabeta receptors #152
      pepsin #153
      key player #153
      arthritic animals #153
      levels pregnancy #153
      mononuclear cells #153
      male rats rats #154
      selfpeptides #154
      immune priming #154
      c4bbinding protein #154
      expression class #154
      critical event #154
      fcgammar #154
      daf1 #154
      joint inflammation #154
      padi4 #155
      infiltrating cells #155
      arthritis rheumatoid #155
      f1 mice #155
      autoantibodies autoimmune #155
      serum synovial fluid #155
      mace acs #155
      stabilin1 #156
      suppressive role #156
      specificities #156
      mhc region #156
      murine keratinocytes #157
      adjuvanticity #157
      downstream signals #157
      parentals #158
      analysis structure #158
      genetic diabetes mellitus #158
      hypersensitivity reaction #158
      meaib #159
      arthritis infectious #159
      systemic mice mice #159
      inbred c3h mice #159
      animals autoimmunity #159
      consensus motif #159
      gamma interferon #161
      factors anti #161
      benzylated #161
      knockout severity #161
      nursed #161
      specific autoimmunity #161
      day onset #161
      psors1 #162
      βarrestin recruitment #162
      cd152 #162
      binding collagen #162
      epitope #162
      rheumatoid autoantigens #162
      arthritis inflammation #162
      anti ccp #162
      mouse type #163
      onset disease #163
      chains humans #163
      laboratory rats #163
      mrl #164
      progesterone effects #164
      endobetanacetylglucosaminidase #164
      autoantibody responses #164
      striking similarities #164
      agalactosyl igg #164
      rats induction #164
      genes qtl #164
      cells macrophages #165
      animal humans immunity #165
      pathogenic pathways #166
      epitope alleles #166
      tolerance induction #166
      nonimmunized #166
      melatonin mice mice #166
      class mice #167
      human autoimmunity #167
      nox2 #167
      ag7 #167
      seronegative #167
      tlymphocyte humans #167
      cd1 #168
      genetic backgrounds #168
      mice cd4 cells #168
      phase disease #168
      p12 #169
      denoted #169
      oxazole #169
      acpa levels #169
      cryogels #170
      joints male #170
      experimental animal #170
      pathogenesis arthritis #170
      lymph node cells #170
      mirp #170
      inherited disorder #170
      oxazolone #171
      encephalomyelitis eae #171
      ros nitric oxide #171
      rat placenta #172
      rheumatoid #172
      single nucleotide polymorphism #172
      peripheral lymphoid organs #172
      autoimmune eae #172
      lst1 #172
      autoimmunity cell #172
      monoclonal autoantibodies #173
      sod3 #173
      inbred dba models #173
      class gene #174
      studies pain #174
      presence autoantibodies #174
      resistant rats #174
      nasal cartilage #174
      maternal decidua #175
      ifn signature #175
      mice mutation #175
      understanding pathogenesis #175
      new mouse model #176
      strains molecular #176
      secondary challenge #176
      tryptophan catabolism #176
      skin disease #176
      moab #176
      mammalian crosses #176
      lymphotoxinα #177
      histocompatibility #178
      ctla‐4 #178
      hladrb1 alleles #178
      dextran sulphate sodium #179
      nod genes #179
      protein anti #179
      alternative pathway complement #179
      immunized #179
      mice role #179
      cgd patients #180
      arthritis methods #180
      complex disease #180
      epitopes female #180
      molecular adaptations #181
      autoimmunity disease #181
      alleles arthritis #181
      genetic influence #181
      hormone melatonin #182
      arginine deiminases #182
      immunoglobulin mice mice #185
      antigen processing presentation #186
      multistep process #186
      cells lymph nodes #186
      rats reactive #186
      drb1 chains #187
      dba #187
      tcell recognition #187
      b10 #187
      substrains #188
      chondritis #188
      molecular peptide #188
      cells disease #189
      mtec #189
      positionally #190
      hnrnpa2b1 #190
      inflamed joint #190
      synovial membranes #190
      oligodendrocyte glycoprotein #191
      cross‐reactivity #192
      ly1 #192
      autoantibody profiles #192
      passive mice mice #193
      fmlf #193
      glycoprotein peptide #194
      cyclic predictive #194
      proteins myelin #194
      chapter 16 #195
      mice mutant #195
      perpetuate #195
      mhv #195
      tcell response #196
      lewis rat #196
      myelin glycoprotein #196
      oophorectomized #196
      mhc class expression #196
      evidence development #197
      multiplex assay #197
      acutephase response #197
      pannus #197
      igmrf #198
      early appearance #198
      genetic links #198
      swedish patients #198
      interleukin17 #199
      rat genome #199
      dr4 antigen #199
      citrullinated peptide #200
      hla association #200
      cell collagen #200
      pathogenesis autoimmune #201
      myelin proteins myelin #202
      instigation #202
      acpa status #202
      myelin proteolipid protein #202
      dendritic cells macrophages #202
      complete elimination #203
      mice cells #203
      class molecules #204
      2 complex #204
      immunization immunoglobulin #204
      spleen staining #204
      native collagen #205
      nonparametric tlymphocytes #205
      ides #205
      dth response #205
      macrophages mice #205
      suppresses #205
      defb4 #206
      wild rats #206
      betaestradiol #206
      alternative complement pathway #207
      mice peptide #207
      interleukin4 mice mice #207
      noxs #207
      parental strains #207
      insulitis diabetes #207
      desmoglein 3 #207
      induced upregulation #207
      intranasal challenge #207
      antigen presenting #208
      severity disease #208
      vivo patients #208
      naive mice #208
      immunization mice #208
      highest probability #208
      immunoglobulin vh #209
      cotwins #209
      disease rheumatoid #209
      citrullinated vimentin #210
      vav1 #210
      specific antibodies #210
      susceptible strains #210
      valuable tools #210
      highfatdiet #210
      natural antibodies #211
      hla dr4 #211
      glucose6 phosphate #211
      diseases genetic #211
      purified protein derivative #211
      cells immobilized #212
      large numbers #212
      association rheumatoid arthritis #212
      antibody binding #213
      psoriasiform #213
      mice injected #213
      tsst1 #214
      mhc class antigens #215
      inbred rat #215
      cytofluorometric #215
      triethylsilane #215
      antigen induced #215
      central tolerance #215
      dissect #216
      training hiit #216
      lower level #216
      joints mice #217
      lentiviral vector #217
      resistant strain #217
      cd23 #217
      induced autoimmune #217
      rats immunization #217
      inflammatory infiltrates #217
      antigen tcell #218
      treatment onset #218
      k8 #219
      autoimmunity #219
      peptide antibodies #219
      fcrγ #219
      granuloma formation #219
      peptidylarginine deiminases #220
      hyl #220
      bone erosions #220
      cells autoimmune #220
      redox signaling #221
      rheumatoid factor #221
      pinealectomy #221
      cyclosporin treatment #221
      agouti rats #221
      cells dendritic #221
      fine specificity #221
      targeted deletion #221
      monoclonal antigens differentiation #222
      cybb #222
      thymectomized #222
      wkymvm #222
      cartilage damage #222
      multiplex #223
      experimental autoimmune neuritis #223
      igg2a #223
      carbamylated #223
      inflammation vivo #224
      expressing #224
      clinical scoring #225
      lew #225
      established disease #225
      interleukin‐10 #225
      cells antigen #225
      pathogenic antibodies #226
      disease locus #226
      j1 #227
      macrophagelike cells #227
      delayed type hypersensitivity #228
      presenting cells #228
      arthritis objective #228
      cell selection #229
      presence anti #229
      site inflammation #230
      eae rats #230
      ls1 #231
      human rheumatoid #231
      reactive oxygen #232
      monoclonal immunohistochemistry #232
      ameliorated #233
      production ros #233
      synovial joints #233
      lack expression #233
      role eosinophils #233
      lower numbers #234
      centimorgan #234
      chronic psychosocial stress #235
      chromosome 14 #235
      staphylococcal infection #235
      mhc gene #235
      specificity animals #236
      immune complex #236
      pathological mechanisms #237
      control strain #237
      progression arthritis #238
      autoimmune chronic #238
      c5 #239
      trait locus #239
      inbred dba tlymphocytes #240
      study plasma #241
      strong influence #242
      joint pain #242
      multicomponent #243
      hla drb1 #243
      protected #243
      positive anti #243
      monoclonal antigen #243
      class genetic #243
      inflammation cartilage #244
      crosses #244
      cutaneous infection #244
      estrus cycle #244
      treatment autoimmune #244
      common denominator #244
      binding antibodies #245
      allelic differences #246
      development emphysema #246
      rt1l #246
      normal cartilage #247
      inbred strain #247
      antibodies anti #247
      new model #247
      florescence #247
      antibody response #247
      efficient expression #248
      activity assays #248
      induced chronic #249
      oxygen species #249
      mouse rat #250
      fragments rats #250
      picryl #250
      node cells #250
      arthritic joints #250
      inflammation score #250
      nadph oxidase #251
      conditional knockout mice #251
      hyperinflammation #251
      treatment rats #251
      develops #251
      mice lymphocytes #252
      role model #252
      mice lack #252
      response disease #252
      dark agouti #252
      class mhc #254
      dinitrofluorobenzene #254
      onset clinical #254
      cartilage matrix #254
      lacking #254
      proteins glycoproteins #254
      lpr mice #254
      inbred c3h #255
      autoimmune response #255
      specific neutralizing #256
      anti arthritic #256
      specific subgroups #256
      postmenopausal bone #256
      inflammatory disorder #256
      disease cell #257
      additive interaction #258
      class mhc molecules #259
      chronic granulomatous #260
      mir144 #260
      relationship immunologic #260
      secondary osteoporosis #261
      mediated suppression #261
      mice expressing #261
      lymphocytes helper #261
      autoimmune neuritis #261
      denatured #261
      immunologic animals #262
      selfantigen #263
      primary immunization #265
      crossreactive #265
      tolerance mice #265
      genetic techniques #265
      pregnancy mice #265
      mouse strain #265
      rats animals #267
      vim2 #267
      antigen specific #267
      cysteine proteases #267
      xid #268
      lentiviral gene #268
      posttranslational modifications #268
      pathogenic roles #269
      mann whitney #269
      complement c5 #270
      oxpl #270
      castrated #271
      selfantigens #271
      melatonin effects #271
      monosodium urate crystals #271
      experimental model #273
      amino acid transporters #273
      lewis rats #274
      nasally #275
      synovial lining #275
      hdac1 #275
      inhibitory peptide #275
      tcells #275
      fcgr3b #276
      macrophages dendritic cells #276
      deiminase type #277
      viral female hepatitis #277
      rheumatoid arthritis association #277
      producing cells #277
      recognize #278
      metabolic properties #278
      colon length #279
      interferongamma #279
      gp70 #279
      induced tolerance #280
      dinucleotide phosphate #280
      passive transfer #281
      recipient mice #281
      neonatal mice #281
      inflammatory conditions #281
      immunological receptors antigen #281
      hemiacetal #282
      factor production #283
      disease susceptibility #283
      inbred nod #283
      isoflavone genistein #283
      igg2b #283
      severe colitis #284
      increased serum levels #284
      aire #284
      helper inducer #284
      endophilin #285
      maintained #285
      complete protection #285
      aureus strain #285
      theilovirus #285
      idiotope #285
      publication animals antibodies #285
      emulsified #286
      hla dr2 #287
      melatonin mice #288
      tlr9 mice #288
      antibody production #288
      myelin basic protein #288
      melatonin release #288
      cells autoimmunity #289
      mice immunized #289
      disease cells #291
      synovial cells #291
      ctla4 expression #291
      rheumatic conditions #292
      autoimmune mechanisms #292
      increased copy #293
      cytokines disease #293
      collagen receptors #293
      induced ros #293
      mouse genes #294
      unique model #294
      c57bl 6 mice #295
      c3h #295
      gastric parietal #295
      antigen processing #295
      immunological receptors #296
      tissue‐specific #296
      6week #296
      nerve conduction #296
      phosphopyruvate #297
      dnfb #297
      murine dendritic cells #297
      helical peptides #297
      gene selection #298
      vivo imaging #298
      ppad #298
      cd19 cells #298
      citrullination #299
      transplantation antigens #299
      solidphase synthesis #299
      tcr beta #300
      neutrophil extracellular traps #301
      posttranslational rats #301
      draining lymph #302
      peptide antibody #302
      alphabeta #302
      extraembryonic tissues #302
      pathogeneses #303
      animals antibodies #303
      strains mice #303
      epidemiological investigation #303
      1 interferon #303
      autoimmune diseases #304
      igg glycosylation #304
      cgd #304
      conditioned disease models #304
      cartilage development #305
      immunological function #305
      mutant strains mice #305
      cells tcr #305
      gammaifn #306
      αgalcer #306
      immunological studies #306
      murine colitis #306
      hcdr3 #306
      inpp4b #307
      immunisation #307
      class histocompatibility #307
      basal metabolic rate #308
      basal metabolic #309
      chromosome 10 #309
      articular cattle cells #310
      arthritis study #310
      multiple sclerosis eae #311
      perpetuation #311
      inflamed joints #312
      synthetic peptide #312
      disease symptoms #312
      alleles animals #312
      exuberant #313
      epitopes #313
      c3bi #313
      induced colitis #314
      activatory #314
      r620w #315
      intradermally #315
      mice genes #315
      trypanosoma brucei brucei #316
      onset rheumatoid #318
      classical risk factors #318
      genetic interactions #319
      tubule cells #319
      galactosyl #319
      genomewide linkage analysis #320
      spleen bone marrow #320
      mice subjected #320
      deiminase #320
      il21r #323
      cells specific #323
      expressing human #324
      daf2 #324
      impact disease #324
      ccp1 #324
      specific cell #325
      rat gene #325
      expression cells #325
      surprisingly #326
      resembles #327
      mgps #327
      c57bl mice #328
      allelic variant #328
      publication adjuvants #329
      constant light #329
      immunoenzyme #329
      complex genes #330
      early arthritis #331
      glycoprotein mog #332
      nucleotide polymorphism #332
      rheumatoid synovial #332
      fcgammariia #332
      mouse hepatitis virus #333
      anticcp #333
      35ssulfate #334
      susceptibility genes #335
      joint tissues #335
      mrl lpr mice #335
      autoimmune inflammation #336
      cell response #338
      delayed onset #340
      cells spleen #340
      epitope specificity #340
      ros oxygen species #341
      adjuvants immunologic #341
      erosive #341
      rat #341
      activation macrophages #341
      animal enzyme inhibitors #342
      6weeks #342
      incident cardiovascular events #342
      specific autoimmune #342
      rats injection #343
      rapid spread #343
      sequence animals #343
      drb1 alleles #343
      diabetic mouse #343
      monoclonals #344
      182780 #344
      acpa positivity #345
      favor #345
      energetic costs #346
      intraperitoneal injection #347
      pemphigus vulgaris pv #348
      complement activity #349
      neuritis #349
      reduced capacity #349
      igg autoantibodies #350
      phenotype rats #351
      thymic selection #352
      methylcholanthrene #352
      anti cyclic #353
      c3h hej #353
      mice induction #353
      immunoregulation #353
      arthritis synovial #354
      autoantigens autoimmune #354
      mice cd4 #354
      splenic macrophages #355
      dsg3 #357
      cells autoantibodies #358
      tbetarii #358
      adjuvant activity #358
      neuritogenic #359
      injected #359
      enos #359
      tcrbeta #360
      pvg #361
      tlr3 #361
      freund #361
      hla transgenic #362
      murine lupus #362
      determines #363
      identification genes #363
      mouse chromosome #363
      allergic encephalomyelitis #363
      generation ros #363
      cells anti #364
      recognized #364
      hladr4 #364
      european journal #366
      sex chromosomes #366
      glycoproteins mice #366
      immune deviation #366
      antiidiotypic antibodies #367
      psychosocial stress #367
      affinity ligand #368
      100 micrograms #368
      ncf2 #368
      toxic shock #368
      loci #368
      autoimmune responses #368
      pentameric #369
      histocompatibility antigens #369
      nasal administration #369
      immune pathogenesis #370
      increased production #370
      regulate #371
      clinical onset #371
      serum transfer #371
      newborn antibodies #372
      role mif #372
      alternative activation #373
      autoantigens #375
      rheumatoid cell #375
      undifferentiated arthritis #376
      acutephase proteins #376
      glucose6 #377
      gia #379
      reparixin #380
      mouse monoclonal antibody #381
      induced lupus #381
      oxidase deficiency #381
      fia #382
      fragments immunoglobulin #382
      granulomatous #383
      specific loci #384
      naive rats #384
      c1a #384
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      shock syndrome #385
      postmenopausal bone loss #385
      pc4 #386
      cell specificity #386
      antioxid #387
      filaggrin #387
      ptpn22 gene #387
      backcrosses #387
      phase response #388
      inbred nod receptors #388
      downregulating #389
      ovulation rate #390
      deficient #390
      greater 50 #390
      peptidylarginine #391
      radiological progression #391
      anaphylatoxin c5a #391
      finetune #392
      il4 il10 #394
      rf1 #394
      ameliorating #395
      autoantibody levels #397
      draining #397
      induced metabolic #397
      juvenile chronic arthritis #398
      regulation animals #399
      protein myelin #399
      immunized mice #399
      reactive oxygen species #400
      inflammatory reactions #400
      genes cells #401
      antibody formation #401
      biacore #403
      inflammation demyelination #403
      immunopeptidome #403
      fcγriib #404
      beta chain #404
      basic protein #405
      experimental #405
      n31 #407
      effects models #407
      rheumatoid case #407
      pam3csk4 #408
      immunogenetics #409
      major locus #409
      3hproline #410
      intracellular processing #410
      diabetes loci #410
      hladrb1 #412
      cd43 #412
      cell phenotypes #412
      susceptibility loci #413
      titres #413
      reproductive performance #414
      characteristic feature #414
      igk #415
      cultured collagen #415
      female mice #416
      levels autoantibodies #416
      synovial inflammation #417
      lupus mice #417
      spontaneous mutation #417
      genetically modified mice #418
      molecular interactions #419
      class hdacs #419
      wtccc #419
      induced pain #419
      hiit #420
      ameliorate #420
      tcell #421
      lower affinity #422
      dr4 #422
      lipidomic #423
      subsets animals #424
      restricted #424
      hyaline cartilage #425
      regulatory animals #426
      inflammatory cells #426
      congenic strain #426
      carbohydrate moiety #429
      nonimmunogenic #430
      postimmunization #430
      nod mouse #430
      epitopes humans #430
      immunoregulatory #431
      il10 mice #433
      patients healthy individuals #433
      cells antibodies #434
      factor 5 #435
      spontaneous autoimmune #435
      cells beta #436
      reactivities #436
      decalcified #437
      crystallizable #437
      chromosomes chromosome #437
      mass spectrometric analysis #437
      specific antigens #438
      mice effects #438
      helperinducer tlymphocytes #438
      immunised #438
      cells #439
      joint swelling #439
      wildtype mice #440
      nod #440
      female immunoglobulin #441
      vitro techniques leukocytes #441
      normal rats rats #441
      effector functions #441
      patients population #442
      complete adjuvant #442
      mice activation #442
      methylβcyclodextrin #443
      mhc class molecules #443
      tlr2 expression #444
      myelin basic #444
      genomewide scan #445
      skeletal muscle function #445
      mouse models #445
      mice humans #445
      systemic mice #445
      ros production #447
      control mice #448
      induced mice #448
      pain model #448
      inbred strains receptors #448
      complement factor #449
      tcell responses #449
      synovial tissue #449
      innate adaptive #450
      apcs #451
      igg anti #451
      reduced production #452
      heterologous #452
      hybridoma cells #452
      differs #454
      lglutamine #456
      cells chronic #456
      raloxifene #457
      inbred c57bl tlymphocytes #457
      lung macrophages #459
      rheumatoid cells #459
      resembling #459
      eae cns #459
      priming #459
      antibodies monoclonal #460
      neutrophil functions #462
      autoantigen #462
      256 #462
      gilt #463
      fab fragments #464
      autoantibody production #465
      salivary glands #466
      receptor tcr #466
      cells lymph #467
      titers #469
      earlier onset #469
      antibody mediated #474
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      anticyclic citrullinated peptide #474
      disease mice #474
      cartilage cells #475
      human autoimmune #476
      mice exhibited #477
      cluster genes #477
      mediated inflammation #478
      therapeutic vaccination #478
      female hla #479
      laboratory rat #479
      apoptosis arthritis #479
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      quantitative trait loci #480
      deacetylase 1 #480
      polymorphonuclear cells #482
      anti idiotypic #482
      immune reactions #484
      immunologists #485
      immunoglobulin male #486
      tcralpha #487
      controlling #487
      jca #487
      oxyntic #487
      insulitis #488
      specific immune #488
      invariant natural #488
      gland animals #489
      normal mice #490
      cytoplasmic calcium #494
      nacetylglucosaminidase #495
      h2b #496
      early rheumatoid #496
      conclude #496
      reactive nitrogen #496
      gammadelta cells #496
      mbp #498
      small effects #498
      receptor 9 #499
      biologicals #500
      nadph #503
      immunoenzyme techniques #503
      autoreactive cd4 #503
      pathogenic #506
      chondrocytes collagen #507
      immunofluorescence analysis #507
      persistent pain #508
      mab mabs #508
      mineral oil #508
      isopropyl #508
      orosomucoid #509
      gingipain #509
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      mhc class #510
      mice knockout mice #510
      systemic spread #511
      differential gene #511
      deficient mice #511
      c3h hej mice #511
      812 #511
      blymphocytes #512
      mrp8 #515
      behavioral alterations #517
      hydroxyquinolines #517
      u1 #518
      antibody complex #518
      suggestive linkage #519
      chronic granulomatous disease #519
      inflammation #519
      tcr recognition #520
      modified form #521
      dextran sulfate sodium #522
      ttg #522
      pcorr #522
      inflammation role #523
      data peptide #523
      encephalitogenic #524
      litter size #524
      p47phox #524
      neutrophil granulocytes #525
      mnc #526
      tconv #526
      mechanical hypersensitivity #526
      maternal antibodies #527
      disease acute #527
      spleen cells #527
      larsen #528
      primed #528
      tolonium #528
      vaccinates #528
      displayed #529
      tolllike receptor tlr4 #529
      ifa #529
      rat rats #529
      autoantibody #530
      cell antibodies #530
      isac #530
      pathogenesis sle #530
      antigen presentation #530
      ratg #531
      epistatic #532
      bred #532
      complex role #533
      lyt2 #533
      posttranslational receptors #534
      spleen lymphocytes #536
      resorptions #536
      translational modification #536
      synovial #537
      urokinase #537
      cells inflammatory #538
      animals #538
      experimental rats #538
      antigen recognition #540
      fibroblast synoviocytes #540
      suppressive #540
      joints #540
      membrane attack complex #541
      rheumatoid humans #543
      specific autoantibodies #544
      protein tyrosine phosphatase #545
      regulating #545
      hypomorphic #546
      shortcut #547
      tlymphocytes #547
      animal gene #547
      immunohistochemical methods #548
      entheses #548
      formyl peptide receptors #548
      mog #550
      immunoglobulin fab #552
      mixed lymphocyte reaction #553
      nox activity #554
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      beta animals #557
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      healthy mice #560
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      negative selection #563
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      deeper layers #565
      immunoglobulin heavy chains #566
      target tissue #566
      darkness #566
      earlier #566
      crucial #567
      outbred #568
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      interferon signature #568
      cells pathogenesis #569
      neutrophilia #569
      mycobacteria #569
      concomitantly #570
      mice compared #571
      btla #572
      transgenic mouse models #572
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      col2 #574
      pepstatins #576
      presenting #576
      terpenes #577
      estrogen treatment #577
      keratinocyte growth factor #578
      prolactin prl #578
      ptm #579
      sera patients #579
      triple helix #580
      methotrexate mice #581
      f1 hybrids #581
      production ifngamma #583
      inflammatory joint #583
      hybridoma #583
      time onset #584
      lymphocyte antigens #584
      exaggerated #584
      antibody reactions #585
      traps nets #590
      environmental triggers #591
      antigen antibody #591
      immunological tolerance #592
      lxrα #592
      oligoclonal #592
      transgenic models #593
      noncollagenous #593
      autoimmune disorders #594
      adaptive immunity #594
      macrophages #594
      clonal expansion #595
      th1 cytokines #595
      multiplexing #595
      xanthine oxidoreductase #596
      cells study #599
      tcell activation #599
      develop #600
      augmented #602
      spite #602
      n85 #602
      th2 cytokines #602
      common diseases #603
      pemphigus vulgaris #603
      mouse monoclonal #603
      phagosomal #604
      cells involved #604
      cells male #604
      oxa #606
      animal rats #606
      mice inbred #606
      class humans #607
      frozen sections #608
      genotype hla #608
      spleen animals #609
      regulatory role #610
      inefficiently #610
      naive #611
      production ifn #611
      positive individuals #612
      quantitative trait locus #615
      autoantibodies #616
      idiotypic #616
      th1 type #616
      acetophenones #616
      mutant strains receptors #616
      alpha chains #616
      class antigens #616
      exponential phase #616
      nonobese #617
      oral immunization #617
      beta type #618
      day mice #619
      wistar restraint #620
      promiscuous #620
      consequent #621
      receptor 3 #621
      inflammatory role #621
      nicotinamide adenine #622
      receptors antigen #624
      fluorine18 #624
      chronic stage #625
      loci identified #625
      cytoplasmic ca2 #628
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      human chondrocytes #2110
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      immune functions #2126
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      inflammatory #2288
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      apocynin #2302
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      healthy donors #2318
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      inflammatory mechanisms #2321
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      cells induced #2331
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      single chain #2639
      sialoglycoproteins #2643
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      osteonectin #2667
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      treated rats #2786
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      sjogren syndrome #2791
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      animal encephalomyelitis autoimmune #2799
      hk #2801
      callithrix #2804
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      prl #2835
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      th1 response #2852
      polymorphonuclear leukocytes #2856
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      dependent cell #2859
      treg cell #2859
      antibodies antinuclear #2864
      polymorphonuclear #2864
      interleukin receptors #2864
      characterising #2865
      splenocytes #2865
      interleukin33 #2869
      rats inbred strains #2869
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      atp synthase #2909
      linked immunosorbent #2911
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      female flow #2943
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      expression macrophages #2944
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      histocytochemistry #2967
      hnrnp #2980
      genetics #2982
      ifn response #2985
      cepacia #2988
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      thymus gland #2997
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      respective #3000
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      cells female #3010
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      therapeutic strategies #3014
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      anthrax #3019
      interferon ifn #3020
      wild type mice #3026
      defensins #3027
      vdr #3031
      lung inflammation #3033
      accelerating #3033
      macrophage migration #3036
      t‐cell #3039
      endo #3039
      synthetic peptides #3040
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      quinoxalines #3047
      cd8 #3048
      immunomodulator #3050
      model mice #3051
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      twin studies #3053
      complex traits #3055
      ppt #3058
      interleukin23 #3061
      profound #3067
      sjögren syndrome #3069
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      salivary #3076
      mediated immune #3077
      role cell #3078
      beta #3080
      destruction #3082
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      nodes #3091
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      receptor 4 #3098
      inbred balb mice #3098
      genetic deletion #3100
      detailed description #3101
      postpartum period #3107
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      antirheumatic #3109
      staphylococcus #3114
      type wt #3120
      neuronal cell #3123
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      suspect #3127
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      glycans #3136
      monoclonal antibody #3137
      psoriasis #3142
      receptors tlrs #3142
      logarithm #3146
      cd4 cd8 #3147
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      cell activity #3154
      molecule #3155
      propria #3155
      cba #3164
      posttranslational modification #3167
      sjogren #3171
      massively #3172
      accumulated #3180
      cell specific #3185
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      dynorphin #3191
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      adult mice #3193
      cells rats #3193
      keratinocytes #3194
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      reactivity #3202
      helper #3204
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      ovx #3208
      serum levels #3210
      antiinflammatory #3211
      erbeta #3211
      phagosomes #3212
      nitroarginine #3212
      abs #3216
      publication arthritis #3224
      cells animals #3224
      gpi #3226
      chromosome 1 #3237
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      collagenous #3247
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      lod score #3252
      bacterial antibodies #3254
      backbone #3257
      nonalcoholic steatohepatitis nash #3260
      female gonadal #3263
      treated animals #3264
      acrylic #3265
      chronic inflammatory #3267
      meps #3270
      immunosorbent assay #3272
      implicate #3274
      proteoglycans #3278
      inflammation interferon #3278
      sch #3280
      arthralgia #3283
      nephritis #3283
      gonadal steroid #3284
      normal rats #3287
      abundantly #3289
      igg1 #3298
      models genetic #3298
      immunoglobulin heavy #3303
      erythematosus #3305
      adaptations #3309
      proteins mice #3309
      characterise #3314
      elicits #3314
      blastocyst #3315
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      diseases autoimmune #3321
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      publication animals #3325
      mice protein #3327
      anticardiolipin #3328
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      gc cells #3331
      serologically #3332
      suppression #3338
      regional lymph nodes #3341
      macromolecular #3343
      clinical phenotypes #3345
      cd62l #3353
      influenced #3355
      trypanosoma #3358
      akr #3371
      vitamin d3 #3373
      editor #3377
      antinuclear antibodies #3382
      sle #3384
      genetic polymorphisms #3385
      ovariectomy #3386
      macroporous #3395
      levels inflammatory #3395
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      mount #3397
      tubercle #3402
      somatic mutations #3406
      receptors transforming #3410
      early phase #3413
      haptens #3413
      positions #3418
      erythematosus systemic #3419
      nk cells #3419
      reacts #3421
      neutrophil activation #3421
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      reply #3432
      proving #3434
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      serum igg #3437
      alleles #3440
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      cauda #3443
      4 months #3444
      injection #3445
      superoxide production #3446
      protein tyrosine #3447
      humans immunization #3448
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      increased sensitivity #3449
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      characterised #3469
      h5n1 #3470
      patients sle #3470
      flow cytometry #3476
      modifying #3477
      multimers #3491
      inflammatory mediators #3491
      proteoglycan #3496
      successes #3497
      il21 #3500
      ly #3501
      elucidate #3503
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      protein processing #3506
      salivary gland #3507
      publication animals animals #3509
      neutrophilic #3510
      pathobiology #3511
      pathological features #3517
      specific cd4 #3519
      globulins #3526
      267 #3528
      deoxyguanosine #3528
      phenotypically #3529
      germline #3529
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      micrometer #3534
      lacrimal #3534
      transglutaminases #3535
      radiolabelled #3539
      regulatory cells tregs #3540
      cyclosporins #3540
      mbq #3541
      dominantly #3548
      histological examination #3554
      investigate #3559
      infections staphylococcus #3561
      mast cells #3563
      cultured disease models #3568
      socs1 #3570
      humans interferon #3571
      histological #3574
      homogenate #3576
      interesting #3580
      gamma #3580
      negative patients #3583
      artificially #3584
      role development #3585
      cytolytic #3589
      hindlimb #3590
      il33 #3593
      compared wild #3597
      triggered #3597
      usage #3601
      immunohistochemical staining #3608
      upregulation #3612
      previous findings #3617
      intranasal #3619
      tcr #3622
      cleave #3624
      potential roles #3624
      genetic association #3629
      rp #3633
      attenuate #3633
      mapping chromosomes #3634
      valuable #3637
      genetic #3637
      adhere #3638
      today #3645
      cultured culture media #3651
      allele #3655
      gene deletion #3657
      enhances #3657
      cd4 positive #3659
      exerts #3663
      clinical severity #3665
      tolllike receptor #3665
      luminol #3667
      95 association #3671
      cd44 #3678
      il23 #3690
      tgf beta #3691
      female genes #3694
      fibronectins #3697
      toll receptors #3700
      igg igm #3702
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      Prominent publications by Rikard Holmdahl

      KOL-Index: 15284

      The purpose of the study was to map the dominant T cell epitope of the CB11 sequence of CII in RTlu haplotype rats and to determine if, when used as a synthetic peptide, it would induce tolerance to protect against CIA. A dominant epitope corresponding to residues 184-198 included in the sequence of the CB11 fragment of bovine CII was identified in proliferation assay using peptides in an epitope scanning system using synthetic peptides of 15 amino acids, overlapping by 12 amino acids. ...

      Conocido por Mucosal Tolerance | Synthetic Peptide | Cell Epitope | Cia Cii | Collagen‐induced Arthritis
      KOL-Index: 14658

      An antibody response to defined epitopes located on the triple helical portion of type II collagen (CII) is associated with the development of collagen-induced arthritis (CIA) and rheumatoid arthritis (RA). Monoclonal antibodies to epitopes associated with arthritis, but not antibodies specific for epitopes not associated with arthritis, induce arthritis in mice, the so-called collagen antibody induced arthritis (CAIA) model. We have selected monoclonal IgG antibodies specific for four ...

      Conocido por Collagen Antibody | Induced Arthritis | Monoclonal Antibodies | Mice Inbred | Specific Epitopes
      KOL-Index: 13984

      The Aq major histocompatibility complex (MHC) class II molecule is associated with susceptibility to murine collagen-induced arthritis (CIA), whereas the closely related H-2Ap molecule is not. To understand the molecular basis for this difference, we have analyzed the ability of H-2Aq and H-2Ap molecules (referred to as Aq and Ap) to bind and present collagen type II (CII)-derived glycosylated and non-glycosylated peptides. T cell clones specific for the immunodominant CII 256-270 ...

      Conocido por Collagen‐induced Arthritis | Transgenic Models | Aq Molecule | Structural Basis | C3h Mice
      KOL-Index: 13727

      BACKGROUND: Autoantibodies to cyclic citrullinated peptides (anti-CCP) are present in most patients with rheumatoid arthritis (RA), and associate with HLA-DRB1 shared epitope (SE) alleles.

      OBJECTIVE: To investigate reactivities of anti-CCP to various citrullinated proteins/peptides, which represent potential autoantigens in RA, and to examine the relationship between such antibodies, and their association with genetic variants within HLA-DRB1 SE alleles.

      METHODS: Serum samples from 291 ...

      Conocido por Citrullinated Antigens | Rheumatoid Arthritis | Drb1 Alleles | Ccp Patients | Antibody Reactivities
      KOL-Index: 13726

      Type II collagen-induced arthritis (CIA) in mice is an autoimmune experimental model for rheumatoid arthritis. Susceptibility to CIA is associated with certain major histocompatibility complex class II haplotypes. The two very closely related haplotypes H-2q and H-2p differ in susceptibility to CIA. Only mice of H-2q (DBA/1, B10G strains) but not mice of H-2p-expressing strains (like strain B10P) develop CIA and an autoimmune response to type II collagen (CII) after immunization with ...

      Conocido por Mice Cia | Beta Chain | Rheumatoid Arthritis | H2q Haplotype | Type Collagen Cii
      KOL-Index: 13513

      INTRODUCTION: It has previously been shown that an increased number of antibodies against citrullinated peptides/proteins (ACPA) predate the onset of rheumatoid arthritis (RA). Over time antibody positivity expands, involving more specific responses when approaching the onset of symptoms. We investigated the impact of human leukocyte antigen-shared epitope (HLA-SE) alleles and smoking on the development of ACPA, as well as in combination with ACPA during the state of quiescent ...

      Conocido por Citrullinated Peptides | Onset Symptoms | Development Rheumatoid Arthritis | Combination Acpa | Hlase Smoking
      KOL-Index: 13230

      OBJECTIVE: High titers of specific anti-citrullinated protein antibodies (ACPAs) are frequently present in the serum of rheumatoid arthritis (RA) patients, but their presence in synovial fluid is less well characterized. The purpose of this study was to compare the levels of antibody to 4 well-defined citrullinated candidate RA autoantigens in serum and synovial fluid and to determine whether antibodies to one citrullinated antigen are dominant over another. Furthermore, we studied their ...

      Conocido por Citrullinated Antigens | Synovial Fluid | Rheumatoid Arthritis Patients | Type Collagen | Antibodies Acpas
      KOL-Index: 12913

      INTRODUCTION: Toll-like receptors (TLRs) are involved in both innate and adaptive immune responses and are likely to play a complex role in the pathogenesis of human rheumatoid arthritis (RA) and experimental arthritis. The objective of this study was to identify the key TLR in pristane-induced arthritis (PIA), a rat model for RA, and to clarify its roles in the initiation and maintenance of arthritis.

      METHODS: Arthritis in DA rats was induced by pristane and the severity was evaluated ...

      Conocido por Induced Arthritis | Tlr3 Expression | Rats Pristane | Receptor 3 | Inbred Strains Severity
      KOL-Index: 12776

      Multiple sclerosis (MS) is a complex chronic neurologic disease with a suspected autoimmune pathogenesis1,2. Although there is evidence that the development of MS is determined by both environmental influences and genes, these factors are largely undefined3,4, except for major histocompatibility (MHC) genes. Linkage analyses and association studies have shown that susceptibility to MS is associated with genes in the human histocompatibility leukocyte antigens (HLA) class II region, but ...

      Conocido por Multiple Sclerosis | Transgenic Mice | Hla Dr2 | Humanized Model | Spontaneous Disease
      KOL-Index: 12721

      Polymorphism of the major histocompatibility complex (MHC) influences susceptibility to experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein (MBP) in rats. Current concepts relate such influences to the capacity of class II molecules to present relevant peptides to autoreactive T cells. We have here analyzed the MHC influence on the immune response and the development of EAE after immunization with the immunodominant peptide MBP-63-88. Analysis of MHC-congenic ...

      Conocido por Myelin Basic Protein | Experimental Autoimmune | Major Histocompatibility | Rats Eae | Immune Response
      KOL-Index: 12691

      OBJECTIVE: The presence of antibodies against cyclic citrullinated peptides has been demonstrated to precede the onset of symptoms of rheumatoid arthritis (RA) by several years. The aim of this study was to analyze antibodies against 10 citrullinated autoantigen-derived peptides for reactivity before the onset of RA symptoms.

      METHODS: A case-control study was conducted within the Medical Biobank of Northern Sweden. The study was performed in 409 individuals, 386 of whom donated 717 blood ...

      Conocido por Citrullinated Peptides | Rheumatoid Arthritis | Onset Symptoms | Antibodies Cep1 | Type Collagen
      KOL-Index: 12510

      Antibodies against type II collagen (anti-CII) are arthritogenic and have a crucial role in the initiation of collagen-induced arthritis. Here, we have determined the dependence of T and B cells in collagen-antibody-induced arthritis (CAIA) during different phases of arthritis. Mice deficient for B and/or T cells were susceptible to the CAIA, showing that the antibodies induce arthritis even in the absence of an adaptive immune system. To determine whether CII-reactive T cells could have ...

      Conocido por Collagen Type | Arthritis Mice | Antigen Tcell | Antibodies Cii | Adaptive Immune
      KOL-Index: 12427

      The nonobese diabetic (NOD) mouse spontaneously develops autoimmune-mediated diseases such as diabetes and Sjögren's syndrome. To investigate whether NOD genes also promote autoimmune-mediated arthritis we established a NOD strain with an MHC class II fragment containing the A(q) class II gene predisposing for collagen induced arthritis (NOD.Q). However, this mouse was resistant to arthritis in contrast to other A(q) expressing strains such as B10.Q and DBA/1. To determine the major ...

      Conocido por Genetic Control | Complement Factor | Induced Arthritis | Locus Chromosome | Mice Inbred

      Gente clave para Rheumatoid Arthritis

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      Rikard Holmdahl:Impacto experto

      Conceptos para los cualesRikard Holmdahltiene influencia directa:Rheumatoid arthritis,  Induced arthritis,  Experimental arthritis,  Collagen type,  Type collagen,  Animal models,  Reactive oxygen species,  Autoimmune diseases.

      Rikard Holmdahl:Impacto de Kol

      Conceptos relacionados con el trabajo de otros autores para los cualesfor which Rikard Holmdahl tiene influencia:Rheumatoid arthritis,  Multiple sclerosis,  Autoimmune diseases,  Oxidative stress,  Animal models,  Reactive oxygen species,  Nadph oxidase.


       

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      National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China | Medical Inflammation Research, MediCity Research Laboratory, University of Turku, Turku,

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