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    • Rikard Holmdahl
    • Rikard Holmdahl

      Rikard Holmdahl

      National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China | Medical ...

       

       

      Kol CV for Rikard Holmdahl

      Year
      2022

      National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China

      Medical Inflammation Research, MediCity Research Laboratory, University of Turku, Turku, Finland

      2021

      The Second Affiliated Hospital of Xi’an Jiaotong University (Xibei Hospital), Xi’an, China

      Department Medical Biochemistry and Biophysics, Division Medical Inflammation Research, Karolinska Institute, 171 77 Stockholm, Sweden;, (M.A.);, (X.C.);, (B.X.);, (G.F.L.);, (M.Y.B.);, (Y.H.);, (L.B.)

      Division of Medical Inflammation Research, Dept. of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden

      2020

      Dept. of Medical Inflammation Research, Section of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm

      Section for Medical Inflammation Research, BMCI11, Lund University, Lund, Sweden

      National & Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital, Xi'an Jiaotong University, 710004 Xi’an, China

      Karolinska Institutet

      2019

      Section for Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Solnavägen 9, 171 65, Solna, Sweden

      Center for Medical Inflammation Research, Southern Medical University, Guangzhou, China

      R. Holmdahl and C.I. Svensson contributed equally to this paper.

      2018

      School of Pharmaceutical Science, Southern Medical University, Guangzhou, China

      Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, Stockholm 17177, Sweden. Electronic address:

      Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden

      Medicity Research Laboratory, University of Turku, Turku, Finland

      2017

      Karolinska Institutet Division of Medical Inflammation Research Stockholm Sweden

      Center for Medical Immunopharmacology Research, Southern Medical University, 510515 Guangzhou, China.

      Medicity Research Laboratory, University of Turku, Turku, Finland, .

       

       

      Rikard Holmdahl: Påvirke statistikk

      Prøve av konsepter som Rikard Holmdahl er blant de beste ekspertene i verden.
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      altered formation #2
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      ptpn22 c129s #2
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      agonist fpr2 #2
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      hiit skeletal muscle #2
      eae protein rna #2
      total abrogation #3
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      keratinocytes langerhans cells #3
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      stages disease development #4
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      glycopeptide specificity #6
      erosive polyarthritis #6
      staphylococcus aureus arthritis #6
      mhcii alleles #6
      transgenic mice arthritis #6
      immunization peptides #6
      polychondritis relapsing #7
      autoantibodies lymphocytes #7
      congenic mouse #7
      induction arthritis #7
      nonarthritogenic #7
      psoriasiform skin disease #7
      glycosylated collagen #7
      congenic strains #7
      cii anti #7
      antibodies citrullinated antigens #7
      murine psoriasis #7
      antibodyinduced arthritis #7
      impact cia #7
      cognate activation #7
      autoimmunity collagen #7
      acpa titres #7
      oestrogen rats #7
      3xi #7
      arthritis strains #7
      mediated vasculitis #7
      g6pi #7
      ciireactive cells #7
      arthritis type collagen #7
      periodontitis arthritis #7
      chronic experimental #7
      collagen arthritis rats #7
      collagen epitope #7
      collagen arthritis cia #7
      arthritis genes #7
      ean animals #7
      impaired induction #7
      locus chromosome #7
      snecs #7
      mice constant darkness #7
      role raloxifene #7
      cab3 #7
      cryogel column #7
      antigens differentiation arthritis #7
      strains disease #7
      rheumatoid arthritis role #7
      mbp peptide #7
      response immunization #7
      animal immunization injections #7
      conventional environment #7
      region syntenic #7
      symptoms disease onset #7
      mouse collagen #7
      macrophages alternative activation #7
      cia mice #7
      autoimmune human #7
      effector phase #7
      regulatory cells macrophages #7
      citrullinated peptide antigens #7
      castrated females #7
      autoantibodies citrullinated peptides #7
      raassociated molecules #7
      rats phases #7
      chronic phase arthritis #7
      hydrolases polymorphism #7
      protective influences #7
      yaa gene #7
      isomerase peptide #7
      cii apc #7
      cia5 #7
      aplec #7
      type collagen #7
      transgenic class #7
      analysis crosses #7
      responses cii #7
      297 cases #8
      onset incidence #8
      dominant cell epitope #8
      hladrb11001 #8
      diseases loci #8
      42 rats #8
      cosphox #8
      eae genetic encephalomyelitis #8
      murinised #8
      polymeric cryogels #8
      haematogenously #8
      experimental autoimmune disease #8
      underlying genes #8
      t‐cell priming #8
      rheumatoid autoimmunity #8
      autoantibodies subset #8
      fcγr2b #8
      rheumatoid chromosome #8
      lyme arthritis severity #8
      destructive effects #8
      neutrophil cytosolic #8
      oia2 #8
      hlase alleles #8
      cia2 #8
      humans experimental arthritis #8
      arthritis lymphocytes #8
      parathyroid glands receptors #8
      experimental binding #8
      supermacroporous cryogel #8
      cia animal model #8
      ptpn22620w #8
      chromosomes loci #8
      sialadenitis mrl #8
      expression hdac3 #8
      α1‐microglobulin #8
      typeii collagen #8
      oxidized peptides #8
      murine locus #8
      ros interplay #8
      inflamed synovia #8
      illness igg #8
      persistent joint pain #8
      patients type collagen #8
      mice techniques #8
      heterologous peptide #8
      antigenspecific priming #8
      clinical signs ean #8
      eae3 #8
      autologous peptide #8
      antibody vivo #8
      mbp mog #8
      mice ifnbeta #8
      rats mhc #8
      hybridomas antibodies #8
      b10 background #8
      treatment monoclonal #8
      induced neuropathology #8
      hdac3 expression #8
      autoantibodies collagen type #8
      mumt mice #8
      onset day day #8
      rt1f #8
      autoimmune congenic mice #8
      antibodies acpas #8
      ifa cii #8
      incidence cia #8
      medium mem #8
      non‐mhc #8
      chronic autoimmune arthritis #8
      hitr #9
      loci rats #9
      pristane #9
      specific sets #9
      experimental arthritis rats #9
      experimental genes #9
      posttranslational glycosylation #9
      cia transgenic mice #9
      adaptive inflammation #9
      inbred lew tlymphocytes #9
      bound carbohydrates #9
      arthritis skg mice #9
      induced metabolic syndrome #9
      il10 role #9
      intranasal animals arthritis #9
      rt1u #9
      collagen female #9
      disease strains #9
      animal models urgent #9
      human immunopeptidome #9
      antibodies vivo #9
      mammalian disease models #9
      serum interferon #9
      idiotype‐specific #9
      eae immunization #9
      2 nadph #9
      alpha1inhibitor3 #9
      ean myelin #9
      early joint erosions #9
      oligomeric matrix #9
      rheumatoid joints #9
      ox19 #9
      oil adjuvants #9
      nodp #9
      psychological tyrosine #9
      b10riii mice #9
      rats rat #9
      inbred dba mice #9
      murine collagen #9
      variants acpa #9
      acpas patients #9
      development autoimmune arthritis #9
      reduced arthritis #9
      histone 1 hdac1 #9
      postmenopausal arthritis #9
      autoimmunogenic #9
      acpas #9
      arthritis cross #9
      illness receptor #9
      class allele #9
      mouse peptide #9
      patients acpas #9
      hgpi325 #9
      specific nox2 #9
      avridine #9
      response mouse #9
      collagen complement #9
      antibody alpha #9
      rheumatoid autoantibodies #9
      differentiation autoimmune #9
      effects mabs #9
      bovine cii #9
      cell‐deficient #10
      immunization rats #10
      mutated mice #10
      cartilage oligomeric #10
      oestrogen #10
      mice nadph #10
      severe erosive #10
      monoclonal arthritis #10
      reactivity acpas #10
      endogenous collagen #10
      mbp peptides #10
      acpa diagnosis #10
      genetic experiments #10
      cells development #10
      citrullinated antigen #10
      o2• h2o2 #10
      cartilage collagen fibrils #10
      native collagen type #10
      extracellular cartilage #10
      hlase smoking #10
      autoimmune disease humans #10
      cii mice #10
      tertbutylacrylamide #10
      prl effects #10
      mice genistein #10
      cd4 cells spleen #10
      knockout nadph #10
      presence acpa #10
      ifnbeta mice #10
      antibodies specific #10
      animal models #10
      mice cii #10
      rheumatoid arthritis dr4 #10
      stock mice #10
      axotomized motor neurons #10
      cells increased production #10
      development severity #10
      passive transfer experiments #10
      onset chromosome #10
      cartilage arthritis #10
      nih heterogeneous stock #10
      beta 11 #10
      acutephase response rats #10
      collagen autoimmunity #10
      abp gene #10
      rats lewis rats #10
      antibody collagen #10
      experimental cartilage #10
      h2ap #10
      activation male #10
      pain animal models #10
      alpha collagen chains #10
      dense fractions #10
      inbred dba #10
      monoclonal antigens rats #10
      cells pia #11
      antibodies association #11
      loci regulating #11
      individuals onset #11
      species respiratory #11
      stromal cells macrophages #11
      mhc control #11
      liver receptor lxrα #11
      antibody type collagen #11
      2xi #11
      potential autoantigens #11
      arthritis absence #11
      inflammatory arthritis role #11
      fragments anti #11
      chondrocytes ecm #11
      84–102 #11
      cia30 #11
      gad6 #11
      naïve cells cells #11
      antigen variability #11
      rat liver rats #11
      mice mhc #11
      ptpn22 smoking #11
      mice cd1 #11
      lentiviral vector expression #11
      dss wt #11
      chronic arthritis #11
      rat arthritis #11
      rat collagen #11
      isotypes #11
      development rheumatoid #11
      nodb10h2b mice #11
      monoclonal rheumatoid factors #11
      tailbase #11
      cia7 #11
      serum concentrations comp #12
      natural polymorphism #12
      frequencies antibodies #12
      increased litter size #12
      rats expression #12
      icmediated #12
      bovine type collagen #12
      myelin ean #12
      fpr2 agonists #12
      natural loss #12
      peptide study #12
      reduces severity #12
      immunodominant #12
      rats cia #12
      illness sex characteristics #12
      mutated mouse #12
      major haplotype #12
      animal immunohistochemistry #12
      cii patients #12
      stages pathogenesis #12
      matrilin #12
      role arthritis #12
      stage cia #12
      backgroundantibodies #12
      autoimmune monoclonal antigens #12
      pia1 #12
      qa2 #12
      genetic contamination #12
      structure antibodies #12
      lung macrophages mice #12
      psoriasis arthritis #12
      riiis #12
      study arthritis #12
      α1ii #12
      mice comp #12
      hydroxylysines #12
      mutation nadph #12
      cross rats #12
      mbp response #12
      antibodies structures #12
      onset symptoms #12
      lymphoid cells development #12
      nonselfdiscrimination #12
      type collagen immunization #12
      associations antibodies #12
      treatment experimental arthritis #12
      cell responses cii #12
      loci disease #12
      chronic erosive arthritis #12
      encephalomyelitis induced #12
      psoriasis mouse model #12
      mtec aire #13
      citrullinated #13
      genes mouse chromosome #13
      dr1 transgenic #13
      nos2derived #13
      joints blood #13
      cells salivary glands #13
      hladrb1 ptpn22 #13
      bcelldeficient mice #13
      complement complement activation #13
      nonobese diabetic mouse #13
      dba molecular #13
      t‐cell epitope #13
      mouse strains #13
      anticii #13
      ccp2 antibodies #13
      oxidase nox2 #13
      mannan #13
      major loci #13
      advanced intercross #13
      lew1w #13
      rfigg #13
      macroscopic scoring #13
      arthritis knowledge #13
      species deficiency #13
      immunohistochemistry interferon #13
      expression egfp #13
      sequence collagen #13
      idd5 #13
      cell epitope #13
      factor isotypes #13
      strains incidence #13
      cyclic citrullinated #13
      ho4 #13
      b10p #13
      24dinitro1fluorobenzene #13
      multispecific #13
      antibodies citrullinated proteins #13
      oxidative regulation #13
      native type collagen #13
      behavioral alterations rats #13
      doses ici #13
      epitope immunization #13
      l012 #13
      levels nabs #13
      development type collagen #13
      μ chain #13
      gut protection #14
      collagen comp #14
      thr233 #14
      deficient production #14
      molecular disease models #14
      immune regulators #14
      antifilaggrin antibodies #14
      cia expression #14
      arthritic paws #14
      collagen disease #14
      presence mcv #14
      experimental interferon #14
      osteoclasts vivo #14
      macrophages immune response #14
      autoimmune arthritis #14
      humans nadph #14
      immunized rat #14
      loci rheumatoid #14
      murine collageninduced arthritis #14
      specific inflammation #14
      efficient promotion #14
      arlacel #14
      smallmolecule compound #14
      autoimmunity animals #14
      mhc class region #14
      sirt1 mmp9 #14
      b6n mice #14
      aggregated nets #14
      involvement cells #14
      loci interaction #14
      protein collagen #14
      nasal inhalation #14
      blymphocyte female humans #14
      candidate autoantigens #14
      peptides anti #14
      apcs macrophages #15
      cdr regions #15
      polychondritis #15
      2 weight #15
      citrullinated peptides patients #15
      raloxifene estradiol #15
      dcii #15
      mice type collagen #15
      ros cii #15
      mice immunization #15
      rt1a #15
      presence anticarp antibodies #15
      tflask #15
      arthritis role #15
      regulation adaptive immunity #15
      osteoporosis development #15
      rheumatoid arthritis presence #15
      aire mtec #15
      immune complex formation #15
      antigenic epitope #15
      mhc class molecule #15
      type collagen development #15
      nodb10h2b #15
      anticollagen #15
      arthritis development #15
      exaggerates #15
      cultured human chondrocytes #15
      rats monoclonal antigens #15
      murine cia #15
      congenic rats #15
      involvement pathogenesis #15
      lentiviral gene delivery #15
      rat genetics #15
      translationally modified #15
      neuritis rats #15
      integrated bioprocess #15
      antibodies arthritis #15
      treatment cia #15
      amps development #15
      monoclonal arthritis rats #15
      monolithic cryogel #15
      experimental allergic neuritis #15
      lethal inflammatory #16
      rt1 #16
      levels natural antibodies #16
      males onset #16
      epitopes mice mice #16
      indirect genetic predisposition #16
      subspecificities #16
      staphylococcal arthritis #16
      nonglycosylated form #16
      antinuclear autoimmunity #16
      lew1 #16
      rno10 #16
      mumt #16
      class transplantation #16
      arthritis severity mice #16
      congenic mice mice #16
      anti‐t #16
      hla–drb1 shared epitope #16
      development rheumatoid arthritis #16
      oligomeric matrix protein #16
      genes animals #16
      pparγ lxrα #16
      rats experimental arthritis #16
      fewer osteoclasts #16
      rheumatoid factor production #16
      disease mice mice #16
      acute inflammation mice #16
      autologous collagen #16
      mhc genes #16
      rheumatoid arthritis genes #16
      mhcii ciita #16
      cep1 #16
      n305 #16
      matrilin proteins #16
      arthritis cii #16
      h2p #16
      human fcγriia #17
      mice rheumatoid arthritis #17
      cells collagen #17
      cartilage collagen #17
      clever1 #17
      nox2 derived #17
      leuphe #17
      arthritis rheumatoid autoantibodies #17
      ethanol development #17
      strains lymphocytes #17
      onset rheumatoid arthritis #17
      collagen induced arthritis #17
      cab4 #17
      skg #17
      rats lewis #17
      triplehelical conformation #17
      collagen specific #17
      polyphosphate4 #17
      progesterone development #17
      rt1av1 #17
      cells female mice #17
      genistein mice #17
      inbred lew #17
      animals congenic #17
      periodontitis antibodies #17
      rheumatoid arthritis subsets #17
      spleen peyers patches #17
      allergic neuritis #17
      cells presenting cells #17
      native denatured #17
      h2z #18
      day immunization #18
      ealkene #18
      collagen autoantibodies #18
      arthritis anti #18
      short‐term administration #18
      day arthritis #18
      defined epitope #18
      disease duration onset #18
      salivary glands mice #18
      genes spleen #18
      cartilage type collagen #18
      galactose moiety #18
      humanized transgenic mice #18
      cuiiida #18
      adjuvant arthritis rats #18
      hybridomas mice mice #18
      langerhans cells cells #18
      expression lxrα #18
      phenotypic feature #18
      anti cd44 #18
      purified anti #18
      addition ros #18
      moginduced eae #18
      dra0101 #18
      autoimmune illness #18
      ros data #18
      keratinocytes induction #18
      joint inflammatory #18
      three‐dimensional culture #19
      mice develop #19
      mrl mp mice #19
      supermacroporous #19
      inflammatory attack #19
      patients polychondritis #19
      rats snp #19
      single intradermal injection #19
      gly262 #19
      citrullinated proteins acpa #19
      tbetarii gene #19
      peyers patches spleen #19
      trimolecular complex #19
      cia eae #19
      blood monocytes neutrophils #19
      elisa cia #19
      vivo elimination #19
      mice congenic mice #19
      protective alleles #19
      collagen response #19
      future utility #19
      protein comp #19
      cd4 transgenic #19
      new avenues #19
      castrated female rats #19
      beta oestradiol #19
      suppression dth #19
      fls tnfα #20
      mbp rats #20
      human rheumatoid arthritis #20
      pvg1av1 #20
      glycosylated #20
      serm raloxifene #20
      role nox #20
      ncr3 #20
      5p14 #20
      mice cia #20
      experimental autoimmunity #20
      response mbp #20
      nox1deficient mice #20
      matrilin1 #20
      littermate #20
      antibody treatment #20
      stress phospholipids #20
      progesterone oestrogen #20
      ciita mhcii #20
      loci chromosomes #20
      enhanced tcr #20
      prominent infiltration #20
      development disease #20
      inflammation mice #20
      highly susceptible #20
      monkeys rodents #20
      knockout mice transgenic #20
      mhc class alleles #20
      5r5 #20
      imaging reactive #20
      underlying gene #20
      rt1d #20
      olahsd #21
      positional cloning #21
      pathogenesis rheumatoid #21
      cells adaptive immune #21
      nox2 mice #21
      n141 #21
      cia treatment #21
      linomide treatment #21
      n286 #21
      triplehelical peptides #21
      nitratenitriteno pathway #21
      ean rats #21
      muscle ros #21
      serum levels comp #21
      drb11001 #21
      onset severity #21
      diseases lymphocytes #21
      experimental rheumatoid #21
      nox2 activity #21
      individual acpa #21
      mice mutant strains #21
      granule mobilization #21
      arthritis pregnancy #21
      α1acidglycoprotein #21
      conserved haplotype #21
      suppressor cytotoxic cells #21
      rats development #21
      illness autoimmune #21
      chronic relapsing #21
      genes controlling #21
      igg fcgammar #21
      supermacroporous cryogels #21
      association pv #22
      ul1 #22
      rats loss #22
      animal epitopes humans #22
      experimental phenotype #22
      270 #22
      samples onset #22
      induced eae #22
      antiidiotypic antibody #22
      c57bl mice subfamily #22
      semiallogenic #22
      rats nonalcoholic steatohepatitis #22
      identification susceptibility genes #22
      vh j558 #22
      cultured hepatic cells #22
      response myelin #22
      determinant selection #22
      mice independent #22
      81a #22
      ccp negative #22
      citrullinated epitopes #23
      arthritis type #23
      comp #23
      tgfbeta resistance #23
      mace association #23
      monoclonal antigens autoimmune #23
      lymphocytes amino #23
      animal genes #23
      citrullinated protein #23
      onset cia #23
      antibodies acpa #23
      inflammation absence #23
      loss collagen #23
      cryogel beads #23
      17 betaoestradiol #23
      anti‐cd5 #23
      experimental chromatography #23
      experimental autoimmune diseases #23
      diseases autoimmunity #23
      rats inbred lew #23
      citrullinated antigens #23
      castration rats #23
      immunopeptides #23
      cells presentation #23
      complex influences #23
      cells b10 #23
      peptide activation #23
      phage clones #23
      4npa #23
      mbp eae #23
      b10r #23
      mediated arthritis #24
      severity ali #24
      subloci #24
      y35 #24
      controls anti #24
      c57bl 10 mice #24
      ftirm #24
      secondary immune response #24
      new mouse #24
      mouse models development #24
      autoantibodies rheumatoid #24
      animal epistasis #24
      levels comp #24
      cells c3h #24
      rat induction #24
      339 #24
      experimental lupus #24
      antinuclear apoptosis #24
      flss patients #24
      postpartum flare #24
      monoclonal anti #24
      chronic autoimmune diseases #24
      severity chronicity #24
      loci chromosome #24
      inflammation arthritis #24
      mice nox2 #24
      experimental cells #24
      bnda #25
      interleukin2 mice receptors #25
      immunodominant epitope #25
      complex male #25
      arthritis experimental arthritis #25
      beta lymphocytes #25
      immunization development #25
      parasitemia survival #25
      proteinarginine deiminase type #25
      relapsing polychondritis #25
      autoantibody response #25
      monocytes nadph #25
      autoimmune messenger #25
      cells immunization #25
      common autoimmune disease #25
      collagen cartilage #25
      production monoclonal #25
      8 antibodies #25
      tolerized rats #25
      rno4 #25
      arginine arthritis #25
      autoimmune diseases humans #25
      cix #25
      massive infiltration #25
      specific epitopes #25
      ros #25
      b6 balb #25
      congenic animals #25
      rat mhc #25
      cell hybridomas #25
      murine lyme arthritis #25
      inbred lew rats #25
      eae development #26
      autoantibodies citrullinated proteins #26
      cells joints #26
      cb11 #26
      polychondritis rp #26
      hydrocarbon oil #26
      nitrophenylalanine #26
      anti citrullinated #26
      post translationally #26
      mice gammadelta cells #26
      granulocytes cells #26
      viable chondrocytes #26
      igg2a mice #26
      glutamax #26
      helperinducer animals antibodies #26
      local exposure #26
      gene regions #26
      ccp2 #27
      intercrossed #27
      physiological level #27
      individuals antibodies #27
      perforin deficiency #27
      immunospecific #27
      hladrb1 shared epitope #27
      c1i #27
      innate interleukin10 #27
      pannus tissue #27
      nonmhc genes #27
      trypsination #27
      disease immunoglobulin #27
      rheumatoid factor isotypes #27
      pointmutation #27
      interleukin21 tlymphocytes #27
      immunodominant response #27
      antibodies type #27
      nr8383 #28
      antibodies mab #28
      cia3 #28
      rat strain #28
      mediated effects #28
      cartilage vivo #28
      w3 25 #28
      severity day #28
      upregulation cytokines #28
      lysine position #28
      anti rat #28
      protein peptides #28
      animal models neurodegeneration #28
      autoimmune inflammatory #28
      chronicity #28
      eae susceptibility #28
      mrna ifngamma #28
      onset day #28
      antily6g #28
      ros induction #28
      antigenspecific tolerance #28
      parotid secretory protein #29
      absence inflammation #29
      smoking presence #29
      phenomes #29
      ros production macrophages #29
      membrane lymphocytes #29
      peptide anti #29
      cfa cia #29
      rfigm #29
      acpa #29
      antibody producing cells #29
      immunopathogenicity #29
      ls2616 #29
      mice mab #29
      suboptimal doses #29
      246trinitrophenyl #29
      glucose transport capacity #29
      chronic dss #29
      hiit exercise #29
      presence synovial fluid #29
      variable heavy chain #30
      paws #30
      ctla4 mice #30
      development experimental #30
      cultivation cells #30
      vpba #30
      chronic autoimmune #30
      hlase #30
      acpa fine #30
      disease immunity #30
      linkage disease #30
      synovial cells patients #30
      treatment raloxifene #30
      increased salt #30
      dba mice #30
      adult thymectomy #30
      chain collagen #30
      vivo exercise #30
      plasminogendeficient mice #30
      translational rats #30
      alphabetat #30
      11 cells #30
      metabolic syndrome rats #30
      vgenes #30
      drugs addition #31
      expressing cells #31
      acute‐phase response #31
      immunization #31
      disease development #31
      selfprotein #31
      perpetuated #31
      nox2 nox1 #31
      synovial fluid blood #31
      monoclonal antibody production #31
      apc development #31
      ige cd23 #31
      human type collagen #31
      trimolecular #31
      hiit training #31
      common chain #31
      pristaneinduced lupus #31
      phytol #31
      rats autoimmune #31
      comparative genetic analysis #31
      littermate controls #31
      psoriasis model #31
      bound peptides #32
      ra33 #32
      caia mice #32
      methods serum samples #32
      presence acpas #32
      cells uterus #32
      differentiation arthritis #32
      role osteoclastogenesis #32
      type antibody #32
      ros rns #32
      rt11 #32
      11 cell #32
      receptor preference #32
      hladrb104 #32
      congenic mice #32
      specificity function #32
      nodes mice #32
      arthritis therapy #32
      acpa rheumatoid arthritis #32
      steen #32
      mucosal tolerance #32
      genomewide genotyping #32
      nonb cells #32
      polymorphic genes #32
      cell ratio #32
      nadph oxidases nox #32
      beta mice #32
      epitope antibodies #32
      influence genes #32
      h2aq #32
      modified collagen #33
      skews #33
      type cross #33
      epitopes antibodies #33
      autoantibody activity #33
      tcell receptor #33
      tolerance immunization #33
      autoimmune demyelinating disease #33
      role vav1 #33
      cytosolic factor #33
      antigenpresenting cells cells #33
      multiplex analysis #33
      delayed type #33
      induced immunization #33
      rheumatoid joint #33
      arthritic mice #33
      cells dendritic cells #34
      joint pathology #34
      c4bp #34
      nox2 deficiency #34
      heterogeneous stock #34
      promiscuous expression #34
      chronic polyarthritis #34
      fpr1 #34
      neurodegeneration role #34
      patients animal models #34
      interferon activity #34
      natural antibodies nabs #34
      accessible sites #35
      complex arthritis #35
      arthritis disease #35
      destructive arthritis #35
      patients populations #35
      vdr cells #35
      psoriasiform skin #35
      triple helical #35
      hybridomas #35
      nets neutrophils #35
      monoclonal rheumatoid #35
      autoreactive #35
      antiarthritis #35
      major regulators #35
      antirat #35
      acs stroke #35
      infectious disease models #35
      phagotope #35
      1xi #35
      development chronic #35
      plasminogen deficiency #35
      female histocompatibility #36
      arthritis cartilage #36
      oxidases rna #36
      h2r #36
      induction tregs #36
      comparative genetics #36
      animals antigen #36
      protein specific #36
      variance animals antibodies #36
      flow cytometry expression #36
      nk cells recognition #36
      cartilage joints #36
      dth #36
      h2g7 #36
      dinitro1 #36
      phagocyte #36
      tolerance tlymphocytes #36
      techniques mice #36
      cii cfa #36
      specificity sera #36
      immunopathological features #37
      acpa positive #37
      lymphocytes disease #37
      synthetic glycopeptides #37
      genetic control #37
      encephalomyelitis #37
      joint cartilage #37
      susceptibility autoimmune diseases #37
      mif pathogenesis #37
      dba1 #37
      oxidases oxidation #37
      recombinant vaccine #37
      spontaneous arthritis #37
      role gamma interferon #37
      rich lipid #37
      peptides binding #37
      cii protein #37
      c129 #37
      target autoantigens #38
      snat #38
      sialophorin #38
      human blood neutrophils #38
      antibodies animals #38
      innovative tools #38
      cochranmantelhaenszel test #38
      animal models pain #38
      nitrogen species #38
      cldn4 #38
      resultsrats #39
      measurement activity #39
      cell tolerance #39
      autoreactive cells #39
      nzw #39
      ccia #39
      ym1 #39
      allogeneically #39
      clonal expansion cells #39
      oestrogen treatment #39
      wasting syndrome #39
      b6n #39
      data myelin #39
      endoβnacetylglucosaminidase #39
      acpa response #39
      benoist #39
      nfr #39
      isostere #40
      antigens arthritis #40
      polyclonal cell activation #40
      addition impact #40
      peptide cell #40
      disease animal models #40
      positive rheumatoid #40
      adjuvant induced #40
      genetic complexity #40
      rt1c #40
      rats anti #41
      priming phase #41
      genes loci #41
      autoimmune inflammatory diseases #41
      ncii #41
      congenic mapping #41
      severity incidence #41
      aq #41
      rat myelin #41
      mhc haplotype #41
      immunocap isac #41
      effects experiments #41
      autoimmune #41
      antibody isotypes #42
      drb1 shared #42
      species receptors #42
      p38 mapk nfκb #42
      expected onset #42
      spleen weight #42
      ptpn22 locus #42
      cartilage bone destruction #42
      th17 axis #42
      articular collagen #42
      mhc class class #42
      fibroblasts mice #42
      pineal gland melatonin #42
      congeneic #43
      cd11bly6g #43
      crosses genetic #43
      mice autoimmune #43
      immunodominant epitopes #43
      type‐ii #43
      lew rats #43
      arthritis data #43
      rats sex #43
      anticitrullinated #43
      collagen #43
      kgf treatment #43
      spinal glia #43
      treatment autoimmune diseases #43
      anticyclic #43
      pc8 #43
      autoreactive cell #43
      lew lymphocytes #43
      neuritis ean #44
      provocations #44
      inflammation animals #44
      mice adulthood #44
      chloro23 #44
      addition order #44
      c4bbinding protein c4bp #44
      homozygous form #44
      genetic linkage analysis #44
      mathis #44
      peptide induced #44
      epitopes lymphocyte #44
      defensins humans #44
      mice mice autoimmune #44
      outbred rats #45
      relapsing disease #45
      susceptibility arthritis #45
      genetic encoding #45
      chromosome development #45
      nzb #45
      phagotopes #45
      potent suppression #45
      disease histocompatibility #45
      rat2 #46
      carp antibodies #46
      lower severity #46
      neuritis autoimmune #46
      affinity purified #46
      mhc class humans #46
      specific tolerance #46
      isosteres #46
      posttranslationally #46
      c227 #46
      alphachains #46
      locus controlling #46
      cocrystallisation #46
      disease induction #46
      eae mbp #46
      idiotypic antibody #47
      f1 hybrid mice #47
      protective allele #47
      posttranslational rats receptors #47
      association hladrb1 alleles #47
      antibody reactivities #47
      rheumatoid factors #47
      intercrosses #47
      complex mediated #47
      diagnostic accuracy diagnosis #47
      synovial lining layer #48
      cia rats #48
      tlr12 #48
      f1 crosses #48
      peptide recognized #48
      mice nzb #48
      humanized model #48
      γchains #48
      experimental arthritis mice #48
      mice carrying #48
      acetylchitobiose #48
      collagen peptide #48
      antibody specificity #48
      collagen glycosylation #48
      lupus disease #48
      immune nervous #49
      tcell stimulation #49
      experimental crosses #49
      polyvinylcaprolactam #49
      monoclonal autoimmune diseases #49
      class major #49
      histone hdacs #49
      mice caia #49
      comp levels #49
      sex genes #49
      mouse cartilage #49
      bystander activation #49
      mice tolerance #50
      ciiia #50
      loci animals #50
      glutamine uptake #50
      complex region #50
      animal cell culture #50
      antigenantibody #50
      alagly #50
      dependent chronic #50
      disease rats #50
      monoclonal epitopes #50
      inflammation kynurenine #50
      anticarbamylated protein #50
      cytometry analyses #50
      parathyroid cells #50
      glycosylated form #50
      tolerized #51
      rheumatoid factor activity #51
      runting #51
      autoantibodies rheumatoid arthritis #51
      evidence animal models #51
      fewer cells #51
      delayed immunization #51
      antibodies cells #51
      tracheal cartilage #51
      cells ova #51
      derived type #51
      c57bl 6j background #51
      aire mice #51
      lentiviral particles #51
      inbred c57bl autoimmune #51
      xor activity #52
      matrix protein #52
      macrophages skin #52
      antigenpresenting cells #52
      model collagen #52
      ptpn22 #52
      melatonin day #53
      arthritis induction #53
      aged peptides #53
      physiological doses #53
      antibodies epitopes #53
      gastric parietal cell #53
      cartilage erosion #53
      patients rheumatic conditions #53
      lysosomal compartments #53
      carbamylated proteins #53
      protein antibodies #53
      production reactive #53
      triple helical structure #53
      induced autoimmunity #53
      major epitope #54
      yaa #54
      crossbreeding #54
      melatonin animals #54
      carbamylated protein #54
      strain rats #54
      animals autoimmune #54
      predating #54
      imitating #54
      antigens myelomonocytic arthritis #54
      rats social isolation #54
      development individuals #54
      nodes lymphocyte #54
      susceptibility autoimmune disease #55
      macrophage mannose receptor #55
      inflammatory manifestations #55
      arthritis genetic #55
      autoimmune nzb #55
      complex genetic disease #55
      autoimmune reactions #55
      cells salivary #56
      selfreactive cells #56
      animals antibody #56
      labels superoxide #56
      alpha1microglobulin #56
      new animal #56
      mhc #56
      arthritis pathogenesis #57
      antibodies #57
      collagen sequence #57
      cd1 mice #57
      antibodies bind #57
      igg abs #57
      vivo depletion #57
      animals antirheumatic #57
      development autoimmune #57
      oestrogen progesterone #58
      schafer #58
      peptide response #58
      rat type #58
      chronic eae #58
      urokinase activity #58
      resistance eae #59
      anticarp antibodies #59
      genes mhc #59
      hydroxylase diet #59
      encephalitogenicity #59
      oligoclonal igg bands #59
      cartilage matrix protein #59
      anti cell #59
      anti cd8 #59
      articular joints #59
      hpaaxis #60
      alternative activation macrophages #60
      macrophage mannose #60
      protein peptide #60
      dichotomous effects #60
      immunohistopathology #60
      inflammatory cells macrophages #60
      assay epitopes #60
      joint erosions #60
      experimental evoked potentials #61
      serum comp #61
      differentiation myelomonocytic arthritis #61
      cells innate immune #61
      incidence severity #61
      epitope spreading #61
      experimental rats rats #61
      species reactive #61
      major histocompatibility #61
      alpha1m #61
      basic characterization #62
      toxin1 #62
      mice susceptibility #62
      placenta uterus #62
      syngeneically #62
      reduced oxidative #62
      interferon‐β #62
      adaptive immune #62
      cyclic sensitivity #62
      antigens class histocompatibility #62
      fpr2 #62
      autoantibody formation #62
      specificity tumor #63
      delayed interferon #63
      collagen cell #63
      peptide specific #63
      induced experimental #63
      post‐partum #63
      igaproducing cells #63
      mice polyi #63
      duval #63
      specific stages #63
      rats strain #63
      hypersensitivity dth #63
      constant darkness #63
      mog1 #63
      protein disease #63
      glycoprotein myelin #63
      nadph oxidases #63
      transfer animals #63
      lower capacity #64
      maternal origin #64
      tolerance model #64
      secondary immune #64
      freund adjuvant #64
      role apc #64
      flss #65
      induced suppression #65
      histocompatibility complex #65
      autoimmunity humans #65
      major subset #65
      hindpaws #65
      weight variation #65
      model chronic #65
      thy1 antigen #66
      hladr2 #66
      chromosomes mammalian #66
      spontaneous disease #66
      acute arthritis #66
      resemblances #66
      negative rheumatoid #66
      phagocytosis oxidative burst #66
      multispecificity #66
      rheumatoid synovial cells #66
      peripheral joints #66
      experimental lymphocytes #66
      fibrinogen genotype #67
      rheumatoid arthritis susceptibility #67
      development cell #67
      experimental encephalomyelitis #67
      myelomonocytic arthritis #67
      dendritic cells epitopes #67
      strains susceptible #67
      mice cell #67
      mice induced #67
      endos #67
      key interactions #67
      experimental allergic #67
      complex class #68
      individuals positive #68
      anti carp #68
      class region #68
      female sex hormones #68
      rheumatoid chromosomes #68
      frequent infections #68
      sodium diethyldithiocarbamate #68
      helper phenotype #68
      cells mhc class #68
      tolerized mice #68
      severity periodontitis #68
      iggrf #68
      frequency antibodies #69
      vertebrate immune #69
      lymphocytes chronic #69
      rheumatoid disease #69
      cells mouse #69
      relapsing #69
      direct damage #69
      zap‐70 #69
      mrl mice #70
      immunoglobulin interferon #70
      presence rheumatoid factor #70
      response type #70
      role cells #70
      translationally #70
      prolonged graft survival #70
      swr #71
      expression pparγ #71
      susceptibility female #71
      cartilage mice #71
      ztm #71
      human psoriasis #71
      cb10 #71
      isolated rats #71
      naïve mice #72
      delayedtype hypersensitivity dth #72
      antibodies binding #72
      autoimmunity lymphocytes #72
      interphalangeal joints #72
      dark agouti rats #72
      study antibodies #72
      lathyritic #72
      napdh #72
      species ros #73
      oxidase complex #73
      type ifn signature #73
      environmental lighting #73
      mrl lpr #73
      membrane animals #73
      bovine type #73
      treatment stages #73
      knockout protein processing #73
      cartilage explants #74
      pregnancyinduced #74
      peptides sequences #74
      antigens class #74
      hypersensitivity delayed #74
      igarf #74
      genetic disease models #75
      dth mice #75
      diabetes arthritis #75
      effects development #75
      inbred dba receptors #75
      oestradiol #75
      acpapositive #75
      cell reactivity #75
      type collagens #76
      anti carbamylated #76
      rat splenocytes #76
      disease rheumatoid arthritis #76
      peptide mhc #76
      cell deficient #77
      nerve conduction velocity #77
      rt1n #77
      oligomeric #77
      regulatory vaccines #77
      lpr mrl #77
      pain inflammation #77
      development insulitis #77
      inbred mouse strains #77
      cyp7a1 #77
      eae induced #77
      rats eae #77
      new animal model #77
      collagen chains #77
      clinical arthritis #78
      cartilage integrity #78
      rats respiratory #78
      autoantigenic #78
      mhc expression #78
      pythons #78
      pathogenesis rheumatoid arthritis #78
      inflammatory autoimmune #79
      susceptibility disease #79
      autoimmune experimental epitopes #79
      1ii #79
      mononuclear lung #79
      shared epitope #79
      chromosome study #80
      oxidases #80
      detection autoantibodies #80
      erosive arthritis #80
      arthritis cells #81
      sex linkage #81
      inflammatory phase #81
      expression ll37 #81
      class antigen expression #81
      aspartic acid position #81
      spleen study #81
      hnrnpa2 #81
      type macrophages #81
      mog mbp #81
      estrogen suppression #81
      induced leukocyte #81
      mhcii expression #81
      mrl mp #81
      dr1 antigen #81
      14weeks #82
      pannus formation #82
      nadphoxidase #82
      expression mhc #83
      bcg infection #83
      tlymphocyte genes #83
      cell independent #83
      drug encephalomyelitis #83
      mice igg #83
      strains animals #84
      arthritis day #84
      multiple sclerosis evidence #84
      epidermal cells #84
      spontaneous development #84
      rat cardiac allografts #84
      naïve cells #84
      reactive cells #84
      antiifngamma #85
      homopentamer #85
      class molecule #85
      inflammation joint #85
      inflammation joints #85
      cells recognize #85
      knockout receptors #85
      preclinical stage #86
      anti cd4 #86
      gfoger #86
      contribution genes #86
      classical humans #86
      severe eae #86
      mutant strains #86
      animal humans #86
      phagocyte nadph #86
      monoclonal antibodies mab #86
      mhc class gene #87
      estrogen induced #87
      alpha1acid glycoprotein #87
      inbred rat strains #87
      smash #87
      copy variation #88
      narac #88
      thps #88
      inguinal lymph nodes #88
      levels anti #88
      fine specificities #88
      arthritic #89
      peptide immunization #89
      depletion cd8 cells #89
      mice antibodies #89
      experimental autoimmune #89
      mabs mab #89
      genetic quantitative #89
      monkeys mice #90
      mediated mechanisms #90
      ilc2 activation #90
      rheumatoid arthritis cells #90
      adjuvant arthritis #90
      genistein treatment #90
      susceptible #90
      autoimmune inbred c57bl #90
      pineal hormone melatonin #90
      arthritis compared #90
      protein induced #91
      cattle collagen #91
      activation cd4 cells #91
      histological sections #91
      synovial fluid serum #91
      backgroundan #91
      cells apc #91
      nod mhc #92
      abdominal region #92
      experimental mouse models #92
      difco #92
      humans immunodominant #92
      anticitrullinated protein #92
      knockout myelin #93
      290 patients #93
      mice melatonin #93
      natural polymorphisms #93
      cellspecific #93
      animals autoantibodies #93
      xor #93
      fcγrs #94
      macrophages development #94
      endosomal acidification #94
      activated cells cells #94
      galactosylated #94
      autosomal genes #94
      moderateintensity exercise #95
      binding integrins #95
      chronic phase disease #95
      induced sarcoma #95
      cell alpha #96
      data rats #96
      lung emphysema #96
      romani #96
      pregnancy disease #96
      ifnbeta #96
      nonglycosylated #96
      messenger tolllike receptor #96
      macrophages stimulation #96
      fetal rejection #96
      complex mice #97
      macrophages fibroblasts #97
      antiimmunoglobulin #97
      cathelicidins #97
      rheumatoid lymphocytes #97
      il33r #97
      hydroxylysine #97
      citrullinated fibrinogen #97
      genetic female genes #97
      acpa igg #98
      swr mice #98
      rheumatoid cartilage #98
      autoimmune rats #98
      autoimmune experimental #98
      ean #98
      collagen cytokines #99
      rat chromosomes #99
      interleukin‐4 #99
      alternative pathways #99
      inducer animals #100
      cultured crosses #100
      tlymphocyte immunity #100
      protein antibody #100
      ccp anti #100
      invading pathogens #100
      peptides cells #100
      thy1 antigens #100
      tap2 #100
      rats monoclonal antibodies #100
      bone degradation #101
      safety drugs #101
      singlenucleotide polymorphism #101
      diarthrodial #101
      eira #101
      fprs #101
      cell determinants #101
      susceptible strain #101
      brucei infection #102
      mouse monoclonal antibodies #102
      candidate autoantigen #102
      eae animal encephalomyelitis #102
      findings treatment #102
      agalactosyl #103
      ros homeostasis #103
      oxidative burst #103
      hla dr1 #103
      pathogenesis emphysema #103
      drb10401 #103
      mhcii #104
      male mice mice #104
      skg mice #104
      mutation mice #104
      f1 males #104
      synchrotron infrared #104
      thelper cells #104
      arthritic disease #104
      haplotypes histocompatibility #104
      nonarthritic #104
      fcγr #105
      vivo macrophages #105
      osteoclasts mice #105
      dmaam #105
      type 22 #105
      development antibodies #105
      hybridoma cell #105
      autoreactivity #105
      arthritis hla #106
      proteoglycan loss #106
      tcell immunity #106
      disease dose #106
      273 #106
      primed cells #106
      limited cross #106
      cells synovial #107
      c3h mice #107
      nzb mice #107
      study tolerance #108
      development autoimmune disease #108
      fpr #108
      littermates #108
      structural polymorphism #109
      citrullinated proteins #109
      presentation cells #109
      delayedtype hypersensitivity #109
      autoantibodies autoantigens #109
      reactive cell #109
      enthesophytes #109
      type hypersensitivity #109
      monoclonal igg #109
      carcinoma tumors #110
      autoimmune encephalomyelitis #110
      streptococcal cell wall #111
      inbred dba microscopy #111
      experimental female #111
      backcross #111
      toxic shock syndrome #111
      mog eae #111
      dba 1j mice #111
      female hypersensitivity #111
      cartilage #111
      anti idiotypic antibodies #112
      alphabeta receptors antigen #112
      humoral autoimmunity #112
      amide bond #112
      presymptomatic individuals #112
      extensive literature search #112
      trait loci #113
      xid mice #113
      restricted cell #113
      autoimmune c57bl mice #113
      mice collageninduced arthritis #113
      db1 #113
      adjuvant properties #113
      oligoclonality #113
      tcra #113
      ifngammaproducing cells #114
      adjuvantinduced arthritis #114
      anti mcv #115
      autoantigens autoimmunity #115
      proinflammatory cytokine #115
      mice disease #115
      rats collagen #115
      drb10402 #115
      ccp patients #116
      susceptibility eae #116
      experimental epitopes #116
      transgenic peptides receptors #116
      lutz #116
      pathogenesis autoimmune diseases #116
      immunosorbents #116
      lymphocyte female #116
      glyco #116
      glycopeptides #116
      antibodies reactive #117
      mice type #117
      fluorescence nf #117
      antiarthritic #117
      congenic lines #117
      encephalomyelitis autoimmune #117
      tolerance induced #117
      samples individuals #118
      myelin oligodendrocyte #118
      rats immunized #118
      class expression #118
      psoriasiform dermatitis #118
      pineal hormone #118
      alpha1acid #118
      α enolase #118
      psa rheumatoid arthritis #119
      rheumatoid arthritis review #119
      response cells #119
      radiological damage #119
      05m #119
      cd4 tcells #119
      neutrophils nets #120
      protein mbp #120
      vivo animal models #121
      experimental animal models #121
      chondrocyte cultures #121
      genes age #122
      immune complex deposition #122
      t‐lymphocyte #122
      transgenic neurons receptors #122
      acpa negative #122
      treatment progesterone #122
      patients acpa #122
      transfer arthritis #122
      pharmacological potential #122
      c5b #123
      type cytokines #123
      symptoms associations #123
      nox2 activation #123
      cell monoclonal #123
      alphabeta cells #123
      cartilage surface #124
      inbred mouse #124
      tlr4 stimulation #124
      preimmunized #125
      oxidases neutrophils #125
      helperinducer #125
      genetic rats #125
      general mechanisms #125
      disease mechanisms #125
      allelic variations #125
      blocking antigens #125
      qtl genes #125
      cryogel #125
      immunodominant peptide #125
      female immunization #126
      nzb nzw #126
      pnipaam #126
      nonobese diabetic #126
      cyclic polymorphism #126
      atp8 #127
      animal enzyme #127
      absence cells #127
      knockout murine #127
      microarray detection #127
      lining layer #128
      anticitrullinated peptide #128
      deiminases #128
      chronic inflammatory disease #128
      dominant epitope #128
      rats patients #129
      bxsb #129
      multiple epitopes #129
      spleen rats #129
      nos2 #130
      vivo absence #130
      disease induced #130
      oestradiol testosterone #130
      cells eae #130
      psd1 #130
      epitope specific #131
      lipomannan #131
      onset arthritis #131
      intercross #132
      induction regulatory cells #132
      disease cgd #132
      mineral oils #132
      kgf #132
      pronociceptive #132
      linomide #132
      reduced severity #133
      rat chromosome #133
      leukosialin #133
      ggaa #133
      myocellular #134
      eae #134
      plasma synovial fluid #134
      interstitial collagens #134
      patients cytokines #134
      accentuate #134
      mice estrogen #134
      knockout receptors antigen #134
      species animals #134
      peptides cyclic #135
      spinal glial #135
      igg immune complexes #135
      intracellular reactive #136
      chronic autoimmune disease #136
      macrophages dendritic #136
      immunizing #136
      stimulated muscle #137
      innate lymphocytes #137
      immunopathological #137
      receptor upregulation #137
      mice deficient #138
      ditiocarb #138
      control development #139
      dmannitol #139
      immunomodulatory drug #139
      autoimmune mice #139
      tcrdelta #140
      thermoresponsive polymer #141
      oligoclonal expansion #141
      producing cell #141
      or113 #142
      single subcutaneous injection #142
      rejection tolerance #142
      smfish #142
      gamma lymphocyte #142
      genetic factors development #142
      interferon‐γ #142
      phadia #142
      tcell alphabeta receptors #143
      mice beta #143
      class haplotypes #143
      cell hybridoma #143
      phosphate isomerase #143
      mhc haplotypes #144
      synovial hyperplasia #144
      rat strains #144
      rheumatoid arthritis #144
      tnf production #145
      inbred buf rats #145
      severe chronic #145
      treatment ici #145
      syngenic #145
      tcr gamma delta #145
      lyme arthritis #145
      rats induced #146
      neonatal growth #146
      function cells #147
      systemic challenge #147
      cellular heterogeneity #147
      pregnancy levels #147
      ccp antibodies #147
      gammainterferon #147
      α2i #148
      redox regulation #148
      interestingly #148
      autoimmune disease #148
      phagocyte nadph oxidase #148
      cell surface antigen #148
      complex diseases #149
      human autoimmune diseases #149
      drb104 #150
      mhc binding #150
      larsen score #150
      humans hybridomas #151
      epicutaneously #151
      mice animals #151
      receptor rats #151
      differential gene expression #151
      levels antibodies #151
      alphabeta receptors #152
      key player #153
      levels pregnancy #153
      arthritic animals #153
      mononuclear cells #153
      pepsin #153
      fcgammar #154
      expression class #154
      daf1 #154
      c4bbinding protein #154
      selfpeptides #154
      critical event #154
      joint inflammation #154
      immune priming #154
      male rats rats #154
      autoantibodies autoimmune #155
      infiltrating cells #155
      f1 mice #155
      arthritis rheumatoid #155
      padi4 #155
      mace acs #155
      serum synovial fluid #155
      suppressive role #156
      mhc region #156
      specificities #156
      stabilin1 #156
      downstream signals #157
      murine keratinocytes #157
      adjuvanticity #157
      genetic diabetes mellitus #158
      analysis structure #158
      hypersensitivity reaction #158
      parentals #158
      arthritis infectious #159
      systemic mice mice #159
      meaib #159
      animals autoimmunity #159
      consensus motif #159
      inbred c3h mice #159
      factors anti #161
      knockout severity #161
      gamma interferon #161
      specific autoimmunity #161
      day onset #161
      nursed #161
      benzylated #161
      epitope #162
      anti ccp #162
      βarrestin recruitment #162
      cd152 #162
      psors1 #162
      arthritis inflammation #162
      rheumatoid autoantigens #162
      binding collagen #162
      onset disease #163
      chains humans #163
      laboratory rats #163
      mouse type #163
      endobetanacetylglucosaminidase #164
      genes qtl #164
      striking similarities #164
      rats induction #164
      agalactosyl igg #164
      autoantibody responses #164
      progesterone effects #164
      mrl #164
      cells macrophages #165
      animal humans immunity #165
      nonimmunized #166
      epitope alleles #166
      tolerance induction #166
      pathogenic pathways #166
      melatonin mice mice #166
      human autoimmunity #167
      tlymphocyte humans #167
      ag7 #167
      class mice #167
      nox2 #167
      seronegative #167
      cd1 #168
      genetic backgrounds #168
      phase disease #168
      mice cd4 cells #168
      denoted #169
      oxazole #169
      acpa levels #169
      p12 #169
      pathogenesis arthritis #170
      joints male #170
      cryogels #170
      inherited disorder #170
      mirp #170
      experimental animal #170
      lymph node cells #170
      oxazolone #171
      encephalomyelitis eae #171
      ros nitric oxide #171
      autoimmune eae #172
      single nucleotide polymorphism #172
      autoimmunity cell #172
      rat placenta #172
      peripheral lymphoid organs #172
      rheumatoid #172
      lst1 #172
      sod3 #173
      monoclonal autoantibodies #173
      inbred dba models #173
      resistant rats #174
      presence autoantibodies #174
      class gene #174
      studies pain #174
      nasal cartilage #174
      ifn signature #175
      understanding pathogenesis #175
      maternal decidua #175
      mice mutation #175
      skin disease #176
      secondary challenge #176
      strains molecular #176
      new mouse model #176
      mammalian crosses #176
      tryptophan catabolism #176
      moab #176
      lymphotoxinα #177
      ctla‐4 #178
      hladrb1 alleles #178
      histocompatibility #178
      protein anti #179
      nod genes #179
      alternative pathway complement #179
      dextran sulphate sodium #179
      mice role #179
      immunized #179
      arthritis methods #180
      cgd patients #180
      complex disease #180
      epitopes female #180
      molecular adaptations #181
      alleles arthritis #181
      autoimmunity disease #181
      genetic influence #181
      hormone melatonin #182
      arginine deiminases #182
      immunoglobulin mice mice #185
      rats reactive #186
      cells lymph nodes #186
      antigen processing presentation #186
      multistep process #186
      drb1 chains #187
      b10 #187
      dba #187
      tcell recognition #187
      substrains #188
      chondritis #188
      molecular peptide #188
      cells disease #189
      mtec #189
      synovial membranes #190
      positionally #190
      inflamed joint #190
      hnrnpa2b1 #190
      oligodendrocyte glycoprotein #191
      autoantibody profiles #192
      ly1 #192
      cross‐reactivity #192
      passive mice mice #193
      fmlf #193
      proteins myelin #194
      glycoprotein peptide #194
      cyclic predictive #194
      perpetuate #195
      mhv #195
      mice mutant #195
      chapter 16 #195
      mhc class expression #196
      tcell response #196
      oophorectomized #196
      lewis rat #196
      myelin glycoprotein #196
      pannus #197
      acutephase response #197
      evidence development #197
      multiplex assay #197
      igmrf #198
      early appearance #198
      swedish patients #198
      genetic links #198
      interleukin17 #199
      dr4 antigen #199
      rat genome #199
      hla association #200
      citrullinated peptide #200
      cell collagen #200
      pathogenesis autoimmune #201
      myelin proteolipid protein #202
      instigation #202
      dendritic cells macrophages #202
      acpa status #202
      myelin proteins myelin #202
      complete elimination #203
      mice cells #203
      2 complex #204
      spleen staining #204
      class molecules #204
      immunization immunoglobulin #204
      nonparametric tlymphocytes #205
      macrophages mice #205
      dth response #205
      suppresses #205
      ides #205
      native collagen #205
      defb4 #206
      betaestradiol #206
      wild rats #206
      interleukin4 mice mice #207
      desmoglein 3 #207
      noxs #207
      mice peptide #207
      alternative complement pathway #207
      insulitis diabetes #207
      intranasal challenge #207
      parental strains #207
      induced upregulation #207
      immunization mice #208
      vivo patients #208
      naive mice #208
      highest probability #208
      antigen presenting #208
      severity disease #208
      cotwins #209
      immunoglobulin vh #209
      disease rheumatoid #209
      valuable tools #210
      highfatdiet #210
      vav1 #210
      specific antibodies #210
      susceptible strains #210
      citrullinated vimentin #210
      glucose6 phosphate #211
      hla dr4 #211
      diseases genetic #211
      natural antibodies #211
      purified protein derivative #211
      large numbers #212
      association rheumatoid arthritis #212
      cells immobilized #212
      psoriasiform #213
      antibody binding #213
      mice injected #213
      tsst1 #214
      mhc class antigens #215
      antigen induced #215
      central tolerance #215
      cytofluorometric #215
      triethylsilane #215
      inbred rat #215
      training hiit #216
      lower level #216
      dissect #216
      lentiviral vector #217
      rats immunization #217
      joints mice #217
      induced autoimmune #217
      inflammatory infiltrates #217
      resistant strain #217
      cd23 #217
      treatment onset #218
      antigen tcell #218
      granuloma formation #219
      peptide antibodies #219
      k8 #219
      fcrγ #219
      autoimmunity #219
      cells autoimmune #220
      bone erosions #220
      hyl #220
      peptidylarginine deiminases #220
      targeted deletion #221
      redox signaling #221
      pinealectomy #221
      cells dendritic #221
      agouti rats #221
      cyclosporin treatment #221
      fine specificity #221
      rheumatoid factor #221
      wkymvm #222
      thymectomized #222
      monoclonal antigens differentiation #222
      cybb #222
      cartilage damage #222
      carbamylated #223
      igg2a #223
      multiplex #223
      experimental autoimmune neuritis #223
      inflammation vivo #224
      expressing #224
      established disease #225
      cells antigen #225
      interleukin‐10 #225
      lew #225
      clinical scoring #225
      pathogenic antibodies #226
      disease locus #226
      macrophagelike cells #227
      j1 #227
      arthritis objective #228
      delayed type hypersensitivity #228
      presenting cells #228
      cell selection #229
      presence anti #229
      site inflammation #230
      eae rats #230
      human rheumatoid #231
      ls1 #231
      reactive oxygen #232
      monoclonal immunohistochemistry #232
      production ros #233
      ameliorated #233
      synovial joints #233
      lack expression #233
      role eosinophils #233
      centimorgan #234
      lower numbers #234
      staphylococcal infection #235
      chromosome 14 #235
      chronic psychosocial stress #235
      mhc gene #235
      specificity animals #236
      immune complex #236
      control strain #237
      pathological mechanisms #237
      progression arthritis #238
      autoimmune chronic #238
      trait locus #239
      c5 #239
      inbred dba tlymphocytes #240
      study plasma #241
      strong influence #242
      joint pain #242
      positive anti #243
      protected #243
      class genetic #243
      multicomponent #243
      hla drb1 #243
      monoclonal antigen #243
      common denominator #244
      treatment autoimmune #244
      crosses #244
      estrus cycle #244
      cutaneous infection #244
      inflammation cartilage #244
      binding antibodies #245
      allelic differences #246
      rt1l #246
      development emphysema #246
      antibody response #247
      normal cartilage #247
      antibodies anti #247
      inbred strain #247
      new model #247
      florescence #247
      activity assays #248
      efficient expression #248
      induced chronic #249
      oxygen species #249
      fragments rats #250
      picryl #250
      node cells #250
      mouse rat #250
      arthritic joints #250
      inflammation score #250
      hyperinflammation #251
      develops #251
      treatment rats #251
      conditional knockout mice #251
      nadph oxidase #251
      role model #252
      response disease #252
      mice lymphocytes #252
      mice lack #252
      dark agouti #252
      cartilage matrix #254
      lpr mice #254
      proteins glycoproteins #254
      dinitrofluorobenzene #254
      lacking #254
      onset clinical #254
      class mhc #254
      inbred c3h #255
      autoimmune response #255
      specific neutralizing #256
      specific subgroups #256
      inflammatory disorder #256
      anti arthritic #256
      postmenopausal bone #256
      disease cell #257
      additive interaction #258
      class mhc molecules #259
      relationship immunologic #260
      mir144 #260
      chronic granulomatous #260
      denatured #261
      mice expressing #261
      secondary osteoporosis #261
      mediated suppression #261
      autoimmune neuritis #261
      lymphocytes helper #261
      immunologic animals #262
      selfantigen #263
      genetic techniques #265
      crossreactive #265
      primary immunization #265
      pregnancy mice #265
      tolerance mice #265
      mouse strain #265
      cysteine proteases #267
      antigen specific #267
      rats animals #267
      vim2 #267
      lentiviral gene #268
      posttranslational modifications #268
      xid #268
      mann whitney #269
      pathogenic roles #269
      oxpl #270
      complement c5 #270
      castrated #271
      monosodium urate crystals #271
      melatonin effects #271
      selfantigens #271
      amino acid transporters #273
      experimental model #273
      lewis rats #274
      nasally #275
      tcells #275
      inhibitory peptide #275
      hdac1 #275
      synovial lining #275
      fcgr3b #276
      macrophages dendritic cells #276
      producing cells #277
      deiminase type #277
      rheumatoid arthritis association #277
      viral female hepatitis #277
      metabolic properties #278
      recognize #278
      interferongamma #279
      colon length #279
      gp70 #279
      dinucleotide phosphate #280
      induced tolerance #280
      immunological receptors antigen #281
      recipient mice #281
      inflammatory conditions #281
      neonatal mice #281
      passive transfer #281
      hemiacetal #282
      isoflavone genistein #283
      disease susceptibility #283
      factor production #283
      inbred nod #283
      igg2b #283
      aire #284
      increased serum levels #284
      severe colitis #284
      helper inducer #284
      complete protection #285
      endophilin #285
      idiotope #285
      theilovirus #285
      maintained #285
      aureus strain #285
      publication animals antibodies #285
      emulsified #286
      hla dr2 #287
      melatonin release #288
      melatonin mice #288
      antibody production #288
      tlr9 mice #288
      myelin basic protein #288
      cells autoimmunity #289
      mice immunized #289
      disease cells #291
      synovial cells #291
      ctla4 expression #291
      rheumatic conditions #292
      autoimmune mechanisms #292
      increased copy #293
      cytokines disease #293
      induced ros #293
      collagen receptors #293
      mouse genes #294
      unique model #294
      c3h #295
      antigen processing #295
      c57bl 6 mice #295
      gastric parietal #295
      nerve conduction #296
      6week #296
      tissue‐specific #296
      immunological receptors #296
      murine dendritic cells #297
      helical peptides #297
      dnfb #297
      phosphopyruvate #297
      ppad #298
      vivo imaging #298
      gene selection #298
      cd19 cells #298
      citrullination #299
      transplantation antigens #299
      solidphase synthesis #299
      tcr beta #300
      neutrophil extracellular traps #301
      posttranslational rats #301
      draining lymph #302
      peptide antibody #302
      alphabeta #302
      extraembryonic tissues #302
      epidemiological investigation #303
      pathogeneses #303
      strains mice #303
      animals antibodies #303
      1 interferon #303
      conditioned disease models #304
      cgd #304
      autoimmune diseases #304
      igg glycosylation #304
      cells tcr #305
      cartilage development #305
      immunological function #305
      mutant strains mice #305
      immunological studies #306
      gammaifn #306
      murine colitis #306
      αgalcer #306
      hcdr3 #306
      class histocompatibility #307
      inpp4b #307
      immunisation #307
      basal metabolic rate #308
      basal metabolic #309
      chromosome 10 #309
      arthritis study #310
      articular cattle cells #310
      multiple sclerosis eae #311
      perpetuation #311
      synthetic peptide #312
      disease symptoms #312
      alleles animals #312
      inflamed joints #312
      exuberant #313
      c3bi #313
      epitopes #313
      induced colitis #314
      activatory #314
      intradermally #315
      mice genes #315
      r620w #315
      trypanosoma brucei brucei #316
      onset rheumatoid #318
      classical risk factors #318
      genetic interactions #319
      galactosyl #319
      tubule cells #319
      spleen bone marrow #320
      genomewide linkage analysis #320
      deiminase #320
      mice subjected #320
      il21r #323
      cells specific #323
      impact disease #324
      ccp1 #324
      expressing human #324
      daf2 #324
      expression cells #325
      rat gene #325
      specific cell #325
      surprisingly #326
      resembles #327
      mgps #327
      c57bl mice #328
      allelic variant #328
      constant light #329
      immunoenzyme #329
      publication adjuvants #329
      complex genes #330
      early arthritis #331
      rheumatoid synovial #332
      fcgammariia #332
      glycoprotein mog #332
      nucleotide polymorphism #332
      mouse hepatitis virus #333
      anticcp #333
      35ssulfate #334
      susceptibility genes #335
      joint tissues #335
      mrl lpr mice #335
      autoimmune inflammation #336
      cell response #338
      epitope specificity #340
      cells spleen #340
      delayed onset #340
      rat #341
      adjuvants immunologic #341
      erosive #341
      activation macrophages #341
      ros oxygen species #341
      animal enzyme inhibitors #342
      specific autoimmune #342
      6weeks #342
      incident cardiovascular events #342
      rapid spread #343
      drb1 alleles #343
      diabetic mouse #343
      sequence animals #343
      rats injection #343
      182780 #344
      monoclonals #344
      acpa positivity #345
      favor #345
      energetic costs #346
      intraperitoneal injection #347
      pemphigus vulgaris pv #348
      reduced capacity #349
      neuritis #349
      complement activity #349
      igg autoantibodies #350
      phenotype rats #351
      thymic selection #352
      methylcholanthrene #352
      c3h hej #353
      immunoregulation #353
      anti cyclic #353
      mice induction #353
      autoantigens autoimmune #354
      arthritis synovial #354
      mice cd4 #354
      splenic macrophages #355
      dsg3 #357
      cells autoantibodies #358
      tbetarii #358
      adjuvant activity #358
      injected #359
      neuritogenic #359
      enos #359
      tcrbeta #360
      tlr3 #361
      pvg #361
      freund #361
      murine lupus #362
      hla transgenic #362
      allergic encephalomyelitis #363
      identification genes #363
      mouse chromosome #363
      generation ros #363
      determines #363
      cells anti #364
      hladr4 #364
      recognized #364
      sex chromosomes #366
      glycoproteins mice #366
      european journal #366
      immune deviation #366
      psychosocial stress #367
      antiidiotypic antibodies #367
      affinity ligand #368
      loci #368
      toxic shock #368
      100 micrograms #368
      ncf2 #368
      autoimmune responses #368
      histocompatibility antigens #369
      nasal administration #369
      pentameric #369
      immune pathogenesis #370
      increased production #370
      clinical onset #371
      regulate #371
      serum transfer #371
      role mif #372
      newborn antibodies #372
      alternative activation #373
      autoantigens #375
      rheumatoid cell #375
      undifferentiated arthritis #376
      acutephase proteins #376
      glucose6 #377
      gia #379
      reparixin #380
      mouse monoclonal antibody #381
      oxidase deficiency #381
      induced lupus #381
      fragments immunoglobulin #382
      fia #382
      granulomatous #383
      granulomatous disease #384
      specific loci #384
      naive rats #384
      c1a #384
      postmenopausal bone loss #385
      shock syndrome #385
      pc4 #386
      cell specificity #386
      antioxid #387
      ptpn22 gene #387
      filaggrin #387
      backcrosses #387
      phase response #388
      inbred nod receptors #388
      downregulating #389
      deficient #390
      ovulation rate #390
      greater 50 #390
      anaphylatoxin c5a #391
      peptidylarginine #391
      radiological progression #391
      finetune #392
      rf1 #394
      il4 il10 #394
      ameliorating #395
      draining #397
      induced metabolic #397
      autoantibody levels #397
      juvenile chronic arthritis #398
      immunized mice #399
      protein myelin #399
      regulation animals #399
      inflammatory reactions #400
      reactive oxygen species #400
      antibody formation #401
      genes cells #401
      biacore #403
      inflammation demyelination #403
      immunopeptidome #403
      beta chain #404
      fcγriib #404
      experimental #405
      basic protein #405
      effects models #407
      rheumatoid case #407
      n31 #407
      pam3csk4 #408
      major locus #409
      immunogenetics #409
      intracellular processing #410
      3hproline #410
      diabetes loci #410
      cd43 #412
      cell phenotypes #412
      hladrb1 #412
      titres #413
      susceptibility loci #413
      characteristic feature #414
      reproductive performance #414
      cultured collagen #415
      igk #415
      levels autoantibodies #416
      female mice #416
      synovial inflammation #417
      spontaneous mutation #417
      lupus mice #417
      genetically modified mice #418
      wtccc #419
      induced pain #419
      class hdacs #419
      molecular interactions #419
      hiit #420
      ameliorate #420
      tcell #421
      dr4 #422
      lower affinity #422
      lipidomic #423
      restricted #424
      subsets animals #424
      hyaline cartilage #425
      inflammatory cells #426
      regulatory animals #426
      congenic strain #426
      carbohydrate moiety #429
      epitopes humans #430
      nod mouse #430
      nonimmunogenic #430
      postimmunization #430
      immunoregulatory #431
      il10 mice #433
      patients healthy individuals #433
      cells antibodies #434
      spontaneous autoimmune #435
      factor 5 #435
      cells beta #436
      reactivities #436
      chromosomes chromosome #437
      decalcified #437
      crystallizable #437
      mass spectrometric analysis #437
      immunised #438
      specific antigens #438
      mice effects #438
      helperinducer tlymphocytes #438
      joint swelling #439
      cells #439
      wildtype mice #440
      nod #440
      female immunoglobulin #441
      normal rats rats #441
      vitro techniques leukocytes #441
      effector functions #441
      complete adjuvant #442
      mice activation #442
      patients population #442
      methylβcyclodextrin #443
      mhc class molecules #443
      myelin basic #444
      tlr2 expression #444
      genomewide scan #445
      systemic mice #445
      mice humans #445
      mouse models #445
      skeletal muscle function #445
      ros production #447
      inbred strains receptors #448
      control mice #448
      pain model #448
      induced mice #448
      synovial tissue #449
      tcell responses #449
      complement factor #449
      innate adaptive #450
      apcs #451
      igg anti #451
      heterologous #452
      hybridoma cells #452
      reduced production #452
      differs #454
      lglutamine #456
      cells chronic #456
      inbred c57bl tlymphocytes #457
      raloxifene #457
      eae cns #459
      rheumatoid cells #459
      resembling #459
      priming #459
      lung macrophages #459
      antibodies monoclonal #460
      neutrophil functions #462
      256 #462
      autoantigen #462
      gilt #463
      fab fragments #464
      autoantibody production #465
      receptor tcr #466
      salivary glands #466
      cells lymph #467
      earlier onset #469
      titers #469
      anticyclic citrullinated peptide #474
      disease mice #474
      antibody mediated #474
      arthritic rats #474
      cartilage cells #475
      human autoimmune #476
      cluster genes #477
      mice exhibited #477
      therapeutic vaccination #478
      mediated inflammation #478
      female hla #479
      apoptosis arthritis #479
      laboratory rat #479
      aggravated #480
      deacetylase 1 #480
      quantitative trait loci #480
      anti idiotypic #482
      polymorphonuclear cells #482
      immune reactions #484
      immunologists #485
      immunoglobulin male #486
      tcralpha #487
      jca #487
      controlling #487
      oxyntic #487
      specific immune #488
      invariant natural #488
      insulitis #488
      gland animals #489
      normal mice #490
      cytoplasmic calcium #494
      nacetylglucosaminidase #495
      h2b #496
      early rheumatoid #496
      reactive nitrogen #496
      gammadelta cells #496
      conclude #496
      mbp #498
      small effects #498
      receptor 9 #499
      biologicals #500
      autoreactive cd4 #503
      immunoenzyme techniques #503
      nadph #503
      pathogenic #506
      immunofluorescence analysis #507
      chondrocytes collagen #507
      isopropyl #508
      persistent pain #508
      mab mabs #508
      mineral oil #508
      gingipain #509
      immunization passive #509
      orosomucoid #509
      mhc class #510
      mice knockout mice #510
      812 #511
      systemic spread #511
      differential gene #511
      c3h hej mice #511
      deficient mice #511
      blymphocytes #512
      mrp8 #515
      hydroxyquinolines #517
      behavioral alterations #517
      antibody complex #518
      u1 #518
      chronic granulomatous disease #519
      suggestive linkage #519
      inflammation #519
      tcr recognition #520
      modified form #521
      dextran sulfate sodium #522
      ttg #522
      pcorr #522
      data peptide #523
      inflammation role #523
      encephalitogenic #524
      litter size #524
      p47phox #524
      neutrophil granulocytes #525
      mechanical hypersensitivity #526
      tconv #526
      mnc #526
      maternal antibodies #527
      disease acute #527
      spleen cells #527
      tolonium #528
      primed #528
      vaccinates #528
      larsen #528
      displayed #529
      tolllike receptor tlr4 #529
      ifa #529
      rat rats #529
      antigen presentation #530
      pathogenesis sle #530
      cell antibodies #530
      isac #530
      autoantibody #530
      ratg #531
      bred #532
      epistatic #532
      lyt2 #533
      complex role #533
      posttranslational receptors #534
      translational modification #536
      resorptions #536
      spleen lymphocytes #536
      urokinase #537
      synovial #537
      animals #538
      experimental rats #538
      cells inflammatory #538
      antigen recognition #540
      suppressive #540
      joints #540
      fibroblast synoviocytes #540
      membrane attack complex #541
      rheumatoid humans #543
      specific autoantibodies #544
      regulating #545
      protein tyrosine phosphatase #545
      hypomorphic #546
      animal gene #547
      shortcut #547
      tlymphocytes #547
      formyl peptide receptors #548
      entheses #548
      immunohistochemical methods #548
      mog #550
      immunoglobulin fab #552
      mixed lymphocyte reaction #553
      nox activity #554
      breeder #555
      beta animals #557
      stronger association #557
      cell epitopes #557
      cells control #558
      early onset #559
      healthy mice #560
      elispot assay #561
      transgenic molecular #562
      ptdins3p #563
      negative selection #563
      inbred strains #563
      neutrophil depletion #564
      deeper layers #565
      therapeutic treatment #565
      immunoglobulin heavy chains #566
      target tissue #566
      earlier #566
      darkness #566
      crucial #567
      outbred #568
      interferon signature #568
      disease loci #568
      cells pathogenesis #569
      mycobacteria #569
      neutrophilia #569
      concomitantly #570
      mice compared #571
      transgenic mouse models #572
      btla #572
      keratin8 #573
      col2 #574
      presenting #576
      pepstatins #576
      estrogen treatment #577
      terpenes #577
      keratinocyte growth factor #578
      prolactin prl #578
      ptm #579
      sera patients #579
      triple helix #580
      methotrexate mice #581
      f1 hybrids #581
      inflammatory joint #583
      production ifngamma #583
      hybridoma #583
      lymphocyte antigens #584
      time onset #584
      exaggerated #584
      antibody reactions #585
      traps nets #590
      environmental triggers #591
      antigen antibody #591
      immunological tolerance #592
      lxrα #592
      oligoclonal #592
      transgenic models #593
      noncollagenous #593
      macrophages #594
      adaptive immunity #594
      autoimmune disorders #594
      multiplexing #595
      th1 cytokines #595
      clonal expansion #595
      xanthine oxidoreductase #596
      cells study #599
      tcell activation #599
      develop #600
      augmented #602
      th2 cytokines #602
      n85 #602
      spite #602
      mouse monoclonal #603
      pemphigus vulgaris #603
      common diseases #603
      cells male #604
      phagosomal #604
      cells involved #604
      oxa #606
      mice inbred #606
      animal rats #606
      class humans #607
      genotype hla #608
      frozen sections #608
      spleen animals #609
      inefficiently #610
      regulatory role #610
      production ifn #611
      naive #611
      positive individuals #612
      quantitative trait locus #615
      mutant strains receptors #616
      alpha chains #616
      exponential phase #616
      acetophenones #616
      class antigens #616
      autoantibodies #616
      idiotypic #616
      th1 type #616
      oral immunization #617
      nonobese #617
      beta type #618
      day mice #619
      wistar restraint #620
      promiscuous #620
      consequent #621
      receptor 3 #621
      inflammatory role #621
      nicotinamide adenine #622
      fluorine18 #624
      receptors antigen #624
      loci identified #625
      chronic stage #625
      animal mice #628
      cytoplasmic ca2 #628
      local injection #629
      cross reactions #630
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      sjögrens syndrome #1719
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      pulmonary aspergillosis #1721
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      intranasally #1740
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      cd11 #1745
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      human chondrocytes #2110
      nose #2117
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      immune functions #2126
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      dnp #2185
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      cell receptors #2256
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      hla #2269
      mph #2274
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      inflammatory #2288
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      apocynin #2302
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      infiltrating macrophages #2309
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      healthy donors #2318
      hydroxylation #2320
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      inflammatory mechanisms #2321
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      p00002 #2326
      antigens histocompatibility #2328
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      cells induced #2331
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      n24 #2338
      lewis #2345
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      receptor α #2353
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      biological agents #2365
      lectins type #2366
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      sex hormone #2366
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      lymphotoxin #2375
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      cxcl1 #2382
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      systemic lupus erythematosus #2397
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      inflammatory reaction #2400
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      peritoneal macrophages #2591
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      proteolipid protein #2632
      ifn α #2634
      single chain #2639
      sialoglycoproteins #2643
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      submandibular gland #2663
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      osteonectin #2667
      brucei #2670
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      n22 #2670
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      igg3 #2698
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      post partum #2731
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      bromocriptine #2768
      transgenic mouse #2772
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      human leukocyte #2774
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      cytolysis #2777
      qtls #2777
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      alcoholic steatohepatitis #2786
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      bone cartilage #2790
      sjogren syndrome #2791
      inbred mrl #2798
      current review #2798
      animal encephalomyelitis autoimmune #2799
      hk #2801
      callithrix #2804
      spleen #2812
      261 #2813
      neuropathology #2817
      genistein #2819
      alpha #2821
      lack #2822
      activated macrophages #2825
      hyaluronidase #2830
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      prl #2835
      olive oil #2838
      demyelinating diseases #2841
      resistant #2842
      hallmark #2843
      glucose uptake #2846
      beta receptor #2847
      beta tgf #2848
      bind #2848
      th1 response #2852
      demyelinating #2852
      polymorphonuclear leukocytes #2856
      phases #2858
      dependent cell #2859
      treg cell #2859
      antibodies antinuclear #2864
      polymorphonuclear #2864
      interleukin receptors #2864
      splenocytes #2865
      characterising #2865
      interleukin33 #2869
      rats inbred strains #2869
      cyanogen bromide #2874
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      guillain #2875
      cells cd8 #2881
      periodontitis #2882
      parvalbumin #2884
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      clone cells #2885
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      igg iga #2891
      migration inhibitory #2892
      costimulatory molecules #2895
      tgfbeta #2895
      innate immune responses #2896
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      antigens class humans #2898
      dq #2905
      antigen hla #2907
      atp synthase #2909
      enhancement #2911
      linked immunosorbent #2911
      studying #2918
      diseases disease #2920
      shortly #2920
      allogenic #2921
      ergometry #2921
      steadily #2925
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      type lectin #2926
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      ifn γ #2931
      autoimmune disorder #2935
      dextran #2939
      female flow #2943
      expression macrophages #2944
      injections #2944
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      proteins peptides #2946
      cd68 #2947
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      cells immune #2955
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      toll receptor #2961
      cell infiltration #2962
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      calcium ions #2964
      qtl #2965
      histocytochemistry #2967
      suppressed #2967
      hnrnp #2980
      genetics #2982
      ifn response #2985
      cepacia #2988
      antirheumatic agents #2993
      elusive #2994
      hdac #2995
      thymus gland #2997
      swedish #2998
      respective #3000
      lineage commitment #3003
      indoleamine #3009
      time points #3009
      cells female #3010
      therapeutic strategies #3014
      innate #3014
      illustrating #3017
      anthrax #3019
      interferon ifn #3020
      wild type mice #3026
      defensins #3027
      vdr #3031
      accelerating #3033
      lung inflammation #3033
      macrophage migration #3036
      t‐cell #3039
      endo #3039
      synthetic peptides #3040
      appearance #3045
      quinoxalines #3047
      cd8 #3048
      immunomodulator #3050
      model mice #3051
      longterm treatment #3052
      twin studies #3053
      complex traits #3055
      ppt #3058
      interleukin23 #3061
      profound #3067
      sjögren syndrome #3069
      prevailing #3073
      salivary #3076
      mediated immune #3077
      role cell #3078
      beta #3080
      destruction #3082
      irrespective #3083
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      nodes #3091
      glutamic #3092
      inhibitory factors #3092
      parvalbumins #3093
      inbred balb mice #3098
      receptor 4 #3098
      genetic deletion #3100
      detailed description #3101
      postpartum period #3107
      germinal #3108
      antirheumatic #3109
      staphylococcus #3114
      type wt #3120
      neuronal cell #3123
      effects treatment #3124
      suspect #3127
      igm igg #3130
      specificity #3131
      glycans #3136
      monoclonal antibody #3137
      receptors tlrs #3142
      psoriasis #3142
      logarithm #3146
      cd4 cd8 #3147
      preformed #3151
      immune systems #3152
      possibility #3153
      cell activity #3154
      molecule #3155
      propria #3155
      cba #3164
      posttranslational modification #3167
      sjogren #3171
      massively #3172
      accumulated #3180
      cell specific #3185
      precedes #3185
      blockage #3187
      tissue specific #3191
      dynorphin #3191
      pertussis toxin #3192
      cells rats #3193
      adult mice #3193
      keratinocytes #3194
      unravel #3199
      reactivity #3202
      helper #3204
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      ovx #3208
      serum levels #3210
      erbeta #3211
      antiinflammatory #3211
      phagosomes #3212
      nitroarginine #3212
      abs #3216
      publication arthritis #3224
      cells animals #3224
      gpi #3226
      chromosome 1 #3237
      class iii #3239
      clarified #3242
      permitting #3246
      collagenous #3247
      macrophage #3247
      lod score #3252
      bacterial antibodies #3254
      backbone #3257
      nonalcoholic steatohepatitis nash #3260
      female gonadal #3263
      treated animals #3264
      acrylic #3265
      chronic inflammatory #3267
      meps #3270
      immunosorbent assay #3272
      implicate #3274
      inflammation interferon #3278
      proteoglycans #3278
      sch #3280
      arthralgia #3283
      nephritis #3283
      gonadal steroid #3284
      normal rats #3287
      abundantly #3289
      igg1 #3298
      models genetic #3298
      immunoglobulin heavy #3303
      erythematosus #3305
      proteins mice #3309
      adaptations #3309
      characterise #3314
      elicits #3314
      blastocyst #3315
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      absence #3318
      diseases autoimmune #3321
      beta receptors #3325
      publication animals #3325
      mice protein #3327
      anticardiolipin #3328
      confirmed #3329
      gc cells #3331
      serologically #3332
      suppression #3338
      regional lymph nodes #3341
      macromolecular #3343
      clinical phenotypes #3345
      cd62l #3353
      influenced #3355
      trypanosoma #3358
      akr #3371
      vitamin d3 #3373
      editor #3377
      antinuclear antibodies #3382
      sle #3384
      genetic polymorphisms #3385
      ovariectomy #3386
      levels inflammatory #3395
      macroporous #3395
      mechanistic studies #3395
      explains #3396
      mount #3397
      tubercle #3402
      somatic mutations #3406
      receptors transforming #3410
      haptens #3413
      early phase #3413
      positions #3418
      nk cells #3419
      erythematosus systemic #3419
      neutrophil activation #3421
      reacts #3421
      penetrant #3425
      reply #3432
      proving #3434
      receptor type #3434
      dendritic cells #3436
      serum igg #3437
      alleles #3440
      permitted #3441
      cauda #3443
      4 months #3444
      injection #3445
      superoxide production #3446
      protein tyrosine #3447
      obscure #3448
      humans immunization #3448
      increased sensitivity #3449
      antimicrobial peptide #3451
      diffusely #3459
      characterised #3469
      patients sle #3470
      h5n1 #3470
      flow cytometry #3476
      modifying #3477
      inflammatory mediators #3491
      multimers #3491
      proteoglycan #3496
      successes #3497
      il21 #3500
      ly #3501
      elucidate #3503
      classical #3505
      developed #3505
      protein processing #3506
      salivary gland #3507
      publication animals animals #3509
      neutrophilic #3510
      pathobiology #3511
      pathological features #3517
      specific cd4 #3519
      globulins #3526
      267 #3528
      deoxyguanosine #3528
      phenotypically #3529
      germline #3529
      predispose #3532
      micrometer #3534
      lacrimal #3534
      transglutaminases #3535
      radiolabelled #3539
      cyclosporins #3540
      regulatory cells tregs #3540
      mbq #3541
      dominantly #3548
      histological examination #3554
      investigate #3559
      infections staphylococcus #3561
      mast cells #3563
      cultured disease models #3568
      socs1 #3570
      humans interferon #3571
      histological #3574
      homogenate #3576
      gamma #3580
      interesting #3580
      negative patients #3583
      artificially #3584
      role development #3585
      cytolytic #3589
      hindlimb #3590
      il33 #3593
      triggered #3597
      compared wild #3597
      usage #3601
      immunohistochemical staining #3608
      upregulation #3612
      previous findings #3617
      intranasal #3619
      tcr #3622
      potential roles #3624
      cleave #3624
      genetic association #3629
      attenuate #3633
      rp #3633
      mapping chromosomes #3634
      valuable #3637
      genetic #3637
      adhere #3638
      today #3645
      cultured culture media #3651
      allele #3655
      gene deletion #3657
      enhances #3657
      cd4 positive #3659
      exerts #3663
      clinical severity #3665
      tolllike receptor #3665
      luminol #3667
      95 association #3671
      cd44 #3678
      il23 #3690
      tgf beta #3691
      female genes #3694
      fibronectins #3697
      toll receptors #3700
      igg igm #3702
      heavy chain #3705
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      Prominent publications by Rikard Holmdahl

      KOL-Index: 15284

      The purpose of the study was to map the dominant T cell epitope of the CB11 sequence of CII in RTlu haplotype rats and to determine if, when used as a synthetic peptide, it would induce tolerance to protect against CIA. A dominant epitope corresponding to residues 184-198 included in the sequence of the CB11 fragment of bovine CII was identified in proliferation assay using peptides in an epitope scanning system using synthetic peptides of 15 amino acids, overlapping by 12 amino acids. ...

      Kjent for Mucosal Tolerance | Synthetic Peptide | Cell Epitope | Cia Cii | Collagen‐induced Arthritis
      KOL-Index: 14658

      An antibody response to defined epitopes located on the triple helical portion of type II collagen (CII) is associated with the development of collagen-induced arthritis (CIA) and rheumatoid arthritis (RA). Monoclonal antibodies to epitopes associated with arthritis, but not antibodies specific for epitopes not associated with arthritis, induce arthritis in mice, the so-called collagen antibody induced arthritis (CAIA) model. We have selected monoclonal IgG antibodies specific for four ...

      Kjent for Collagen Antibody | Induced Arthritis | Monoclonal Antibodies | Mice Inbred | Specific Epitopes
      KOL-Index: 13984

      The Aq major histocompatibility complex (MHC) class II molecule is associated with susceptibility to murine collagen-induced arthritis (CIA), whereas the closely related H-2Ap molecule is not. To understand the molecular basis for this difference, we have analyzed the ability of H-2Aq and H-2Ap molecules (referred to as Aq and Ap) to bind and present collagen type II (CII)-derived glycosylated and non-glycosylated peptides. T cell clones specific for the immunodominant CII 256-270 ...

      Kjent for Collagen‐induced Arthritis | Transgenic Models | Aq Molecule | Structural Basis | C3h Mice
      KOL-Index: 13727

      BACKGROUND: Autoantibodies to cyclic citrullinated peptides (anti-CCP) are present in most patients with rheumatoid arthritis (RA), and associate with HLA-DRB1 shared epitope (SE) alleles.

      OBJECTIVE: To investigate reactivities of anti-CCP to various citrullinated proteins/peptides, which represent potential autoantigens in RA, and to examine the relationship between such antibodies, and their association with genetic variants within HLA-DRB1 SE alleles.

      METHODS: Serum samples from 291 ...

      Kjent for Citrullinated Antigens | Rheumatoid Arthritis | Drb1 Alleles | Ccp Patients | Antibody Reactivities
      KOL-Index: 13726

      Type II collagen-induced arthritis (CIA) in mice is an autoimmune experimental model for rheumatoid arthritis. Susceptibility to CIA is associated with certain major histocompatibility complex class II haplotypes. The two very closely related haplotypes H-2q and H-2p differ in susceptibility to CIA. Only mice of H-2q (DBA/1, B10G strains) but not mice of H-2p-expressing strains (like strain B10P) develop CIA and an autoimmune response to type II collagen (CII) after immunization with ...

      Kjent for Mice Cia | Beta Chain | Rheumatoid Arthritis | H2q Haplotype | Type Collagen Cii
      KOL-Index: 13513

      INTRODUCTION: It has previously been shown that an increased number of antibodies against citrullinated peptides/proteins (ACPA) predate the onset of rheumatoid arthritis (RA). Over time antibody positivity expands, involving more specific responses when approaching the onset of symptoms. We investigated the impact of human leukocyte antigen-shared epitope (HLA-SE) alleles and smoking on the development of ACPA, as well as in combination with ACPA during the state of quiescent ...

      Kjent for Citrullinated Peptides | Onset Symptoms | Development Rheumatoid Arthritis | Combination Acpa | Hlase Smoking
      KOL-Index: 13230

      OBJECTIVE: High titers of specific anti-citrullinated protein antibodies (ACPAs) are frequently present in the serum of rheumatoid arthritis (RA) patients, but their presence in synovial fluid is less well characterized. The purpose of this study was to compare the levels of antibody to 4 well-defined citrullinated candidate RA autoantigens in serum and synovial fluid and to determine whether antibodies to one citrullinated antigen are dominant over another. Furthermore, we studied their ...

      Kjent for Citrullinated Antigens | Synovial Fluid | Rheumatoid Arthritis Patients | Type Collagen | Antibodies Acpas
      KOL-Index: 12913

      INTRODUCTION: Toll-like receptors (TLRs) are involved in both innate and adaptive immune responses and are likely to play a complex role in the pathogenesis of human rheumatoid arthritis (RA) and experimental arthritis. The objective of this study was to identify the key TLR in pristane-induced arthritis (PIA), a rat model for RA, and to clarify its roles in the initiation and maintenance of arthritis.

      METHODS: Arthritis in DA rats was induced by pristane and the severity was evaluated ...

      Kjent for Induced Arthritis | Tlr3 Expression | Rats Pristane | Receptor 3 | Inbred Strains Severity
      KOL-Index: 12776

      Multiple sclerosis (MS) is a complex chronic neurologic disease with a suspected autoimmune pathogenesis1,2. Although there is evidence that the development of MS is determined by both environmental influences and genes, these factors are largely undefined3,4, except for major histocompatibility (MHC) genes. Linkage analyses and association studies have shown that susceptibility to MS is associated with genes in the human histocompatibility leukocyte antigens (HLA) class II region, but ...

      Kjent for Multiple Sclerosis | Transgenic Mice | Hla Dr2 | Humanized Model | Spontaneous Disease
      KOL-Index: 12721

      Polymorphism of the major histocompatibility complex (MHC) influences susceptibility to experimental autoimmune encephalomyelitis (EAE) induced by myelin basic protein (MBP) in rats. Current concepts relate such influences to the capacity of class II molecules to present relevant peptides to autoreactive T cells. We have here analyzed the MHC influence on the immune response and the development of EAE after immunization with the immunodominant peptide MBP-63-88. Analysis of MHC-congenic ...

      Kjent for Myelin Basic Protein | Experimental Autoimmune | Major Histocompatibility | Rats Eae | Immune Response
      KOL-Index: 12691

      OBJECTIVE: The presence of antibodies against cyclic citrullinated peptides has been demonstrated to precede the onset of symptoms of rheumatoid arthritis (RA) by several years. The aim of this study was to analyze antibodies against 10 citrullinated autoantigen-derived peptides for reactivity before the onset of RA symptoms.

      METHODS: A case-control study was conducted within the Medical Biobank of Northern Sweden. The study was performed in 409 individuals, 386 of whom donated 717 blood ...

      Kjent for Citrullinated Peptides | Rheumatoid Arthritis | Onset Symptoms | Antibodies Cep1 | Type Collagen
      KOL-Index: 12510

      Antibodies against type II collagen (anti-CII) are arthritogenic and have a crucial role in the initiation of collagen-induced arthritis. Here, we have determined the dependence of T and B cells in collagen-antibody-induced arthritis (CAIA) during different phases of arthritis. Mice deficient for B and/or T cells were susceptible to the CAIA, showing that the antibodies induce arthritis even in the absence of an adaptive immune system. To determine whether CII-reactive T cells could have ...

      Kjent for Collagen Type | Arthritis Mice | Antigen Tcell | Antibodies Cii | Adaptive Immune
      KOL-Index: 12427

      The nonobese diabetic (NOD) mouse spontaneously develops autoimmune-mediated diseases such as diabetes and Sjögren's syndrome. To investigate whether NOD genes also promote autoimmune-mediated arthritis we established a NOD strain with an MHC class II fragment containing the A(q) class II gene predisposing for collagen induced arthritis (NOD.Q). However, this mouse was resistant to arthritis in contrast to other A(q) expressing strains such as B10.Q and DBA/1. To determine the major ...

      Kjent for Genetic Control | Complement Factor | Induced Arthritis | Locus Chromosome | Mice Inbred

      Nøkkelpersoner for Rheumatoid Arthritis

      Toppkols i verden
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      Paul Emery
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      Josef Sebastian Smolen
      rheumatoid arthritis systemic lupus erythematosus radiographic progression
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      James F Fries
      rheumatoid arthritis physical function systemic lupus erythematosus
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      John Turner Sharp
      rheumatoid arthritis radiographic progression joint space width
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      Frederick J Wolfe
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      Matthew H Liang
      rheumatoid arthritis systemic lupus erythematosus lyme disease

      Rikard Holmdahl:Ekspertvirkning

      Konsepter somRikard Holmdahlhar direkte innflytelse:Rheumatoid arthritis,  Induced arthritis,  Experimental arthritis,  Collagen type,  Type collagen,  Animal models,  Reactive oxygen species,  Autoimmune diseases.

      Rikard Holmdahl:Kol Impact

      Konsepter relatert til arbeidet til andre forfattere somfor which Rikard Holmdahl har innflytelse:Rheumatoid arthritis,  Multiple sclerosis,  Autoimmune diseases,  Oxidative stress,  Animal models,  Reactive oxygen species,  Nadph oxidase.


       

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      National and Local Joint Engineering Research Center of Biodiagnosis and Biotherapy, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China | Medical Inflammation Research, MediCity Research Laboratory, University of Turku, Turku,

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