Prominent publications by Thierry E Appelboom

KOL Index score: 11118

OBJECTIVE: T cells are involved in the pathogenesis of rheumatoid arthritis (RA). In animal models of autoimmune diseases, blockade of costimulatory molecules on antigen-presenting cells has been demonstrated to be effective in preventing or treating this disease by preventing T cell activation. To date, the effect of costimulatory blockade in patients with RA is unknown. The goal of this multicenter, multinational study was to determine the safety and preliminary efficacy of ...

Known for Costimulatory Blockade |  Rheumatoid Arthritis |  Autoimmune Diseases |  Cell Activation |  Animal Models
KOL Index score: 11061

OBJECTIVE: To study the relationship of spinal inflammation and fatty degeneration (FD) as detected by MRI and new bone formation seen on conventional radiographs (CRs) in ankylosing spondylitis (AS).

METHODS: CRs at baseline, 2 years and 5 years and spinal MRIs at baseline and 2 years of 73 AS patients treated with infliximab in European AS Infliximab Cohort were available. Relative risks (RR) were calculated with a general linear model after adjustment for within-patient ...

Known for New Bone Formation |  2 Years |  Ankylosing Spondylitis |  Inflammation Baseline |  Spinal Lesions
KOL Index score: 9335

Abstract. Although fluoride salts have been shown to be capable of linearly increasing spinal bone mineral density (BMD) in postmenopausal osteoporosis, the effects of this gain in density on the vertebral fracture rate remain controversial. We conducted a 2-year multicenter, prospective, randomized, double-masked clinical trial in 354 osteoporotic women with vertebral fractures (mean age 65.7 years). They received either fluoride (208 patients), given as sodium fluoride (50 mg/day) or ...

Known for Postmenopausal Osteoporosis |  Vertebral Fractures |  Fluoride Salts |  2 Years |  Density Calcium
KOL Index score: 7546

Mycophenolate mofetil (MMF) is a new immunosuppressive agent currently used in organ transplantation and under evaluation in immune-mediated inflammatory disorders such as rheumatoid arthritis. Although MMF was shown to inhibit purine nucleotide synthesis in lymphocytes, it is still unclear whether it might also exert direct antiinflammatory actions in vivo. To address this question, we evaluated the effects of MMF administration on the responses of mice to a single challenge with ...

Known for Mycophenolate Mofetil |  Murine Endotoxemia |  Antiinflammatory Properties |  Inbred Balb Mice |  Nitric Oxide
KOL Index score: 7302

OBJECTIVES: We compare the symptomatic effects of 300 or 600mg daily of ASU in patients with knee osteoarthritis.

METHODS: A multicenter, double blind, study comparing a daily intake of 300mg or 600mg of ASU and placebo. The study lasted 3 months and involved patients of both genders, aged 45 to 80 years and presenting with femoro-tibial knee osteoarthritis. The primary endpoint was NSAIDs and analgesics intake between D30 and D90.

RESULTS: All efficacy parameters were significantly ...

Known for Asu Placebo |  Knee Osteoarthritis |  Daily Intake |  Soybean Unsaponifiables |  Symptomatic Effects
KOL Index score: 6737

Various proteases are expressed in the minor salivary glands (MSG) of patients with Sjögren's syndrome (SS), and as we have already shown, prolactin is neosynthesized in the acinar cells of patients with SS. The present study aims to characterize the influence of PRL on the expression of cathepsin B and D in the MSG of patients with SS. Cathepsin B and D expression was investigated immunohistochemically in MSG of 30 patients with SS and 15 healthy volunteers. The presence of cathepsin B ...

Known for Salivary Glands |  Expression Cathepsin |  Sjögrens Syndrome |  Prolactin Prl |  Patients Sjögren
KOL Index score: 6535

OBJECTIVE: Tumor necrosis factor alpha (TNFalpha) is a proinflammatory cytokine involved in the pathogenesis of Sjögren's syndrome (SS), and blockade of TNFalpha may reduce the activity of the disease. The purpose of this study was to evaluate the safety and potential efficacy of infliximab, a chimeric human-mouse anti-TNFalpha monoclonal antibody, in patients with active primary SS.

METHODS: This was a single-center, open-label pilot study. Sixteen patients with active primary SS ...

Known for Infliximab Patients |  Primary Sjögren |  Salivary Flow |  Clinical Benefit |  Dry Eyes
KOL Index score: 6084

In this randomized, double-blind, double-dummy trial, 113 patients with acute sciatica were treated with a single 15-mg dose of meloxicam given intramuscularly (n = 54) or orally (n = 59). There was a significant improvement in induced pain (as measured by using the straight-leg-raising test) in both treatment groups at 60 minutes (P < 0.005), and there was a significant difference in favor of the intramuscular formulation in terms of the time to maximum improvement of induced pain (P = ...

Known for Acute Sciatica |  Oral Meloxicam |  Intramuscular Formulation |  Local Tolerability |  30 Minutes


Thierry E Appelboom: Influence Statistics

Sample of concepts for which Thierry E Appelboom is among the top experts in the world.
Concept World rank
serumtreated zymosan serum #1
radiological modification #1
om8980 #1
polymorphonuclear cell adherence #1
diseases art #1
flexofytol evaluated #1
effects om8980 #1
fibroblastic tissue edema #1
patients flexofytol #1
core femur head #1
fat cell replacement #1
unique factor c5a #1
adhesiveness zymosan #1
rheumatologists publication #1
radical immunodiffusion #1
sausage fingers #1
c5a activation products #1
presented features sle #1
hagg stimulation #1
trabecular bone necrosis #1
difference raynaud phenomenon #1
large unique factor #1
osteonecrosis biopsy #1
report diffuse #1
neck diffuse low #1
fibroblastic tissue evidence #1
ancient numerous examples #1
ability serumtreated zymosan #1
art large avenue #1
fresh serum variations #1
il1 kda #1
1 hagg stimulation #1
il1 activity measurable #1
hagg il1 #1
activation products zymosan #1
response heataggregated igg #1
zymosan smaller quantities #1
century arthritis #1
publication art arthritis #1
biooptimized extract #1
activation products pmn #1
publication arthritis acquired #1
painful hip radiological #1
idiopathic osteonecrosis core #1

Key People For Rheumatoid Arthritis

Top KOLs in the world
Paul Emery
rheumatoid arthritis ankylosing spondylitis radiographic progression
Josef Sebastian Smolen
rheumatoid arthritis systemic lupus erythematosus radiographic progression
James F Fries
rheumatoid arthritis physical function systemic lupus erythematosus
John Turner Sharp
rheumatoid arthritis radiographic progression joint space width
Frederick J Wolfe
rheumatoid arthritis work disability rheumatic diseases
Matthew H Liang
rheumatoid arthritis systemic lupus erythematosus lyme disease

Thierry E Appelboom:Expert Impact

Concepts for whichThierry E Appelboomhas direct influence:Rheumatoid arthritis,  Femoral head,  Salivary glands,  Hyaluronic acid,  Ankylosing spondylitis,  Infliximab patients,  Magnetic resonance,  Postmenopausal osteoporosis.

Thierry E Appelboom:KOL impact

Concepts related to the work of other authors for whichfor which Thierry E Appelboom has influence:Rheumatoid arthritis,  Femoral head,  Ankylosing spondylitis,  Bone marrow,  Inosine pranobex,  Autoimmune diseases,  Sjögren syndrome.



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Hopital Erasme Brussels, Belgium. | University of Brussels, Belgium | Hopital Erasme, Brussels, Belgium. | Department of Rheumatology, Erasme Hospital, University of Brussels, 808 Route de Lennik, 1070, Brussels, Belgium | Service de rhumatologie, hô

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