Direct Impact

Concepts for which Loretta Mueller has direct influence:

chronic migraine
extended release
cyclobenzaprine hydrochloride
primary objective
evaluate effectiveness
treated amrix
15mg prophylaxis

External impact

Concepts related to the work of other authors for which Loretta Mueller has influence:

monoclonal antibodies
prostate cancer
hk2‐expressing tumors
il‐4 plasma
derived tumor
cell-defined antigens
enzymatic activity

Prominent publications by Loretta Mueller

KOL-Index: 23 Semaphorin 4D (SEMA4D or CD100) is a member of the semaphorin family of proteins and an important mediator of the movement and differentiation of multiple cell types, including those of the immune, vascular, and nervous systems. Blocking the binding of SEMA4D to its receptors can result in physiologic changes that may have implications in cancer, autoimmune, and neurological disease. To ...
Known for
Antibody Semaphorin | Generation Characterization | Sema4d Generated
KOL-Index: 14 OBJECTIVE: The objective of this study was to determine whether differences in urinary proinflammatory cytokines, interleukin-1beta (IL-1beta), interleukin-6 (IL-6), and tumor necrosis factor alpha (TNF-alpha), exist between migraineurs and nonheadache control subjects, and between nonhormonal migraine and menstrual migraine. Any differences noted would expand and clarify a neuroimmune ...
Known for
Migraine Pathogenesis Focus | Il-1beta Il-6 | Current Theories | 19 Women
KOL-Index: 10 Many biological processes result in either cell death or cessation of cell growth. However, plasmid- and retrovirus-based mammalian expression vectors in which it has been possible to construct representative cDNA libraries cannot be readily recovered from cells that are not actively dividing. This has limited the efficiency of selection of recombinant genes that mediate either lytic events ...
Known for
Libraries Recovered | Cytotoxic Target | Representative Cdna | Genes Mammalian
KOL-Index: 6 The GAGA transcription factor of Drosophila melanogaster is ubiquitous and plays multiple roles. Characterization of cDNA clones and detection by domain- specific antibodies has revealed that the 70-90 kDa major GAGA species are encoded by two open reading frames producing GAGA factor proteins of 519 amino acids (GAGA-519) and 581 amino acids (GAGA-581), which share a common N-terminal ...
Known for
Purified Recombinant | Isoforms Gaga | Embryogenesis Homomeric
KOL-Index: 2 The primary objective of the study is to evaluate the effectiveness and safety of cyclobenzaprine hydrochloride extended release (Amrix 15mg/day) for the prophylaxis of chronic migraine compared to a placebo medication. A second objective, is to find out whether there is an improvement in quality of sleep and self-reported depression in patients taking Amrix 15mg daily. The hypothesis is ...
Known for
Migraine Treated | Objective Evaluate | Amrix 15mg | Effectiveness Safety

Vaccinex, Inc., Rochester, New York, USA

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