Prominent publications by Thomas Eggermann

KOL Index score: 17339

BACKGROUND: Cystinuria is a common inherited disorder of defective renal reabsorption of cystine, ornithine, lysine and arginine leading to nephrolithiasis. Two responsible genes have been identified so far: Mutations in the SLC3A1 gene encoding the heavy chain rbAT of the renal cystine transport system rbAT/b(0,+)AT cause cystinuria type I, while variants in SLC7A9, the gene of its light chain b(0,+)AT, have been demonstrated in non-type I cystinuria. In this study, we searched for ...

Conocido por Slc7a9 Gene |  mutations slc3a1 |  type cystinuria |  pediatric patients |  acid transport
KOL Index score: 13510

Autosomal recessive polycystic kidney disease (ARPKD) is an important cause of childhood renal- and liver-related morbidity and mortality. The clinical spectrum is widely variable. About 30 to 50% of affected individuals die in the neonatal period, while others survive into adulthood. ARPKD is caused by mutations in the PKHD1 (polycystic kidney and hepatic disease 1) gene on chromosome 6p12, which is among the largest human genes, with a minimum of 86 exons assembled into a variety of ...

Conocido por Pkhd1 Mutations |  autosomal recessive |  polycystic kidney |  neonatal period |  cell surface arpkd
KOL Index score: 13495

Silver-Russell syndrome (SRS) is a heterogeneous disorder associated with intrauterine and postnatal growth restriction, body asymmetry, a relative macrocephaly, a characteristic triangular face and further dysmorphisms. In about 50% of patients, genetic/epigenetic alterations can be detected: >38% of patients show a hypomethylation of the IGF2/H19 imprinting region in 11p15, whereas the additional 10% carry a maternal uniparental disomy of chromosome 7. In single cases, cytogenetic ...

Conocido por 12q14 Microdeletion Syndrome |  srs phenotype |  chromosomal imbalances |  relative macrocephaly |  silver russell
KOL Index score: 13184

Autosomal recessive polycystic kidney disease (ARPKD/PKHD1) is an important cause of renal-related and liver-related morbidity and mortality in childhood. Recently mutations in the PKHD1 gene on chromosome 6p21.1-p12 have been identified as the molecular cause of ARPKD. The longest continuous open reading frame (ORF) is encoded by a 67-exon transcript and predicted to yield a 4074-amino acid protein ("polyductin") of thus far unknown function. By now, a total of 29 different PKHD1 ...

Conocido por Arpkd Pkhd1 |  autosomal recessive |  polycystic kidney |  missense mutation |  detection rate
KOL Index score: 13133

Autosomal recessive polycystic kidney disease (ARPKD) is one of the most common hereditary renal cystic diseases in children. The clinical spectrum ranges from stillbirth and neonatal demise to survival into adulthood. In a given family, however, patients usually display comparable phenotypes. Many families who lost a child with severe ARPKD desire an early and reliable prenatal diagnosis (PD). Given the limitations of antenatal ultrasound, this is only feasible by molecular genetics ...

Conocido por Pkhd1 Mutations |  prenatal diagnosis |  polycystic kidney |  autosomal recessive polymorphism |  cell surface arpkd
KOL Index score: 11422

CONTEXT: Around 50% of children with Silver-Russell syndrome (SRS) carry a hypomethylation of the imprinting control region 1 at the IGF2/H19 locus on 11p15, the functional significance of which is unknown.

OBJECTIVE: We aimed to compare the genotype in SRS with the endocrine phenotype.

DESIGN: The retrospective study included all SRS children who were treated during the last 18 yr at our hospital and for comparison a cohort of GH treated nonsyndromic short children born small for ...

Conocido por Children Srs |  russell syndrome |  11p15 epimutation |  gh therapy |  growth factor
KOL Index score: 11409

Infantile spinal muscular atrophy (SMA) is a neuromuscular disease caused by homozygous deletion of the SMN1 gene in more than 90% of patients. Identification of carriers for the SMN1 deletion is important for diagnostic purposes and for genetic counseling. The current practical implications of SMN2 copy number determination are limited but may be important, for example, for future drug trials. Here we present a new rapid and reliable approach to determine the copy numbers of the SMN1 ...

Conocido por Smn2 Copy |  taqman technology |  motor neuron |  smn1 gene |  childhood survival
KOL Index score: 11295

Cystinuria is a common inherited aminoaciduria resulting in nephrolithiasis. Mutations in two genes, SLC3A1 and SLC7A9, have been identified in cystinuric patients. Considering the population-specific distribution of genetic variants in the SLC3A1 gene, we focused our study on mutations in SLC3A1 and SLC7A9 described more than once in the literature. We evaluated the usefulness of this restricted analysis as a diagnostic approach. Furthermore, the data obtained were used to estimate the ...

Conocido por Slc7a9 Genes |  mutations slc3a1 |  molecular genetic testing |  genomic variants |  cystinuric patients
KOL Index score: 11236

The chromosomal region 11p15 contains two imprinting control regions (ICRs) and is a key player in molecular processes regulated by genomic imprinting. Genomic as well as epigenetic changes affecting 11p15 are associated either with Silver-Russell syndrome (SRS) or Beckwith-Wiedemann syndrome (BWS). In the last years, a growing number of patients affected by imprinting disorders (IDs) have reported carrying the diease-specific 11p15 hypomethylation patterns as well as methylation changes ...

Conocido por Imprinting Disorders |  srs bws |  uniparental disomies |  patients molecular |  chromosomal region
KOL Index score: 10983

Autosomal recessive polycystic kidney disease (ARPKD) is a severe form of polycystic kidney disease that presents primarily in infancy and childhood and that is characterized by enlarged kidneys and congenital hepatic fibrosis. We have identified PKHD1, the gene mutated in ARPKD. PKHD1 extends over > or =469 kb, is primarily expressed in human fetal and adult kidney, and includes a minimum of 86 exons that are variably assembled into a number of alternatively spliced transcripts. The ...

Conocido por 1 Gene |  hepatic disease |  polycystic kidney |  messenger receptors |  human pair
KOL Index score: 10524

Silver-Russell syndrome (SRS) is a heterogeneous disorder characterised by severe intrauterine and postnatal growth retardation, limb and body asymmetry, a typical facial appearance and less common dysmorphisms. Recently, epimutations and maternal duplications affecting the short arm of chromosome 11 have been shown to have a crucial role in the aetiology of the disease. Disturbances in the same genomic region cause the overgrowth disorder Beckwith-Wiedemann syndrome (BWS). In BWS, ...

Conocido por 11p15 Imprinting |  srs bws |  human pair |  preschool chromosomes |  body asymmetry
KOL Index score: 10204

The D-amino acid oxidase activator gene (G72) has been found associated with several psychiatric disorders such as schizophrenia, major depression, and bipolar disorder. Impaired performance in verbal fluency tasks is an often replicated finding in the mentioned disorders. In functional neuroimaging studies, this dysfunction has been linked to signal changes in prefrontal and lateral temporal areas and could possibly constitute an endophenotype. Therefore, it is of interest whether genes ...

Conocido por Brain Activation |  healthy individuals |  genetic variation |  verbal fluency |  g72 gene
KOL Index score: 9994

OBJECTIVE: Silver-Russell syndrome is a heterogenous disorder characterized by severe intrauterine growth restriction, lack of catch-up after birth, and specific dysmorphisms. In approximately 10% of patients, maternal uniparental disomy of chromosome 7 is detectable, but hypomethylation of the imprinting in 11p15 is the major epigenetic disturbance in Silver-Russell syndrome. The use of strict clinical criteria, indeed, results in relatively high detection rates for the 11p15 ...

Conocido por Russell Syndrome |  genetic testing |  growth retardation |  maternal uniparental disomy |  human pair
KOL Index score: 9936

Impaired performance in verbal fluency tasks is an often replicated finding in schizophrenia. In functional neuroimaging studies, this dysfunction has been linked to signal changes in prefrontal and temporal areas. Since schizophrenia has a high heritability, it is of interest whether susceptibility genes for the disorder, such as NRG1, modulate verbal fluency performance and its neural correlates. Four hundred twenty-nine healthy individuals performed a semantic and a lexical verbal ...

Conocido por Brain Activation |  verbal fluency |  healthy individuals |  genetic variation |  speech production
KOL Index score: 9935

Silver-Russell syndrome (SRS) describes a malformation syndrome with severe intrauterine and postnatal growth retardation. Currently, two major (epi)mutations have been described: while approximately 10% of patients carry a maternal uniparental disomy of chromosome 7 (UPD7), 35-60% show a hypomethylation at the H19 differentially methylated regions (DMRs) in 11p15. Until recently, a Southern-blot based test was routinely used to identify epimutation carriers. Nevertheless, this test was ...

Conocido por Russell Syndrome |  epigenetic alterations |  human pair |  multiple chromosomes |  methylation epigenesis

Gente clave para Russell Syndrome

Los KOLs mas influyentes del mundo
Thomas *********
russell syndrome human pair uniparental disomy
Gudrun ********* *****
imprinted genes cleft palate genomic imprinting
Irène ********
wiedemann syndrome silver russell imprinting disorders
Nathalie *******
russell silver beckwith wiedemann icr1 hypomethylation
Sylvie *********
alkaline solution mechanical properties wiedemann syndrome
Emma * ********
russell syndrome developmental disorders pathogenic variants

Thomas Eggermann:Impacto experto

Conceptos para los cualesThomas Eggermanntiene influencia directa:Russell syndrome,  Human pair,  Uniparental disomy,  Imprinting disorders,  Brain activation,  Healthy individuals,  Growth retardation,  Silverrussell syndrome.

Thomas Eggermann:Impacto de Kol

Conceptos relacionados con el trabajo de otros autores para los cualesfor which Thomas Eggermann tiene influencia:Dna methylation,  Imprinted genes,  Spinal muscular atrophy,  Genomic imprinting,  Polycystic kidney,  Human pair,  Uniparental disomy.



¿Es este tu perfil? manage_accounts Reclama tu perfil content_copy Copiar URL code Incrustar el enlace a su perfil

Institute of Human Genetics, Medical Faculty, RWTH Aachen, Aachen, Germany | Institute of Human Genetics, Medical Faculty, RWTH Aachen, 52074 Aachen, Germany | Institute of Human Genetics, Medical Faculty, RWTH Aachen University, Pauwelsstr. 30, 5207