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    • Saccharomyces Cerevisiae
    • Dietrich Averbeck
    • Dietrich Averbeck: Influence Statistics

      Dietrich Averbeck

      Dietrich Averbeck

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      Laboratory of Cellular and Molecular Radiobiology, PRISME, UMR CNRS 5822/IN2P3, IP2I, Lyon-Sud Medical School, University Lyon 1, 69921 Oullins, France;, ...

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      Dietrich Averbeck:Expert Impact

      Concepts for whichDietrich Averbeckhas direct influence:Saccharomyces cerevisiae,Bergamot oil,Genetic effects,Photobiological activity,Dna repair,8 mop,Yeast saccharomyces,Eukaryotic cells.

      Dietrich Averbeck:KOL impact

      Concepts related to the work of other authors for whichfor which Dietrich Averbeck has influence:Essential oils,Chemical composition,Dna damage,Antimicrobial activity,Deinococcus radiodurans,Homologous recombination,Fanconi anemia.

      KOL Resume for Dietrich Averbeck

      Year
      2021

      Laboratory of Cellular and Molecular Radiobiology, PRISME, UMR CNRS 5822/IN2P3, IP2I, Lyon-Sud Medical School, University Lyon 1, 69921 Oullins, France;,

      2020

      DRE-D3P, CEA, Fontenay-aux-Roses, France.

      2019

      Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), DRF, Fontenay-aux-Roses Cedex, France;, View further author information

      2018

      Commissariat à l'Energie Atomique et aux Energies Alternatives (CEA), DRF, Fontenay-aux-Roses 18 route du Panorama, 92265, Fontenay-aux-Roses Cedex, France; Institut Curie-Recherche, UMR3348 CNRS/IC, Centre Universitaire, 91405 Orsay Cedex, France. Electronic address:

      2016

      e Institut Curie-Recherche, UMR3348 CNRS/IC, Centre Universitaire, Orsay , France ;

      2014

      Institut de Radioprotection et de Sûreté Nucléaire, IRSN/PRP-HOM, BP 17, Fontenay-aux-Roses Cedex 92262, France.

      2011

      Institut Curie-Section de Recherche, Centre Universitaire Paris-Sud, Bâtiment 110 91405 Orsay, France

      2010

      Institut Curie, 91405 Orsay, France

      2009

      Dietrich Averbeck, Institut Curie-Section de Recherche, UMR2027 CNRS/I.C., Centre Universitaire, F-91405 ORSAY Cedex, France.

      Institut Curie Section de Recherche, UMR2027 CNRS/I.C., INSERM, Centre Universitaire d’Orsay, Bât. 110, F-91405 Orsay Cedex, France

      2008

      Institut Curie, Paris, France

      2007

      Institut Curie Section de Recherche, UMR2027 CNRS/I.C., INSERM, LCR n°28 CEA, Centre Universitaire d'Orsay, Orsay Cedex, France

      2006

      Institut Curie, Section Recherche, UMR 2027 CNRS, Centre Universitaire de Paris-Sud, Bâtiment 110, 91405, Orsay Cedex, France

      2005

      Institut Curie-Section de Recherche, UMR2027 CNRS/I.C., Bât. 110, Centre Universitaire d’Orsay, F-91405 Orsay Cedex, France

      2002

      Institut Curie-Section de Recherche, Centre Universitaire d’Orsay, Orsay, France

      2001

      UMR 2027 CNRS‐Institut Curie, Section de recherche, Centre Universitaire Bat. 110 Orsay cedex France

      2000

      Institut Curie — Section de Recherche, UMR218 CNRS, 26 Rue d'Ulm, 75248 Paris Cedex 05, France;

      1999

      UMR 178 CNRS/IC, institut Curie-Recherche, 26, rue d'Ulm, 75248 Paris cedex 05, France

      1998

      UMR218 CNRS, Institut Curie, 75005, Paris Cédex, France

      1997

      Institut Curie, Section de Recherche, Pavillon Pasteur, 26 rue d'Ulm, 75231 Paris, cedex 5, France

      1995

      Institut Curie - Biologie, URA 1292 du CNRS, 26 rue d'Ulm, 75231 Paris cedex 05 France

      1994

      Institut Curie—Biologie, CNRS URA 1292, 26 rue d'Ulm, 75231, Paris cedex 05, France

      1993

      Institut Curie-Section de Biologie, CNRS URA 1292, Paris, France

      1992

      Institut Curie, Section de Biologie, CNRS URA 1292 et 1387-P, 26 rue d'Ulm, 75231 Paris Cedex, France

      1991

      Institut Curie — Biologie, CNRS UA 1292, 26 rue d’ Ulm, 75231, Paris Cedex 05, France

      1990

      Institut Curie-Section de Biologie, CNRS UA 1292, 26, Rue d'Ulm, F-75231 Paris Cédex 05 France

      1989

      Institut Curie - Biologie, URA 1292 CNRS, 26 rue d’Ulm, 75231, Paris cedex 05, France

      1988

      Section de Biologie, Institut Curie, 26 rue d'Ulm, 75231, Paris Cédex 05, France

      1987

      Institut Curie — Biologie, 26 rue d'Ulm, 75231 Paris Cedex 05, France

      Istituto de Mutagenesi e Differenziamento C.N.R., 10 Via Svezia, 1-56100, Pisa, Italy

      1986

      Institut Curie, Biologie, 26 rue d'Ulm, 75231 Paris Cédex 05, France

      1985

      Section de Biologie, Institut Curie, F-75231, Paris, Cedex 05, France

      1984

      Institut Curie-Biologie, 26 rue d'Ulm, F-75231 Paris Cedex 05, France

      1983

      lnstitut Curie, Biologie, 75005 Paris, France

      1982

      Section de Biologie, Institut Curie, 26, Rue d’Ulm, 75231, Paris Cedex 05, France

      1981

      Institut Curie, Section de Biologie, 26 rue d'Ulm, F-75005, Paris, France

      1980

      Institut Curie, Section de Biologie, 26, rue d'Ulm, 75231 Paris Cedex 05, France

      1979

      Institut Curie, 26, rue d’Ulm, Paris, 75005, France.

      1978

      Fondation Curie — Institut du Radium, Biologie, Bâtiment 110, 91405 Orsay France

      1977

      Fondation Curie-Institut du Radium, Biologie, Bâtiment 110, F-91405, Orsay, France

      1975

      Fondation Curie - Institut du Radium, Biologie, Bâtiment 110, 91405-Orsay France

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      Sample of concepts for which Dietrich Averbeck is among the top experts in the world.
      Concept World rank
      conventional heating incubator #1
      radiobiology reactive #1
      mepyps pyps #1
      cps bifunctional #1
      reactivities ribonucleoprotein #1
      induction cls #1
      458trimethylpsoralen 458 #1
      replication inhibition dsbs #1
      furocoumarins eukaryotic #1
      monofunctional furocoumarins 3cps #1
      uva eukaryotic #1
      yeast photodynamic treatment #1
      fungal furocoumarins #1
      furocoumarins 3 #1
      genespecific induction #1
      wildtype d7 #1
      pps mutagenic #1
      biadducts bifunctional furocoumarin #1
      italicum induced #1
      saturated dioxin ring #1
      photobiological activity pps #1
      derivatives uptake process #1
      photoinduced lesions #1
      ancient time fact #1
      mepyps 5mop #1
      bergamot oil #1
      16dioxapyrene 16dp #1
      monoadducts induced #1
      16dp uva dna #1
      photoinduced inhibition growth #1
      mop treated #1
      equitoxic damage #1
      basal dsb level #1
      bacteriophage ms2 order #1
      crosslinking capacities 5mop #1
      reirradiation conditions #1
      dsbs chok1 #1
      retained elution #1
      photolesions genotoxicity #1
      specific photoadducts #1
      treatment mepyps #1
      cytotoxicity gene induction #1
      g1 homologous recombination #1
      substitutées sur #1
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      Prominent publications by Dietrich Averbeck

      KOL-Index: 15007

      The induction of genetic effects was studied in a diploid strain of Saccharomyces cerevisiae (D7) after treatments with the monofunctional furocoumarins 7-methylpyrido[3,4-c]psoralen (MePyPs), pyrido[3,4-c]psoralen (PyPs) and 3-carbethoxypsoralen (3-CPs) and the bifunctional furocoumarins 5-methoxypsoralen (5-MOP) and 8-methoxypsoralen (8-MOP) in the presence of 365-nm radiation. The DNA photobinding of radioactively labelled MePyPs, 3-CPs, 5-MOP and 8-MOP was determined in parallel. The ...

      Known for Diploid Yeast | 5mop 8mop | Genotoxic Effects | Bifunctional Furocoumarins | Dna Monoadducts
      KOL-Index: 13149

      Abstract— For the same furocoumarin 8-MOP and the same total number of photoadditions, the genetic activity of DNA monoadducts and a mixture of mono- and biadducts photoinduced by the bifunctional furocoumarin 8-methoxypsoralen (8-MOP) is compared in the yeast Saccharomyces cerevisiae. In the presence of 8-MOP, 405 nm irradiation induces only monoadducts, whereas 365 nm irradiation induces mono- and biadducts (interstrand cross-links) in DNA. This is shown by heat ...

      Known for Dna Monoadducts | 365 Nm Irradiation | 8 Mop | Induction Mutations | Genetic Saccharomyces
      KOL-Index: 12372

      Abstract— DNA damage induced by 8-methoxypsoralen (8-MOP) plus near UV light (UVA) was analyzed in diploid yeast using the alkaline step elution technique. The presence of 8-MOP and UVA induced DNA interstrand cross-links was revealed by the increase of DNA retained on elution filters as compared to untreated controls. The fraction of DNA retained on filters increased linearly with UVA dose. The amount of cross-links was estimated from the fraction of DNA retained on filters using a dose ...

      Known for Genetic Effects | Dna Cross | 8 Mop | 365 Nm | Ultraviolet Rays Uva
      KOL-Index: 11489

      The relationship between the induction of the genes RAD54 and RNR2 and the induction and repair of specific DNA lesions was studied in the yeast Saccharomyces cerevisiae using Rad54-lacZ and RNR2-lacZ fusion strains. Gene induction was followed by measuring beta-galactosidase activity. At comparable levels of furocoumarin-DNA photoadducts, RAD54 was more effectively induced by bifunctional than by monofunctional furocoumarins indicating that mixtures of monoadducts (MA) and interstrand ...

      Known for Saccharomyces Cerevisiae | Gene Induction | Dna Repair | Cell Growth | Fungal Proteins
      KOL-Index: 10682

      The induction and repair of different types of photodamage and photogenotoxicity in eukaryotic cells have been the subject of many studies. Little is known about possible links between these phenomena and the induction of DNA damage-inducible genes. We explored this relationship using the yeast Saccharomyces cerevisiae, a pertinent eukaryotic model. Previous results showed that the photogenotoxic potential of 8-methoxypsoralen (8-MOP) plus UVA is higher than that of UV (254 nm). ...

      Known for Gene Induction | Dna Repair | 254 Nm | 8mop Uva | Saccharomyces Cerevisiae
      KOL-Index: 9974

      The genetic effects of two mono-functional photosensitizing furocoumarins, 3-carbethoxypsoralen (3-CPs) and angelicin, were compared with those of two bi-functional furocoumarins, 8-methoxypsoralen and psoralen in Saccharomyces cerevisiae. A drug concentration of 5 X 10(-5) M plus various doses of 365-nm irradiation at a dose rate of 1.2 kJ m-2 min-1 were used. Per dose of 365-nm irradiation, the frequency of induced nuclear events such as gene mutation and mitotic recombination ...

      Known for Saccharomyces Cerevisiae | Gene Conversion | Functional Furocoumarins | Viable Cell | Mitotic Recombination
      KOL-Index: 9532

      The induction of lethal effects and 6-thioguanine-resistant (6-TGr) mutants were studied in Chinese hamster V79 cells after treatment with the two bifunctional furocoumarins 5- and 8-methoxypsoralens (5-MOP, 8-MOP) in the presence of 365-nm radiation (UVA). The in vivo DNA-photobinding capacity of these two compounds was measured and in parallel the cross-linking capacities of 5-MOP and 8-MOP were determined using the alkaline elution technique. The results show that 5-MOP plus UVA was ...

      Known for 5mop 8mop | Dna Photoadducts | Genotoxic Effects | Chinese Hamster | Cell Survival
      KOL-Index: 9522

      Primary skin fibroblast cell lines from patients with Fanconi anemia were cotransfected with UV-irradiated pSV2neo plasmids and high molecular weight DNA from normal human cells. Restoration of a normal cellular resistance to mitomycin C (MMC) was observed provided that a Fanconi anemia cell line is selected for DNA-mediated transformation (neo gene) and that at least two successive rounds of transfection are performed. Cells were selected by taking advantage of the higher proliferation ...

      Known for Fanconi Anemia | Crosslinking Agents | Normal Human | Southern Blot Analysis | Mitomycin Mmc
      KOL-Index: 9513

      In order to get an insight into the possible genotoxicity of essential oils (EOs) used in traditional pharmacological applications we tested five different oils extracted from the medicinal plants Origanum compactum, Coriandrum sativum, Artemisia herba alba, Cinnamomum camphora (Ravintsara aromatica) and Helichrysum italicum (Calendula officinalis) for genotoxic effects using the yeast Saccharomyces cerevisiae. Clear cytotoxic effects were observed in the diploid yeast strain D7, with ...

      Known for Saccharomyces Cerevisiae | Essential Oils | Helichrysum Italicum | Medicinal Plants | Nuclear Genetic Events
      KOL-Index: 9128

      Several approaches are described aiming at a better understanding of the genotoxicity of psoralen photoinduced lesions in DNA. Psoralens can photoinduce different types of photolesions including 3,4- and 4',5'-monoadducts and interstrand cross-links, oxidative damage (in the case of 3-carbethoxypsoralen (3-CPs)) and even pyrimidine dimers (in the case of 7-methylpyrido(3,4-c)psoralen (MePyPs)). The characterization and detection of different types of lesions has been essential for the ...

      Known for Repair Photolesions | Oxidative Damage | Psoralen Lesions | Pyrimidine Dimers | Induced Dna
      KOL-Index: 9116

      Recently, the risk associated with low doses of ionizing radiation has gained new interest. Here, we analyze and discuss the major differences between two reports recently published on this issue; the report of the French Academy of Sciences and of the French Academy of Medicine published in March 2005, and the BEIR VII—Phase 2 Report of the American National Academy of Sciences published as a preliminary version in July 2005. The conclusion of the French Report is that the linear ...

      Known for Low Doses | Ionizing Radiation | Biological Neoplasms | French Report | Detrimental Effects
      KOL-Index: 9098

      We report on the uptake, toxicity, and degradation of magnetic nanowires by NIH/3T3 mouse fibroblasts. Magnetic nanowires of diameters 200 nm and lengths between 1 and 40 μm are fabricated by controlled assembly of iron oxide (γ-Fe(2)O(3)) nanoparticles. Using optical and electron microscopy, we show that after 24 h incubation the wires are internalized by the cells and located either in membrane-bound compartments or dispersed in the cytosol. Using fluorescence microscopy, the ...

      Known for Magnetic Nanowires | Living Cells | Cell Proliferation | Iron Oxide | Fluorescence Microscopy
      KOL-Index: 8810

      Chromosomal repair was studied in stationary-phase Saccharomyces cerevisiae, including rad52/rad52 mutant strains deficient in repairing double-strand breaks (DSBs) by homologous recombination. Mutant strains suffered more chromosomal fragmentation than RAD52/RAD52 strains after treatments with cobalt-60 gamma irradiation or radiomimetic bleomycin, except after high bleomycin doses when chromosomes from rad52/rad52 strains contained fewer DSBs than chromosomes from RAD52/RAD52 strains. ...

      Known for Saccharomyces Cerevisiae | Dna Damage | Homologous Recombination | Strand Breaks | Mutant Strains
      KOL-Index: 8740

      Non-homologous end joining (NHEJ) and homologous recombination (HR) are two pathways that can compete or cooperate for DNA double-strand break (DSB) repair. NHEJ was previously shown to act throughout the cell cycle whereas HR is restricted to late S/G2. Paradoxically, we show here that defect in XRCC4 (NHEJ) leads to over-stimulation of HR when cells were irradiated in G1, not in G2. However, XRCC4 defect did not modify the strict cell cycle regulation for HR (i.e. in S/G2) as attested ...

      Known for Homologous Recombination | G1 G2 | Cell Cycle | Gene Conversion | Dna Double

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      Laboratory of Cellular and Molecular Radiobiology, PRISME, UMR CNRS 5822/IN2P3, IP2I, Lyon-Sud Medical School, University Lyon 1, 69921 Oullins, France;, Claire.Rodriguez-Lafrasse@univ-lyon1.fr | DRE-D3P, CEA, Fontenay-aux-Roses, France. | Commissari

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