Shin‐ichiro Hamano

Shin‐ichiro Hamano

From The Laboratory For Neurogenetics (Drs. Sugawara And Yamakawa, And E. Mazaki–miyazaki), Riken, Brain Science Institute, Saitama; National Epilepsy Center (Drs. Fukushima, ...

Direct Impact

Concepts for which Shin‐ichiro Hamano has direct influence:

west syndrome
status epilepticus
cortical tubers
acute encephalopathy
benign infantile seizures
psychological distress
cerebrospinal fluid

External impact

Concepts related to the work of other authors for which Shin‐ichiro Hamano has influence:

west syndrome
status epilepticus
infantile spasms
candidate genes
monoamine metabolites
acute encephalopathy
rotaviral diarrhea

Prominent publications by Shin‐ichiro Hamano

KOL-Index: 72 PURPOSE: We studied children younger than 6years old who developed catastrophic epilepsy and were registered in the FACE study group to clarify their clinical characteristics and prevalence of seizure as well as epilepsy types. SUBJECTS: Subjects were prospectively recruited from children with epilepsy who satisfied the following criteria and underwent intensive examination between 2009 and ...
Known for
14 Collaborative Centers | Frequent Epileptic Syndrome | Generalized Tonic Seizures | Children Epilepsy
KOL-Index: 46 PURPOSE: We aimed to study the efficacy of adrenocorticotropic hormone (ACTH) treatment on infantile spasms with different aetiologies. In particular, we were interested in patients with structural-acquired aetiology. METHODS: Patients with infantile spasms, who were treated with ACTH, were divided into three groups based on the aetiologies: unknown aetiology with normal development ...
Known for
Normal Unknown | Spasms Structural | Aetiology Combined | Infantile
KOL-Index: 37 OBJECTIVE: To identify the risk factors for psychological distress in electroencephalography (EEG) technicians during the coronavirus disease 2019 (COVID-19) pandemic. METHOD: In this national-level cross-sectional survey initiated by Japan Young Epilepsy Section (YES-Japan), which is a national chapter of The Young Epilepsy Section of the International League Against Epilepsy (ILAE-YES), a ...
Known for
173 Technicians | Psychological Stress | International League | Quasi-
KOL-Index: 37 BACKGROUND: We aimed to demonstrate the biochemical characteristics of vitamin B6-dependent epilepsy, with a particular focus on pyridoxal 5'-phosphate and pyridoxal in the cerebrospinal fluid. METHODS: Using our laboratory database, we identified patients with vitamin B6-dependent epilepsy and extracted their data on the concentrations of pyridoxal 5'-phosphate, pyridoxal, pipecolic acid, ...
Known for
Cerebrospinal Fluid Pyridoxal Concentrations | Pyridoxal 5-Phosphate Deficiency | Vitamin Dependent | Monoamine Neurotransmitters
KOL-Index: 36 BACKGROUND: No dosing regimen has been established for the initial treatment of pediatric status epilepticus with intravenous midazolam. We therefore evaluated the efficacy, safety, and pharmacokinetics of bolus and continuous midazolam infusion. METHODS: This open-label, prospective, multicenter study involved 34 Japanese children with status epilepticus unresponsive to diazepam. An initial ...
Known for
Midazolam Infusion | Bolus Continuous | Pharmacokinetics Intravenous
KOL-Index: 30 Many algorithms to detect copy number variations (CNVs) using exome sequencing (ES) data have been reported and evaluated on their sensitivity and specificity, reproducibility, and precision. However, operational optimization of such algorithms for a better performance has not been fully addressed. ES of 1199 samples including 763 patients with different disease profiles was performed. ES ...
Known for
Cnvs Exome | Efficient Cnv Selection | Unrelated | Biases
KOL-Index: 24 High-dose phenobarbital (PB) therapy is effective for refractory status epilepticus. We reviewed medical records of patients with intractable partial epilepsies on whom performed non-intravenous high-dose PB therapy. Thirteen patients received PB rectally or orally at a dosage of 20-30mg/kg/day initially, and the PB dosage was gradually reduced to a maintenance dosage of 5-10mg/kg/day ...
Known for
Orally Dosage | Intravenous Therapy | Childhood Phenobarbital | Seizures Seizure
KOL-Index: 24 Mowat-Wilson syndrome (MWS) is a multiple congenital anomaly syndrome characterized by moderate or severe intellectual disability, a characteristic facial appearance, microcephaly, epilepsy, agenesis or hypoplasia of the corpus callosum, congenital heart defects, Hirschsprung disease, and urogenital/renal anomalies. It is caused by de novo heterozygous loss of function mutations including ...
Known for
Nonsense Frameshift Mutations | Wild-Type Zeb2 | Hypoplasia | Congenital Heart Defects
KOL-Index: 23 We report on a 6-month-old malformed female infant with a de novo interstitial duplication of an 8q22-q24 segment. She had an excess dark-band on the 8q distal region by GTG-banded chromosome analysis, which was likely to be 8q23. We performed FISH analysis using cosmid probes mapped to 8q23 and proved that the patient had an 8q duplication including the 8q23 region.
Known for
8q Distal Region | Novo Interstitial Duplication | Gtg-Banded Chromosome | 6-Month-Old Malformed Female Infant
KOL-Index: 23 BACKGROUND: To differentiate the features of electroencephalography (EEG) after status epileptics in febrile children with final diagnosis of either febrile seizure (FS) or acute encephalopathy for an early diagnosis. METHODS: We retrospectively collected data from 68 children who had status epilepticus and for whom EEGs were recorded within 120 h. These included subjects with a final ...
Known for
Epileptic Status | Usual Inspection | Prolonged Febrile | Severe Grades

From the Laboratory for Neurogenetics (Drs. Sugawara and Yamakawa, and E. Mazaki–Miyazaki), RIKEN, Brain Science Institute, Saitama; National Epilepsy Center (Drs. Fukushima, Shimomura, Fujiwara, and Inoue), Shizuoka Medical Institute of Neurological

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