Marcelle Aparecida de Barros

Marcelle Aparecida de Barros

College Of Medicine, University Of Saskatchewan, S7n, Saskatoon, Sk, 0w8, Canada Pharmalytics Research Institute, University Of Saskatchewan, S7n 3r2, Saskatoon, Sk, Canada

Direct Impact

Concepts for which Marcelle Aparecida de Barros has direct influence:

fluphenazine decanoate
reduced haloperidol
plasma concentrations
rat bile
therapeutic monitoring
psychotropic drugs
intersubject variation

External impact

Concepts related to the work of other authors for which Marcelle Aparecida de Barros has influence:

melphalan hcl
propylene glycol
autologous transplantation
myeloablative conditioning
pretreatment period
symptomatic myeloma
center open

Prominent publications by Marcelle Aparecida de Barros

KOL-Index: 27 Chlorpromazine N-oxide, fluphenazine N4'-oxide, prochlorperazine N4'-oxide, sulforidazine N-oxide, and trifluoperazine N4'-oxide were synthesized by oxidation of the designated nitrogen atom in the N-10 side chain of the respective parent drug with 3-chloroperoxybenzoic acid. In the case of trifluoperazine, a stepwise increase in the amount of oxidant yielded the N1',N4'-dioxide and ...
Known for
Hydrogen Peroxide Oxidation | 3-Chloroperoxybenzoic Acid | Stepwise | Designated Nitrogen Atom
KOL-Index: 26 When undertaking development of methodology to analyse a compound containing an N-oxide, it is important to consider whether the compound is the N-oxide of a tertiary aliphatic amine such as trimethylamine, or tertiary arylalkylamine such as dimethylphenylamine, or heteroaromatic amine such as pyridine or quinoline. The first two types are referred to here as aliphatic tertiary amines. It is ...
Known for
Quinoline | Aliphatic Tertiary | Reducing Agents
KOL-Index: 23 Metabolism of the anorectic agent, fenfluramine, was studied in man to detect phenolic and/or alcoholic metabolites.2. Two new metabolites identified as 1-(m-trifluoromethylphenyl)-2-propanol and 1-(m-trifluoromethylphenyl)-1,2-propanediol, were detected in human urine by g.l.c. and g.l.c.-mass spectrometry.
Known for
1-M | Metabolites Fenfluramine
KOL-Index: 23 The in vivo metabolism of compounds which contain N-oxide groups, either aliphatic or heteroaromatic tertiary amines, has not been extensively studied. Just as there are differences in the enzymes involved in the oxidation of the two different types of tertiary amines to their N-oxides, it might be expected that there will be differences in the effect such a group has on the overall ...
Known for
Compounds Oxide | Aliphatic Tertiary | Differences Metabolism
KOL-Index: 22 This study demonstrated that the mere fact that two multisource drug formulations are bioequivalent with the same reference formulation does not guarantee that they are bioequivalent with each other. The present unscaled bioequivalence limits (BEL) of 0.80 to 1.25 permitted far greater deviation from unity of the geometric mean ratio (GMR) for multisource formulations with low within-subject ...
Known for
Gmr | Mere | Unscaled Bioequivalence Limits | Narrow Therapeutic Range
KOL-Index: 22 1. To expedite direct studies on phase II metabolites of fluphenazine, pure fluphenazine or 7-hydroxyfluphenazine were incubated with a rabbit hepatic microsomal immobilized enzyme system. After purification and recrystallization a high yield (60%) of 7-hydroxy-beta-D-O-glucuronyl-fluphenazine was obtained. 2. The structure of this glucuronide was proven unambiguously by mass spectrometry ...
Known for
Tertiary Aliphatic Nitrogen Atoms | Phenolic Ether Glucuronide | Side-Chain Primary Alcohol Function | Chain Fluphenazine
KOL-Index: 20 Antisera to fluphenazine sulfoxide were raised in New Zealand white rabbits to an immunogen synthesized by covalent linkage of bovine serum albumin to 10-[[3-[4-(4-carboxybutyl)-1-piperazinyl] propyl]]-2-trifluoromethyl-10H-phenothiazine 5-sulfoxide. With use of an antiserum, a radioimmunoassay for fluphenazine sulfoxide was developed that is able to quantitate 0.156 ng ml-1 using only a 200 ...
Known for
Zealand White Rabbits | Sulfoxide Antiserum | 200 Microliter Plasma Sample | Oral Intramuscular Fluphenazine
KOL-Index: 19 The role of metabolites in bioequivalence studies has been a contentious issue for many years. Many papers have published recommendations for the use of metabolite data based on anecdotal evidence from the results of bioequivalence studies. Such anecdotal evidence has validity, but the arguments lack weight because the “correct” answers are always unknown. A more promising area of ...
Known for
Principles Recommendations | Role Metabolites | Bioequivalence Anecdotal
KOL-Index: 19 1. The metabolism of chlorpromazine N-oxide was studied in female rats after a 20 mg/kg single i.p. dose. 2. Metabolites identified in urine and faeces were chlorpromazine, 7-hydroxychlorpromazine, chlorpromazine sulphoxide, N-desmethylchlorpromazine and N-desmethylchlorpromazine sulphoxide. As these same five metabolites were previously shown to be present after oral administration this ...
Known for
Biliary Metabolites | Faeces Chlorpromazine | Bile Identified | Qualitative Differences
KOL-Index: 18 The levels of fluphenazine and fluphenazine sulphoxide in schizophrenic patients who were randomly assigned to receive either 5 mg or 25 mg of fluphenazine decanoate every two weeks were monitored. Patients treated with 25 mg of fluphenazine decanoate required three months to reach a steady-state plasma level, indicating that those patients who are being converted from oral to depot ...
Known for
Neurological Side-Effects | Fluphenazine Months | Steady-State Plasma Level | Statistically Relationship

College of Medicine, University of Saskatchewan, S7N, Saskatoon, SK, 0W8, Canada Pharmalytics Research Institute, University of Saskatchewan, S7N 3R2, Saskatoon, SK, Canada

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