Direct Impact

Concepts for which Paul James Brindley has direct influence:

schistosoma mansoni
liver fluke
opisthorchis viverrini
urogenital schistosomiasis
nematospiroides dubius
developmental stages
aspartic protease

External impact

Concepts related to the work of other authors for which Paul James Brindley has influence:

schistosoma mansoni
clonorchis sinensis
blood fluke
opisthorchis viverrini
urogenital schistosomiasis
lao pdr
hepatobiliary abnormalities

Prominent publications by Paul James Brindley

Cholangiocarcinoma


[ PUBLICATION ]
KOL-Index: 99 Cholangiocarcinoma (CCA) is a highly lethal adenocarcinoma of the hepatobiliary system, which can be classified as intrahepatic, perihilar and distal. Each anatomic subtype has distinct genetic aberrations, clinical presentations and therapeutic approaches. In endemic regions, liver fluke infection is associated with CCA, owing to the oncogenic effect of the associated chronic biliary tract ...
Known for
Fluke Intrahepatic | Lethal Insights | Chronic Biliary | Pathogenesis Cca
KOL-Index: 80 Liver flukes, such as Clonorchis sinensis and Opisthorchis viverrini, are food-borne parasites that have a major impact on the health of humans and animals, particularly in Asia. However, the impact of C. sinensis and O. viverrini, in particular, is exacerbated in that these parasites can induce a malignant, untreatable cancer (cholangiocarcinoma, CCA) in chronically infected people. As a ...
Known for
Chronically Infected People | Next-Generation Technologies | Unique Biological Biotechnological Prospects | 1 Carcinogens
KOL-Index: 72 Targeting chokepoint enzymes in metabolic pathways has led to new drugs for cancers, autoimmune disorders and infectious diseases. This is also a cornerstone approach for discovery and development of anthelmintics against nematode and flatworm parasites. Here, we performed omics-driven knowledge-based identification of chokepoint enzymes as anthelmintic targets. We prioritized 10 of 186 ...
Known for
Anthelmintics Nematode | Pan Intestinal | Inhibitors Broad | Identification Small
KOL-Index: 70 Helminths are the cause of some of the major infectious diseases of humanity in what is still a "wormy" world. There is, in East and Southeast Asia, a high prevalence of several helminthiases which occur primarily in rural, impoverished areas of low-income and developing countries throughout the tropics and subtropics. Subsequent to various parasite genome projects that commenced in the ...
Known for
Humanity | Southeast Asian | Chapter 11 Wormy Genomics | Schistosoma Japonicum
KOL-Index: 64 CRISPR/Cas9-based genome editing has yet to be reported in species of the Platyhelminthes. We tested this approach by targeting omega-1 (ω1) of Schistosoma mansoni as proof of principle. This secreted ribonuclease is crucial for Th2 polarization and granuloma formation. Schistosome eggs were exposed to Cas9 complexed with guide RNA complementary to ω1 by electroporation or by transduction ...
Known for
Edited Eggs | Omega-1 | Mansoni | Programmed Gene
KOL-Index: 62 Helminthiases are extremely prevalent in the developing world. In addition, the chronic infection with some parasitic worms are classified as carcinogenic. Therefore, it is utmost importance to understand the parasite-host interactions, the mechanisms underlay carcinogenesis and how they could be counteracted. This knowledge may ultimately guide novel control strategies that include ...
Known for
Knowledge Chemical | Parasite Host | Infections Helminthiases | Strategies Carcinogenic
KOL-Index: 59

Background: Schistosoma haematobium, the helminth causing urogenital schistosomiasis, is a known bladder carcinogen. Despite the causal link between S. haematobium and bladder cancer, the underlying mechanisms are poorly understood. S. haematobium oviposition in the bladder is associated with angiogenesis and urothelial hyperplasia. These changes may be pre-carcinogenic events in the ...

Known for
Pbackground | Eggs Bladder | Ipse Mutant Protein | Interleukin-4-Inducing Principle
KOL-Index: 52 Peptides, bound to the tegument of live Schistosoma japonicum schistosomula, were differentially screened by phage display in vitro using three rounds of reverse absorption and bio-panning. Three M13 phage peptides were isolated and identified by determination of their recovery rate, immunohistochemical localization, immunoblot analysis, and their anti-schistosomal effects in vivo and in ...
Known for
Surface Membrane | Binding Properties | Recovery Rate | Mppzl4 Bind
KOL-Index: 48 The foodborne trematodiases refer to a cluster of zoonotic neglected tropical diseases caused by trematodes, with transmission involving ingestion of contaminated plants, fishes, and crustaceans. Over 40 million people are infected with foodborne trematodes and 750 million are at risk of infection. From a public health point of view, important species include Clonorchis sinensis, ...
Known for
Foodborne Trematodes | Opisthorchiasis | Fasciola Gigantica
KOL-Index: 45 Schistosomiasis, caused mainly by Schistosoma japonicum, S. mansoni, and S. hematobium, remains one of the most prevalent and serious parasitic diseases worldwide. The blood flukes have a complex life cycle requiring adaptation for survival in fresh water as free-living forms and as parasites in snail intermediate and vertebrate definitive hosts. Functional genomics analyses, including ...
Known for
Japonicum Mansoni | Blood Flukes | Biology Host | Transcriptomic Proteomic

Department of Biology, Vanderbilt University, Nashville, Tennessee 37235

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