Prominent publications by Elizabeth Kerr Warrington

KOL Index score: 12241

An expanded hexanucleotide repeat in the C9ORF72 gene has recently been identified as a major cause of familial frontotemporal lobar degeneration and motor neuron disease, including cases previously identified as linked to chromosome 9. Here we present a detailed retrospective clinical, neuroimaging and histopathological analysis of a C9ORF72 mutation case series in relation to other forms of genetically determined frontotemporal lobar degeneration ascertained at a specialist centre. ...

Known for Repeat Expansion |  C9orf72 Mutation |  Frontotemporal Dementia |  Motor Neuron Disease |  Lobar Degeneration
KOL Index score: 11769

Mutations in the progranulin gene (GRN) are a major cause of frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions (FTLD-U) but the distinguishing clinical and anatomical features of this subgroup remain unclear. In a large UK cohort we found five different frameshift and premature termination mutations likely to be causative of FTLD in 25 affected family members. A previously described 4-bp insertion mutation in GRN exon 2 comprised the majority of cases in ...

Known for Progranulin Gene |  Grn Carriers |  Age Onset |  Patients Ftld |  Distinct Clinical
KOL Index score: 11154

Relating clinical symptoms to neuroanatomical profiles of brain damage and ultimately to tissue pathology is a key challenge in the field of neurodegenerative disease and particularly relevant to the heterogeneous disorders that comprise the frontotemporal lobar degeneration spectrum. Here we present a retrospective analysis of clinical, neuropsychological and neuroimaging (volumetric and voxel-based morphometric) features in a pathologically ascertained cohort of 95 cases of ...

Known for Lobar Degeneration |  Tau Pathology |  Tdp43 Type |  Neurodegenerative Disease |  Semantic Dementia
KOL Index score: 9986

The primary progressive aphasias (PPA) are paradigmatic disorders of language network breakdown associated with focal degeneration of the left cerebral hemisphere. Here we addressed brain correlates of PPA in a detailed neuroanatomical analysis of the third canonical syndrome of PPA, logopenic/phonological aphasia (LPA), in relation to the more widely studied clinico-anatomical syndromes of semantic dementia (SD) and progressive nonfluent aphasia (PNFA). 32 PPA patients (9 SD, 14 PNFA, 9 ...

Known for Language Network |  Ppa Lpa |  White Matter |  Phonological Aphasia |  Progressive Brain
KOL Index score: 9198

Visual crowding is a form of masking in which target identification is hindered by excessive feature integration from other stimuli in the vicinity. It has previously been suggested that excessive visual crowding constitutes one specific form of early-visual-processing deficit, which may be observed in individuals with posterior cortical atrophy (PCA). This study investigated whether excessive visual crowding plays a significant role in the acquired dyslexia of two PCA patients, whose ...

Known for Letter Confusability |  Visual Crowding |  Posterior Cortical Atrophy |  Pca Patients |  Reading Accuracy
KOL Index score: 9161

A significant minority of Alzheimer's disease patients present with posterior cortical atrophy (PCA). PCA is characterized by visuospatial and visuoperceptual deficits, and relatively preserved memory, whereas patients with typical Alzheimer's disease (tAD) mostly present with early episodic memory deficits. We used two unbiased image analysis techniques to assess atrophy patterns in 48 PCA, 30 tAD, and 50 healthy controls. FreeSurfer was used to measure cortical thickness, and ...

Known for Cortical Thickness |  Pca Tad |  Typical Alzheimer |  Based Morphometry |  Disease Atrophy
KOL Index score: 8928

BACKGROUND: The language profile of behavioral variant frontotemporal dementia (bvFTD) remains to be fully defined.

OBJECTIVE: We aimed to quantify the extent of language deficits in this patient group.

METHODS: We assessed a cohort of patients with bvFTD (n = 24) in relation to patients with semantic variant primary progressive aphasia (svPPA; n = 14), nonfluent variant primary progressive aphasia (nfvPPA; n = 18), and healthy age-matched individuals (n = 24) cross-sectionally and ...

Known for Patients Bvftd |  Frontotemporal Dementia |  Behavioral Variant |  Progressive Aphasia |  Language Deficits
KOL Index score: 8507

Sixteen affected individuals are described from two families with early onset autosomal dominant familial Alzheimer's disease. A mutation at codon 139 in the presenilin 1 gene on chromosome 14 results in a methionine to valine substitution which cosegregates with the disease in these families. Onset of dementia was before the age of 50 years in all individuals. The ages at onset within each family were tightly clustered but were significantly different between the families; this ...

Known for Presenilin 1 Gene |  M139v Mutation |  Familial Alzheimer |  Disease Families |  Cognitive Decline
KOL Index score: 7982

The neuropsychological features of the primary progressive aphasia (PPA) syndromes continue to be defined. Here we describe a detailed neuropsychological case study of a patient with a mutation in the progranulin (GRN) gene who presented with progressive word-finding difficulty. Key neuropsychological features in this case included gravely impoverished propositional speech with anomia and prolonged word-finding pauses, impaired speech repetition most marked for sentences, and severely ...

Known for Progressive Aphasia |  Neuropsychological Features |  Ppa Syndrome |  Speech Repetition |  Semantic Impairment
KOL Index score: 7128

BACKGROUND: Encephalitis associated with antibodies to voltage-gated potassium channels (VGKC-Ab) is characterized by epilepsy, behavioral changes, and anterograde memory impairment. Magnetic resonance imaging reveals abnormal signal predominantly restricted to the mediotemporal lobes.

OBJECTIVE: To determine the temporal extent and potential reversibility of retrograde amnesia in 3 patients with VGKC-Ab-associated encephalitis.

DESIGN: Case report.

SETTING: Clinical. Patients Three ...

Known for Retrograde Amnesia |  Gated Potassium |  Encephalitis Antibodies |  Magnetic Resonance Imaging |  Memory Impairment
KOL Index score: 7089

Visual crowding is a form of masking in which single-letter identification is compromised by the presence of additional letters or other simple visual forms in close proximity. This behavioural phenomenon has been studied most frequently in the context of amblyopic and normal peripheral vision. In the current study, we investigate this phenomenon in the context of two patients with peripheral dyslexia and a third with visual disorientation consequent to bilateral posterior cortical ...

Known for Posterior Cortical Atrophy |  Visual Crowding |  Magnetic Resonance |  Letter Reading |  Processing Deficit
KOL Index score: 6953

Posterior cortical atrophy (PCA) is characterized by a progressive decline in higher-visual object and space processing, but the extent to which these deficits are underpinned by basic visual impairments is unknown. This study aimed to assess basic and higher-order visual deficits in 21 PCA patients. Basic visual skills including form detection and discrimination, color discrimination, motion coherence, and point localization were measured, and associations and dissociations between ...

Known for Cortical Thickness |  Basic Visual |  Pca Patients |  Space Perception |  Progressive Decline


Elizabeth Kerr Warrington: Influence Statistics

Sample of concepts for which Elizabeth Kerr Warrington is among the top experts in the world.
Concept World rank
control subjects retention #1
unilateral ect method #1
method language laterality #1
rfr attack #1
severe prosopagnosia stroke #1
abstract contrast #1
reading error analysis #1
verbal sections #1
independence output systems #1
original patient kf #1
abnormal colour images #1
delia language #1
input written #1
amnesic patients pictures #1
picks patient #1
letters explanations #1
impaired semantic category #1
visual objects knowledge #1
single semantic errors #1
recognition associate learning #1
countries famous people #1
language male methods #1
excessive rebound inhibition #1
hemisphere performances #1
series reading skills #1
comprehension country #1
experiment rk #1
storage semantic #1
generation colour #1
category specificity organization #1
groups gda #1
mirror images patient #1
relative impairment #1
retardation seventysix children #1
neighbourhood formal testing #1
tasks shortterm retention #1
kinds memory memory #1
success study retention #1
lobe tactile #1
word comprehension test #1
attention naming ability #1
numerical calculation bet #1
hemisphere lesions deficit #1
lefthanders degree #1
oldfield score #1
complete dissociation study #1
memory deficits relation #1
finger differentiation #1
tasks perceptual categorization #1
rox retrieval #1

Key People For Posterior Cortical Atrophy

Top KOLs in the world
Neill R Graff‐Radford
alzheimer disease african americans lewy bodies
Mario F Mendez
frontotemporal dementia alzheimer disease emotional blunting
David F Tang‐Wai
frontotemporal dementia alzheimer disease cognitive impairment
Ronald Carl Petersen
mild cognitive impairment alzheimer disease lewy bodies
David S Knopman
alzheimer disease atherosclerosis risk mild cognitive impairment
Sebastian J Crutch
posterior cortical atrophy alzheimer disease cortical thickness

Elizabeth Kerr Warrington:Expert Impact

Concepts for whichElizabeth Kerr Warringtonhas direct influence:Posterior cortical atrophy,  Selective impairment,  Object recognition,  Semantic dementia,  Semantic memory,  Amnesic patients,  Single case study,  Orally spelled.

Elizabeth Kerr Warrington:KOL impact

Concepts related to the work of other authors for whichfor which Elizabeth Kerr Warrington has influence:Frontotemporal dementia,  Semantic memory,  Alzheimer disease,  Temporal lobe,  Magnetic resonance,  Primary progressive aphasia,  Multiple sclerosis.



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Dementia Research Centre, UCL Institute of Neurology, Queen Square, WC1N 3BG, London, UK | Dementia Research Centre, UCL Institute of Neurology, London, UK, View further author information | Dementia Research Centre, UCL Institute of Neurology, Unive

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