Olivier Picone: Influence Statistics

Olivier Picone

Olivier Picone

Université de Paris, Paris, France | FHU PREMA, Paris, France | Groupe de Recherche sur les Infections pendant la Grossesse (GRIG), Vélizy, France | Assistance ...

Olivier Picone: Expert Impact

Concepts for which Olivier Picone has direct influence: Hospital admission , Ifn immunity , 70 years , Neutralizing type , Type ifns , Child child , Inborn errors .

Olivier Picone: KOL impact

Concepts related to the work of other authors for which for which Olivier Picone has influence: Sarscov2 infection , Immune response , Inborn errors , Cytokine storm , Neutralizing antibodies , Coronavirus disease covid19 , Viral load .

KOL Resume for Olivier Picone


Université de Paris, Paris, France


Hôpital L Mourier, Colombes, France, University of Paris

ISARIC Global Support Centre, Centre for Tropical Medicine and Global Health, University of Oxford, New Richards Building, Old Road Campus, Oxford, OX3 7LG UK


Hôpital Louis Mourier, Colombes, France

Prominent publications by Olivier Picone

KOL-Index: 11302 . Circulating autoantibodies (auto-Abs) neutralizing high concentrations (10 ng/mL, in plasma diluted 1 to 10) of IFN-α and/or -ω are found in about 10% of patients with critical COVID-19 pneumonia, but not in subjects with asymptomatic infections. We detect auto-Abs neutralizing 100-fold lower, more physiological, concentrations of IFN-α and/or -ω (100 pg/mL, in 1/10 dilutions of plasma) in ...
Known for Neutralizing Type | Critical Covid19 | 70 Years | Auto Abs
KOL-Index: 8938 . Clinical outcome upon infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ranges from silent infection to lethal coronavirus disease 2019 (COVID-19). We have found an enrichment in rare variants predicted to be loss-of-function (LOF) at the 13 human loci known to govern Toll-like receptor 3 (TLR3)- and interferon regulatory factor 7 (IRF7)-dependent type I ...
Known for Ifn Immunity | Inborn Errors | Rare Variants | Viral Receptor
KOL-Index: 8109 . Interindividual clinical variability in the course of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is vast. We report that at least 101 of 987 patients with life-threatening coronavirus disease 2019 (COVID-19) pneumonia had neutralizing immunoglobulin G (IgG) autoantibodies (auto-Abs) against interferon-ω (IFN-ω) (13 patients), against the 13 types of IFN-α (36), ...
Known for Interferon Type | Patients Autoabs | Critical Disease | Ifn Immunity
KOL-Index: 7359 . BACKGROUND: Humoral response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurs within the first weeks after coronavirus disease 2019 (COVID-19). Those antibodies exert a neutralizing activity against SARS-CoV-2, whose evolution over time after COVID-19 as well as efficiency against novel variants are poorly characterized. METHODS: In this prospective study, sera of 107 ...
Known for Neutralizing Antibodies | 6 Months | Spike Glycoprotein | Ancestral Strain
KOL-Index: 7175 . Little is known on the association between clinical factors and coronavirus disease 2019 (COVID-19) more than 15 days after diagnosis. We conducted a multicentric prospective cohort of COVID-19 hospitalized patients to describe clinical, biological, and virological characteristics at hospital admission and over time, according to mortality up to Day 60 after admission. For the analysis of ...
Known for Hospital Admission | Viral Load | Covid‐19 Patients | Multivariate Analysis
KOL-Index: 5849 . BACKGROUND: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. METHODS: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January ...
Known for Hospital Admission | Covid19 Symptoms | Adults Children | Patients Admitted
KOL-Index: 5747 . Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection fatality rate (IFR) doubles with every 5 y of age from childhood onward. Circulating autoantibodies neutralizing IFN-α, IFN-ω, and/or IFN-β are found in ∼20% of deceased patients across age groups, and in ∼1% of individuals aged <70 y and in >4% of those >70 y old in the general population. With a sample of 1,261 ...
Known for Ifn Autoantibodies | Neutralizing Type | Risk Covid19 | Cov2 Adult
KOL-Index: 5568 . Autosomal inborn errors of type I IFN immunity and autoantibodies against these cytokines underlie at least 10% of critical COVID-19 pneumonia cases. We report very rare, biochemically deleterious X-linked TLR7 variants in 16 unrelated male individuals aged 7 to 71 years (mean: 36.7 years) from a cohort of 1,202 male patients aged 0.5 to 99 years (mean: 52.9 years) with unexplained ...
Known for Child Child | Ifn Immunity | Tlr7 Deficiency | Covid19 Pneumonia
KOL-Index: 4788 . OBJECTIVES: Molecular assays on nasopharyngeal swabs remain the cornerstone of COVID-19 diagnostic. The high technicalities of nasopharyngeal sampling and molecular assays, as well as scarce resources of reagents, limit our testing capabilities. Several strategies failed, to date, to fully alleviate this testing process (e.g. saliva sampling or antigen testing on nasopharyngeal samples). ...
Known for New Testing Alternatives | Serum Antigen | Acute Covid19 | Symptoms Onset
KOL-Index: 2571 . AIMS: The role of renin-angiotensin-aldosterone system (RAAS) blockers on the course of coronavirus disease 2019 (COVID-19) is debated. We assessed the association between chronic use of RAAS blockers and mortality among inpatients with COVID-19 and explored reasons for discrepancies in the literature. METHODS AND RESULTS: We included adult hypertensive patients from a prospective ...
Known for Blockers Angiotensin | Hazard Ratios | Enzyme Inhibitors | 1 Receptor
KOL-Index: 2097 . INTRODUCTION: Pregnant women are at increased risk for COVID-19, and COVID-19 vaccine is the most promising solution to overcome the current pandemic. This study was conducted to evaluate pregnant women's perceptions and acceptance of COVID-19 vaccination. MATERIALS & METHODS: A cross-sectional study was conducted from February 18 to April 5 2021. An anonymous survey was distributed in 7 ...
Known for Pregnant Women | Influenza Vaccine
KOL-Index: 1113 . Background: This research prioritization aimed to identify major research gaps in maternal, newborn, child and adolescent health (MNCAH) to help mitigate the direct and indirect effects of the COVID-19 pandemic. Methods: We adapted the Child Health and Nutrition Research Initiative methodology. We defined scope, domains, themes and scoring criteria. We approached diverse global experts via ...
Known for Health Covid19 | Nutrition Initiative
KOL-Index: 973 . Background: There is potentially considerable variation in the nature and duration of the care provided to hospitalised patients during an infectious disease epidemic or pandemic. Improvements in care and clinician confidence may shorten the time spent as an inpatient, or the need for admission to an intensive care unit (ICU) or high dependency unit (HDU). On the other hand, limited ...
Known for Hospitalised Patients | Hospital Admission | Large International
KOL-Index: 352 . Life-threatening 'breakthrough' cases of critical COVID-19 are attributed to poor or waning antibody response to the SARS-CoV-2 vaccine in individuals already at risk. Pre-existing autoantibodies (auto-Abs) neutralizing type I IFNs underlie at least 15% of critical COVID-19 pneumonia cases in unvaccinated individuals; however, their contribution to hypoxemic breakthrough cases in ...
KOL-Index: 262
Known for Covid19 Communicable

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Université de Paris, Paris, France | FHU PREMA, Paris, France | Groupe de Recherche sur les Infections pendant la Grossesse (GRIG), Vélizy, France | Assistance Publique-Hôpitaux de Paris APHP, Nord, Service de Gynécologie Obstétrique, Hôpital Louis M