Minna Hendolin

Minna Hendolin

Sitra—the Finnish Innovation Fund, 00180 Helsinki, Finland;, Minna.hendolin@sitra.fi

Direct Impact

Concepts for which Minna Hendolin has direct influence:

severe covid-19
chromosome xq23
haematopoietic stem cells
sleep apnoea
citizen trust
prostate cancer
public engagement relating

External impact

Concepts related to the work of other authors for which Minna Hendolin has influence:

atrial fibrillation
jak2 v617f somatic mutation
myeloproliferative cancer
primary open-angle glaucoma
age-related macular degeneration
polygenic effects
yap1 gene

Prominent publications by Minna Hendolin

KOL-Index: 53 Polygenic risk scores (PRSs) have shown promise in predicting susceptibility to common diseases1–3. We estimated their added value in clinical risk prediction of five common diseases, using large-scale biobank data (FinnGen; n = 135,300) and the FINRISK study with clinical risk factors to test genome-wide PRSs for coronary heart disease, type 2 diabetes, atrial fibrillation, breast cancer ...
Known for
Diabetes Breast | Fibrillation Prostate | Thresholds | Early-Onset Coronary Heart
KOL-Index: 39 Primary open-angle glaucoma (POAG), is a heritable common cause of blindness world-wide. To identify risk loci, we conduct a large multi-ethnic meta-analysis of genome-wide association studies on a total of 34,179 cases and 349,321 controls, identifying 44 previously unreported risk loci and confirming 83 loci that were previously known. The majority of loci have broadly consistent effects ...
Known for
Integration | Lines | Glaucoma | Fine-Mapping
KOL-Index: 15 Myeloproliferative neoplasms (MPNs) are blood cancers that are characterized by the excessive production of mature myeloid cells and arise from the acquisition of somatic driver mutations in haematopoietic stem cells (HSCs). Epidemiological studies indicate a substantial heritable component of MPNs that is among the highest known for cancers1. However, only a limited number of genetic risk ...
Known for
Longer Telomere Length | Mature Myeloid Cells | Large-Scale Genome-Wide | 17 Mpn Loci
KOL-Index: 12 Autosomal genetic analyses of blood lipids have yielded key insights for coronary heart disease (CHD). However, X chromosome genetic variation is understudied for blood lipids in large sample sizes. We now analyze genetic and blood lipid data in a high-coverage whole X chromosome sequencing study of 65,322 multi-ancestry participants and perform replication among 456,893 European ...
Known for
Adipose Tissue | Lipids | Increased Gluteofemoral Fat | Reduced Visceral Adiposity
KOL-Index: 11 BACKGROUND: Obstructive sleep apnoea (OSA) is associated with higher body mass index (BMI), diabetes, older age and male gender, which are all risk factors for severe COVID-19.We aimed to study if OSA is an independent risk factor for COVID-19 infection or for severe COVID-19. METHODS: OSA diagnosis and COVID-19 infection were extracted from the hospital discharge, causes of death and ...
Known for
Covariates | Higher Mass | Older Age | Finngen
KOL-Index: 2 The potential for the use of real-world data (RWD) to generate real-world evidence (RWE) that can inform clinical decision-making and health policy is increasingly recognized, albeit with hesitancy in some circles. If used appropriately, the rapidly expanding wealth of health data could improve healthcare research, delivery of care, and patient outcomes. However, this depends on two key ...
Known for
Frameworks | Rapidly Expanding Wealth | European Union Citizens | Gradual Steady Growth

Sitra—The Finnish Innovation Fund, 00180 Helsinki, Finland;, minna.hendolin@sitra.fi

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