• Disease
  • Haemophilia
  • Haemophilia Patients
  • Goris Roosendaal

    Prominent publications by Goris Roosendaal

    KOL Index score: 14945

    OBJECTIVE: Hemophilic arthropathy, with characteristics of inflammatory (rheumatoid arthritis) and degenerative (osteoarthritis) joint damage, occurs at an early age, is associated with minor comorbidity, and is restricted to 3 pairs of large joints. The aim of this study was to determine whether commonly used serum and/or urinary biomarkers of cartilage and bone turnover for which assay kits are commercially available are associated with the severity of joint damage in patients with ...

    Also Ranks for: Cartilage Damage |  hemophilic arthropathy |  oligomeric matrix |  pettersson score |  urinary ctxii
    KOL Index score: 10001

    Mild haemophilia A is a rare disease with a relatively mild phenotype. Treatment with factor VIII (FVIII) is indicated after trauma or for surgery only. FVIII infusion may result in the development of inhibiting antibodies against FVIII. This study describes the relation between age and other risk factors for inhibitor development in mild haemophilia. A retrospective cohort study was conducted among all patients with mild haemophilia (FVIII 0.05-0.40 IU mL(-1)) registered at the van ...

    Also Ranks for: Mild Haemophilia |  inhibitor development |  factor viii fviii |  peak treatment |  age patients
    KOL Index score: 9713

    Prophylaxis is the recommended treatment for children with severe haemophilia A, but whether prophylaxis should be continued in adulthood is still under debate. Previous studies with limited follow-up have suggested that some patients may be able to stop prophylaxis in adulthood, while maintaining good joint health. This single-centre observational cohort study examined patients with severe haemophilia A born 1970-1988 without inhibitor development, and assessed the long-term ...

    Also Ranks for: Severe Haemophilia |  joint status |  patients prophylaxis |  bleeding rates |  hemarthrosis hemophilia
    KOL Index score: 9674

    OBJECTIVE: Joint bleeding, or hemarthrosis, leads in time to severe joint damage. This study was carried out to test the in vitro thresholds of exposure time and concentration that lead to irreversible joint damage, to add to the discussion on the usefulness of aspiration of the joint after a hemorrhage.

    METHODS: Explants of healthy human articular cartilage tissue were cultured in the presence or absence of 50% (volume/volume) blood for 1, 2, 3, or 4 days or in the presence of 0%, 5%, ...

    Also Ranks for: Cartilage Damage |  blood joint |  matrix metalloproteinases |  exposure human |  aged proteoglycans
    KOL Index score: 9366

    To prevent hemophilic arthropathy, prophylactic treatment of children with severe hemophilia should be started before joint damage has occurred. However, treatment is expensive, and the burden of regular venipunctures in young children is high. With the aim of providing information on starting prophylaxis on the basis of individual patient characteristics, the effect of postponing prophylaxis on long-term arthropathy was studied in a cohort of 76 patients with severe hemophilia born ...

    Also Ranks for: Severe Hemophilia |  prophylactic treatment |  joint bleed |  pettersson score |  patients prophylaxis
    KOL Index score: 9303

    Studies have shown that joint bleeding leads to cartilage degradation independent of concurrent synovitis. We hypothesized that the blood-induced cartilage damage is because of increased chondrocyte apoptosis after short-term exposure of whole blood or isolated mononuclear cells plus red blood cells to cartilage. Human cartilage tissue samples were co-cultured for 4 days with whole blood (50% v/v) or with mononuclear cells plus red blood cells (50% v/v equivalents). Cartilage matrix ...

    Also Ranks for: Chondrocyte Apoptosis |  cartilage blood |  proteoglycan synthesis |  4 day |  joint bleeding
    KOL Index score: 9179

    An increased prevalence of hypertension is reported in haemophilia patients, but data from large, unbiased studies are lacking. The aim of our study was to cross-sectionally assess the prevalence of hypertension in a large cohort of 701 haemophilia patients. Blood pressure (BP) measurements performed in 386 Dutch and 315 UK haemophilia patients aged 30 years or older were analysed and compared with the general age-matched male population. Mean values of up to three BP measurements were ...

    Also Ranks for: Haemophilia Patients |  increased prevalence |  blood pressure |  renal function |  hypertension higher
    KOL Index score: 8758

    INTRODUCTION: With increasing life expectancy, more haemophilia patients will be confronted with age-related problems. To ensure optimal care, it is important to know the occurrence of both fatal and non-fatal cardiovascular disease, malignancies and other types of co-morbidity in these patients. Our aim was to retrospectively assess the occurrence of co-morbidity and causes of death in a substantial birth-cohort of haemophilia patients.

    METHODS: Data on all types of co-morbidity were ...

    Also Ranks for: Haemophilia Patients |  general population occurrence |  cardiovascular disease |  intracranial bleeding |  myocardial infarction
    KOL Index score: 8429

    Patients with haemophilia are now widely advised to participate in sports. However, no extensive data are available about their actual participation. A self-administered questionnaire was used to investigate sports participation by persons with haemophilia in the Netherlands. All 293 questionnaires that were distributed have been returned; 217 were from people with severe haemophilia A or B (this is 40% of the severely affected Dutch population with haemophilia). Of this group, 155 (71%) ...

    Also Ranks for: Dutch Persons |  sports participation |  hemophilia humans |  severe haemophilia |  extensive data
    KOL Index score: 8347

    A multicentre study was performed to compare clotting factor use and outcome between on-demand and prophylactic treatment strategies for patients with severe haemophilia. Data on treatment and outcome of 49 Dutch patients with severe haemophilia, born 1970-80, primarily treated with prophylaxis, were compared with those of 106 French patients, who were primarily treated on demand. Dutch patients received intermediate dose prophylaxis, for a median duration of 12.7 years. Patients ...

    Also Ranks for: Severe Haemophilia |  demand treatment |  patients prophylaxis |  clotting factor |  joint bleeds
    KOL Index score: 8248

    OBJECTIVE: It has been reported that interleukin (IL)-10 limits blood-induced cartilage damage. Our aim was to study the effect of IL-4 alone and in combination with IL-10 on blood-induced cartilage damage.

    DESIGN: Healthy human full thickness cartilage explants were cultured for 4 days in the presence of 50% v/v blood. IL-4, IL-10, or a combination of both cytokines was added during blood exposure. Cartilage matrix turnover was determined after a recovery period; additionally cytokine ...

    Also Ranks for: Cartilage Damage |  il4 il10 |  blood induced |  chondrocyte apoptosis |  interleukin10 interleukin4


    Goris Roosendaal: Influence Statistics

    Sample of concepts for which Goris Roosendaal is among the top experts in the world.
    Concept World rank
    perls il6 #1
    resembles degenerative #1
    episodes haemophilia #1
    examples postbleeding approaches #1
    intraarticular bleeding #1
    median total interruption #1
    synovial joints muscles #1
    therapy hemarthrosis #1
    evaluation pettersson #1
    children recombinant product #1
    stopped prophylaxis #1
    postbleeding protocol #1
    postbleeding approaches function #1
    hemophilia exposure #1
    postbleeding approaches #1
    postbleeding mechanisms #1
    treatment severe haemophilia #1
    utmost people #1
    periarticular aneurysm #1
    joint bleed treatment #1
    treatment hemarthrosis hemophilia #1
    morbidity haemophilia #1
    haemophilia work #1
    haemophilia leads #1
    muscles picture #1
    bleeds occur #1
    n6 cartilage #1
    haemophilia postbleeding protocol #1
    bleed 2 #1
    joint bleed #1
    work postbleeding mechanisms #1
    functional milestones examples #1
    bleeding leads #1
    synovium characteristics #1
    arthropathy characteristics #1
    exposure blood #1
    endstage arthropathy #1
    arthropathy resembles #1
    n10 safranin #1
    picture utmost #1
    intraarticular hemorrhage #1
    synovitis involved #2

    Key People For Haemophilia Patients

    Top KOLs in the world
    Pier Mannuccio Mannuccio Mannucci
    willebrand factor venous thromboembolism myocardial infarction
    Eveline Pauline Mauser‐Bunschoten
    factor viii haemophilia patients willebrand disease
    Erik Berntorp
    factor viii severe haemophilia willebrand disease
    Elena M Santagostino
    inhibitor development speakers bureau factor viii
    Alessandro GRINGERI
    factor viii haemophilia patients inhibitor development
    Christine A Lee
    factor viii severe haemophilia willebrand disease

    Goris Roosendaal:Expert Impact

    Concepts for whichGoris Roosendaalhas direct influence:Haemophilia patients,  Synovial tissue,  Joint damage,  Severe haemophilia,  Cartilage damage,  Joint bleed,  Severe hemophilia,  Factor viii.

    Goris Roosendaal:KOL impact

    Concepts related to the work of other authors for whichfor which Goris Roosendaal has influence:Severe haemophilia,  Factor viii,  Hemophilia humans,  Immune tolerance,  Inhibitor development,  Gene therapy,  Articular cartilage.



    Is this your profile? manage_accounts Claim your profile content_copy Copy URL code Embed Link to your profile

    Distinguished Professor of Medicine, Dean and Associate Vice Chancellor, Translational Medicine, University of California, San Diego School of Medicine, La Jolla, California | Bruce Professor and Vice Chair of Internal Medicine, University of Nebrask