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  • Bipolar Disorder
  • Ellen Leibenluft

    Prominent publications by Ellen Leibenluft

    KOL Index score: 16577

    Importance: Psychiatric comorbidity complicates clinical care and confounds efforts to elucidate the pathophysiology of commonly occurring symptoms in youths. To our knowledge, few studies have simultaneously assessed the effect of 2 continuously distributed traits on brain-behavior relationships in children with psychopathology.

    Objective: To determine shared and unique effects of 2 major dimensions of child psychopathology, irritability and anxiety, on neural responses to facial ...

    Also Ranks for: Anxiety Irritability |  neural mechanisms |  amygdala connectivity |  mood disorders |  magnetic resonance
    KOL Index score: 16329

    Adolescents' propensity for risk-taking and reward-seeking behaviors suggests a heightened sensitivity for reward, reflected by greater feedback-related activity changes in reward circuitry (e.g., nucleus accumbens), and/or a lower sensitivity to potential harm reflected by weaker feedback-related activity changes in avoidance circuitry (e.g., amygdala) relative to adults. Responses of nucleus accumbens and amygdala to valenced outcomes (reward receipt and reward omission) were assayed ...

    Also Ranks for: Nucleus Accumbens |  adolescents adults |  greater activation |  reward circuitry |  heightened sensitivity
    KOL Index score: 15924

    OBJECTIVE: Extensive work implicates abnormal amygdala activation in emotional facial expression processing in adults with callous-unemotional traits. However, no research has examined amygdala response to emotional facial expressions in adolescents with disruptive behavior and callous-unemotional traits. Moreover, despite high comorbidity of callous-unemotional traits and attention deficit hyperactivity disorder (ADHD), no research has attempted to distinguish neural correlates of ...

    Also Ranks for: Fearful Expressions |  unemotional traits |  disruptive behavior disorders |  amygdala response |  youths adhd
    KOL Index score: 15298

    OBJECTIVE: While adolescent anxiety disorders represent prevalent, debilitating conditions, few studies have explored their brain physiology. Using event-related functional magnetic resonance imaging (fMRI) and a behavioral measure of attention to angry faces, the authors evaluated differences in response between healthy adolescents and adolescents with generalized anxiety disorder.

    METHOD: In the primary trials of interest, 18 adolescents with generalized anxiety disorder and 15 ...

    Also Ranks for: Angry Faces |  generalized anxiety disorder |  prefrontal cortex |  attentional bias |  healthy adolescents
    KOL Index score: 15024

    In recent years, increasing numbers of children have been diagnosed with bipolar disorder. In some cases, children with unstable mood clearly meet current diagnostic criteria for bipolar disorder, and in others, the diagnosis is unclear. Severe mood dysregulation is a syndrome defined to capture the symptomatology of children whose diagnostic status with respect to bipolar disorder is uncertain, that is, those who have severe, nonepisodic irritability and the hyperarousal symptoms ...

    Also Ranks for: Bipolar Disorder |  severe mood dysregulation |  diagnostic boundaries |  patient groups |  nonepisodic irritability
    KOL Index score: 14376

    OBJECTIVE: To understand disorder-unique and common pathophysiology, studies in multiple patient groups with overlapping symptoms are needed. Deficits in emotion processing and hyperarousal symptoms are prominent features of bipolar disorder, attention deficit hyperactivity disorder (ADHD), and severe mood dysregulation. The authors compared amygdala response during emotional and nonemotional ratings of neutral faces in youths with these disorders as well as a group of healthy comparison ...

    Also Ranks for: Severe Mood Dysregulation |  neutral faces |  bipolar disorder |  emotion processing |  amygdala activation
    KOL Index score: 14242

    OBJECTIVE: Researchers disagree as to whether irritability is a diagnostic indicator for pediatric mania in bipolar disorder. The authors compared the behavioral and psychophysiological correlates of irritability among children with severe mood dysregulation (i.e., nonepisodic irritability and hyperarousal without episodes of euphoric mood) and narrow-phenotype bipolar disorder (i.e., a history of at least one manic or hypomanic episode with euphoric mood) as well as those with no ...

    Also Ranks for: Severe Mood Dysregulation |  bipolar disorder |  irritability children |  disruptive behavior |  narrow phenotype
    KOL Index score: 13591

    OBJECTIVE: Bipolar disorder affects 0.5%-1.5% of individuals in the United States. The typical age at onset is late adolescence or early adulthood, placing women at risk for episodes throughout their reproductive years. General guidelines for the treatment of bipolar disorder are available from the American Psychiatric Association, but additional issues arise when these guidelines are applied in the treatment of peripartum women. The authors summarize knowledge regarding the management ...

    Also Ranks for: Bipolar Disorder |  postpartum period |  mood stabilizers |  pregnancy management |  general guidelines
    KOL Index score: 13166

    OBJECTIVE: Deficits in motor inhibition may contribute to impulsivity and irritability in children with bipolar disorder. Studies of the neural circuitry engaged during failed motor inhibition in pediatric bipolar disorder may increase our understanding of the pathophysiology of the illness. The authors tested the hypothesis that children with bipolar disorder and comparison subjects would differ in ventral prefrontal cortex, striatal, and anterior cingulate activation during ...

    Also Ranks for: Bipolar Disorder |  motor inhibition |  neural circuitry |  children adhd |  comparison subjects
    KOL Index score: 13075

    BACKGROUND: Irritability and the new DSM-5 diagnostic category of Disruptive Mood Dysregulation Disorder (DMDD) have been conceptualised as related to mood disorder. Irritability is common in Attention Deficit Hyperactivity Disorder (ADHD) but little is known about its association with depression risk in this group. This study aims to establish levels of irritability and prevalence of DMDD in a clinical sample of children with ADHD, and examine their association with anxiety, depression ...

    Also Ranks for: Irritability Depression |  children adhd |  association anxiety |  mood disorder |  attention deficit
    KOL Index score: 12972

    OBJECTIVE: To assess the psychometrics of the schedule for affective disorders and schizophrenia for school-age children present and lifetime version (K-SADS-PL) in diagnosing DSM-IV psychiatric disorders and subsyndromal symptomatology in preschool children.

    METHOD: Parents were interviewed about their children using the K-SADS-PL, and they completed the early childhood inventory-4 (ECI-4) and child behavior checklist for ages 1(1/2)-5 years (CBCL). Discriminant, divergent, and ...

    Also Ranks for: Preschool Children |  affective disorders |  child behavior |  convergent validity |  psychometric study
    KOL Index score: 11945

    Several lines of evidence implicate the amygdala in face-emotion processing, particularly for fearful facial expressions. Related findings suggest that face-emotion processing engages the amygdala within an interconnected circuitry that can be studied using a functional-connectivity approach. Past work also underscores important functional changes in the amygdala during development. Taken together, prior research on amygdala function and development reveals a need for more work examining ...

    Also Ranks for: Amygdala Response |  facial expressions |  adolescents adults |  fearful faces |  functional connectivity
    KOL Index score: 11775

    BACKGROUND: Fear conditioning and extinction have been implicated in the pathogenesis of anxiety disorders. However, due to ethical and methodological limitations, few studies have examined these learning processes across development, particularly among anxious individuals. The present study examined differences in fear conditioning and extinction in anxious and nonanxious youth and adults using a novel task designed to be more tolerable for children than existing paradigms.

    METHODS: ...

    Also Ranks for: Fear Conditioning |  anxious youth |  classical extinction |  unconditioned stimulus |  anxiety disorders
    KOL Index score: 11768

    We examined neural activations during decision-making using fMRI paired with the wheel of fortune task, a newly developed two-choice decision-making task with probabilistic monetary gains. In particular, we assessed the impact of high-reward/risk events relative to low-reward/risk events on neural activations during choice selection and during reward anticipation. Seventeen healthy adults completed the study. We found, in line with predictions, that (i) the selection phase predominantly ...

    Also Ranks for: Reward Anticipation |  choice selection |  fmri study |  ventral striatum |  neural activations
    KOL Index score: 11698

    OBJECTIVE: There is increasing scientific and clinical attention to chronic irritability in youth. However, little is known about the predictive validity and clinical significance of chronic irritability during early childhood. This prospective, longitudinal study examined associations of chronic irritability with psychiatric disorders and parental psychopathology in a large community sample of preschoolers.

    METHOD: Four hundred sixty-two preschool-age children were assessed at 3 and 6 ...

    Also Ranks for: Preschool Irritability |  psychiatric disorders |  age 6 |  longitudinal associations |  depression anxiety


    Ellen Leibenluft: Influence Statistics

    Sample of concepts for which Ellen Leibenluft is among the top experts in the world.
    Concept World rank
    episodes distinct #1
    leibenluft #1
    mood oscillations coupling #1
    irritability trajectory #1
    menstrual cycle mood #1
    dbds trauma exposure #1
    uf riskarchitecture #1
    frustration youths #1
    disorders irritability #1
    uf microstructure endophenotype #1
    irritability phasic #1
    hostility contrast #1
    childhood developmental disorder #1
    impairment irritability #1
    treatment outbursts #1
    smd children #1
    unstable mood #1
    endophenotype wm tracts #1
    youths hv #1
    dmdd tonic irritability #1
    mood weather #1
    bipolar illness timing #1
    uncinate fasciculus riskarchitecture #1
    irritability followup #1
    genetic studies irritability #1
    stability dmdd symptoms #1
    psychiatry irritability #1
    smd criteria #1
    discharge rates pbd #1
    irritability emotion regulation #1
    irritability higher #1
    dmdd adhd #1
    hc participants age #1
    irritability bidirectional associations #1
    irritability current data #1
    hallmark symptoms mania #1
    irritability 3 #1
    happiness irritability #1
    pathophysiology control network #1
    prominent mood swings #1
    corpus callosum endophenotype #1
    frustration humans #1
    maternal depression irritability #1
    discharge rate adults #1
    adolescents irritability #1
    relation perpetration #1
    anxiety unipolar depression #1
    rcbd bipolar disorder #1
    cognitive ability errors #1
    youths adults #1

    Key People For Bipolar Disorder

    Top KOLs in the world
    Eduardo Eduard
    bipolar disorder cognitive impairment acute mania
    Robert M Post
    bipolar disorder affective illness depressed patients
    Susan L McElroy
    bipolar disorder binge eating bulimia nervosa
    Paul E Keck
    bipolar disorder acute mania united states
    Joseph R Calabrese
    bipolar disorder suicidal ideation rapid cycling
    Gary S Sachs
    bipolar disorder rapid cycling acute mania

    Ellen Leibenluft:Expert Impact

    Concepts for whichEllen Leibenlufthas direct influence:Bipolar disorder,  Anxiety disorders,  Severe mood dysregulation,  Pediatric bipolar disorder,  Bipolar illness,  Neural correlates,  Severe mood,  Temper loss.

    Ellen Leibenluft:KOL impact

    Concepts related to the work of other authors for whichfor which Ellen Leibenluft has influence:Bipolar disorder,  Attentional bias,  Social anxiety,  Depressive symptoms,  Emotion regulation,  Functional connectivity,  Magnetic resonance.



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    NIMH | Emotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, Maryland, USA | National Institute of Mental Health | Emotion and Development Branch, National Institute of Mental Health, National I