Prominent publications by Paul David Griffiths

KOL Index score: 12334

BACKGROUND: In-utero MRI (iuMRI) has shown promise as an adjunct to ultrasound but the comparative diagnostic performance has been poorly defined. We aimed to assess whether the diagnostic accuracy and confidence of the prenatal diagnosis of fetal brain abnormalities is improved with iuMRI and assess the clinical impact and patient acceptability of iuMRI.

METHODS: We did a multicentre, prospective, cohort study in the UK, at 16 fetal medicine centres, of pregnant women aged 16 years or ...

Known for Fetal Brain Abnormalities |  24 Weeks |  Iumri Diagnostic Accuracy |  Patient Acceptability |  Prospective Cohort
KOL Index score: 7515

BACKGROUND: Ultrasonography has been the mainstay of antenatal screening programmes in the UK for many years. Technical factors and physical limitations may result in suboptimal images that can lead to incorrect diagnoses and inaccurate counselling and prognostic information being given to parents. Previous studies suggest that the addition of in utero magnetic resonance imaging (iuMRI) may improve diagnostic accuracy for fetal brain abnormalities. These studies have limitations, ...

Known for Iumri Ultrasonography |  Brain Abnormalities |  Prenatal Diagnosis |  Fetal Developmental |  Resonance Imaging
KOL Index score: 7039

PurposeTo refine methods that assess structural brain abnormalities and calculate intracranial volumes in fetuses with congenital heart diseases (CHD) using in utero MR (iuMR) imaging. Our secondary objective was to assess the prevalence of brain abnormalities in this high-risk cohort and compare the brain volumes with normative values.MethodsWe performed iuMR on 16 pregnant women carrying a fetus with CHD and gestational age ≥ 28-week gestation and no brain abnormality on ...

Known for Congenital Heart |  Fetuses Chd |  Brain Abnormalities |  Intracranial Volume |  Fetal Echocardiography
KOL Index score: 6773

PURPOSE: Upon inhalation, xenon diffuses into the bloodstream and is transported to the brain, where it dissolves in various compartments of the brain. Although up to five chemically distinct peaks have been previously observed in (129) Xe rat head spectra, to date only three peaks have been reported in the human head. This study demonstrates high resolution spectroscopy and chemical shift imaging (CSI) of (129) Xe dissolved in the human head at 1.5 Tesla.

METHODS: A (129) Xe ...

Known for Xe Dissolved |  Human Head |  Chemical Shift |  15 Tesla |  Resonance Imaging
KOL Index score: 6714

OBJECTIVE: Lissencephaly is a rare disorder of cortical developmental, which usually carries increased risk of recurrence in future pregnancies. In this prospective observational study, we wished to test the hypothesis that sulcation patterns can be used to diagnose lissencephaly successfully on in utero MR (iuMR) imaging in the third-trimester but not in the late second-trimester fetus.

METHODS: Pregnant females were recruited into this study if they had an increased risk of fetal ...

Known for Fetus Increased Risk |  Iumr Imaging |  Prenatal Diagnosis |  Gestational Age |  Earlier Pregnancy
KOL Index score: 6521

ObjectivesThis systematic review was undertaken to define the diagnostic performance of in utero MR (iuMR) imaging when attempting to confirm, exclude or provide additional information compared with the information provided by prenatal ultrasound scans (USS) when there is a suspicion of foetal brain abnormality.MethodsElectronic databases were searched as well as relevant journals and conference proceedings. Reference lists of applicable studies were also explored. Data extraction was ...

Known for Foetal Brain |  Iumr Imaging |  Prenatal Diagnosis |  Diagnostic Performance |  Humans Magnetic

Schizencephaly revisited

KOL Index score: 6150

PurposeIn this paper, I will report the range of appearances of schizencephaly in children and fetuses by reviewing a 10-year experience from a single centre and detail classification systems for the different forms of schizencephaly. This will lead to re-assessment of possible aetiological and mechanistic causes of schizencephaly.MethodsAll cases of pediatric and fetal schizencephaly were located on the local database between 2007 and 2016 inclusive. The studies were reviewed for the ...

Known for Brain Abnormalities |  Newborn Magnetic |  Septum Pellucidum |  Studies Reviewed |  Cortical Formation
KOL Index score: 5408

AIM: To measure possible change in diagnostic confidence by performing in utero magnetic resonance imaging (iuMRI) studies on fetuses with brain abnormalities recognised on ultrasonography (US).

MATERIALS AND METHODS: The analyses are based on the primary cohort from the prospective MERIDIAN study, which consisted of 570 fetuses with brain abnormalities detected on US, with iuMRI performed within 2 weeks of US and complete outcome reference data. The cohort was recruited between July ...

Known for Diagnostic Confidence |  Meridian Cohort |  Utero Mri |  Brain Abnormalities |  Female Fetus
KOL Index score: 5343

PurposeTo describe the normal linear measurements of the skull (bi-parietal diameter and occipito-frontal diameter) and intracranial volumes (ventricular volume, brain parenchymal volume, extra-axial volume and total intra-cranial volume) in normal fetuses.Materials and methodsWe recruited pregnant women from low-risk pregnancies whose fetuses had normal ultrasound and in utero MR studies. All volunteers had in utero MR imaging on the same 1.5T MR scanner with a protocol consisting of ...

Known for Fetal Brain |  Volume Imaging |  Normal Fetuses |  Gestational Ages |  Occipitofrontal Diameter
KOL Index score: 3538

BACKGROUND: In utero MRI (iuMRI) detects fetal brain abnormalities more accurately than ultrasonography and provides additional clinical information in around half of pregnancies. We aimed to study whether postnatal neuroimaging after age 6 months changes the diagnostic accuracy of iuMRI and its ability to predict developmental outcome.

METHODS: Families enrolled in the MERIDIAN study whose child survived to age 3 years were invited to have a case note review and assessment of ...

Known for Fetal Brain |  Meridian Study |  Utero Mri |  Ultrasonography Prenatal |  Male Neurodevelopmental
KOL Index score: 3415

ObjectiveTo formulate a classification system for foetal cortical formation abnormalities (CFAs) based on in utero magnetic resonance (iuMR) appearances and trial it in 356 cases.MethodsThis retrospective study included all cases of foetal CFA diagnosed between 2000 and 2017 from seven centres in Italy and UK. All of the studies were reviewed by a panel of paediatric neuroradiologists experienced in iuMR with the aid of an algorithm designed to categorise the ...

Known for Cortical Formation Abnormalities |  Cfa Studies |  Cases Classification |  Utero Magnetic Resonance |  Female Fetus
KOL Index score: 2816

OBJECTIVE: To analyze a large retrospective cohort of fetuses in which the cavum septi pellucidi and vergae (CSPV) was not present or was not in its expected position on in-utero magnetic resonance imaging (iuMRI), in order to describe the possible causes of that finding and provide a diagnostic approach to assess such cases in clinical practice using iuMRI.

METHODS: This was a retrospective study of fetuses that underwent iuMRI at a single institution, over an 18-year period (2000-2017 ...

Known for Obstetrics Gynecology |  Resonance Imaging |  Septi Pellucidi |  Study Fetuses |  John Wiley
KOL Index score: 2391

There are a number of reasons why a pregnant woman might be considered to have an increased risk of carrying a fetus with a brain abnormality, but they fall broadly into two groups. First, there may be a relevant family history usually, but not always, when a fetus/child from a previous pregnancy has a developmental brain abnormality and a clinical geneticist judges that there is a risk of recurrence. Second, there may be findings in their current pregnancy that increases the risk of the ...

Known for Brain Abnormalities |  Utero Mri |  Resonance Imaging |  Antenatal Ultrasonography |  Prenatal Diagnosis
KOL Index score: 2019

ObjectivesIn utero magnetic resonance (iuMR) imaging to diagnose foetal brain abnormalities has been established and is supported by meta-analyses of retrospective and prospective studies. In this paper we describe and classify the iuMR errors made in the largest diagnostic accuracy study to date (MERIDIAN). We also correlate the error rates and types with the prior experience of the reporting radiologists in order to inform how to provide a national programme with the best diagnostic ...

Known for Foetal Brain |  Accuracy Study |  Outcome Reference Diagnosis |  Pregnancy Prenatal |  Humans Magnetic
KOL Index score: 1825

AIM: To estimate the rate of unexpected brain abnormalities detected by in utero magnetic resonance imaging (iuMRI) in fetuses without abnormalities at ultrasonography (USS).

MATERIALS AND METHODS: A prospective cohort study of pregnant women whose fetus had no structural brain (or body) abnormalities recognised on antenatal ultrasonography. Women were recruited from 12 centres across the UK and underwent iuMRI at 18 gestational weeks or more in the [blinded for review]. The imaging ...

Known for Utero Mri |  Brain Abnormalities |  Imaging Pregnancy |  Humans Magnetic |  Prenatal Diagnosis


Paul David Griffiths: Influence Statistics

Sample of concepts for which Paul David Griffiths is among the top experts in the world.
Concept World rank
270 fetuses #2

Key People For Brain Abnormalities

Top KOLs in the world
Alan Charles Evans
cortical thickness magnetic resonance cerebral cortex
Thompson Thompson
cortical thickness brain structure white matter
Robin MacGregor Murray
bipolar disorder episode psychosis obstetric complications
Arthur W Toga’
white matter brain structure alzheimer disease
Anthony James Barkovich
brain injury corpus callosum magnetic resonance
Karl John Friston
active inference effective connectivity dynamic causal modelling

Paul David Griffiths:Expert Impact

Concepts for whichPaul David Griffithshas direct influence:Brain abnormalities,  Corpus callosum,  Fetal brain abnormalities,  Structural brain abnormalities,  Developmental outcome,  Ganglionic eminence anomalies,  Diagnostic confidence,  Fetal brain.

Paul David Griffiths:KOL impact

Concepts related to the work of other authors for whichfor which Paul David Griffiths has influence:Fetal mri,  Resonance imaging,  Prenatal diagnosis,  Brain abnormalities,  Gestational age,  Normal fetuses,  Corpus callosum.



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