 | Robert Andrew Moore |
Prominent publications by Robert Andrew Moore
Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews
[ PUBLICATION ]
BACKGROUND: Chronic pain is defined as pain lasting beyond normal tissue healing time, generally taken to be 12 weeks. It contributes to disability, anxiety, depression, sleep disturbances, poor quality of life, and healthcare costs. Chronic pain has a weighted mean prevalence in adults of 20%.For many years, the treatment choice for chronic pain included recommendations for rest and inactivity. However, exercise may have specific benefits in reducing the severity of chronic pain, as ...
| Also Ranks for: Chronic Pain | physical activity | cochrane reviews | quality life | exercise intervention |
Single dose oral ibuprofen plus paracetamol (acetaminophen) for acute postoperative pain
[ PUBLICATION ]
BACKGROUND: Combining two different analgesics in fixed doses in a single tablet can provide better pain relief than either drug alone in acute pain. This appears to be broadly true across a range of different drug combinations, in postoperative pain and migraine headache. Some combinations of ibuprofen and paracetamol are available for use without prescription in some acute pain situations.
OBJECTIVES: To assess the efficacy and adverse effects of single dose oral ibuprofen plus ...
| Also Ranks for: Ibuprofen Paracetamol | postoperative pain | single dose | rescue medication | proportion participants |
BACKGROUND: There is good evidence that combining two different analgesics in fixed doses in a single tablet can provide better pain relief in acute pain and headache than either drug alone, and that the drug-specific effects are essentially additive. This appears to be broadly true in postoperative pain and migraine headache across a range of different drug combinations and when tested in the same and different trials. Some combinations of ibuprofen and codeine are available without ...
| Also Ranks for: Ibuprofen Codeine | postoperative pain | single dose | combination placebo | rescue medication |
BACKGROUND: Combining two different analgesics in fixed doses in a single tablet can provide better pain relief than either drug alone in acute pain. This appears to be broadly true across a range of different drug combinations, in postoperative pain and migraine headache. Fixed-dose combinations of ibuprofen and oxycodone are available, and the drugs may be separately used in combination in some acute pain situations.
OBJECTIVES: To assess the analgesic efficacy and adverse effects of a ...
| Also Ranks for: Ibuprofen Oxycodone | postoperative pain | single dose | rescue medication | proportion participants |
BACKGROUND: This review is an update of a review published in 2011, itself a major update of previous reviews published in 2005 and 2000, investigating the effects of gabapentin in chronic neuropathic pain (pain due to nerve damage). Antiepileptic drugs are used to manage chronic neuropathic pain and fibromyalgia.
OBJECTIVES: To assess the analgesic efficacy and adverse effects of gabapentin in chronic neuropathic pain and fibromyalgia.
SEARCH METHODS: We identified randomised trials of ...
| Also Ranks for: Chronic Neuropathic Pain | tier evidence | postherpetic neuralgia | gabapentin placebo | adverse event |
Physical activity and exercise for chronic pain in adults: an overview of Cochrane Reviews
[ PUBLICATION ]
BACKGROUND: Chronic pain is defined as pain lasting beyond normal tissue healing time, generally taken to be 12 weeks. It contributes to disability, anxiety, depression, sleep disturbances, poor quality of life, and healthcare costs. Chronic pain has a weighted mean prevalence in adults of 20%.For many years, the treatment choice for chronic pain included recommendations for rest and inactivity. However, exercise may have specific benefits in reducing the severity of chronic pain, as ...
| Also Ranks for: Chronic Pain | physical activity | quality life | exercise intervention | cochrane reviews |
BACKGROUND: Migraine is a common disabling condition and a burden for the individual, health services, and society. Effective abortive treatments include the triptan and non-steroidal anti-inflammatory classes of drugs. These drugs have different mechanisms of action and combining them may provide better relief. Sumatriptan plus naproxen is now available in combination form for the acute treatment of migraine.
OBJECTIVES: To determine the efficacy and tolerability of sumatriptan plus ...
| Also Ranks for: Naproxen Sumatriptan | acute migraine | combination placebo | pain adverse events | topic serotonin |
BACKGROUND: This is an updated version of the original Cochrane review published in October 2013 on 'Sumatriptan plus naproxen for acute migraine attacks in adults'.Migraine is a common disabling condition and a burden for the individual, health services, and society. It affects two to three times more women than men, and is most common in the age range 30 to 50 years. Effective abortive treatments include the triptan and non-steroidal anti-inflammatory classes of drugs. These drugs have ...
| Also Ranks for: Naproxen Sumatriptan | acute migraine | combination placebo | pain adverse events | participants treatment |
BACKGROUND: Migraine is a common, disabling condition and a burden for the individual, health services and society. Many sufferers choose not to, or are unable to, seek professional help and rely on over-the-counter analgesics. Co-therapy with an antiemetic should help to reduce nausea and vomiting commonly associated with migraine headaches.
OBJECTIVES: To determine the efficacy and tolerability of aspirin, alone or in combination with an antiemetic, compared to placebo and other active ...
| Also Ranks for: Acute Migraine Headaches | aspirin placebo | combination metoclopramide | nausea vomiting | inflammatory agents |
BACKGROUND: Gabapentin is commonly used to treat neuropathic pain (pain due to nerve damage). This review updates a review published in 2014, and previous reviews published in 2011, 2005 and 2000.
OBJECTIVES: To assess the analgesic efficacy and adverse effects of gabapentin in chronic neuropathic pain in adults.
SEARCH METHODS: For this update we searched CENTRAL), MEDLINE, and Embase for randomised controlled trials from January 2014 to January 2017. We also searched the reference ...
| Also Ranks for: Neuropathic Pain | gabapentin placebo | participants studies | moderatequality evidence | moderate benefit |
BACKGROUND: Topical creams with capsaicin are used to treat peripheral neuropathic pain. Following application to the skin capsaicin causes enhanced sensitivity, followed by a period with reduced sensitivity and, after repeated applications, persistent desensitisation. High-concentration (8%) capsaicin patches were developed to increase the amount of capsaicin delivered; rapid delivery was thought to improve tolerability because cutaneous nociceptors are 'defunctionalised' quickly. The ...
| Also Ranks for: Topical Capsaicin | chronic neuropathic pain | 12 weeks | active treatment | efficacy outcomes |
BACKGROUND: Ketoprofen is a non-selective non-steroidal anti-inflammatory drug (NSAID) used to treat acute and chronic painful conditions. Dexketoprofen is the (S)-enantiomer, which is believed to confer analgesia. Theoretically dexketoprofen is expected to provide equivalent analgesia to ketoprofen at half the dose, with a consequent reduction in gastrointestinal adverse events.
OBJECTIVES: To assess efficacy, duration of action, and associated adverse events of single dose oral ...
| Also Ranks for: Single Dose | acute postoperative pain | oral ketoprofen | rescue medication | efficacy adverse events |
BACKGROUND: Amitriptyline is a tricyclic antidepressant that is widely used to treat chronic neuropathic pain (pain due to nerve damage) and fibromyalgia, and is recommended in many guidelines. These types of pain can be treated with antidepressant drugs in doses below those at which the drugs act as antidepressants.
OBJECTIVES: To assess the analgesic efficacy of amitriptyline for chronic neuropathic pain and fibromyalgia.To assess the adverse events associated with the clinical use of ...
| Also Ranks for: Neuropathic Pain | amitriptyline fibromyalgia | placebo participants | adverse event | lack efficacy |
Single dose oral analgesics for acute postoperative pain in adults ‐ an overview of Cochrane reviews
[ PUBLICATION ]
BACKGROUND: This is an updated version of the original Cochrane overview published in Issue 9, 2011. That overview considered both efficacy and adverse events, but adverse events are now dealt with in a separate overview.Thirty-nine Cochrane reviews of randomised trials have examined the analgesic efficacy of individual drug interventions in acute postoperative pain. This overview brings together the results of those individual reviews and assesses the reliability of available ...
| Also Ranks for: Cochrane Reviews | oral analgesics | single dose | acute postoperative pain | hours placebo |
BACKGROUND: Inadequate pain management after surgery increases the risk of postoperative complications and may predispose for chronic postsurgical pain. Perioperative ketamine may enhance conventional analgesics in the acute postoperative setting.
OBJECTIVES: To evaluate the efficacy and safety of perioperative intravenous ketamine in adult patients when used for the treatment or prevention of acute pain following general anaesthesia.
SEARCH METHODS: We searched CENTRAL, MEDLINE and ...
| Also Ranks for: Postoperative Pain | intravenous ketamine | 24 hours | rest movement | opioid consumption |
Robert Andrew Moore: Influence Statistics
| Concept | World rank |
|---|---|
| nnt intraoperative awareness | #1 |
| vomiting migraine headaches | #1 |
| dihydrocodeine neuropathic pain | #1 |
| compared combination monotherapy | #1 |
| postherpetic neuralgia studies | #1 |
| partial enriched enrollment | #1 |
| 10 active placebo | #1 |
| placebo randomised trials | #1 |
| 6 hours gabapentin | #1 |
| 50 pain relief | #1 |
| evidence morphine | #1 |
| oral ibuprofen codeine | #1 |
| plasma intrathecal heroin | #1 |
| update included studies | #1 |
| 120 naproxen | #1 |
| rubefacients salicylates | #1 |
| immpact definition | #1 |
| imipramine neuropathic pain | #1 |
| participants desipramine | #1 |
| pregabalin trials fm | #1 |
| classic design mtr | #1 |
| placebo acute | #1 |
| participants achieving | #1 |
| placebo active control | #1 |
| evidence levetiracetam | #1 |
| topical nsaid | #1 |
| hours headache relief | #1 |
| older people anaemia | #1 |
| nnt codeine | #1 |
| eugynon | #1 |
| placebo 600 dose | #1 |
| 200 400 ibuprofen | #1 |
| chronic pain efficacy | #1 |
| children scarboxymethylcysteine | #1 |
| participants hydromorphone | #1 |
| moderate benefit | #1 |
| 50 pain | #1 |
| overview acute pain | #1 |
| model etoricoxib | #1 |
| nausea nnt | #1 |
| 85 combination | #1 |
| nnt rescue | #1 |
| cfb 12 weeks | #1 |
| naproxen acute | #1 |
| unpublished legacy studies | #1 |
| aspirin 1000 placebo | #1 |
| capsaicin chronic | #1 |
| reviews single review | #1 |
| codeine studies | #1 |
| dose rofecoxib | #1 |
Key People For Neuropathic Pain
Robert Andrew Moore:Expert Impact
Concepts for whichRobert Andrew Moorehas direct influence:Neuropathic pain, Acute postoperative pain, Postoperative pain, Chronic pain, Single dose, Pain relief, Acute pain, Cancer pain.
Robert Andrew Moore:KOL impact
Concepts related to the work of other authors for whichfor which Robert Andrew Moore has influence:Neuropathic pain, Randomized controlled trials, Postoperative nausea, Rheumatoid arthritis, Cochrane library, Efficacy safety, Quality life.
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