• KOL
    • Photodynamic Therapy
    • Brian Campbell Wilson
    • Brian Campbell Wilson: Influence Statistics

      Brian Campbell Wilson

      Brian Campbell Wilson

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      Princess Margaret Cancer Centre, University Health Network, Toronto, Canada | University Health Network, Princess Margaret Cancer Centre, Toronto, Canada | Department of ...

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      Brian Campbell Wilson:Expert Impact

      Concepts for whichBrian Campbell Wilsonhas direct influence:Photodynamic therapy,Singlet oxygen,Prostate cancer,Fluorescence imaging,Photodynamic therapy pdt,Optical coherence,Optical properties,Raman spectroscopy.

      Brian Campbell Wilson:KOL impact

      Concepts related to the work of other authors for whichfor which Brian Campbell Wilson has influence:Photodynamic therapy,Prostate cancer,Singlet oxygen,Optical properties,Raman spectroscopy,Turbid media,Tumor cells.

      KOL Resume for Brian Campbell Wilson

      Year
      2022

      Princess Margaret Cancer Centre, University Health Network, Toronto, Canada

      2021

      Princess Margaret Cancer Centre, University Health Network and Department of Medical Biophysics, University of Toronto, Toronto, ON M5S 1A1, Canada;, (L.P.);, (B.C.W.)

      University of Toronto, Faculty of Medicine, Department of Medical Biophysics, 101 College St., Toronto, M5G 1L7, Canada.

      2020

      Princess Margaret Cancer Center/University Health Network, 101 College Street, Toronto, ON M5G 1L7, Canada.

      Department of Medical Biophysics, University of Toronto, Toronto, Ontario, M5G 1L7, Canada

      2019

      Department of Medical Biophysics, University of Toronto

      Univ. Health Network (Canada)

      2018

      Princess Margaret Cancer Centre, University of Toronto, Toronto, Ontario, Canada.

      Department of Medical Biophysics, University of Toronto, Ontario, Canada

      2017

      University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, CanadabUniversity of Toronto, Department of Medical Biophysics, Toronto, Ontario, Canada.

      2016

      Princess Margaret Cancer Ctr. (Canada)

      University Health Network/University of Toronto, Canada

      2015

      Dept. Medical Biophysics, University of Toronto/University Health Network, Toronto, ON, M5G 1L7, Canada

      The Princess Margaret Cancer Centre, University Health Network

      Ontario Cancer Institute, University of Toronto, Ontario; and.

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      Sample of concepts for which Brian Campbell Wilson is among the top experts in the world.
      Concept World rank
      oca melanoma #1
      methods absorption coefficient #1
      detection neoplastic tissue #1
      orthotopic prostate tumors #1
      photosensitizing drugs photofrin #1
      metastatic lesions bone #1
      nct02191488 #1
      ductal human spectrometry #1
      bioluminescence imaging response #1
      tetawg #1
      sv calculations #1
      melanoma drs #1
      photodynamic therapy prostate #1
      roi pdt treatment #1
      gaba spectrometry #1
      1o2 signal #1
      parental rif1 #1
      hydrophobic protoporphyrin #1
      optical properties vivo #1
      delivered light fluence #1
      collection fibers study #1
      cardiac dynamics embryo #1
      quantitative multiplex sers #1
      indoles male mesoporphyrins #1
      human gliomas statistics #1
      unencumbered movement #1
      risk patient morbidity #1
      ncrs difference #1
      sers nps tissues #1
      prostate ptt #1
      proteincontaining #1
      micromirror addition #1
      hpd dihaematoporphyrin #1
      pdt mixed metastases #1
      photosensitizer oxygen concentrations #1
      afv hgl #1
      individual vessel response #1
      threshold normal brain #1
      pre‐clinical investigation #1
      controlled skin exposures #1
      ¹o₂rx #1
      combined fluorescence reflectance #1
      ppix quantitative ppix #1
      surgically exposed prostate #1
      collagenasetreated region #1
      advoripluc #1
      detector fluence rate #1
      heat generation depth #1
      pdt kp #1
      authors optimization gain #1
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      Prominent publications by Brian Campbell Wilson

      KOL-Index: 14003

      The subcellular and, specifically, mitochondrial localization of the photodynamic sensitizers Photofrin and aminolevulinic acid (ALA)-induced protoporphyrin-IX (PpIX) has been investigated in vitro in radiation-induced fibrosarcoma (RIF) tumor cells. Comparisons were made of parental RIF-1 cells and cells (RIF-8A) in which resistance to Photofrin-mediated photodynamic therapy (PDT) had been induced. The effect on the uptake kinetics of Photofrin of coincubation with one of the ...

      Known for Aminolevulinic Acid | Subcellular Localization | Induced Fibrosarcoma | Mediated Photodynamic | Pdt Resistance
      KOL-Index: 12798

      PURPOSE: To investigate relationships between magnetic resonance (MR) imaging measurements and the underlying composition of normal and malignant prostate tissue.

      MATERIALS AND METHODS: Twenty-four patients (median age, 63 years; age range, 44-72 years) gave informed consent to be examined for this research ethics board-approved study. Before undergoing prostatectomy, patients were examined with T2-weighted, diffusion-weighted, T2 mapping, and dynamic contrast material-enhanced MR ...

      Known for Prostate Tissue | Percentage Area | Adc Ktrans | Image Interpretation | Luminal Space
      KOL-Index: 12522

      OBJECT: The aim of this study was to investigate the relationships between intraoperative fluorescence, features on MR imaging, and neuropathological parameters in 11 cases of newly diagnosed glioblastoma multiforme (GBM) treated using protoporphyrin IX (PpIX) fluorescence-guided resection.

      METHODS: In 11 patients with a newly diagnosed GBM, δ-aminolevulinic acid (ALA) was administered to enhance endogenous synthesis of the fluorophore PpIX. The patients then underwent ...

      Known for Malignant Glioma | Magnetic Resonance | Tumor Resection | Intraoperative Fluorescence | Aminolevulinic Acid
      KOL-Index: 12028

      Abstract We are reporting our experience with intraoperative PDT in 32 patients with malignant supratentorial gliomas; in 19 cases the tumour was recurrent. There were 20 males and 12 females with an age range of 17-73 (mean = 45) yr. The first 8 patients in this series received HpD (Photofrin I) and the next 24 received DHE (Photofrin II). A photo-illuminating device, of the author's design, was coupled to an argon dye pump laser in order to deliver light at 630 nm to a tumour cavity ...

      Known for Brain Tumour | Photodynamic Therapy | Pdt Patients | Observation Year | Age Range
      KOL-Index: 11408

      OBJECT: Accurate discrimination between tumor and normal tissue is crucial for optimal tumor resection. Qualitative fluorescence of protoporphyrin IX (PpIX), synthesized endogenously following δ-aminolevulinic acid (ALA) administration, has been used for this purpose in high-grade glioma (HGG). The authors show that diagnostically significant but visually imperceptible concentrations of PpIX can be quantitatively measured in vivo and used to discriminate normal from neoplastic brain ...

      Known for Quantitative Fluorescence | Neoplastic Tissue | Ppix Concentration | Intracranial Tumors | Diagnostic Imaging
      KOL-Index: 10726

      BACKGROUND: Near-infrared Raman spectroscopy is a promising optical technique for GI tissue diagnosis. This study assessed the diagnostic potential of near-infrared Raman spectroscopy in the colon by evaluating its ability to distinguish between adenomatous and hyperplastic polyps.

      METHODS: Ex vivo and in vivo Raman spectra of colon polyps were collected by using a custom-built, fiber-optic, near-infrared Raman spectroscopic system. Multivariate statistical techniques, including ...

      Known for Diagnostic Potential | Hyperplastic Polyps | Infrared Raman | Specificity Spectroscopy | 95 Accuracy
      KOL-Index: 10575

      OBJECT: Complete resection of skull base meningiomas provides patients with the best chance for a cure; however, surgery is frequently difficult given the proximity of lesions to vital structures, such as cranial nerves, major vessels, and venous sinuses. Accurate discrimination between tumor and normal tissue is crucial for optimal tumor resection. Qualitative assessment of protoporphyrin IX (PpIX) fluorescence following the exogenous administration of 5-aminolevulinic acid (ALA) has ...

      Known for Skull Base | Aminolevulinic Acid | Visible Fluorescence | Complete Resection | Induced Protoporphyrin
      KOL-Index: 10491

      A mobile isocentric C-arm (Siemens PowerMobil) has been modified in our laboratory to include a large area flat-panel detector (in place of the x-ray image intensifier), providing multi-mode fluoroscopy and cone-beam computed tomography (CT) imaging capability. This platform represents a promising technology for minimally invasive, image-guided surgical procedures where precision in the placement of interventional tools with respect to bony and soft-tissue structures is critical. The ...

      Known for Flat‐panel Detector | Minimally Invasive | Image Quality | Surgical Guidance | Computerassisted Imaging
      KOL-Index: 10328

      The objective of this work was to determine changes in the ultrasound properties of heated tissues, with potential application to monitoring of minimally invasive thermal therapy (MITT). Changes in backscatter coefficients and frequency-dependent attenuation coefficients were measured over the frequency range 2.5 MHz to 5 MHz from heated samples of store-bought fresh bovine liver, which was used as a tissue model. Individual liver samples were heated from 37 degrees C to either 50 ...

      Known for Ultrasound Properties | Liver Tissue | Backscatter Coefficient | 50 Degrees | Initial Level
      KOL-Index: 10150

      The concept of metronomic photodynamic therapy (mPDT) is presented, in which both the photosensitizer and light are delivered continuously at low rates for extended periods of time to increase selective tumor cell kill through apoptosis. The focus of the present preclinical study is on mPDT treatment of malignant brain tumors, in which selectivity tumor cell killing versus damage to normal brain is critical. Previous studies have shown that low-dose PDT using 5-aminolevulinic acid ...

      Known for Brain Tumor | Metronomic Photodynamic Therapy | Mpdt Treatment | Light Delivery | Extended Periods
      KOL-Index: 9703

      The concept of metronomic photodynamic therapy (mPDT) is presented, in which both the photosensitizer and light are delivered continuously at low rates for extended periods of time to increase selective tumor cell kill through apoptosis. The focus of the present preclinical study is on mPDT treatment of malignant brain tumors, in which selectivity tumor cell killing versus damage to normal brain is critical. Previous studies have shown that low-dose PDT using 5-aminolevulinic acid ...

      Known for Metronomic Photodynamic Therapy | Brain Tumor | Technical Feasibility | Mpdt Treatment | Light Delivery
      KOL-Index: 9570

      BACKGROUND: Normal epithelial cells undergo anoikis, or apoptosis on loss of anchorage to the extracellular matrix, by initiating the death receptor pathway of caspase activation. However, malignant epithelial cells with metastatic potential resist anoikis and can survive in an anchorage-independent fashion. We hypothesized that c-Fas-associated death domain-like interleukin-1-converting enzyme-like inhibitory protein (FLIP), an endogenous inhibitor of death receptor signaling, may ...

      Known for Anoikis Resistance | Inhibitory Protein | Death Receptor | Flip Expression | Caspase Activation
      KOL-Index: 9543

      The absorption and transport scattering coefficients of biological tissues determine the radial dependence of the diffuse reflectance that is due to a point source. A system is described for making remote measurements of spatially resolved absolute diffuse reflectance and hence noninvasive, noncontact estimates of the tissue optical properties. The system incorporated a laser source and a CCD camera. Deflection of the incident beam into the camera allowed characterization of the source ...

      Known for Absorption Coefficients | Biological Tissue | Reflectance Measurements | Optical Scattering | Spatially Resolved
      KOL-Index: 9478

      OBJECT: Previous studies in high-grade gliomas (HGGs) have indicated that protoporphyrin IX (PpIX) accumulates in higher concentrations in tumor tissue, and, when used to guide surgery, it has enabled improved resection leading to increased progression-free survival. Despite the benefits of complete resection and the advances in fluorescence-guided surgery, few studies have investigated the use of PpIX in low-grade gliomas (LGGs). Here, the authors describe their initial experience with ...

      Known for Quantitative Fluorescence | Aminolevulinic Acid | Glioma Surgery | Induced Protoporphyrin | Diagnostic Performance
      KOL-Index: 9084

      Molecular beacons are FRET-based target-activatable probes. They offer control of fluorescence emission in response to specific cancer targets, thus are useful tools for in vivo cancer imaging. Photodynamic therapy (PDT) is a cell-killing process by light activation of a photosensitizer (PS) in the presence of oxygen. The key cytotoxic agent is singlet oxygen ((1)O(2)). By combining these two principles (FRET and PDT), we have introduced a concept of photodynamic molecular beacons (PMB) ...

      Known for Activatable Photosensitizer | Singlet Oxygen | Photodynamic Molecular | Cancer Cells | Fluorescence Emission

      Key People For Photodynamic Therapy

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      Princess Margaret Cancer Centre, University Health Network, Toronto, Canada | University Health Network, Princess Margaret Cancer Centre, Toronto, Canada | Department of Medical Biophysics, University of Toronto, Toronto, Ontario, Canada | Princess M

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