• Disease
  • Soft
  • Soft Tissue
  • Cyril Fisher†

    Prominent publications by Cyril FISHER†

    KOL Index score: 18213

    BACKGROUND: Effective targeted treatment is unavailable for most sarcomas and doxorubicin and ifosfamide-which have been used to treat soft-tissue sarcoma for more than 30 years-still have an important role. Whether doxorubicin alone or the combination of doxorubicin and ifosfamide should be used routinely is still controversial. We assessed whether dose intensification of doxorubicin with ifosfamide improves survival of patients with advanced soft-tissue sarcoma compared with ...

    Also Ranks for: Doxorubicin Ifosfamide |  3 trial |  tissue sarcoma |  metastatic soft |  controlled phase
    KOL Index score: 17051

    Adipocytic tumors are the most common type of soft tissue neoplasms. Distinguishing atypical lipomatous tumor-well-differentiated liposarcoma (WDL) from benign adipocytic neoplasms and dedifferentiated liposarcoma (DDL) from pleomorphic or myxoid liposarcoma (LPS) can be difficult. WDL and DDL characteristically harbor amplifications of the MDM2 and CDK4 cell cycle oncogenes with protein overexpression and can also overexpress the cell cycle regulator p16. We assessed the utility of ...

    Also Ranks for: Adipocytic Tumors |  dedifferentiated liposarcoma |  p16 cdk4 |  diagnostic utility |  wdls ddls
    KOL Index score: 15883

    Although separating gastrointestinal stromal tumor (GIST) from mesenteric fibromatosis and sclerosing mesenteritis is clinically important, this distinction sometimes poses problems for practicing pathologists. In the STI571 (Gleevec, Imatinib) era, the problem may be further compounded when protocol-driven staining for CD117 (c-kit) is performed on spindle cell proliferations presenting in the bowel wall and mesentery using an antibody known to react with the majority of mesenteric ...

    Also Ranks for: Mesenteric Fibromatosis |  sclerosing mesenteritis |  gastrointestinal stromal tumor |  catenin immunohistochemistry |  bowel wall
    KOL Index score: 15788

    PEComas, occasionally associated with the tuberous sclerosis complex, are defined by the presence of perivascular epithelioid cells that coexpress muscle and melanocytic markers. This family of tumors includes angiomyolipoma (AML), clear cell sugar tumor of the lung (CCST), lymphangioleiomyomatosis (LAM), and very rare tumors in other locations. Because non-AML/non-LAM PEComas are extremely rare and their natural history and prognostic features undefined, we present our experience with ...

    Also Ranks for: Soft Tissue |  s100 protein |  local neoplasms |  2 cases |  gynecologic origin
    KOL Index score: 15693

    Sclerosing epithelioid fibrosarcoma (SEF) and low-grade fibromyxoid sarcoma (LGFMS) are 2 distinct types of sarcoma, with a subset of cases showing overlapping morphologic and immunohistochemical features. LGFMS is characterized by expression of the MUC4 protein, and about 90% of cases display a distinctive FUS-CREB3L2 gene fusion. In addition, SEF is often MUC4 positive, but is genetically less well studied. Fluorescence in situ hybridization (FISH) studies have shown involvement of the ...

    Also Ranks for: Epithelioid Fibrosarcoma |  gene fusion |  lgfms sef |  rna binding |  situ hybridization
    KOL Index score: 15400

    An immunohistochemical study to determine the pattern of immunoreactivity for bcl-2 oncoprotein was performed in 380 spindle cell tumors of soft tissue, skin, serosal surfaces, and gastrointestinal tract. The cases studied included examples of benign, reactive spindle cell proliferations to benign and malignant spindle cell neoplasms, including nodular fasciitis (10), fibromatosis (5), dermatofibroma (10), dermatofibrosarcoma protuberans (18), Kaposi's sarcoma (15), spindle cell ...

    Also Ranks for: Soft Tissue |  spindle cell |  gastrointestinal tract |  expression bcl2 |  tumor diagnosis
    KOL Index score: 14057

    Desmoplastic small round cell tumor is a rare tumor typically involving peritoneum. Although the histogenesis of desmoplastic small round cell tumor has yet to be elucidated, immunophenotypical and morphological analysis shows a characteristic divergent phenotype overlapping with other round cell tumors such as Ewing’s sarcoma/primitive neuroectodermal tumor, rhabdomyosarcoma, small cell mesothelioma, and carcinoma. Detection of the EWS-WT1 gene fusion is characteristic of desmoplastic ...

    Also Ranks for: Round Cell |  desmoplastic small |  tumor carcinoma |  oncogene proteins |  gene fusion
    KOL Index score: 13971

    Until recently, the standard approach of most laboratories in distinguishing epithelioid pleural mesothelioma from metastatic adenocarcinoma has been a negative result from a panel of adeno-carcinoma-associated antibodies. However, several “mesothelium-associated” antibodies have been proposed as useful in this situation, and we have applied four of these putative mesothelioma markers—thrombomodulin, cytokeratin 5/6, calretinin, and CD44H—to a series of 61 epithelioid pleural ...

    Also Ranks for: Pleural Mesothelioma |  distinguishing epithelioid |  neoplasm antigens |  adenocarcinoma metastatic |  differential humans
    KOL Index score: 13585

    Low-grade fibromyxoid sarcoma (LGFMS) is an indolent, late-metastasizing malignant soft-tissue tumor that is often mistaken for either more benign or more malignant tumor types. Cytogenetic analyses have identified a recurrent balanced translocation t(7;16) (q32–34;p11), later shown by molecular genetic approaches to result in a FUS/CREB3L2 fusion gene. Whereas preliminary studies suggest that this gene rearrangement is specific for LGFMS, its incidence in this tumor type and the ...

    Also Ranks for: Fusion Gene |  human pair |  fibromyxoid sarcoma |  transcription factors |  tissue tumor
    KOL Index score: 13070

    We demonstrate that the cytogenetically defined translocation t(X;18)(p11.2;q11.2) found in human synovial sarcoma results in the fusion of the chromosome 18 SYT gene to either of two distinct genes, SSX1 or SSX2, at Xp11.2. The SSX1 and SSX2 genes encode closely related proteins (81% identity) of 188 amino acids that are rich in charged amino acids. The N-terminal portion of each SSX protein exhibits homology to the Kruppel-associated box (KRAB), a transcriptional repressor domain ...

    Also Ranks for: Human Synovial Sarcoma |  genetic tumor cells |  sequence homology |  fusion transcripts |  amino acid
    KOL Index score: 12554

    OBJECTIVE: To determine if it is possible to exclude staging bone scans in a greater proportion of patients if more consideration is given to T stage and Gleason score, as recent guidelines from the National Institute of Clinical Excellence state that routine staging bone scans for prostate cancer are unnecessary in patients with a prostate specific antigen level (PSA) of < 10 ng/mL and Gleason scores of < 8.

    PATIENTS AND METHODS: We identified a cohort of consecutive patients with ...

    Also Ranks for: Bone Scans |  prostate cancer |  gleason score |  patients psa |  stage t4
    KOL Index score: 12363

    Background: The establishment of a universally acceptable staging system for soft tissue sarcomas has been hampered by the low incidence, various grading systems, and lack of consensus regarding the value of different prognostic factors. We aimed to evaluate prognostic factors in patients with extremity soft tissue sarcomas and to test the validity of the AJCC/UICC staging system.Methods: Prospectively collected data from 316 previously untreated patients with primary extremity soft ...

    Also Ranks for: Soft Tissue |  grade size |  neoplasm recurrence |  distant metastasis |  disease specific
    KOL Index score: 12149

    AIMS: Extraskeletal myxoid chondrosarcoma is a rare low-grade soft-tissue sarcoma with locally aggressive and metastasizing potential. Extraskeletal myxoid chondrosarcoma has distinctive clinical, light microscopic, immunophenotypic, cytogenetic and ultrastructural features. Evidence that extraskeletal myxoid chondrosarcoma often shows neuroendocrine features was first provided by Chhieng et al. on the basis of an immunohistochemical and ultrastructural study of seven cases. Our study ...

    Also Ranks for: Myxoid Chondrosarcoma |  neuroendocrine differentiation |  cases synaptophysin |  immunoelectron microscopy |  neurosecretory granules


    Cyril FISHER†: Influence Statistics

    Sample of concepts for which Cyril FISHER† is among the top experts in the world.
    Concept World rank
    leiomyosarcomas frequency #1
    lipoma myositis ossificans #1
    synovial sarcomas abdomen #1
    mss mpnst #1
    ris sporadic sarcomas #1
    pleomorphic undifferentiated #1
    sef lgfms sef #1
    paratesticular region cases #1
    stromal cyst formation #1
    malignancy avf #1
    desmin follow #1
    propensity multifocal disease #1
    endosialin immunohistochemistry #1
    patients abdominal radiation #1
    18p11p13 #1
    pcr rt–pcr #1
    clinical familiarity #1
    histologically diverse neoplasms #1
    cadherin epithelial differentiation #1
    s100 protein cases #1
    rearranged myoepithelial #1
    sarcomas leiomyosarcomas #1
    cd34 immunoreactivity bcl2 #1
    paratesticular liposarcoma #1
    myoepithelioma neoplasms #1
    monophasic type #1
    dako ck20 #1
    surgery rpls #1
    gynecologic origin pecomas #1
    combination cdk4 #1
    abdomen 10 patients #1
    bcl2 dermatofibroma #1
    pcr foxo1 #1
    sts differential fibroma #1
    pair synovial translocation #1
    poor prognosis size #1
    soft tissue tumours #1
    dako berep4 #1
    perineurial antigens #1
    pec pecoma #1
    electron microscopy followup #1
    local neoplasms pecomas #1
    s100 antigens #1
    diagnosis synovial translocation #1
    ema mss #1
    pulmonary myxoid #1
    rna extraction rtpcr #1
    patients gemcitabine docetaxel #1
    perineuriallike cells #1
    calponin monophasic tumours #1

    Key People For Soft Tissue

    Top KOLs in the world
    Christopher D M FLETCHER†
    soft tissue situ hybridization fibrous histiocytoma
    Murray, F Brennan
    gastric cancer soft tissue pancreatic adenocarcinoma
    Jean Michel Coindre
    soft tissue french sarcoma situ hybridization
    Cyril FISHER†
    soft tissue synovial sarcoma situ hybridization
    Cristina R Antonescu
    situ hybridization soft tissue gastrointestinal stromal
    James M Woodruff
    synovial sarcoma soft tissue 5 years

    Cyril FISHER†:Expert Impact

    Concepts for whichCyril FISHER†has direct influence:Soft tissue,  Synovial sarcoma,  Epithelioid sarcoma,  Situ hybridization,  Royal marsden hospital,  Prostate cancer,  Soft tissue tumours,  Soft tissue sarcomas.

    Cyril FISHER†:KOL impact

    Concepts related to the work of other authors for whichfor which Cyril FISHER† has influence:Synovial sarcoma,  Soft tissue,  Prostate cancer,  Situ hybridization,  Germ cell,  Human herpesvirus,  Differential diagnosis.



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    Department of Histopathology, 1732University Hospitals Birmingham NHS Foundation Trust, Birmingham, UK. | University Hospitals Birmingham NHS Foundation Trust, Birmingham B15 2GW, UK;, cyrilfisher@gmail.com | Division of Molecular Pathology, The Inst